Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

Organotypic co-cultures bridge the gap between standard two-dimensional culture and mouse models. Such assays increase the fidelity of pre-clinical studies, to better inform lead compound development and address the increasing attrition rates of lead compounds within the pharmaceutical industry, whi...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 16887 - 15
Main Authors:	Conway, James R. W., Vennin, Claire, Cazet, Aurélie S., Herrmann, David, Murphy, Kendelle J., Warren, Sean C., Wullkopf, Lena, Boulghourjian, Alice, Zaratzian, Anaiis, Da Silva, Andrew M., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.12.2017 Nature Publishing Group
Subjects:	13/51 631/67/70 631/80/79/750 Animal models Animals Atomic force microscopy Cancer Cell culture Cell Culture Techniques - methods Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Coculture Techniques Collagen Collagen (type I) Collagen - chemistry Collagen - isolation & purification Extracellular Matrix - metabolism Gefitinib - pharmacology Humanities and Social Sciences Humans Invasiveness Macropodidae - metabolism Mice Microscopy Microscopy, Atomic Force multidisciplinary Pharmaceutical industry Rats Scanning electron microscopy Science Science (multidisciplinary) Tendons - metabolism Tumor cell lines Ultrastructure
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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