Structural biology of the multidrug and toxic compound extrusion superfamily transporters

Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across ce...

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Veröffentlicht in:	Biochimica et biophysica acta. Biomembranes Jg. 1862; H. 12; S. 183154
Hauptverfasser:	Kusakizako, Tsukasa, Miyauchi, Hirotake, Ishitani, Ryuichiro, Nureki, Osamu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.12.2020
Schlagworte:	Archaea - metabolism Archaeal Proteins - chemistry Archaeal Proteins - classification Archaeal Proteins - metabolism ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - classification ATP-Binding Cassette Transporters - metabolism Crystal structure Humans MATE superfamily Molecular Dynamics Simulation Multi-drug resistance Organic Cation Transport Proteins - chemistry Organic Cation Transport Proteins - classification Organic Cation Transport Proteins - metabolism Plant Proteins - chemistry Plant Proteins - classification Plant Proteins - metabolism Plants - metabolism Protein Structure, Tertiary Structural biology Substrate Specificity Transporter MATE superfamily Multi-drug resistance Transporter Structural biology Crystal structure
ISSN:	0005-2736, 1879-2642, 1879-2642
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Abstract	Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across cellular and organellar membranes, and is present in the three domains of life. The major substrates of the bacterial MATE transporters are cationic compounds, including clinically important antibiotics, and thereby MATE transporters confer multi-drug resistance to pathogenic bacteria. The plant MATE transporters are important for the accumulation of various metabolites in organelles, including vacuoles. The human MATE transporters are expressed in the brush-border membrane of the kidney, and are involved in the clearance of cationic drugs from the body. During the past decade, progress in structural biology has clarified the transport mechanism of these MATE transporters in atomic detail. The present review summarizes the reported structures of MATE family transporters, along with their structure-guided functional analyses. This integrated view of the structures of MATE transporters provides novel insights into their transport mechanism. •MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters.•MATE is involved in the transport of various xenobiotics and metabolites across cellular and organellar membranes.•The present review summarizes the reported structures of MATE family transporters.•The integrated view of the structures of MATE transporters provides novel insights into their transport mechanism.
AbstractList	Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across cellular and organellar membranes, and is present in the three domains of life. The major substrates of the bacterial MATE transporters are cationic compounds, including clinically important antibiotics, and thereby MATE transporters confer multi-drug resistance to pathogenic bacteria. The plant MATE transporters are important for the accumulation of various metabolites in organelles, including vacuoles. The human MATE transporters are expressed in the brush-border membrane of the kidney, and are involved in the clearance of cationic drugs from the body. During the past decade, progress in structural biology has clarified the transport mechanism of these MATE transporters in atomic detail. The present review summarizes the reported structures of MATE family transporters, along with their structure-guided functional analyses. This integrated view of the structures of MATE transporters provides novel insights into their transport mechanism. •MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters.•MATE is involved in the transport of various xenobiotics and metabolites across cellular and organellar membranes.•The present review summarizes the reported structures of MATE family transporters.•The integrated view of the structures of MATE transporters provides novel insights into their transport mechanism. Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across cellular and organellar membranes, and is present in the three domains of life. The major substrates of the bacterial MATE transporters are cationic compounds, including clinically important antibiotics, and thereby MATE transporters confer multi-drug resistance to pathogenic bacteria. The plant MATE transporters are important for the accumulation of various metabolites in organelles, including vacuoles. The human MATE transporters are expressed in the brush-border membrane of the kidney, and are involved in the clearance of cationic drugs from the body. During the past decade, progress in structural biology has clarified the transport mechanism of these MATE transporters in atomic detail. The present review summarizes the reported structures of MATE family transporters, along with their structure-guided functional analyses. This integrated view of the structures of MATE transporters provides novel insights into their transport mechanism.Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across cellular and organellar membranes, and is present in the three domains of life. The major substrates of the bacterial MATE transporters are cationic compounds, including clinically important antibiotics, and thereby MATE transporters confer multi-drug resistance to pathogenic bacteria. The plant MATE transporters are important for the accumulation of various metabolites in organelles, including vacuoles. The human MATE transporters are expressed in the brush-border membrane of the kidney, and are involved in the clearance of cationic drugs from the body. During the past decade, progress in structural biology has clarified the transport mechanism of these MATE transporters in atomic detail. The present review summarizes the reported structures of MATE family transporters, along with their structure-guided functional analyses. This integrated view of the structures of MATE transporters provides novel insights into their transport mechanism. Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across cellular and organellar membranes, and is present in the three domains of life. The major substrates of the bacterial MATE transporters are cationic compounds, including clinically important antibiotics, and thereby MATE transporters confer multi-drug resistance to pathogenic bacteria. The plant MATE transporters are important for the accumulation of various metabolites in organelles, including vacuoles. The human MATE transporters are expressed in the brush-border membrane of the kidney, and are involved in the clearance of cationic drugs from the body. During the past decade, progress in structural biology has clarified the transport mechanism of these MATE transporters in atomic detail. The present review summarizes the reported structures of MATE family transporters, along with their structure-guided functional analyses. This integrated view of the structures of MATE transporters provides novel insights into their transport mechanism.
ArticleNumber	183154
Author	Miyauchi, Hirotake Ishitani, Ryuichiro Nureki, Osamu Kusakizako, Tsukasa
Author_xml	– sequence: 1 givenname: Tsukasa surname: Kusakizako fullname: Kusakizako, Tsukasa – sequence: 2 givenname: Hirotake surname: Miyauchi fullname: Miyauchi, Hirotake – sequence: 3 givenname: Ryuichiro surname: Ishitani fullname: Ishitani, Ryuichiro email: ishitani@bs.s.u-tokyo.ac.jp – sequence: 4 givenname: Osamu surname: Nureki fullname: Nureki, Osamu email: nureki@bs.s.u-tokyo.ac.jp
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31866287$$D View this record in MEDLINE/PubMed
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Keywords	MATE superfamily Multi-drug resistance Transporter Structural biology Crystal structure
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Snippet	Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE...
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SubjectTerms	Archaea - metabolism Archaeal Proteins - chemistry Archaeal Proteins - classification Archaeal Proteins - metabolism ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - classification ATP-Binding Cassette Transporters - metabolism Crystal structure Humans MATE superfamily Molecular Dynamics Simulation Multi-drug resistance Organic Cation Transport Proteins - chemistry Organic Cation Transport Proteins - classification Organic Cation Transport Proteins - metabolism Plant Proteins - chemistry Plant Proteins - classification Plant Proteins - metabolism Plants - metabolism Protein Structure, Tertiary Structural biology Substrate Specificity Transporter
Title	Structural biology of the multidrug and toxic compound extrusion superfamily transporters
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