Human organs-on-chips for disease modelling, drug development and personalized medicine

The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and path...

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Bibliographic Details
Published in:	Nature reviews. Genetics Vol. 23; no. 8; pp. 467 - 491
Main Author:	Ingber, Donald E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.08.2022 Nature Publishing Group
Subjects:	631/1647/767 631/532 631/61 Agriculture Animal Genetics and Genomics Animal models Animals Biochips Biomedical and Life Sciences Biomedicine Cancer Research Drug Development Fluid flow Gene Function Genetic disorders Human Genetics Humans Lab-On-A-Chip Devices Microbiomes Microfluidics Pathophysiology Pharmaceutical industry Physiology Precision Medicine Rare Diseases Review Review Article
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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