The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond

Epilepsy is one of the most common and disabling chronic neurological disorders. Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic drugs, are the mainstay of symptomatic epilepsy treatment. Epilepsy is a multifaceted complex disease and so is its treatment. Cu...

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Bibliographic Details
Published in:	CNS drugs Vol. 35; no. 9; pp. 935 - 963
Main Authors:	Löscher, Wolfgang, Klein, Pavel
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.09.2021 Springer Nature B.V
Subjects:	Anesthesia Animals Anticonvulsants Anticonvulsants - administration & dosage Anticonvulsants - chemistry Antiepileptic agents Anxiety disorders Bipolar disorder Bromides - administration & dosage Bromides - chemistry Cannabidiol Carbamates - administration & dosage Carbamates - chemistry Central nervous system Chlorophenols - administration & dosage Chlorophenols - chemistry Convulsions & seizures Drug development Drug resistance Drug Therapy, Combination - methods Epilepsy Epilepsy - drug therapy Epilepsy - metabolism Epilepsy - physiopathology Etiology Glutamate receptors Glutamic acid receptors (ionotropic) Headache Humans Ion channels Medical treatment Medicine Medicine & Public Health Migraine Neuralgia Neurological diseases Neurological disorders Neurology Neurosciences Patients Pharmaceutical industry Pharmacokinetics Pharmacology Pharmacotherapy Psychiatry Psychopharmacology Quality of life Regulatory approval Review Review Article Salts Seizures Seizures - drug therapy Seizures - metabolism Seizures - physiopathology Tetrazoles - administration & dosage Tetrazoles - chemistry Traumatic brain injury Treatment Outcome
ISSN:	1172-7047, 1179-1934, 1179-1934
Online Access:	Get full text
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