Exosome engineering in cell therapy and drug delivery

Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells...

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Vydané v:Inflammopharmacology Ročník 31; číslo 1; s. 145 - 169
Hlavní autori: Sadeghi, Somaye, Tehrani, Fahimeh Ramezani, Tahmasebi, Safa, Shafiee, Abbas, Hashemi, Seyed Mahmoud
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cham Springer International Publishing 01.02.2023
Springer Nature B.V
Predmet:
Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Drug Delivery Systems - methods
Exosomes
Gastroenterology
Immunology
Pharmaceutical Preparations
Pharmacology/Toxicology
Review
Rheumatology
Extracellular vesicles
Exosome
Targeted delivery
Therapeutic applications
Cargo incorporation
ISSN:0925-4692, 1568-5608, 1568-5608
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Abstract Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.
AbstractList Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.
Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.
Author Sadeghi, Somaye
Tahmasebi, Safa
Tehrani, Fahimeh Ramezani
Hashemi, Seyed Mahmoud
Shafiee, Abbas
Author_xml – sequence: 1
  givenname: Somaye
  surname: Sadeghi
  fullname: Sadeghi, Somaye
  organization: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR
– sequence: 2
  givenname: Fahimeh Ramezani
  surname: Tehrani
  fullname: Tehrani, Fahimeh Ramezani
  email: ramezani@endocrine.ac.ir
  organization: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
– sequence: 3
  givenname: Safa
  surname: Tahmasebi
  fullname: Tahmasebi, Safa
  organization: Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences
– sequence: 4
  givenname: Abbas
  surname: Shafiee
  fullname: Shafiee, Abbas
  email: a.shafiee@uq.edu.au
  organization: The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Herston Biofabrication Institute, Metro North Hospital and Health Service
– sequence: 5
  givenname: Seyed Mahmoud
  orcidid: 0000-0003-1389-5803
  surname: Hashemi
  fullname: Hashemi, Seyed Mahmoud
  email: smmhashemi@sbmu.ac.ir
  organization: Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Medical Nanotechnology and tissue engineering Research Center, Shahid Beheshti University of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36609717$$D View this record in MEDLINE/PubMed
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2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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Issue 1
Keywords Extracellular vesicles
Exosome
Targeted delivery
Therapeutic applications
Cargo incorporation
Language English
License 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
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SubjectTerms Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Drug Delivery Systems - methods
Exosomes
Gastroenterology
Immunology
Pharmaceutical Preparations
Pharmacology/Toxicology
Review
Rheumatology
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Title Exosome engineering in cell therapy and drug delivery
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