The precursors of CD8 + tissue resident memory T cells: from lymphoid organs to infected tissues

CD8 tissue resident memory T cells (T cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to T cell formation are therefore of substantial biomedical interest. Prior work has demonstrated that signals present in the inflamed tissue micro-...

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Bibliographic Details
Published in:Nature reviews. Immunology Vol. 22; no. 5; pp. 283 - 293
Main Authors: Kok, Lianne, Masopust, David, Schumacher, Ton N
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.05.2022
Subjects:
CD8 antigen
CD8-Positive T-Lymphocytes
Cell Differentiation
Cell Lineage
Humans
Immune system
Immunologic Memory
Immunological memory
Inflammation
Lymphocytes
Lymphocytes T
Memory cells
Memory T Cells
Pathogens
Progenitor cells
Tissues
ISSN:1474-1733, 1474-1741, 1474-1741
Online Access:Get full text
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Summary:CD8 tissue resident memory T cells (T cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to T cell formation are therefore of substantial biomedical interest. Prior work has demonstrated that signals present in the inflamed tissue micro-environment can promote the differentiation of memory precursor cells into mature T cells, and it was therefore long assumed that T cell formation adheres to a 'local divergence' model, in which T cell lineage decisions are exclusively made within the tissue. However, a growing body of work provides evidence for a 'systemic divergence' model, in which circulating T cells already become preconditioned to preferentially give rise to the T cell lineage, resulting in the generation of a pool of T cell-poised T cells within the lymphoid compartment. Here, we review the emerging evidence that supports the existence of such a population of circulating T cell progenitors, discuss current insights into their formation and highlight open questions in the field.
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ISSN:1474-1733
1474-1741
1474-1741
DOI:10.1038/s41577-021-00590-3