Cellular degradation systems in ferroptosis

In eukaryotic cells, macromolecular homeostasis requires selective degradation of damaged units by the ubiquitin-proteasome system (UPS) and autophagy. Thus, dysfunctional degradation systems contribute to multiple pathological processes. Ferroptosis is a type of iron-dependent oxidative cell death...

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Bibliographic Details
Published in:	Cell death and differentiation Vol. 28; no. 4; pp. 1135 - 1148
Main Authors:	Chen, Xin, Yu, Chunhua, Kang, Rui, Kroemer, Guido, Tang, Daolin
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2021
Subjects:	Animals Antioxidants Autophagic Cell Death - physiology Autophagy Autophagy - physiology Cell death Circadian rhythms Degradation Ferritin Ferroptosis Ferroptosis - physiology Glutathione HMGB1 protein Homeostasis Humans Lipid peroxidation Lipids Lysosomes - metabolism Lysosomes - pathology Macromolecules Molecular Chaperones - metabolism Phagocytosis Proteasomes Repressors Signal Transduction - physiology TOR protein Ubiquitin
ISSN:	1350-9047, 1476-5403, 1476-5403
Online Access:	Get full text
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