Characteristics of emergency patients with markedly elevated D-dimer levels

Background: Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them. Methods: D-dimer was detected in consecutive 813 patients entering the emergency d...

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Vydáno v:	Scientific reports Ročník 10; číslo 1; s. 7784
Hlavní autoři:	Tang, Ning, Pan, Yinyin, Xu, Chao, Li, Dengju
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 08.05.2020 Nature Publishing Group
Témata:	631/45 692/53 Adolescent Adult Aged Aged, 80 and over Anticoagulants Antithrombin Biomarkers Blood Coagulation Disorders - blood Blood Coagulation Disorders - diagnosis Blood Coagulation Disorders - etiology Blood Coagulation Disorders - therapy Child Differential diagnosis Disease Susceptibility Emergencies Emergency medical care Emergency medical services Emergency Service, Hospital Female Fibrin Fibrinogen Degradation Products - metabolism Health risk assessment Humanities and Social Sciences Humans Male Malignancy Middle Aged Mortality multidisciplinary Patients Plasmin Science Science (multidisciplinary) Sepsis Stroke Thrombin Thromboembolism Thrombomodulin Trauma Young Adult
ISSN:	2045-2322, 2045-2322
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Abstract	Background: Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them. Methods: D-dimer was detected in consecutive 813 patients entering the emergency department of our hospital, for the patients with D-dimer levels above 5.0 µg/mL, the final diagnoses and 28-day mortality were confirmed, and the levels of thrombomodulin (TM), thrombin-antithrombin complex (TAT) and plasmin-antiplasmin complex (PAP) on admission were detected. Results: There were 148 emergency patients with D-dimer levels higher than 5.0 µg/mL mainly due to sepsis, malignancy, trauma, venous thromboembolism (VTE), cerebrovascular accident, and so on. Both of the TM and TAT levels among these diagnoses were significantly different ( p < 0.001). The elevated TM (>13.3 TU/mL) had a predictive value of 96.0% for excluding VTE, and the normal TM had a predictive value of 90.4% for excluding sepsis. The overall 28-day mortality of these patients with D-dimer >5.0 ug/mL was 14.2%, the TAT level on admission was independently associated with 28-day mortality (odds ratio 1.014, 95% CI 1.001–1.027, P = 0.030). Conclusions: The medical emergencies associated with markedly elevated D-dimer levels were revealed, specific markers of endothelial dysfunction and thrombin generation measured by automatic analyzer have the potential to distinguish diagnoses and predict outcomes in these patients.
AbstractList	Background: Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them. Methods: D-dimer was detected in consecutive 813 patients entering the emergency department of our hospital, for the patients with D-dimer levels above 5.0 µg/mL, the final diagnoses and 28-day mortality were confirmed, and the levels of thrombomodulin (TM), thrombin-antithrombin complex (TAT) and plasmin-antiplasmin complex (PAP) on admission were detected. Results: There were 148 emergency patients with D-dimer levels higher than 5.0 µg/mL mainly due to sepsis, malignancy, trauma, venous thromboembolism (VTE), cerebrovascular accident, and so on. Both of the TM and TAT levels among these diagnoses were significantly different (p < 0.001). The elevated TM (>13.3 TU/mL) had a predictive value of 96.0% for excluding VTE, and the normal TM had a predictive value of 90.4% for excluding sepsis. The overall 28-day mortality of these patients with D-dimer >5.0 ug/mL was 14.2%, the TAT level on admission was independently associated with 28-day mortality (odds ratio 1.014, 95% CI 1.001–1.027, P = 0.030). Conclusions: The medical emergencies associated with markedly elevated D-dimer levels were revealed, specific markers of endothelial dysfunction and thrombin generation measured by automatic analyzer have the potential to distinguish diagnoses and predict outcomes in these patients. Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them.BACKGROUNDMarkedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them.D-dimer was detected in consecutive 813 patients entering the emergency department of our hospital, for the patients with D-dimer levels above 5.0 µg/mL, the final diagnoses and 28-day mortality were confirmed, and the levels of thrombomodulin (TM), thrombin-antithrombin complex (TAT) and plasmin-antiplasmin complex (PAP) on admission were detected.METHODSD-dimer was detected in consecutive 813 patients entering the emergency department of our hospital, for the patients with D-dimer levels above 5.0 µg/mL, the final diagnoses and 28-day mortality were confirmed, and the levels of thrombomodulin (TM), thrombin-antithrombin complex (TAT) and plasmin-antiplasmin complex (PAP) on admission were detected.There were 148 emergency patients with D-dimer levels higher than 5.0 µg/mL mainly due to sepsis, malignancy, trauma, venous thromboembolism (VTE), cerebrovascular accident, and so on. Both of the TM and TAT levels among these diagnoses were significantly different (p < 0.001). The elevated TM (>13.3 TU/mL) had a predictive value of 96.0% for excluding VTE, and the normal TM had a predictive value of 90.4% for excluding sepsis. The overall 28-day mortality of these patients with D-dimer >5.0 ug/mL was 14.2%, the TAT level on admission was independently associated with 28-day mortality (odds ratio 1.014, 95% CI 1.001-1.027, P = 0.030).RESULTSThere were 148 emergency patients with D-dimer levels higher than 5.0 µg/mL mainly due to sepsis, malignancy, trauma, venous thromboembolism (VTE), cerebrovascular accident, and so on. Both of the TM and TAT levels among these diagnoses were significantly different (p < 0.001). The elevated TM (>13.3 TU/mL) had a predictive value of 96.0% for excluding VTE, and the normal TM had a predictive value of 90.4% for excluding sepsis. The overall 28-day mortality of these patients with D-dimer >5.0 ug/mL was 14.2%, the TAT level on admission was independently associated with 28-day mortality (odds ratio 1.014, 95% CI 1.001-1.027, P = 0.030).The medical emergencies associated with markedly elevated D-dimer levels were revealed, specific markers of endothelial dysfunction and thrombin generation measured by automatic analyzer have the potential to distinguish diagnoses and predict outcomes in these patients.CONCLUSIONSThe medical emergencies associated with markedly elevated D-dimer levels were revealed, specific markers of endothelial dysfunction and thrombin generation measured by automatic analyzer have the potential to distinguish diagnoses and predict outcomes in these patients. Background: Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them. Methods: D-dimer was detected in consecutive 813 patients entering the emergency department of our hospital, for the patients with D-dimer levels above 5.0 µg/mL, the final diagnoses and 28-day mortality were confirmed, and the levels of thrombomodulin (TM), thrombin-antithrombin complex (TAT) and plasmin-antiplasmin complex (PAP) on admission were detected. Results: There were 148 emergency patients with D-dimer levels higher than 5.0 µg/mL mainly due to sepsis, malignancy, trauma, venous thromboembolism (VTE), cerebrovascular accident, and so on. Both of the TM and TAT levels among these diagnoses were significantly different ( p < 0.001). The elevated TM (>13.3 TU/mL) had a predictive value of 96.0% for excluding VTE, and the normal TM had a predictive value of 90.4% for excluding sepsis. The overall 28-day mortality of these patients with D-dimer >5.0 ug/mL was 14.2%, the TAT level on admission was independently associated with 28-day mortality (odds ratio 1.014, 95% CI 1.001–1.027, P = 0.030). Conclusions: The medical emergencies associated with markedly elevated D-dimer levels were revealed, specific markers of endothelial dysfunction and thrombin generation measured by automatic analyzer have the potential to distinguish diagnoses and predict outcomes in these patients. Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy, rapid differential diagnosis was crucial for them. D-dimer was detected in consecutive 813 patients entering the emergency department of our hospital, for the patients with D-dimer levels above 5.0 µg/mL, the final diagnoses and 28-day mortality were confirmed, and the levels of thrombomodulin (TM), thrombin-antithrombin complex (TAT) and plasmin-antiplasmin complex (PAP) on admission were detected. There were 148 emergency patients with D-dimer levels higher than 5.0 µg/mL mainly due to sepsis, malignancy, trauma, venous thromboembolism (VTE), cerebrovascular accident, and so on. Both of the TM and TAT levels among these diagnoses were significantly different (p < 0.001). The elevated TM (>13.3 TU/mL) had a predictive value of 96.0% for excluding VTE, and the normal TM had a predictive value of 90.4% for excluding sepsis. The overall 28-day mortality of these patients with D-dimer >5.0 ug/mL was 14.2%, the TAT level on admission was independently associated with 28-day mortality (odds ratio 1.014, 95% CI 1.001-1.027, P = 0.030). The medical emergencies associated with markedly elevated D-dimer levels were revealed, specific markers of endothelial dysfunction and thrombin generation measured by automatic analyzer have the potential to distinguish diagnoses and predict outcomes in these patients.
ArticleNumber	7784
Author	Li, Dengju Pan, Yinyin Tang, Ning Xu, Chao
Author_xml	– sequence: 1 givenname: Ning surname: Tang fullname: Tang, Ning email: tonyjesus@126.com organization: Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 2 givenname: Yinyin surname: Pan fullname: Pan, Yinyin organization: Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 3 givenname: Chao surname: Xu fullname: Xu, Chao organization: Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 4 givenname: Dengju surname: Li fullname: Li, Dengju organization: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
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Cites_doi	10.1016/j.thromres.2018.01.037 10.1016/j.blre.2015.10.002 10.1007/s00380-010-0028-x 10.1002/ajh.2830390106 10.1046/j.1538-7836.2003.00029.x 10.1055/s-0037-1616068 10.1097/ACO.0000000000000295 10.3233/CH-151993 10.1111/jth.12155 10.1055/s-0037-1615025 10.1007/BF01709751 10.1111/j.1538-7836.2008.02981.x 10.1016/bs.acc.2014.12.001 10.1111/jth.14134 10.1001/jama.2016.0287 10.1111/ijlh.12665 10.1007/s00281-011-0282-8 10.1097/MD.0000000000004710 10.1002/ams2.372 10.1186/cc2459 10.1159/000237464
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References	Suzuki (CR6) 2018; 16 Samuelson Bannow, Konkle (CR7) 2018; 163 Conway (CR12) 2012; 34 Kinasewitz (CR17) 2004; 8 Iba (CR5) 2019; 6 Linkins, Takach Lapner (CR1) 2017; 39 Olson (CR3) 2015; 69 Taylor, Toh, Hoots, Wada, Levi (CR2) 2001; 86 Wada (CR11) 2013; 11 Iba (CR14) 2016; 30 Gando, Nanzaki, Sasaki, Kemmotsu (CR20) 1998; 79 Guan, Li, Gong, Lan, Zhang (CR22) 2016; 95 Vincent (CR8) 1996; 22 Aleksic (CR16) 2003; 1 Helling, Stephan, Pindur (CR19) 2015; 61 Jo (CR21) 2010; 25 Singer (CR9) 2016; 315 Boehme (CR18) 1996; 87 Furuno, Mitsuyama, Hidaka, Tanaka, Hara (CR13) 1997; 112 Davenport, Brohi (CR4) 2016; 29 Wada (CR15) 1992; 39 Righini, Perrier, De Moerloose, Bounameaux (CR10) 2008; 6 T Iba (64853_CR5) 2019; 6 BT Samuelson Bannow (64853_CR7) 2018; 163 T Iba (64853_CR14) 2016; 30 FB Taylor Jr. (64853_CR2) 2001; 86 JL Vincent (64853_CR8) 1996; 22 H Wada (64853_CR11) 2013; 11 H Helling (64853_CR19) 2015; 61 K Suzuki (64853_CR6) 2018; 16 Y Jo (64853_CR21) 2010; 25 LA Linkins (64853_CR1) 2017; 39 EM Conway (64853_CR12) 2012; 34 X Guan (64853_CR22) 2016; 95 M Righini (64853_CR10) 2008; 6 N Aleksic (64853_CR16) 2003; 1 M Singer (64853_CR9) 2016; 315 S Gando (64853_CR20) 1998; 79 MW Boehme (64853_CR18) 1996; 87 JD Olson (64853_CR3) 2015; 69 T Furuno (64853_CR13) 1997; 112 H Wada (64853_CR15) 1992; 39 RA Davenport (64853_CR4) 2016; 29 GT Kinasewitz (64853_CR17) 2004; 8
References_xml	– volume: 163 start-page: 138 year: 2018 end-page: 145 ident: CR7 article-title: Laboratory biomarkers for venous thromboembolism risk in patients with hematologic malignancies: A review publication-title: Thromb. Res. doi: 10.1016/j.thromres.2018.01.037 – volume: 30 start-page: 149 year: 2016 end-page: 155 ident: CR14 article-title: Potential diagnostic markers for disseminated intravascular coagulation of sepsis publication-title: Blood reviews. doi: 10.1016/j.blre.2015.10.002 – volume: 25 start-page: 509 year: 2010 end-page: 514 ident: CR21 article-title: Re-elevation of D-dimer as a predictor of re-dissection and venous thromboembolism after Stanford type B acute aortic dissection publication-title: Heart Vessels. doi: 10.1007/s00380-010-0028-x – volume: 39 start-page: 20 year: 1992 end-page: 24 ident: CR15 article-title: Plasmathrombomodulin as a marker of vascular disorders in thrombotic thrombocytopenic purpura and disseminated intravascular coagulation publication-title: Am. J. Hematol. doi: 10.1002/ajh.2830390106 – volume: 1 start-page: 88 year: 2003 end-page: 94 ident: CR16 article-title: Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study publication-title: J. Thromb. Haemost. doi: 10.1046/j.1538-7836.2003.00029.x – volume: 87 start-page: 134 year: 1996 end-page: 140 ident: CR18 article-title: Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: and studies publication-title: Immunology. – volume: 86 start-page: 1327 year: 2001 end-page: 1330 ident: CR2 article-title: Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation publication-title: Thromb. Haemost. doi: 10.1055/s-0037-1616068 – volume: 29 start-page: 212 year: 2016 end-page: 219 ident: CR4 article-title: Cause of trauma-induced coagulopathy publication-title: Curr. Opin. Anaesthesiol. doi: 10.1097/ACO.0000000000000295 – volume: 61 start-page: 185 year: 2015 end-page: 193 ident: CR19 article-title: Coagulation and complement system in critically ill patients publication-title: Clin. Hemorheol. Microcirc. doi: 10.3233/CH-151993 – volume: 11 start-page: 761 year: 2013 end-page: 767 ident: CR11 article-title: The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines publication-title: J. Thromb. Haemost. doi: 10.1111/jth.12155 – volume: 79 start-page: 1111 year: 1998 end-page: 1115 ident: CR20 article-title: Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation publication-title: Thromb. Haemost. doi: 10.1055/s-0037-1615025 – volume: 22 start-page: 707 year: 1996 end-page: 710 ident: CR8 article-title: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine publication-title: Intensive Care Med. doi: 10.1007/BF01709751 – volume: 6 start-page: 1059 year: 2008 end-page: 1071 ident: CR10 article-title: D-Dimer for venous thromboembolism diagnosis: 20 years later publication-title: J. Thromb. Haemost. doi: 10.1111/j.1538-7836.2008.02981.x – volume: 69 start-page: 1 year: 2015 end-page: 46 ident: CR3 article-title: D-dimer: An Overview of Hemostasis and Fibrinolysis, Assays, and Clinical Applications publication-title: Adv. Clin. Chem. doi: 10.1016/bs.acc.2014.12.001 – volume: 16 start-page: 1442 year: 2018 end-page: 1444 ident: CR6 article-title: A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH publication-title: J. Thromb. Haemost. doi: 10.1111/jth.14134 – volume: 315 start-page: 801 year: 2016 end-page: 810 ident: CR9 article-title: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) publication-title: JAMA. doi: 10.1001/jama.2016.0287 – volume: 39 start-page: 98 year: 2017 end-page: 103 ident: CR1 article-title: Review of D-dimer testing: Good, Bad, and Ugly publication-title: Int. J. Lab. Hematol. doi: 10.1111/ijlh.12665 – volume: 34 start-page: 107 year: 2012 end-page: 125 ident: CR12 article-title: Thrombomodulin and its role in inflammation publication-title: Semin. Immunopathol. doi: 10.1007/s00281-011-0282-8 – volume: 95 start-page: e4710 year: 2016 ident: CR22 article-title: The hemostatic disturbance in patients with acute aortic dissection: A prospective observational study publication-title: Med. doi: 10.1097/MD.0000000000004710 – volume: 6 start-page: 223 year: 2019 end-page: 232 ident: CR5 article-title: Diagnosis of sepsis-induced disseminated intravascular coagulation and coagulopathy publication-title: Acute Med. Surg. doi: 10.1002/ams2.372 – volume: 8 start-page: R82 year: 2004 end-page: R90 ident: CR17 article-title: Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism publication-title: Crit. Care. doi: 10.1186/cc2459 – volume: 112 start-page: 262 year: 1997 end-page: 269 ident: CR13 article-title: The role of neutrophil elastase inhuman pulmonary artery endothelial cell injury publication-title: Int. Arch. Allergy Immunol. doi: 10.1159/000237464 – volume: 1 start-page: 88 year: 2003 ident: 64853_CR16 publication-title: J. Thromb. Haemost. doi: 10.1046/j.1538-7836.2003.00029.x – volume: 87 start-page: 134 year: 1996 ident: 64853_CR18 publication-title: Immunology. – volume: 69 start-page: 1 year: 2015 ident: 64853_CR3 publication-title: Adv. Clin. Chem. doi: 10.1016/bs.acc.2014.12.001 – volume: 61 start-page: 185 year: 2015 ident: 64853_CR19 publication-title: Clin. Hemorheol. Microcirc. doi: 10.3233/CH-151993 – volume: 6 start-page: 1059 year: 2008 ident: 64853_CR10 publication-title: J. Thromb. Haemost. doi: 10.1111/j.1538-7836.2008.02981.x – volume: 95 start-page: e4710 year: 2016 ident: 64853_CR22 publication-title: Med. doi: 10.1097/MD.0000000000004710 – volume: 315 start-page: 801 year: 2016 ident: 64853_CR9 publication-title: JAMA. doi: 10.1001/jama.2016.0287 – volume: 30 start-page: 149 year: 2016 ident: 64853_CR14 publication-title: Blood reviews. doi: 10.1016/j.blre.2015.10.002 – volume: 39 start-page: 20 year: 1992 ident: 64853_CR15 publication-title: Am. J. Hematol. doi: 10.1002/ajh.2830390106 – volume: 11 start-page: 761 year: 2013 ident: 64853_CR11 publication-title: J. Thromb. Haemost. doi: 10.1111/jth.12155 – volume: 112 start-page: 262 year: 1997 ident: 64853_CR13 publication-title: Int. Arch. Allergy Immunol. doi: 10.1159/000237464 – volume: 86 start-page: 1327 year: 2001 ident: 64853_CR2 publication-title: Thromb. Haemost. doi: 10.1055/s-0037-1616068 – volume: 39 start-page: 98 year: 2017 ident: 64853_CR1 publication-title: Int. J. Lab. Hematol. doi: 10.1111/ijlh.12665 – volume: 34 start-page: 107 year: 2012 ident: 64853_CR12 publication-title: Semin. Immunopathol. doi: 10.1007/s00281-011-0282-8 – volume: 22 start-page: 707 year: 1996 ident: 64853_CR8 publication-title: Intensive Care Med. doi: 10.1007/BF01709751 – volume: 8 start-page: R82 year: 2004 ident: 64853_CR17 publication-title: Crit. Care. doi: 10.1186/cc2459 – volume: 79 start-page: 1111 year: 1998 ident: 64853_CR20 publication-title: Thromb. Haemost. doi: 10.1055/s-0037-1615025 – volume: 25 start-page: 509 year: 2010 ident: 64853_CR21 publication-title: Heart Vessels. doi: 10.1007/s00380-010-0028-x – volume: 163 start-page: 138 year: 2018 ident: 64853_CR7 publication-title: Thromb. Res. doi: 10.1016/j.thromres.2018.01.037 – volume: 16 start-page: 1442 year: 2018 ident: 64853_CR6 publication-title: J. Thromb. Haemost. doi: 10.1111/jth.14134 – volume: 29 start-page: 212 year: 2016 ident: 64853_CR4 publication-title: Curr. Opin. Anaesthesiol. doi: 10.1097/ACO.0000000000000295 – volume: 6 start-page: 223 year: 2019 ident: 64853_CR5 publication-title: Acute Med. Surg. doi: 10.1002/ams2.372
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Snippet	Background: Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of... Markedly elevated D-dimer levels can occur in emergency patients with various clinical situations, and is likely to indicate the presence of coagulopathy,...
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SubjectTerms	631/45 692/53 Adolescent Adult Aged Aged, 80 and over Anticoagulants Antithrombin Biomarkers Blood Coagulation Disorders - blood Blood Coagulation Disorders - diagnosis Blood Coagulation Disorders - etiology Blood Coagulation Disorders - therapy Child Differential diagnosis Disease Susceptibility Emergencies Emergency medical care Emergency medical services Emergency Service, Hospital Female Fibrin Fibrinogen Degradation Products - metabolism Health risk assessment Humanities and Social Sciences Humans Male Malignancy Middle Aged Mortality multidisciplinary Patients Plasmin Science Science (multidisciplinary) Sepsis Stroke Thrombin Thromboembolism Thrombomodulin Trauma Young Adult
Title	Characteristics of emergency patients with markedly elevated D-dimer levels
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