Tumour-infiltrating lymphocytes: from prognosis to treatment selection

Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent o...

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Published in:British journal of cancer Vol. 128; no. 3; pp. 451 - 458
Main Authors: Brummel, Koen, Eerkens, Anneke L, de Bruyn, Marco, Nijman, Hans W
Format: Journal Article
Language:English
Published: England Nature Publishing Group 02.02.2023
Subjects:
Biomarkers
Cells
Clinical trials
Humans
Immune checkpoint inhibitors
Immunotherapy
Lymphocytes
Lymphocytes, Tumor-Infiltrating
Medical prognosis
Melanoma
Meta-analysis
Neoplasms - pathology
Neoplasms - therapy
Ovarian cancer
Prognosis
Systematic review
Tumors
ISSN:0007-0920, 1532-1827, 1532-1827
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Abstract Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials.
AbstractList Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials.
Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials.Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials.
Author Brummel, Koen
Eerkens, Anneke L
Nijman, Hans W
de Bruyn, Marco
Author_xml – sequence: 1
  givenname: Koen
  surname: Brummel
  fullname: Brummel, Koen
  organization: University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands
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  givenname: Anneke L
  orcidid: 0000-0001-8823-196X
  surname: Eerkens
  fullname: Eerkens, Anneke L
  organization: University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands
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  givenname: Marco
  orcidid: 0000-0001-9819-9131
  surname: de Bruyn
  fullname: de Bruyn, Marco
  organization: University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands
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  givenname: Hans W
  orcidid: 0000-0002-1821-3042
  surname: Nijman
  fullname: Nijman, Hans W
  email: h.w.nijman@umcg.nl
  organization: University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands. h.w.nijman@umcg.nl
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References 37443345 - Br J Cancer. 2023 Sep;129(5):737-738. doi: 10.1038/s41416-023-02335-6.
37507542 - Br J Cancer. 2023 Sep;129(5):739-740. doi: 10.1038/s41416-023-02368-x.
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Snippet Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive...
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StartPage 451
SubjectTerms Biomarkers
Cells
Clinical trials
Humans
Immune checkpoint inhibitors
Immunotherapy
Lymphocytes
Lymphocytes, Tumor-Infiltrating
Medical prognosis
Melanoma
Meta-analysis
Neoplasms - pathology
Neoplasms - therapy
Ovarian cancer
Prognosis
Systematic review
Tumors
Title Tumour-infiltrating lymphocytes: from prognosis to treatment selection
URI https://www.ncbi.nlm.nih.gov/pubmed/36564565
https://www.proquest.com/docview/2777534666
https://www.proquest.com/docview/2758117066
Volume 128
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