Tumour-infiltrating lymphocytes: from prognosis to treatment selection

Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent o...

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Bibliographic Details
Published in:British journal of cancer Vol. 128; no. 3; pp. 451 - 458
Main Authors: Brummel, Koen, Eerkens, Anneke L, de Bruyn, Marco, Nijman, Hans W
Format: Journal Article
Language:English
Published: England Nature Publishing Group 02.02.2023
Subjects:
Biomarkers
Cells
Clinical trials
Humans
Immune checkpoint inhibitors
Immunotherapy
Lymphocytes
Lymphocytes, Tumor-Infiltrating
Medical prognosis
Melanoma
Meta-analysis
Neoplasms - pathology
Neoplasms - therapy
Ovarian cancer
Prognosis
Systematic review
Tumors
ISSN:0007-0920, 1532-1827, 1532-1827
Online Access:Get full text
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Summary:Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials.
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ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-022-02119-4