7-ketocholesterol induces endothelial-mesenchymal transition and promotes fibrosis: implications in neovascular age-related macular degeneration and treatment

Oxidized cholesterols and lipids accumulate in Bruch’s membrane in age-related macular degeneration (AMD). It remains unknown what causal relationship exists between these substances and AMD pathophysiology. We addressed the hypothesis that a prevalent form, 7-ketocholesterol (7KC), promotes choroid...

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Vydáno v:	Angiogenesis (London) Ročník 24; číslo 3; s. 583 - 595
Hlavní autoři:	Wang, Haibo, Ramshekar, Aniket, Kunz, Eric, Hartnett, M. Elizabeth
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Springer Netherlands 01.08.2021 Springer Nature B.V
Témata:	Actin Age Age related diseases Animals Biomedical and Life Sciences Biomedicine Cadherins Cancer Research Cardiology Cell Biology Cell death Cell migration Cell Movement - drug effects Choroid - blood supply Choroid - metabolism Choroid - pathology Choroidal Neovascularization - chemically induced Choroidal Neovascularization - metabolism Choroidal Neovascularization - pathology Collagen Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Eye diseases Fibroblast activation protein Fibrosis Growth factors Ketocholesterols - adverse effects Ketocholesterols - pharmacology Lesions Lipids Macular degeneration Macular Degeneration - chemically induced Macular Degeneration - metabolism Macular Degeneration - pathology Mesenchyme Mice Muscles Oncology Ophthalmology Original Paper Proteins Rac1 protein Smad3 protein Smooth muscle Transforming growth factor-b Vascular endothelial growth factor Vascularization Choroidal endothelial cells Non-responsive (or unresponsive) neovascular AMD Endothelial-mesenchymal transition Macular fibrosis Age-related macular degeneration 7-ketocholesterol
ISSN:	0969-6970, 1573-7209, 1573-7209
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