Structural biology of the multidrug and toxic compound extrusion superfamily transporters

Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across ce...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Biochimica et biophysica acta. Biomembranes Ročník 1862; číslo 12; s. 183154
Hlavní autoři:	Kusakizako, Tsukasa, Miyauchi, Hirotake, Ishitani, Ryuichiro, Nureki, Osamu
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.12.2020
Témata:	Archaea - metabolism Archaeal Proteins - chemistry Archaeal Proteins - classification Archaeal Proteins - metabolism ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - classification ATP-Binding Cassette Transporters - metabolism Crystal structure Humans MATE superfamily Molecular Dynamics Simulation Multi-drug resistance Organic Cation Transport Proteins - chemistry Organic Cation Transport Proteins - classification Organic Cation Transport Proteins - metabolism Plant Proteins - chemistry Plant Proteins - classification Plant Proteins - metabolism Plants - metabolism Protein Structure, Tertiary Structural biology Substrate Specificity Transporter MATE superfamily Multi-drug resistance Transporter Structural biology Crystal structure
ISSN:	0005-2736, 1879-2642, 1879-2642
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across cellular and organellar membranes, and is present in the three domains of life. The major substrates of the bacterial MATE transporters are cationic compounds, including clinically important antibiotics, and thereby MATE transporters confer multi-drug resistance to pathogenic bacteria. The plant MATE transporters are important for the accumulation of various metabolites in organelles, including vacuoles. The human MATE transporters are expressed in the brush-border membrane of the kidney, and are involved in the clearance of cationic drugs from the body. During the past decade, progress in structural biology has clarified the transport mechanism of these MATE transporters in atomic detail. The present review summarizes the reported structures of MATE family transporters, along with their structure-guided functional analyses. This integrated view of the structures of MATE transporters provides novel insights into their transport mechanism. •MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters.•MATE is involved in the transport of various xenobiotics and metabolites across cellular and organellar membranes.•The present review summarizes the reported structures of MATE family transporters.•The integrated view of the structures of MATE transporters provides novel insights into their transport mechanism.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0005-2736 1879-2642 1879-2642
DOI:	10.1016/j.bbamem.2019.183154