Exosome engineering in cell therapy and drug delivery

Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Inflammopharmacology Ročník 31; číslo 1; s. 145 - 169
Hlavní autoři: Sadeghi, Somaye, Tehrani, Fahimeh Ramezani, Tahmasebi, Safa, Shafiee, Abbas, Hashemi, Seyed Mahmoud
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.02.2023
Springer Nature B.V
Témata:
Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Drug Delivery Systems - methods
Exosomes
Gastroenterology
Immunology
Pharmaceutical Preparations
Pharmacology/Toxicology
Review
Rheumatology
Extracellular vesicles
Exosome
Targeted delivery
Therapeutic applications
Cargo incorporation
ISSN:0925-4692, 1568-5608, 1568-5608
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0925-4692
1568-5608
1568-5608
DOI:10.1007/s10787-022-01115-7