Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease

Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications of sickle cell disease (SCD), including stroke. However, little information exists on the association and interactions for the common African ancestral α-thalassemia mutation (-α3.7 deletion) and β-g...

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Bibliographic Details
Published in:	PLoS genetics Vol. 14; no. 3; p. e1007293
Main Authors:	Raffield, Laura M., Ulirsch, Jacob C., Naik, Rakhi P., Lessard, Samuel, Handsaker, Robert E., Jain, Deepti, Kang, Hyun M., Pankratz, Nathan, Auer, Paul L., Bao, Erik L., Smith, Joshua D., Lange, Leslie A., Lange, Ethan M., Li, Yun, Thornton, Timothy A., Young, Bessie A., Abecasis, Goncalo R., Laurie, Cathy C., Nickerson, Deborah A., McCarroll, Steven A., Correa, Adolfo, Wilson, James G., Lettre, Guillaume, Sankaran, Vijay G., Reiner, Alex P.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.03.2018 Public Library of Science (PLoS)
Subjects:	Adult alpha-Globins - genetics alpha-Thalassemia - genetics Anemia, Sickle Cell - blood Anemia, Sickle Cell - genetics Anemia, Sickle Cell - physiopathology Biology and Life Sciences Black or African American Cohort Studies DNA Copy Number Variations Erythrocytes, Abnormal Glomerular Filtration Rate Glycated Hemoglobin - metabolism Hemoglobin, Sickle - genetics Humans Medicine and Health Sciences People and places Phenotype Sickle Cell Trait Young Adult
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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