A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis

While DNA replication and mitosis occur in a sequential manner, precisely how cells maintain their temporal separation and order remains elusive. Here, we unveil a double-negative feedback loop between replication intermediates and an M-phase-specific structure-selective endonuclease, MUS81-SLX4, wh...

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Veröffentlicht in:	Developmental cell Jg. 39; H. 6; S. 740 - 755
Hauptverfasser:	Duda, Heike, Arter, Meret, Gloggnitzer, Jiradet, Teloni, Federico, Wild, Philipp, Blanco, Miguel G, Altmeyer, Matthias, Matos, Joao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.12.2016
Schlagworte:	CDC2 Protein Kinase - metabolism Cell Cycle Proteins - metabolism Cell Death Cell Survival Chromosomes, Human - metabolism DNA Damage DNA Fragmentation DNA Replication DNA-Binding Proteins - metabolism Endonucleases - metabolism HeLa Cells Humans Mitosis Models, Biological Phosphorylation Protein Binding Recombinases - metabolism S Phase MUS81 DNA replication WEE1 SLX4 EME2 cell cycle PLK1 chromosome pulverization CDK1
ISSN:	1878-1551
Online-Zugang:	Weitere Angaben
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