Human organs-on-chips for disease modelling, drug development and personalized medicine

The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and path...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nature reviews. Genetics Ročník 23; číslo 8; s. 467 - 491
Hlavní autor: Ingber, Donald E
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.08.2022
Témata:
Animal models
Animals
Biochips
Drug Development
Fluid flow
Genetic disorders
Humans
Lab-On-A-Chip Devices
Microbiomes
Microfluidics
Pathophysiology
Pharmaceutical industry
Physiology
Precision Medicine
Rare Diseases
ISSN:1471-0056, 1471-0064, 1471-0064
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and pathophysiology with high fidelity. Here, I review how single and multiple human organ chip systems have been used to model complex diseases and rare genetic disorders, to study host-microbiome interactions, to recapitulate whole-body inter-organ physiology and to reproduce human clinical responses to drugs, radiation, toxins and infectious pathogens. I also address the challenges that must be overcome for organ chips to be accepted by the pharmaceutical industry and regulatory agencies, as well as discuss recent advances in the field. It is evident that the use of human organ chips instead of animal models for drug development and as living avatars for personalized medicine is ever closer to realization.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-022-00466-9