Latency and interval therapy affect the evolution in metastatic colorectal cancer

While comparison of primary tumor and metastases has highlighted genomic heterogeneity in colorectal cancer (CRC), previous studies have focused on a single metastatic site or limited genomic testing. Combining data from whole exome and ultra-deep targeted sequencing, we explored possible evolutiona...

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Veröffentlicht in:	Scientific reports Jg. 10; H. 1; S. 581
Hauptverfasser:	Nikbakht, Hamid, Jessa, Selin, Sukhai, Mahadeo A., Arseneault, Madeleine, Zhang, Tong, Letourneau, Louis, Thomas, Mariam, Bourgey, Mathieu, Roehrl, Michael H. A., Eveleigh, Robert, Chen, Eric X., Krzyzanowska, Monika, Moore, Malcolm J., Giesler, Amanda, Yu, Celeste, Bedard, Philippe L., Kamel-Reid, Suzanne, Majewski, Jacek, Siu, Lillian L., Riazalhosseini, Yasser, Graham, Donna M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 17.01.2020 Nature Publishing Group
Schlagworte:	45/22 45/23 631/67/69 692/4017 Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics DNA Copy Number Variations DNA Mutational Analysis Evolution Female Gene Frequency Gene Regulatory Networks Genetic Heterogeneity Heterogeneity High-Throughput Nucleotide Sequencing Humanities and Social Sciences Humans Latency Lesions Liver Liver Neoplasms - genetics Liver Neoplasms - secondary Lung cancer Lung Neoplasms - genetics Lung Neoplasms - secondary Male Metastases Metastasis multidisciplinary Mutation Science Science (multidisciplinary) Time Factors Tumors Whole Exome Sequencing
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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