DNA Damage and Repair Biomarkers of Immunotherapy Response

DNA-damaging agents are widely used in clinical oncology and exploit deficiencies in tumor DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic strategy, the interaction of tumor DNA damage with the immune system has recently come into focus, and it is now clear that t...

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Veröffentlicht in:	Cancer discovery Jg. 7; H. 7; S. 675
Hauptverfasser:	Mouw, Kent W, Goldberg, Michael S, Konstantinopoulos, Panagiotis A, D'Andrea, Alan D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2017
Schlagworte:	Antineoplastic Agents - immunology Antineoplastic Agents - therapeutic use Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology DNA Damage - drug effects DNA Damage - immunology DNA Repair - drug effects DNA Repair - immunology Genomic Instability - drug effects Genomic Instability - immunology Humans Immunotherapy - adverse effects Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy
ISSN:	2159-8290, 2159-8290
Online-Zugang:	Weitere Angaben
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