Neurological symptoms and axonal damage in COVID-19 survivors: are there sequelae?

The persistence of neurological symptoms after SARS-CoV-2 infection, as well as the presence of late axonal damage, is still unknown. We performed extensive systemic and neurological follow-up evaluations in 107 out of 193 consecutive patients admitted to the COVID-19 medical unit, University Hospit...

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Vydané v:	Immunologic research Ročník 69; číslo 6; s. 553 - 557
Hlavní autori:	Bozzetti, Silvia, Ferrari, Sergio, Zanzoni, Serena, Alberti, Daniela, Braggio, Michele, Carta, Sara, Piraino, Francesco, Gabbiani, Daniele, Girelli, Domenico, Nocini, Riccardo, Monaco, Salvatore, Crisafulli, Ernesto, Mariotto, Sara
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Springer US 01.12.2021 Springer Nature B.V
Predmet:	Adult Aged Aged, 80 and over Ageusia - pathology Ageusia - virology Allergology Anosmia - pathology Anosmia - virology Axons - pathology Axons - virology Biomedical and Life Sciences Biomedicine Coronaviruses COVID-19 COVID-19 - pathology Disease Progression Fatigue - pathology Fatigue - virology Female Humans Immunology Internal Medicine Italy Male Medicine/Public Health Memory Disorders - pathology Memory Disorders - virology Middle Aged Myalgia Myalgia - pathology Myalgia - virology Nervous System Diseases - pathology Nervous System Diseases - virology Neurofilament Proteins - blood Neurological complications Olfaction disorders Original Original Article Patients SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Italy COVID-19 Neurofilament SARS-CoV-2 Hypogeusia NfL Hyposmia
ISSN:	0257-277X, 1559-0755, 1559-0755
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Shrnutí:	The persistence of neurological symptoms after SARS-CoV-2 infection, as well as the presence of late axonal damage, is still unknown. We performed extensive systemic and neurological follow-up evaluations in 107 out of 193 consecutive patients admitted to the COVID-19 medical unit, University Hospital of Verona, Italy between March and June 2020. We analysed serum neurofilament light chain (NfL) levels in all cases including a subgroup ( n = 29) of patients with available onset samples. Comparisons between clinical and biomarker data were then performed. Neurological symptoms were still present in a significant number ( n = 49) of patients over the follow-up. The most common reported symptoms were hyposmia ( n = 11), fatigue ( n = 28), myalgia ( n = 14), and impaired memory ( n = 11) and were more common in cases with severe acute COVID-19. Follow-up serum NfL values (15.2 pg/mL, range 2.4–62.4) were within normal range in all except 5 patients and did not differentiate patients with vs without persistent neurological symptoms. In patients with available onset and follow-up samples, a significant ( p < 0.001) decrease of NfL levels was observed and was more evident in patients with a severe acute disease. Despite the common persistence of neurological symptoms, COVID-19 survivors do not show active axonal damage, which seems a peculiar feature of acute SARS-CoV-2 infection.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0257-277X 1559-0755 1559-0755
DOI:	10.1007/s12026-021-09220-5