Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment

Obesity is a leading contributing factor to cancer development worldwide. Epidemiological evidence suggests that diet affects cancer risk and also substantially alters therapeutic outcome. Therefore, studying the impact of diet in the development and treatment of cancer should be a clinical priority...

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Veröffentlicht in:Trends in cancer Jg. 5; H. 11; S. 693
Hauptverfasser: Peck, Barrie, Schulze, Almut
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.11.2019
Schlagworte:
cancer metabolism
lipids
environmental heterogeneity
cancer
diet
tumor microenvironment
nutrient stress
obesity
ISSN:2405-8025, 2405-8025
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Zusammenfassung:Obesity is a leading contributing factor to cancer development worldwide. Epidemiological evidence suggests that diet affects cancer risk and also substantially alters therapeutic outcome. Therefore, studying the impact of diet in the development and treatment of cancer should be a clinical priority. In this Review, we set out the evidence supporting the role of lipid metabolism in shaping the tumor microenvironment (TME) and cancer cell phenotype. We will discuss how dietary lipids can impact phenotype thereby affecting disease trajectory and treatment response. Finally, we will posit potential strategies on how this knowledge can be exploited to increase treatment efficacy and patient survival.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2405-8025
2405-8025
DOI:10.1016/j.trecan.2019.09.007