Exosome engineering in cell therapy and drug delivery

Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells...

Full description

Saved in:
Bibliographic Details
Published in:Inflammopharmacology Vol. 31; no. 1; pp. 145 - 169
Main Authors: Sadeghi, Somaye, Tehrani, Fahimeh Ramezani, Tahmasebi, Safa, Shafiee, Abbas, Hashemi, Seyed Mahmoud
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.02.2023
Springer Nature B.V
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Drug Delivery Systems - methods
Exosomes
Gastroenterology
Immunology
Pharmaceutical Preparations
Pharmacology/Toxicology
Review
Rheumatology
Extracellular vesicles
Exosome
Targeted delivery
Therapeutic applications
Cargo incorporation
ISSN:0925-4692, 1568-5608, 1568-5608
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.
AbstractList Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.
Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low immunogenicity, high physicochemical stability, capacity to penetrate into tissues, and the innate capacity to communicate with other cells over long distances. Exosome-based liquid biopsy has been potentially used for the diagnosis and prognosis of a range of disorders. Exosomes deliver therapeutic agents, including immunological modulators, therapeutic drugs, and antisense oligonucleotides to certain targets, and can be used as vaccines, though their clinical application is still far from reality. Producing exosomes on a large-scale is restricted to their low circulation lifetime, weak targeting capacity, and inappropriate controls, which need to be refined before being implemented in practice. Several bioengineering methods have been used for refining therapeutic applications of exosomes and promoting their effectiveness, on the one hand, and addressing the existing challenges, on the other. In the short run, new diagnostic platforms and emerging therapeutic strategies will further develop exosome engineering and therapeutic potential. This requires a thorough analysis of exosome engineering approaches along with their merits and drawbacks, as outlined in this paper. The present study is a comprehensive review of novel techniques for exosome development in terms of circulation time in the body, targeting capacity, and higher drug loading/delivery efficacies.
Author Sadeghi, Somaye
Tahmasebi, Safa
Tehrani, Fahimeh Ramezani
Hashemi, Seyed Mahmoud
Shafiee, Abbas
Author_xml – sequence: 1
  givenname: Somaye
  surname: Sadeghi
  fullname: Sadeghi, Somaye
  organization: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR
– sequence: 2
  givenname: Fahimeh Ramezani
  surname: Tehrani
  fullname: Tehrani, Fahimeh Ramezani
  email: ramezani@endocrine.ac.ir
  organization: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
– sequence: 3
  givenname: Safa
  surname: Tahmasebi
  fullname: Tahmasebi, Safa
  organization: Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences
– sequence: 4
  givenname: Abbas
  surname: Shafiee
  fullname: Shafiee, Abbas
  email: a.shafiee@uq.edu.au
  organization: The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Herston Biofabrication Institute, Metro North Hospital and Health Service
– sequence: 5
  givenname: Seyed Mahmoud
  orcidid: 0000-0003-1389-5803
  surname: Hashemi
  fullname: Hashemi, Seyed Mahmoud
  email: smmhashemi@sbmu.ac.ir
  organization: Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Medical Nanotechnology and tissue engineering Research Center, Shahid Beheshti University of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36609717$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1P3DAYhK0KVJaPP8ABReqll8Brx5-XShUCWgmJC5wtb_zuYpS1t3aC2H_fhAVaOHCyLD8zmvHsk52YIhJyTOGUAqizQkFpVQNjNVBKRa2-kBkVUtdCgt4hMzBM1Fwatkf2S3kAAKmk-Ur2GinBKKpmRFw8pZJWWGFchoiYQ1xWIVYtdl3V32N2603loq98HpaVxy48Yt4ckt2F6woevZwH5O7y4vb8V319c_X7_Od13XLF-9rrOTDZCPQCuKQolXBeO8fb8SZaxjnouXeLOVNOtN6bRnHjvfCNomJhoDkgP7a-62G-Qt9i7LPr7DqHlcsbm1yw719iuLfL9GiNZg2TajT4_mKQ058BS29XoUzdXMQ0FMuUpEaPYfSIfvuAPqQhx7GebZjgUkr6bHjyf6K3KK8_OgJsC7Q5lZJx8YZQsNNsdjubHWezz7PZSaQ_iNrQuz6kqVXoPpc2W2lZT9th_hf7E9VfZJ2rQA
CitedBy_id crossref_primary_10_1007_s11845_024_03789_0
crossref_primary_10_1007_s12010_025_05309_x
crossref_primary_10_1016_j_mcn_2025_104004
crossref_primary_10_2147_IJN_S420301
crossref_primary_10_1186_s40779_024_00564_1
crossref_primary_10_1002_advs_202309491
crossref_primary_10_1007_s12672_024_01262_z
crossref_primary_10_1021_acsabm_4c01920
crossref_primary_10_1186_s12951_025_03238_9
crossref_primary_10_1016_j_prp_2025_155991
crossref_primary_10_3390_jfb16070255
crossref_primary_10_1080_1061186X_2025_2535375
crossref_primary_10_3390_ijms242417317
crossref_primary_10_1016_j_jddst_2025_107381
crossref_primary_10_1016_j_bcab_2024_103396
crossref_primary_10_1007_s11064_024_04157_1
crossref_primary_10_1016_j_jpha_2025_101261
crossref_primary_10_1186_s12951_025_03589_3
crossref_primary_10_3390_separations10030218
crossref_primary_10_2174_0109298665347753241028072130
crossref_primary_10_1002_jex2_70064
crossref_primary_10_1007_s12013_024_01357_y
crossref_primary_10_1016_j_canlet_2025_218034
crossref_primary_10_1016_j_prenap_2024_100053
crossref_primary_10_3390_biomedicines12081806
crossref_primary_10_1016_j_omton_2024_200800
crossref_primary_10_1039_D4NR02191F
crossref_primary_10_1155_sci_4888569
crossref_primary_10_3390_pharmaceutics17010051
crossref_primary_10_1016_j_ejphar_2025_178042
crossref_primary_10_1016_j_jconrel_2023_11_057
crossref_primary_10_1016_j_jphotobiol_2025_113125
crossref_primary_10_1016_j_jconrel_2025_02_033
crossref_primary_10_1016_j_brainresbull_2025_111256
crossref_primary_10_1097_TP_0000000000005309
crossref_primary_10_1016_j_biomaterials_2025_123552
crossref_primary_10_1016_j_fbio_2025_105985
crossref_primary_10_3389_fimmu_2023_1090416
crossref_primary_10_1093_burnst_tkae023
crossref_primary_10_3389_fcell_2024_1344705
crossref_primary_10_3390_ijms25010060
crossref_primary_10_3390_ijms25074024
crossref_primary_10_3390_biology14091112
crossref_primary_10_1002_adhm_202403531
crossref_primary_10_1021_acsabm_5c00096
crossref_primary_10_3390_vaccines12020200
crossref_primary_10_1007_s10238_025_01659_2
crossref_primary_10_1186_s12935_025_03795_x
crossref_primary_10_3390_ijms25126533
crossref_primary_10_1080_17435889_2025_2493037
crossref_primary_10_34172_apb_2024_052
crossref_primary_10_1016_j_ejpb_2024_114298
crossref_primary_10_3390_bioengineering12050525
crossref_primary_10_1016_j_molimm_2025_04_008
crossref_primary_10_3389_fbioe_2023_1215650
crossref_primary_10_1016_j_jddst_2025_106607
crossref_primary_10_62347_KIXF4662
crossref_primary_10_1016_j_drup_2024_101058
crossref_primary_10_1186_s12935_024_03456_5
crossref_primary_10_12677_jcpm_2025_42218
crossref_primary_10_3390_cells12141826
crossref_primary_10_1016_j_apsb_2024_05_010
crossref_primary_10_3390_biomedicines13010233
crossref_primary_10_1002_bmm2_70012
crossref_primary_10_2147_IJN_S445101
crossref_primary_10_1016_j_drup_2025_101275
crossref_primary_10_3389_fonc_2024_1458616
crossref_primary_10_1016_j_cej_2025_160915
crossref_primary_10_1007_s12032_025_02852_9
crossref_primary_10_1016_j_bcp_2025_117019
crossref_primary_10_1002_ijc_35241
crossref_primary_10_3390_antiox12061210
crossref_primary_10_1016_j_bioactmat_2025_02_018
crossref_primary_10_1016_j_apsb_2025_03_040
crossref_primary_10_1080_1061186X_2025_2546492
crossref_primary_10_3390_ijms25116187
crossref_primary_10_3389_fcell_2025_1561856
crossref_primary_10_1002_adhm_202500795
crossref_primary_10_1016_j_mtbio_2025_102267
crossref_primary_10_1016_j_tice_2025_102749
crossref_primary_10_1186_s12967_024_06029_2
crossref_primary_10_1016_j_bioactmat_2024_04_007
crossref_primary_10_3390_encyclopedia3010021
crossref_primary_10_1016_j_jddst_2025_106740
crossref_primary_10_2147_IJN_S463145
crossref_primary_10_1186_s12967_025_06522_2
crossref_primary_10_1016_j_intimp_2024_112732
crossref_primary_10_1016_j_jddst_2025_107033
crossref_primary_10_1111_cpr_13677
crossref_primary_10_1002_ddr_70025
crossref_primary_10_20517_evcna_2025_07
crossref_primary_10_2147_IJN_S453739
crossref_primary_10_3389_fneur_2023_1324216
crossref_primary_10_1016_j_biopha_2024_117248
crossref_primary_10_1002_mco2_709
crossref_primary_10_2174_0113816128338023241210140702
crossref_primary_10_3389_fcell_2025_1608480
crossref_primary_10_3390_ijms24087647
crossref_primary_10_3390_ijms25137151
crossref_primary_10_1039_D5MH00593K
crossref_primary_10_1016_j_ijbiomac_2025_147724
crossref_primary_10_1038_s41392_025_02312_w
crossref_primary_10_1182_bloodadvances_2023012464
crossref_primary_10_1016_j_jddst_2024_105562
crossref_primary_10_3390_vaccines12030280
crossref_primary_10_1080_07853890_2025_2534851
crossref_primary_10_1186_s12967_024_05338_w
crossref_primary_10_1021_acsabm_5c00288
crossref_primary_10_1016_j_biopha_2024_117296
crossref_primary_10_1016_j_jddst_2025_107340
crossref_primary_10_3390_biomedicines12010123
crossref_primary_10_3390_pharmaceutics16060709
crossref_primary_10_3389_fimmu_2023_1161628
crossref_primary_10_3390_ijms25168762
crossref_primary_10_1002_smll_202401990
crossref_primary_10_1021_acsnano_5c07135
crossref_primary_10_2147_IJN_S547834
crossref_primary_10_3390_pharmaceutics15051465
crossref_primary_10_3390_biomedicines12081842
crossref_primary_10_1186_s12935_025_03900_0
crossref_primary_10_1039_D5PM00097A
crossref_primary_10_1080_21645515_2024_2345940
crossref_primary_10_3389_fbioe_2024_1428793
crossref_primary_10_1016_j_jddst_2024_106259
crossref_primary_10_3389_fcvm_2024_1436764
crossref_primary_10_1186_s13046_025_03371_1
crossref_primary_10_1002_mco2_660
crossref_primary_10_1002_advs_202401069
crossref_primary_10_1111_1759_7714_15495
crossref_primary_10_1186_s13287_025_04548_3
crossref_primary_10_1016_j_jcyt_2023_09_003
crossref_primary_10_1002_advs_202507974
crossref_primary_10_1016_j_omtn_2024_102128
crossref_primary_10_1016_j_jddst_2024_105571
crossref_primary_10_2147_IJN_S502591
crossref_primary_10_1186_s12935_023_02990_y
crossref_primary_10_1002_mef2_70031
crossref_primary_10_1002_jev2_70097
crossref_primary_10_1186_s12964_024_01870_w
crossref_primary_10_59717_j_xinn_med_2025_100132
crossref_primary_10_1093_gastro_goaf024
crossref_primary_10_1007_s10787_024_01438_7
crossref_primary_10_1007_s10565_024_09867_4
crossref_primary_10_2147_IJN_S498599
crossref_primary_10_1016_j_colsurfb_2025_114661
crossref_primary_10_1016_j_bbcan_2024_189238
crossref_primary_10_3390_ijms26125828
crossref_primary_10_3390_ijms241813767
crossref_primary_10_3390_foods13050712
crossref_primary_10_1016_j_ijbiomac_2025_145463
crossref_primary_10_1186_s12967_025_06578_0
crossref_primary_10_3390_vaccines12060670
crossref_primary_10_1016_j_jconrel_2025_113620
crossref_primary_10_1186_s12951_024_02852_3
crossref_primary_10_1016_j_ecoenv_2025_119006
crossref_primary_10_1002_advs_202407850
crossref_primary_10_1016_j_intimp_2025_115136
crossref_primary_10_3390_life15010070
crossref_primary_10_1007_s12032_025_02626_3
crossref_primary_10_1097_jagr_0000000000000024
crossref_primary_10_1186_s13287_025_04517_w
crossref_primary_10_3389_fmed_2025_1599392
crossref_primary_10_1186_s13287_024_04125_0
crossref_primary_10_1016_j_jare_2025_06_024
crossref_primary_10_1186_s40104_025_01247_0
crossref_primary_10_1007_s12672_024_01007_y
crossref_primary_10_1186_s12645_025_00334_1
crossref_primary_10_1002_advs_202304389
crossref_primary_10_1186_s12951_025_03352_8
crossref_primary_10_1016_j_drudis_2024_104061
crossref_primary_10_1016_j_lfs_2024_123108
crossref_primary_10_1016_j_apmt_2024_102395
crossref_primary_10_1016_j_prp_2024_155785
crossref_primary_10_2147_IJN_S529311
crossref_primary_10_1007_s12265_023_10438_x
crossref_primary_10_3390_brainsci14090899
crossref_primary_10_3390_cancers17132186
crossref_primary_10_1007_s12672_024_00974_6
crossref_primary_10_3390_bios14060307
crossref_primary_10_3389_fbioe_2024_1363780
crossref_primary_10_4252_wjsc_v17_i7_107080
crossref_primary_10_1007_s12272_023_01477_8
crossref_primary_10_2147_IJN_S451642
crossref_primary_10_3390_pharmaceutics16081029
crossref_primary_10_3390_genes15111423
crossref_primary_10_1007_s10157_024_02536_0
crossref_primary_10_1186_s12943_024_02215_4
Cites_doi 10.1038/nmat2442
10.1093/cvr/cvz040
10.1016/j.matdes.2020.108805
10.3389/fbioe.2021.701504
10.18632/oncotarget.2301
10.1039/D0RA02414G
10.7150/thno.30853
10.1021/acsami.0c10458
10.4049/jimmunol.1600731
10.3390/v13081499
10.1080/08820139.2020.1801720
10.1021/acs.biomac.7b01176
10.1021/acsnano.6b07607
10.1038/nbt.1807
10.1002/adma.202005709
10.3389/fcell.2021.751079
10.3389/fimmu.2021.711565
10.1021/bc500291r
10.2217/nnm.13.206
10.1021/acsami.6b14633
10.1016/j.jconrel.2014.11.029
10.1016/j.biomaterials.2019.05.004
10.1039/D0TB00744G
10.1161/JAHA.118.008737
10.1007/s00018-016-2309-8
10.1021/acsnano.5b06939
10.1002/adtp.201900111
10.1080/2331205X.2019.1635806
10.3389/fcell.2021.754630
10.1016/j.apsb.2016.02.001
10.3390/bioengineering5020048
10.1038/s41598-016-0001-8
10.3389/fsufs.2019.00023
10.3389/fphar.2020.590470
10.1080/10717544.2020.1748758
10.1021/acs.molpharmaceut.5b00144
10.1038/srep10112
10.1007/s12035-014-9054-5
10.1021/acsbiomaterials.1c00868
10.1111/cpr.12956
10.1248/bpb.b18-00133
10.3390/nano12030524
10.1021/acsami.7b06464
10.3389/fimmu.2018.00738
10.3390/biomedicines9081061
10.1002/adfm.201909125
10.1002/sctm.20-0197
10.1080/20013078.2019.1648995
10.1016/j.intimp.2019.105879
10.2217/nnm-2016-0102
10.1002/jev2.12057
10.1007/s11064-019-02925-y
10.1021/acs.chemrev.1c00484
10.1002/sctm.18-0226
10.1039/C5NR07144E
10.1016/j.nano.2018.05.020
10.1039/C8NR03970D
10.1039/C7NR04425A
10.3389/fcell.2020.00737
10.1186/s12951-019-0560-5
10.1021/nn404501g
10.1016/j.jacc.2017.11.013
10.1016/j.biomaterials.2020.120539
10.1080/07388551.2020.1805406
10.1186/s12964-019-0390-y
10.1038/aps.2017.12
10.1016/j.biomaterials.2013.11.083
10.1016/j.tibtech.2017.03.004
10.1016/j.biomaterials.2019.119475
10.1007/s11302-009-9132-8
10.1186/s41544-019-0034-9
10.1007/s13765-018-0394-0
10.5812/ans.98722
10.1016/j.bioactmat.2020.12.008
10.1007/s13770-021-00361-0
10.1080/20013078.2020.1816710
10.7150/thno.52570
10.1126/science.aau6977
10.1002/cbic.202100359
10.1016/j.actbio.2018.12.045
10.1021/acs.molpharmaceut.8b00901
10.1080/20013078.2018.1522236
10.1038/s41569-020-0389-5
10.1615/CritRevTherDrugCarrierSyst.2021036301
10.3390/ijms18061122
10.1002/jcb.26099
10.1080/20013078.2017.1422676
10.1016/j.jcyt.2018.02.311
10.2147/IJN.S133430
10.1021/acsami.7b18135
10.1007/s10616-016-9952-7
10.7150/ijbs.53671
10.1186/s13045-021-01141-y
10.3389/fbioe.2020.586130
10.3390/pharmaceutics10040218
10.1007/s12010-018-2813-4
10.1080/1061186X.2021.1894436
10.1016/j.bioactmat.2020.09.011
10.1016/j.biomaterials.2013.09.052
10.1039/C9NR02791B
10.1016/j.ajps.2019.04.002
10.1016/j.jare.2021.01.001
10.1016/j.biomaterials.2018.06.029
10.3390/polym13152529
10.3390/polym12123044
10.1186/s13578-019-0282-2
10.3389/fphar.2015.00286
10.1038/nri855
10.7150/thno.17092
10.1021/acs.nanolett.8b02689
10.3390/jcm10040711
10.1186/s13024-017-0165-0
10.3390/pr9020356
10.1016/j.jconrel.2020.12.053
10.3402/jev.v5.31053
10.3389/fbioe.2020.00997
10.1021/acs.chemmater.9b00050
10.3389/fimmu.2022.993967
10.1016/j.febslet.2004.06.082
10.26508/lsa.202000875
10.1039/C9NR05865F
10.1016/j.lfs.2020.118493
10.1016/j.bioactmat.2019.11.002
10.1021/acs.analchem.8b05204
10.1038/s41598-019-46407-1
10.1016/j.biomaterials.2016.09.031
10.1186/s13287-020-01920-3
10.1021/bc050308l
10.2147/IJN.S154458
10.3390/pharmaceutics14030653
10.1007/s11101-010-9183-z
10.1016/j.jbiotec.2013.03.013
10.3390/cancers13174435
10.3390/ijms22179543
10.1016/j.nano.2017.09.011
10.1158/0008-5472.CAN-17-2880
10.2147/OTT.S173110
10.1016/j.addr.2020.04.004
10.1016/j.jconrel.2019.11.009
10.3390/nano11061481
10.1038/nbt.3330
10.1016/j.impact.2020.100261
10.1016/j.omtm.2018.03.008
10.1007/s13346-021-01087-1
10.1111/bph.15432
10.1016/j.biomaterials.2017.10.012
10.1002/mabi.201900042
10.1038/s41565-017-0012-z
10.1039/C7NR06966A
10.1002/mrm.25376
10.1016/j.jconrel.2020.07.042
10.3389/fchem.2022.910341
10.2147/IJN.S264498
10.1038/mt.2012.180
10.1016/j.ijpharm.2021.121087
10.1080/20013078.2018.1440131
10.1039/D2RA02351B
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023.
The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Copyright_xml – notice: The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
– notice: 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
– notice: The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023.
– notice: The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X7
7XB
8FE
8FH
8FI
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GNUQQ
HCIFZ
LK8
M7P
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
7X8
5PM
DOI 10.1007/s10787-022-01115-7
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
ProQuest Biological Science Collection
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
SciTech Premium Collection
ProQuest One Community College
ProQuest Hospital Collection
ProQuest One Health & Nursing
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Complete
ProQuest Health & Medical Research Collection
Health Research Premium Collection
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
ProQuest Central Student

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
EISSN 1568-5608
EndPage 169
ExternalDocumentID PMC9823267
36609717
10_1007_s10787_022_01115_7
Genre Journal Article
Review
GroupedDBID ---
-Y2
-~C
.86
.VR
06C
06D
0R~
0VY
1N0
1SB
2.D
203
28-
29I
29~
2J2
2JN
2JY
2KG
2KM
2LR
2VQ
2~H
30V
36B
4.4
406
408
40D
40E
53G
5GY
5VS
67Z
6NX
8TC
8UJ
95-
95.
95~
96X
AABHQ
AACDK
AAHNG
AAIAL
AAJBT
AAJKR
AANXM
AANZL
AAPKM
AARHV
AARTL
AASML
AATNV
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
ABAKF
ABBBX
ABBRH
ABDBE
ABDBF
ABDZT
ABECU
ABFTV
ABHLI
ABHQN
ABIPD
ABJNI
ABJOX
ABKCH
ABKTR
ABMNI
ABMQK
ABNWP
ABPLI
ABQBU
ABQSL
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABWNU
ABXPI
ACAOD
ACDTI
ACGFS
ACHSB
ACHXU
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPIV
ACSNA
ACUHS
ACZOJ
ADHHG
ADHIR
ADHKG
ADJJI
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADYPR
ADZKW
AEBTG
AEFQL
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AEMSY
AENEX
AEOHA
AEPYU
AESKC
AETLH
AEVLU
AEVUW
AEXYK
AFBBN
AFDZB
AFEXP
AFLOW
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGDS
AGJBK
AGMZJ
AGQEE
AGQMX
AGQPQ
AGRTI
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHIZS
AHKAY
AHPBZ
AHSBF
AHYZX
AIAKS
AIGIU
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMFWP
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AYFIA
AZFZN
B-.
B0M
BA0
BBWZM
BDATZ
BGNMA
BSONS
CAG
COF
CS3
CSCUP
DDRTE
DNIVK
DPUIP
DU5
EAP
EAS
EBLON
EBS
EIOEI
EJD
EMB
EMK
EMOBN
EN4
ESBYG
EST
ESX
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ7
H13
HF~
HG5
HG6
HMJXF
HRMNR
HVGLF
HZ~
IHE
IJ-
IKXTQ
IMOTQ
ITM
IWAJR
IXC
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JZLTJ
KAT
KDC
KOV
KPH
LLZTM
M4Y
MA-
MK0
N2Q
NB0
NDZJH
NF0
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OVD
P19
P9S
PF0
PT4
PT5
QOK
QOR
QOS
R4E
R89
R9I
RHV
RNI
ROL
RPX
RSV
RZK
S16
S1Z
S26
S27
S28
S37
S3B
SAP
SBL
SBY
SCLPG
SDH
SDM
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TSG
TSK
TSV
TT1
TUC
TUS
U2A
U9L
UG4
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WK8
YLTOR
Z45
ZMTXR
ZOVNA
~8M
~A9
~EX
63Z
7X7
8FI
AAYXX
ABFSG
ABRTQ
ACSTC
AEZWR
AFFHD
AFHIU
AFKRA
AFOHR
AHWEU
AIXLP
ATHPR
BBNVY
BENPR
BHPHI
CCPQU
CITATION
FYUFA
HCIFZ
HMCUK
M7P
PHGZM
PHGZT
PQGLB
UKHRP
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FE
8FH
AZQEC
DWQXO
GNUQQ
LK8
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
7X8
5PM
ID FETCH-LOGICAL-c474t-d8b02635ed50461e675ad8aa4c4615c24408bdafb27a5cdd93749dd5d3715f903
IEDL.DBID RSV
ISICitedReferencesCount 213
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000910809100004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0925-4692
1568-5608
IngestDate Tue Nov 04 02:06:39 EST 2025
Thu Sep 04 17:55:01 EDT 2025
Tue Oct 07 07:40:34 EDT 2025
Mon Jul 21 06:03:39 EDT 2025
Tue Nov 18 22:30:50 EST 2025
Sat Nov 29 08:01:14 EST 2025
Thu Apr 10 07:09:00 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Extracellular vesicles
Exosome
Targeted delivery
Therapeutic applications
Cargo incorporation
Language English
License 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-d8b02635ed50461e675ad8aa4c4615c24408bdafb27a5cdd93749dd5d3715f903
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0003-1389-5803
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC9823267
PMID 36609717
PQID 3254666167
PQPubID 7435111
PageCount 25
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9823267
proquest_miscellaneous_2761986158
proquest_journals_3254666167
pubmed_primary_36609717
crossref_primary_10_1007_s10787_022_01115_7
crossref_citationtrail_10_1007_s10787_022_01115_7
springer_journals_10_1007_s10787_022_01115_7
PublicationCentury 2000
PublicationDate 2023-02-01
PublicationDateYYYYMMDD 2023-02-01
PublicationDate_xml – month: 02
  year: 2023
  text: 2023-02-01
  day: 01
PublicationDecade 2020
PublicationPlace Cham
PublicationPlace_xml – name: Cham
– name: Switzerland
– name: Dordrecht
PublicationSubtitle Experimental and Therapeutic Studies
PublicationTitle Inflammopharmacology
PublicationTitleAbbrev Inflammopharmacol
PublicationTitleAlternate Inflammopharmacology
PublicationYear 2023
Publisher Springer International Publishing
Springer Nature B.V
Publisher_xml – name: Springer International Publishing
– name: Springer Nature B.V
References D Bellavia (1115_CR10) 2017; 7
A Aryani (1115_CR6) 2016; 53
T Yamashita (1115_CR154) 2018; 41
LT Schiller (1115_CR126) 2018; 9
L Duan (1115_CR26) 2021; 22
X Xu (1115_CR153) 2021; 269
KB Johnsen (1115_CR56) 2016; 68
J Bai (1115_CR8) 2020; 15
ES Choi (1115_CR20) 2019; 19
G Kim (1115_CR61) 2020; 317
L Zhu (1115_CR164) 2017; 9
J Phan (1115_CR109) 2018; 7
N Parada (1115_CR104) 2021; 8;31
J Ghitman (1115_CR38) 2020; 193
R Rahbarghazi (1115_CR114) 2019; 17
X Luan (1115_CR85) 2017; 38
JP Armstrong (1115_CR5) 2017; 11
G Fuhrmann (1115_CR35) 2015; 205
G Jia (1115_CR53) 2018; 178
Y Tian (1115_CR136) 2014; 35
OM Elsharkasy (1115_CR31) 2020; 159
M Ahmad (1115_CR1) 2013; 2
W Wei (1115_CR146) 2021; 11
M Taghavi-Farahabadi (1115_CR132) 2021; 50
1115_CR30
T Tian (1115_CR137) 2018; 150
MI Mosquera-Heredia (1115_CR98) 2021; 9
A Butreddy (1115_CR13) 2021; 11
T Kanuma (1115_CR58) 2017; 198
Z Ye (1115_CR156) 2018; 10
J Wang (1115_CR141) 2017; 9
G Liang (1115_CR76) 2020; 18
YT Sato (1115_CR125) 2016; 6
Z Li (1115_CR74) 2020; 9
TC Pham (1115_CR108) 2021; 10
J Wang (1115_CR142) 2017; 9
Y Cao (1115_CR14) 2019; 13
CK Das (1115_CR23) 2018; 16
Y Han (1115_CR45) 2021; 9
D Jafari (1115_CR51) 2020; 40
Y Mima (1115_CR93) 2015; 12
MK White (1115_CR148) 2017; 118
D Egger (1115_CR29) 2018; 5
K Laulagnier (1115_CR68) 2004; 572
M Morishita (1115_CR97) 2016; 111
A Dutta (1115_CR28) 2022; 4
Y Liang (1115_CR77) 2020; 12
S Modani (1115_CR94) 2021; 29
X Wang (1115_CR143) 2018; 7
A Ferrero-Andrés (1115_CR32) 2020; 12
NP Hessvik (1115_CR47) 2016; 73
G Baek (1115_CR7) 2019; 8
RC de Abreu (1115_CR25) 2020; 17
L Hu (1115_CR49) 2015; 74
L Sercombe (1115_CR127) 2015; 6
JL Hood (1115_CR48) 2016; 11
NL Syn (1115_CR131) 2017; 35
G De (1115_CR24) 2014; 5
T Smyth (1115_CR130) 2014; 25
Z Li (1115_CR73) 2018; 19
D Chen (1115_CR16) 2021
H Choi (1115_CR21) 2021; 18
K Park (1115_CR106) 2013; 7
1115_CR115
X Yu (1115_CR157) 2014; 35
JY Kim (1115_CR59) 2018; 61
Y Yang (1115_CR155) 2018; 7
M Maumus (1115_CR88) 2020; 8
S Rayamajhi (1115_CR116) 2020; 8
B-C Lee (1115_CR70) 2021; 10
MS Kim (1115_CR60) 2018; 14
Y Zhou (1115_CR163) 2019; 1
Y Jiang (1115_CR55) 2020; 54
W Nan (1115_CR101) 2022; 11;10
A Shafiee (1115_CR128) 2021; 10
C Liu (1115_CR81) 2019; 9
P Akuma (1115_CR2) 2019; 3
B-C Lee (1115_CR69) 2020; 11
J Zou (1115_CR167) 2019; 91
A Longatti (1115_CR84) 2018; 10
SA Kooijmans (1115_CR65) 2016; 5
C Meyer (1115_CR92) 2017; 12
Y Liang (1115_CR78) 2021; 11
Y Qu (1115_CR113) 2009; 5
Z Weng (1115_CR147) 2021; 14
SA Kooijmans (1115_CR64) 2012; 7
S Sadeghi (1115_CR119) 2020; 1; 262
1115_CR124
E Marbán (1115_CR87) 2018; 71
M Moloudizargari (1115_CR95) 2022; 13
Y Li (1115_CR72) 2018; 14
X Jia (1115_CR54) 2021; 7
S Fu (1115_CR33) 2020; 20
J Zhao (1115_CR162) 2019; 115
S Zhang (1115_CR160) 2021; 6
H Wei (1115_CR145) 2021; 17
B Balachandran (1115_CR9) 2019; 6
W Liao (1115_CR79) 2019; 86
KM McAndrews (1115_CR89) 2021; 19;4
F Said Hassane (1115_CR120) 2006; 17
Y Wan (1115_CR140) 2018; 78
W Meng (1115_CR90) 2020; 27
KI Mentkowski (1115_CR91) 2019; 9
H Kim (1115_CR63) 2021; 13
J Liu (1115_CR82) 2019; 223
Z Wu (1115_CR150) 2021; 6
SC Carreira (1115_CR15) 2016; 8
H Chen (1115_CR18) 2021; 8;9
SA Kooijmans (1115_CR66) 2018; 10
SG Antimisiaris (1115_CR4) 2018; 10
S Sadeghi (1115_CR118) 2020; 80
WJ Goh (1115_CR40) 2018; 19
SC Jang (1115_CR52) 2014; 9
I Nakase (1115_CR100) 2015; 5
X Zhang (1115_CR161) 2021; 33
N Kučuk (1115_CR67) 2021; 22
G Liang (1115_CR75) 2018; 13
D Perocheau (1115_CR107) 2021; 178
D Ha (1115_CR44) 2016; 6
J Zimmermann (1115_CR166) 2018; 20
Y Zhang (1115_CR159) 2020; 15
M Zhuang (1115_CR165) 2020; 12
L Taiariol (1115_CR133) 2021; 122
SK Limoni (1115_CR80) 2019; 187
J He (1115_CR46) 2021; 12
K Wang (1115_CR144) 2021; 9
F Pi (1115_CR110) 2018; 13
S Salunkhe (1115_CR122) 2020; 326
KE Gilligan (1115_CR39) 2017; 18
DW Hwang (1115_CR50) 2019; 2
SLP Sajnani (1115_CR121) 2021; 25;608
J Lee (1115_CR71) 2022; 12
A Gorshkov (1115_CR42) 2022; 12
Y Zhang (1115_CR158) 2019; 9
C Théry (1115_CR135) 2002; 2
L Vymetalova (1115_CR139) 2020; 45
E Blanco (1115_CR11) 2015; 33
P García-Manrique (1115_CR36) 2018; 7
M Liu (1115_CR83) 2021; 9
H Cheng (1115_CR19) 2019; 211
PKF Damasceno (1115_CR22) 2020; 8
L Alvarez-Erviti (1115_CR3) 2011; 29
M Xu (1115_CR152) 2020; 11;8
MÁ Brennan (1115_CR12) 2020; 30
M Sancho-Albero (1115_CR123) 2020; 10
1115_CR96
SA Dusoswa (1115_CR27) 2019; 8
A Gebeyehu (1115_CR37) 2021; 38
Y Takahashi (1115_CR134) 2013; 165
A Von Schulze (1115_CR138) 2020; 6
E-R N’Diaye (1115_CR99) 2022; 14
S-I Ohno (1115_CR103) 2013; 21
I Podolak (1115_CR111) 2010; 9
N Parada (1115_CR105) 2021; 31
R Kalluri (1115_CR57) 2020; 7;367(6478)
FX Guix (1115_CR43) 2017; 12
E Willms (1115_CR149) 2018; 9
Y Xu (1115_CR151) 2019; 4
H Gomari (1115_CR41) 2018; 11
H Qi (1115_CR112) 2016; 10
JJ Richardson (1115_CR117) 2019; 31
Z-W Luo (1115_CR86) 2019; 11
M Shafiei (1115_CR129) 2021; 13
G Kim (1115_CR62) 2021; 330
1115_CR17
AE Nel (1115_CR102) 2009; 8
References_xml – volume: 8
  start-page: 543
  issue: 7
  year: 2009
  ident: 1115_CR102
  publication-title: Nat Mater
  doi: 10.1038/nmat2442
– volume: 115
  start-page: 1205
  issue: 7
  year: 2019
  ident: 1115_CR162
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvz040
– volume: 193
  year: 2020
  ident: 1115_CR38
  publication-title: Mater Des
  doi: 10.1016/j.matdes.2020.108805
– volume: 9
  start-page: 701504
  year: 2021
  ident: 1115_CR83
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2021.701504
– volume: 5
  start-page: 7734
  issue: 17
  year: 2014
  ident: 1115_CR24
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.2301
– volume: 10
  start-page: 23975
  issue: 40
  year: 2020
  ident: 1115_CR123
  publication-title: RSC Adv
  doi: 10.1039/D0RA02414G
– volume: 9
  start-page: 1015
  issue: 4
  year: 2019
  ident: 1115_CR81
  publication-title: Theranostics
  doi: 10.7150/thno.30853
– volume: 12
  start-page: 36938
  issue: 33
  year: 2020
  ident: 1115_CR77
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.0c10458
– volume: 198
  start-page: 4707
  issue: 12
  year: 2017
  ident: 1115_CR58
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1600731
– ident: 1115_CR96
  doi: 10.3390/v13081499
– volume: 50
  start-page: 1042
  issue: 8
  year: 2021
  ident: 1115_CR132
  publication-title: Immunol Invest
  doi: 10.1080/08820139.2020.1801720
– volume: 19
  start-page: 22
  issue: 1
  year: 2018
  ident: 1115_CR40
  publication-title: Biomacromol
  doi: 10.1021/acs.biomac.7b01176
– volume: 11
  start-page: 69
  issue: 1
  year: 2017
  ident: 1115_CR5
  publication-title: ACS Nano
  doi: 10.1021/acsnano.6b07607
– volume: 29
  start-page: 341
  issue: 4
  year: 2011
  ident: 1115_CR3
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1807
– volume: 33
  start-page: 2005709
  issue: 14
  year: 2021
  ident: 1115_CR161
  publication-title: Adv Mater
  doi: 10.1002/adma.202005709
– ident: 1115_CR17
  doi: 10.3389/fcell.2021.751079
– ident: 1115_CR124
  doi: 10.3389/fimmu.2021.711565
– volume: 25
  start-page: 1777
  issue: 10
  year: 2014
  ident: 1115_CR130
  publication-title: Bioconjug Chem
  doi: 10.1021/bc500291r
– volume: 9
  start-page: 177
  issue: 2
  year: 2014
  ident: 1115_CR52
  publication-title: Nanomedicine
  doi: 10.2217/nnm.13.206
– volume: 9
  start-page: 5100
  issue: 6
  year: 2017
  ident: 1115_CR164
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.6b14633
– volume: 205
  start-page: 35
  year: 2015
  ident: 1115_CR35
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2014.11.029
– volume: 211
  start-page: 14
  year: 2019
  ident: 1115_CR19
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.05.004
– volume: 8
  start-page: 4552
  issue: 21
  year: 2020
  ident: 1115_CR116
  publication-title: J Mater Chem B
  doi: 10.1039/D0TB00744G
– volume: 7
  issue: 15
  year: 2018
  ident: 1115_CR143
  publication-title: J Am Heart Assoc
  doi: 10.1161/JAHA.118.008737
– volume: 73
  start-page: 4717
  issue: 24
  year: 2016
  ident: 1115_CR47
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-016-2309-8
– volume: 10
  start-page: 3323
  issue: 3
  year: 2016
  ident: 1115_CR112
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b06939
– volume: 2
  start-page: 1900111
  issue: 11
  year: 2019
  ident: 1115_CR50
  publication-title: Adv Ther
  doi: 10.1002/adtp.201900111
– volume: 6
  start-page: 1635806
  issue: 1
  year: 2019
  ident: 1115_CR9
  publication-title: Cogent Med
  doi: 10.1080/2331205X.2019.1635806
– volume: 9
  start-page: 754630
  year: 2021
  ident: 1115_CR144
  publication-title: Fron Cell Dev Biol
  doi: 10.3389/fcell.2021.754630
– volume: 6
  start-page: 287
  issue: 4
  year: 2016
  ident: 1115_CR44
  publication-title: Acta Pharmaceutica Sinica B
  doi: 10.1016/j.apsb.2016.02.001
– volume: 5
  start-page: 48
  issue: 2
  year: 2018
  ident: 1115_CR29
  publication-title: Bioengineering
  doi: 10.3390/bioengineering5020048
– volume: 6
  start-page: 1
  issue: 1
  year: 2016
  ident: 1115_CR125
  publication-title: Sci Rep
  doi: 10.1038/s41598-016-0001-8
– volume: 3
  start-page: 23
  year: 2019
  ident: 1115_CR2
  publication-title: Front Sustain Food Syst
  doi: 10.3389/fsufs.2019.00023
– volume: 11
  start-page: 1954
  year: 2021
  ident: 1115_CR146
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2020.590470
– volume: 27
  start-page: 585
  issue: 1
  year: 2020
  ident: 1115_CR90
  publication-title: Drug Deliv
  doi: 10.1080/10717544.2020.1748758
– volume: 12
  start-page: 2429
  issue: 7
  year: 2015
  ident: 1115_CR93
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.5b00144
– volume: 5
  start-page: 1
  issue: 1
  year: 2015
  ident: 1115_CR100
  publication-title: Sci Rep
  doi: 10.1038/srep10112
– volume: 53
  start-page: 818
  issue: 2
  year: 2016
  ident: 1115_CR6
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-014-9054-5
– volume: 7
  start-page: 4430
  issue: 9
  year: 2021
  ident: 1115_CR54
  publication-title: ACS Biomater Sci Eng
  doi: 10.1021/acsbiomaterials.1c00868
– volume: 54
  start-page: e12956
  issue: 1
  year: 2020
  ident: 1115_CR55
  publication-title: Cell Prolif
  doi: 10.1111/cpr.12956
– volume: 41
  start-page: 835
  issue: 6
  year: 2018
  ident: 1115_CR154
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b18-00133
– volume: 12
  start-page: 524
  issue: 3
  year: 2022
  ident: 1115_CR42
  publication-title: Nanomaterials
  doi: 10.3390/nano12030524
– volume: 9
  start-page: 27441
  issue: 33
  year: 2017
  ident: 1115_CR142
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.7b06464
– volume-title: Potential of surface modified exosomes for extended intravitreal drug delivery
  year: 2021
  ident: 1115_CR16
– volume: 9
  start-page: 738
  year: 2018
  ident: 1115_CR149
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00738
– volume: 9
  start-page: 1061
  issue: 8
  year: 2021
  ident: 1115_CR98
  publication-title: Biomedicines
  doi: 10.3390/biomedicines9081061
– volume: 30
  start-page: 1909125
  issue: 37
  year: 2020
  ident: 1115_CR12
  publication-title: Adv Func Mater
  doi: 10.1002/adfm.201909125
– volume: 10
  start-page: 27
  issue: 1
  year: 2021
  ident: 1115_CR128
  publication-title: Stem Cells Transl Med
  doi: 10.1002/sctm.20-0197
– volume: 8
  start-page: 1648995
  issue: 1
  year: 2019
  ident: 1115_CR27
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2019.1648995
– volume: 80
  year: 2020
  ident: 1115_CR118
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2019.105879
– volume: 11
  start-page: 1745
  issue: 13
  year: 2016
  ident: 1115_CR48
  publication-title: Nanomedicine
  doi: 10.2217/nnm-2016-0102
– volume: 10
  issue: 4
  year: 2021
  ident: 1115_CR108
  publication-title: J Extracell Vesicles
  doi: 10.1002/jev2.12057
– volume: 45
  start-page: 204
  issue: 1
  year: 2020
  ident: 1115_CR139
  publication-title: Neurochem Res
  doi: 10.1007/s11064-019-02925-y
– volume: 122
  start-page: 340
  issue: 1
  year: 2021
  ident: 1115_CR133
  publication-title: Chem Rev
  doi: 10.1021/acs.chemrev.1c00484
– volume: 8
  start-page: 880
  issue: 9
  year: 2019
  ident: 1115_CR7
  publication-title: Stem Cells Transl Med
  doi: 10.1002/sctm.18-0226
– volume: 8
  start-page: 7474
  issue: 14
  year: 2016
  ident: 1115_CR15
  publication-title: Nanoscale
  doi: 10.1039/C5NR07144E
– volume: 14
  start-page: 1973
  issue: 7
  year: 2018
  ident: 1115_CR72
  publication-title: Nanomed Nanotechnol Biol Med
  doi: 10.1016/j.nano.2018.05.020
– volume: 10
  start-page: 14230
  issue: 29
  year: 2018
  ident: 1115_CR84
  publication-title: Nanoscale
  doi: 10.1039/C8NR03970D
– volume: 9
  start-page: 15598
  issue: 40
  year: 2017
  ident: 1115_CR141
  publication-title: Nanoscale
  doi: 10.1039/C7NR04425A
– volume: 8
  start-page: 737
  year: 2020
  ident: 1115_CR22
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2020.00737
– volume: 18
  start-page: 1
  issue: 1
  year: 2020
  ident: 1115_CR76
  publication-title: J Nanobiotechnol
  doi: 10.1186/s12951-019-0560-5
– volume: 7
  start-page: 7442
  issue: 9
  year: 2013
  ident: 1115_CR106
  publication-title: ACS Nano
  doi: 10.1021/nn404501g
– ident: 1115_CR115
– volume: 71
  start-page: 193
  issue: 2
  year: 2018
  ident: 1115_CR87
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2017.11.013
– volume: 269
  year: 2021
  ident: 1115_CR153
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120539
– volume: 40
  start-page: 1098
  issue: 8
  year: 2020
  ident: 1115_CR51
  publication-title: Crit Rev Biotechnol
  doi: 10.1080/07388551.2020.1805406
– volume: 17
  start-page: 1
  issue: 1
  year: 2019
  ident: 1115_CR114
  publication-title: Cell Commun Signal
  doi: 10.1186/s12964-019-0390-y
– volume: 7
  start-page: 1525
  year: 2012
  ident: 1115_CR64
  publication-title: Int J Nanomed
– volume: 38
  start-page: 754
  issue: 6
  year: 2017
  ident: 1115_CR85
  publication-title: Acta Pharmacol Sin
  doi: 10.1038/aps.2017.12
– volume: 35
  start-page: 2383
  issue: 7
  year: 2014
  ident: 1115_CR136
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.11.083
– volume: 35
  start-page: 665
  issue: 7
  year: 2017
  ident: 1115_CR131
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2017.03.004
– volume: 223
  year: 2019
  ident: 1115_CR82
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.119475
– volume: 5
  start-page: 163
  issue: 2
  year: 2009
  ident: 1115_CR113
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-009-9132-8
– volume: 1
  start-page: 1
  issue: 1
  year: 2019
  ident: 1115_CR163
  publication-title: ExRNA
  doi: 10.1186/s41544-019-0034-9
– volume: 61
  start-page: 599
  issue: 6
  year: 2018
  ident: 1115_CR59
  publication-title: Appl Biol Chem
  doi: 10.1007/s13765-018-0394-0
– ident: 1115_CR30
  doi: 10.5812/ans.98722
– volume: 6
  start-page: 1957
  issue: 7
  year: 2021
  ident: 1115_CR160
  publication-title: Bioact Mater
  doi: 10.1016/j.bioactmat.2020.12.008
– volume: 18
  start-page: 499
  issue: 4
  year: 2021
  ident: 1115_CR21
  publication-title: Tissue Eng Regener Med
  doi: 10.1007/s13770-021-00361-0
– volume: 9
  start-page: 1816710
  issue: 1
  year: 2020
  ident: 1115_CR74
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2020.1816710
– volume: 6
  start-page: 42
  year: 2020
  ident: 1115_CR138
  publication-title: J Cancer Metastasis Treat
– volume: 11
  start-page: 3183
  issue: 7
  year: 2021
  ident: 1115_CR78
  publication-title: Theranostics
  doi: 10.7150/thno.52570
– volume: 7;367(6478)
  start-page: eaau6977
  year: 2020
  ident: 1115_CR57
  publication-title: Science
  doi: 10.1126/science.aau6977
– volume: 4
  start-page: 939197
  year: 2022
  ident: 1115_CR28
  publication-title: Nanotechnol
– volume: 22
  start-page: 3360
  issue: 24
  year: 2021
  ident: 1115_CR26
  publication-title: ChemBioChem
  doi: 10.1002/cbic.202100359
– volume: 86
  start-page: 1
  year: 2019
  ident: 1115_CR79
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2018.12.045
– volume: 16
  start-page: 24
  issue: 1
  year: 2018
  ident: 1115_CR23
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.8b00901
– volume: 13
  start-page: 1499
  issue: 2
  year: 2019
  ident: 1115_CR14
  publication-title: ACS Nano
– volume: 7
  start-page: 1522236
  issue: 1
  year: 2018
  ident: 1115_CR109
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2018.1522236
– volume: 17
  start-page: 685
  issue: 11
  year: 2020
  ident: 1115_CR25
  publication-title: Nat Rev Cardiol
  doi: 10.1038/s41569-020-0389-5
– volume: 38
  start-page: 53
  issue: 5
  year: 2021
  ident: 1115_CR37
  publication-title: Crit Rev Ther Drug Carrier Syst
  doi: 10.1615/CritRevTherDrugCarrierSyst.2021036301
– volume: 18
  start-page: 1122
  issue: 6
  year: 2017
  ident: 1115_CR39
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18061122
– volume: 118
  start-page: 3586
  issue: 11
  year: 2017
  ident: 1115_CR148
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.26099
– volume: 7
  start-page: 1422676
  issue: 1
  year: 2018
  ident: 1115_CR36
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2017.1422676
– volume: 20
  start-page: S106
  issue: 5
  year: 2018
  ident: 1115_CR166
  publication-title: Cytotherapy
  doi: 10.1016/j.jcyt.2018.02.311
– volume: 12
  start-page: 3153
  year: 2017
  ident: 1115_CR92
  publication-title: Int J Nanomed
  doi: 10.2147/IJN.S133430
– volume: 10
  start-page: 12341
  issue: 15
  year: 2018
  ident: 1115_CR156
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.7b18135
– volume: 68
  start-page: 2125
  issue: 5
  year: 2016
  ident: 1115_CR56
  publication-title: Cytotechnology
  doi: 10.1007/s10616-016-9952-7
– volume: 17
  start-page: 163
  issue: 1
  year: 2021
  ident: 1115_CR145
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.53671
– volume: 14
  start-page: 1
  issue: 1
  year: 2021
  ident: 1115_CR147
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-021-01141-y
– volume: 11;8
  start-page: 586130
  year: 2020
  ident: 1115_CR152
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2020.586130
– volume: 10
  start-page: 218
  issue: 4
  year: 2018
  ident: 1115_CR4
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics10040218
– volume: 187
  start-page: 352
  issue: 1
  year: 2019
  ident: 1115_CR80
  publication-title: Appl Biochem Biotechnol
  doi: 10.1007/s12010-018-2813-4
– volume: 29
  start-page: 925
  issue: 9
  year: 2021
  ident: 1115_CR94
  publication-title: J Drug Target
  doi: 10.1080/1061186X.2021.1894436
– volume: 6
  start-page: 823
  issue: 3
  year: 2021
  ident: 1115_CR150
  publication-title: Bioact Mater
  doi: 10.1016/j.bioactmat.2020.09.011
– volume: 35
  start-page: 278
  issue: 1
  year: 2014
  ident: 1115_CR157
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.09.052
– volume: 11
  start-page: 20884
  issue: 43
  year: 2019
  ident: 1115_CR86
  publication-title: Nanoscale
  doi: 10.1039/C9NR02791B
– volume: 15
  start-page: 461
  issue: 4
  year: 2020
  ident: 1115_CR8
  publication-title: Asian J Pharm Sci
  doi: 10.1016/j.ajps.2019.04.002
– volume: 8;31
  start-page: 61
  year: 2021
  ident: 1115_CR104
  publication-title: J Adv Res
  doi: 10.1016/j.jare.2021.01.001
– volume: 178
  start-page: 302
  year: 2018
  ident: 1115_CR53
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.06.029
– volume: 13
  start-page: 2529
  issue: 15
  year: 2021
  ident: 1115_CR129
  publication-title: Polymers
  doi: 10.3390/polym13152529
– volume: 12
  start-page: 3044
  issue: 12
  year: 2020
  ident: 1115_CR32
  publication-title: Polymers
  doi: 10.3390/polym12123044
– volume: 9
  start-page: 1
  issue: 1
  year: 2019
  ident: 1115_CR158
  publication-title: Cell Biosci
  doi: 10.1186/s13578-019-0282-2
– volume: 6
  start-page: 286
  year: 2015
  ident: 1115_CR127
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2015.00286
– volume: 2
  start-page: 569
  issue: 8
  year: 2002
  ident: 1115_CR135
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri855
– volume: 7
  start-page: 1333
  issue: 5
  year: 2017
  ident: 1115_CR10
  publication-title: Theranostics
  doi: 10.7150/thno.17092
– volume: 19
  start-page: 19
  issue: 1
  year: 2018
  ident: 1115_CR73
  publication-title: Nano Lett
  doi: 10.1021/acs.nanolett.8b02689
– volume: 10
  start-page: 711
  issue: 4
  year: 2021
  ident: 1115_CR70
  publication-title: J Clin Med
  doi: 10.3390/jcm10040711
– volume: 8;9
  start-page: 751079
  year: 2021
  ident: 1115_CR18
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.751079
– volume: 12
  start-page: 1
  issue: 1
  year: 2017
  ident: 1115_CR43
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-017-0165-0
– volume: 9
  start-page: 356
  issue: 2
  year: 2021
  ident: 1115_CR45
  publication-title: Processes
  doi: 10.3390/pr9020356
– volume: 330
  start-page: 684
  year: 2021
  ident: 1115_CR62
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.12.053
– volume: 5
  start-page: 31053
  issue: 1
  year: 2016
  ident: 1115_CR65
  publication-title: J Extracell Vesicles
  doi: 10.3402/jev.v5.31053
– volume: 8
  start-page: 997
  year: 2020
  ident: 1115_CR88
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2020.00997
– volume: 31
  start-page: 2191
  issue: 7
  year: 2019
  ident: 1115_CR117
  publication-title: Chem Mater
  doi: 10.1021/acs.chemmater.9b00050
– volume: 13
  start-page: 993967
  year: 2022
  ident: 1115_CR95
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.993967
– volume: 572
  start-page: 11
  issue: 1–3
  year: 2004
  ident: 1115_CR68
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2004.06.082
– volume: 19;4
  start-page: e202000875
  issue: 9
  year: 2021
  ident: 1115_CR89
  publication-title: Life Sci Alliance
  doi: 10.26508/lsa.202000875
– volume: 12
  start-page: 173
  issue: 1
  year: 2020
  ident: 1115_CR165
  publication-title: Nanoscale
  doi: 10.1039/C9NR05865F
– volume: 1; 262
  start-page: 118493
  year: 2020
  ident: 1115_CR119
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2020.118493
– volume: 4
  start-page: 366
  year: 2019
  ident: 1115_CR151
  publication-title: Bioact Mater
  doi: 10.1016/j.bioactmat.2019.11.002
– volume: 91
  start-page: 2425
  issue: 3
  year: 2019
  ident: 1115_CR167
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.8b05204
– volume: 9
  start-page: 1
  issue: 1
  year: 2019
  ident: 1115_CR91
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-46407-1
– volume: 111
  start-page: 55
  year: 2016
  ident: 1115_CR97
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2016.09.031
– volume: 11
  start-page: 1
  issue: 1
  year: 2020
  ident: 1115_CR69
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-020-01920-3
– volume: 17
  start-page: 849
  issue: 3
  year: 2006
  ident: 1115_CR120
  publication-title: Bioconjug Chem
  doi: 10.1021/bc050308l
– volume: 13
  start-page: 585
  year: 2018
  ident: 1115_CR75
  publication-title: Int J Nanomed
  doi: 10.2147/IJN.S154458
– volume: 14
  start-page: 653
  issue: 3
  year: 2022
  ident: 1115_CR99
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics14030653
– volume: 9
  start-page: 425
  issue: 3
  year: 2010
  ident: 1115_CR111
  publication-title: Phytochem Rev
  doi: 10.1007/s11101-010-9183-z
– volume: 165
  start-page: 77
  issue: 2
  year: 2013
  ident: 1115_CR134
  publication-title: J Biotechnol
  doi: 10.1016/j.jbiotec.2013.03.013
– volume: 13
  start-page: 4435
  issue: 17
  year: 2021
  ident: 1115_CR63
  publication-title: Cancers
  doi: 10.3390/cancers13174435
– volume: 22
  start-page: 9543
  issue: 17
  year: 2021
  ident: 1115_CR67
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms22179543
– volume: 14
  start-page: 195
  issue: 1
  year: 2018
  ident: 1115_CR60
  publication-title: Nanomed Nanotechnol Biol Med
  doi: 10.1016/j.nano.2017.09.011
– volume: 78
  start-page: 798
  issue: 3
  year: 2018
  ident: 1115_CR140
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-17-2880
– volume: 11
  start-page: 5753
  year: 2018
  ident: 1115_CR41
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S173110
– volume: 159
  start-page: 332
  year: 2020
  ident: 1115_CR31
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2020.04.004
– volume: 317
  start-page: 273
  year: 2020
  ident: 1115_CR61
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2019.11.009
– volume: 11
  start-page: 1481
  issue: 6
  year: 2021
  ident: 1115_CR13
  publication-title: Nanomaterials
  doi: 10.3390/nano11061481
– volume: 33
  start-page: 941
  issue: 9
  year: 2015
  ident: 1115_CR11
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.3330
– volume: 20
  start-page: 100261
  year: 2020
  ident: 1115_CR33
  publication-title: NanoImpact
  doi: 10.1016/j.impact.2020.100261
– volume: 9
  start-page: 278
  year: 2018
  ident: 1115_CR126
  publication-title: Mol Therapy-Methods Clin Dev
  doi: 10.1016/j.omtm.2018.03.008
– volume: 12
  start-page: 2385
  issue: 10
  year: 2021
  ident: 1115_CR46
  publication-title: Drug Deliv Transl Res
  doi: 10.1007/s13346-021-01087-1
– volume: 178
  start-page: 2375
  issue: 12
  year: 2021
  ident: 1115_CR107
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.15432
– volume: 150
  start-page: 137
  year: 2018
  ident: 1115_CR137
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2017.10.012
– volume: 31
  start-page: 61
  year: 2021
  ident: 1115_CR105
  publication-title: J Adv Res
  doi: 10.1016/j.jare.2021.01.001
– volume: 2
  start-page: 13
  issue: 4
  year: 2013
  ident: 1115_CR1
  publication-title: J Pharm Altern Med
– volume: 19
  start-page: 1900042
  issue: 7
  year: 2019
  ident: 1115_CR20
  publication-title: Macromol Biosci
  doi: 10.1002/mabi.201900042
– volume: 13
  start-page: 82
  issue: 1
  year: 2018
  ident: 1115_CR110
  publication-title: Nat Nanotechnol
  doi: 10.1038/s41565-017-0012-z
– volume: 10
  start-page: 2413
  issue: 5
  year: 2018
  ident: 1115_CR66
  publication-title: Nanoscale
  doi: 10.1039/C7NR06966A
– volume: 74
  start-page: 266
  issue: 1
  year: 2015
  ident: 1115_CR49
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.25376
– volume: 326
  start-page: 599
  year: 2020
  ident: 1115_CR122
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.07.042
– volume: 11;10
  start-page: 910341
  year: 2022
  ident: 1115_CR101
  publication-title: Front Chem
  doi: 10.3389/fchem.2022.910341
– volume: 15
  start-page: 6917
  year: 2020
  ident: 1115_CR159
  publication-title: Int J Nanomed
  doi: 10.2147/IJN.S264498
– volume: 21
  start-page: 185
  issue: 1
  year: 2013
  ident: 1115_CR103
  publication-title: Mol Ther
  doi: 10.1038/mt.2012.180
– volume: 25;608
  start-page: 121087
  year: 2021
  ident: 1115_CR121
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2021.121087
– volume: 7
  start-page: 1440131
  issue: 1
  year: 2018
  ident: 1115_CR155
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2018.1440131
– volume: 12
  start-page: 18475
  issue: 29
  year: 2022
  ident: 1115_CR71
  publication-title: RSC Adv
  doi: 10.1039/D2RA02351B
SSID ssj0006769
Score 2.652403
SecondaryResourceType review_article
Snippet Cell-derived exosomes have opened new horizons in modern therapy for advanced drug delivery and therapeutic applications, due to their key features such as low...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 145
SubjectTerms Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Drug Delivery Systems - methods
Exosomes
Gastroenterology
Immunology
Pharmaceutical Preparations
Pharmacology/Toxicology
Review
Rheumatology
SummonAdditionalLinks – databaseName: Biological Science Database
  dbid: M7P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB50FfHi-7G-iCBe3OD2lbQnEXHxouxBwVtJk1QXtNXtrrj_3kybbVlFLx5LEpJ0JsmXzMw3ACcGYSvteJwi-jUXlJDRiImUOpp7qfBEN01kmWyC392Fj49R3z64Fdatcronlhu1yiW-kZ97SNxuDhPGL97eKWaNQuuqTaExDwvIkuCVrnv9eidG982Sa881w2CRa4NmbOicUVWKvuyYbT2gfPZg-oE2fzpNfrOclgdSb_W_U1mDFQtFyWWlO-swp7MNWLq1xvYNOO1XtNaTDrlvorSKDjkl_YbwerIJwfVnXuSvmuiG3JAMMoJGAVIFeE2IyBRRw_ETUfoFfUEmW_DQu76_uqE2HQOVPvdHVIVJF6lrtAqQpV2bq4ZQoRC-NF-BdDF3daJEmrhcBFIpA3z8SKlAedwJ0qjrbUMryzO9C0SFqc-6ibmZK-2jO5YbsUS6jg44N6CDtcGZyiKWlqscU2a8xA3LMsovNvKLS_nFvA1ndZu3iqnjz9oHU9nEdtUWcSOYNhzXxWa94f8Smc7HReziu09oJhy2YafSiLo7jzGk5DKt-Yyu1BWQy3u2JBs8l5zeUWigLfbbmWpVM6zfZ7H39yz2Ydk1mKxyMj-A1mg41oewKD9Gg2J4VK6VL90zGKA
  priority: 102
  providerName: ProQuest
Title Exosome engineering in cell therapy and drug delivery
URI https://link.springer.com/article/10.1007/s10787-022-01115-7
https://www.ncbi.nlm.nih.gov/pubmed/36609717
https://www.proquest.com/docview/3254666167
https://www.proquest.com/docview/2761986158
https://pubmed.ncbi.nlm.nih.gov/PMC9823267
Volume 31
WOSCitedRecordID wos000910809100004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1568-5608
  dateEnd: 20241207
  omitProxy: false
  ssIdentifier: ssj0006769
  issn: 0925-4692
  databaseCode: M7P
  dateStart: 20230101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1568-5608
  dateEnd: 20241207
  omitProxy: false
  ssIdentifier: ssj0006769
  issn: 0925-4692
  databaseCode: 7X7
  dateStart: 20230101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1568-5608
  dateEnd: 20241207
  omitProxy: false
  ssIdentifier: ssj0006769
  issn: 0925-4692
  databaseCode: BENPR
  dateStart: 20230101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1568-5608
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0006769
  issn: 0925-4692
  databaseCode: RSV
  dateStart: 19970101
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dT9swED_xpWkvg8EYHVAZCfFCIzVftvO4TUW8rIr4Ut8iJ3agEkunpkX0v-cun3QwpPESKbIdx-dz_HPu7ncAx4iwtbFdYRH6xQOK5FbAVWrZRripclU_jZMi2YQYDuVoFIRVUFhee7vXJsniS_0s2A2VyyLvc8qP7ltiFdZxu5O0HC8ub5rvLzltFgx7DnbOA6cKlXn9Gcvb0QuM-dJV8i97abENnW2-bwBb8KmCnex7qSefYcVk2_DhV2VY34aTsKSwXvTYVRuRlffYCQtbcuvFDviDx0k--W2YaYkM2ThjZABgZTDXgqlMMz2d3zJt7snvY_EFrs8GVz_PrSr1gpV4wptZWsZ9oqkx2idGdoPHCqWlUl6Cd37iUJ7qWKs0doTyE60R5HiB1r52he2nQd_dhbVskpk9YFqmHu_HeArXxiPXKyfgceLYxhcCAQbvgF3PQJRUvOSUHuM-ahmVSXARCi4qBBeJDpw2bf6UrBxv1j6oJzaqVmgeuZQIAMEJx-KjphjXFslLZWYyzyOH_vFIHLDswNdSD5ruXM6JfgtbiyUNaSoQb_dySTa-K_i7A4kwlvrt1XrSvta_R_Ht_6rvw0cH8VjpYH4Aa7Pp3BzCRvIwG-fTLqyKkSiusgvrPwbD8KJLbq9ht1hLT_HVEuc
linkProvider Springer Nature
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgigXHqXAQgEjQS9sROIkdnJACEGrVm1Xe1ikvQUndtqVSlI2u0D-VH9jZ_LUUtFbDxyjPMf5PB7b33wD8BYjbG0cV1oU_eIEJRBWKFRqOUa6qXKVncZJVWxCjkbBdBqO1-CizYUhWmXrEytHrfOE1sg_uCTcjoOJkJ_Of1pUNYp2V9sSGjUsDk35G6dsxceDr_h_33G-tzv5sm81VQWsxJPewtJBbJMCi9E-iY0bjJiVDpTyEjzyE04lmGOt0phL5Sda4_jthVr72pWOn4a2i8-9BbfRj0uikMlpN8GziS5aaftxNFuEvEnSaVL1sGtYxJ2n6u6-JVcHwivR7VWS5l87tdUAuPfgf2u6h3C_CbXZ57pvPII1k23C3eOGTLAJO-NatrscskmfhVYM2Q4b94Le5WPwd__kRf7DMNOLN7JZxmjTg9UJbCVTmWZ6vjxh2pwR16Xcgm83Yt0TWM_yzDwDpoPUE3YsQlsbj-hmPBRxwh3jS4lBlRiA0_77KGm02KkkyFnUq0gTXiLES1ThJZIDeN_dc14rkVx79XaLhajxSkXUA2EAb7rT6E-ovVRm8mURcVrXCtDgYABPawR2r3OFIMkxvFuuYLO7gLTKV89ks9NKszwMMHSn9w5bFPef9W8rnl9vxWvY2J8cH0VHB6PDF3CPY_xZE-q3YX0xX5qXcCf5tZgV81dVP2Xw_abRfQl4-HUv
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwED6Ngqa9MChsFLZhJLQXGq35ZSeP09ZqCKgq0aG9WU7sQKWRVE2L1v9-d0marOuGhHiMbMf2-Rx_F999B_AREbY2tissQr9ooATcCrlKLNsIN1Gu6iVRXCSbEMNhcHUVju5E8Rfe7qsryTKmgVia0vnJVCcndwLfUNEs8kSnXOm-JZ7AU4-SBpG9_v1H_S0mB86Cbc_BgfDQqcJmHn7H-tG0gTc33Sbv3Z0WR9Jg9_8n8wKeV3CUnZb68xK2TNqG7W_VhXsbjkcltfWyy8ZNpFbeZcds1JBeL1-B37_J8uy3YaYhOGSTlNHFACuDvJZMpZrp2eIn0-aa_EGWr-Fy0B-fXVhVSgYr9oQ3t3QQ9Yi-xmifmNoNmhtKB0p5MT75sUP5qyOtksgRyo-1RvDjhVr72hW2n4Q9dw9aaZaaN8B0kHi8F6F1ro1HLllOyKPYsY0vBAIP3gF7tRoyrvjKKW3GtWyYlklwEgUnC8FJ0YFPdZtpydbx19oHq0WW1c7NpUsJAhC0cCz-UBfjniN5qdRki1w69O8nwAkHHdgvdaLuzuWcaLmwtVjTlroC8Xmvl6STXwWvdxggvKV-uyudaYb1-Cze_lv197A9Oh_Ir5-HX97BjoOQrfRBP4DWfLYwh_As_jOf5LOjYiPdAo_JGlE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exosome+engineering+in+cell+therapy+and+drug+delivery&rft.jtitle=Inflammopharmacology&rft.au=Sadeghi%2C+Somaye&rft.au=Tehrani%2C+Fahimeh+Ramezani&rft.au=Tahmasebi%2C+Safa&rft.au=Shafiee%2C+Abbas&rft.date=2023-02-01&rft.issn=1568-5608&rft.eissn=1568-5608&rft.volume=31&rft.issue=1&rft.spage=145&rft_id=info:doi/10.1007%2Fs10787-022-01115-7&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0925-4692&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0925-4692&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0925-4692&client=summon