Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression
Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrin...
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| Published in: | British journal of cancer Vol. 125; no. 2; pp. 164 - 175 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
20.07.2021
Nature Publishing Group |
| Subjects: | |
| ISSN: | 0007-0920, 1532-1827, 1532-1827 |
| Online Access: | Get full text |
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| Abstract | Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance. |
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| AbstractList | Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance. Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient's prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance.Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient's prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance. |
| Author | Christofori, Gerhard Tiede, Stefanie Lüönd, Fabiana |
| Author_xml | – sequence: 1 givenname: Fabiana surname: Lüönd fullname: Lüönd, Fabiana organization: Department of Biomedicine, University of Basel – sequence: 2 givenname: Stefanie surname: Tiede fullname: Tiede, Stefanie organization: Department of Biomedicine, University of Basel – sequence: 3 givenname: Gerhard orcidid: 0000-0002-8696-9896 surname: Christofori fullname: Christofori, Gerhard email: gerhard.christofori@unibas.ch organization: Department of Biomedicine, University of Basel |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33824479$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41388-019-0899-y 10.1158/0008-5472.CAN-14-3476 10.1038/nprot.2016.138 10.1038/nature13556 10.1038/nature16064 10.1016/j.cell.2011.05.040 10.1016/j.cell.2013.11.029 10.1038/nature10694 10.1038/nm.3121 10.1038/s41572-019-0111-2 10.1038/nature14897 10.1038/labinvest.2012.91 10.1158/2159-8290.CD-12-0462 10.1038/nature11412 10.1038/nrc3726 10.1038/nmeth.2639 10.1038/nature12627 10.1016/j.cell.2011.02.013 10.1038/nature03799 10.1038/s41467-018-07130-z 10.1016/j.cell.2017.12.007 10.1038/nature22816 10.1016/j.stem.2015.08.014 10.1038/nature13187 10.1186/s12885-015-1386-7 10.1038/nrc3261 10.1038/nm.3915 10.1038/nrc.2017.126 10.1016/j.ccr.2012.10.012 10.1038/nrc3971 10.1038/nature14665 10.1073/pnas.1618091114 10.1016/j.ccell.2018.12.002 10.1038/nature10983 10.1038/nature10762 10.1038/s41586-019-0915-y 10.1038/s41586-018-0040-3 10.1038/ncb1998 10.1038/nature11154 10.1016/j.canlet.2019.10.013 10.1016/j.molonc.2010.11.003 10.1038/s41568-018-0083-7 10.1038/s41467-019-08595-2 10.1186/bcr3687 10.1038/415530a 10.1186/bcr2635 10.1016/j.cell.2016.06.028 10.1016/j.cell.2009.11.025 10.1016/j.stem.2018.11.011 10.1038/nature15260 10.1016/j.cell.2012.04.024 10.1038/nature09807 10.1016/j.devcel.2018.05.025 10.1016/j.cell.2014.07.013 10.1038/s41588-020-0628-z 10.1016/j.cell.2008.03.027 10.1038/s41556-018-0196-y 10.1038/508052a 10.1158/0008-5472.CAN-11-1818 10.1016/j.cell.2013.06.005 10.1038/nri3789 10.1016/j.stem.2020.02.008 10.1002/path.4540 10.1016/j.ceb.2016.07.005 10.1038/nature15748 10.1038/nature08489 10.1038/s41556-019-0353-y 10.1038/nrc.2017.118 10.1158/0008-5472.CAN-07-2148 10.1038/nature10933 10.1016/j.cell.2012.04.023 10.1038/nm.3886 10.1016/j.ccr.2012.09.022 10.1038/nature09515 10.1038/s41467-018-07406-4 10.1016/j.tcb.2018.12.001 10.1158/0008-5472.CAN-14-0923 10.1038/s41467-019-10269-y 10.1038/nature14669 10.1016/j.celrep.2019.10.107 10.1016/j.celrep.2015.11.025 10.1038/s41467-017-02481-5 10.1186/bcr3217 10.1038/s41556-019-0346-x 10.1016/j.cell.2011.11.016 10.1016/j.ccell.2016.07.009 10.1016/S1535-6108(03)00132-6 10.1038/onc.2014.475 10.1182/blood-2003-08-2807 10.1038/ncb3513 10.1038/s41568-019-0149-1 10.1016/j.ccell.2019.02.010 10.1038/nrc1388 10.1002/path.4345 10.1016/S1470-2045(07)70140-7 10.1016/j.cell.2011.07.026 10.1038/s41586-019-1019-4 10.1038/s41577-019-0218-4 10.1038/nature14403 10.1038/nmeth.3370 10.1016/j.ajpath.2017.04.022 10.1084/jem.20181827 10.1073/pnas.1508541113 10.1126/science.959840 10.1016/j.celrep.2018.04.007 10.1038/35021093 10.1016/j.cell.2017.01.018 10.1186/s13073-020-00728-3 10.1158/0008-5472.CAN-12-2217 10.1016/j.celrep.2018.08.053 10.1016/j.ccr.2014.03.021 10.1038/s41556-018-0236-7 10.1038/nrc2618 10.1038/nature12626 10.1038/nm.3394 10.1016/j.cell.2018.11.046 10.1101/gad.242511.114 10.3389/fonc.2018.00381 10.1038/nature09460 10.1038/nature14347 10.1016/j.devcel.2018.05.027 10.1016/j.molcel.2015.10.031 10.1038/ncomms6871 10.1016/0022-5193(82)90388-5 10.1038/nprot.2017.003 10.1016/j.celrep.2016.02.034 10.1038/ncb1658 10.1126/science.1228522 10.1158/0008-5472.CAN-14-3363 10.1016/j.cell.2011.09.024 10.1016/j.celrep.2013.11.014 10.1038/s41568-019-0209-6 10.1038/nature15742 10.1038/nature12628 10.1038/nprot.2014.006 10.1038/nrclinonc.2016.144 10.15252/emmm.201809085 10.1038/s41586-019-1526-3 10.1038/s41580-020-0237-9 10.1098/rsif.2017.0512 |
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| References | Picelli, Faridani, Bjorklund, Winberg, Sagasser, Sandberg (CR135) 2014; 9 Shah, Morin, Khattra, Prentice, Pugh, Burleigh (CR19) 2009; 461 Merino, Weber, Serrano, Vaillant, Liu, Pal (CR34) 2019; 10 Cheung, Padmanaban, Silvestri, Schipper, Cohen, Fairchild (CR70) 2016; 113 Mani, Guo, Liao, Eaton, Ayyanan, Zhou (CR55) 2008; 133 Gilkes, Semenza, Wirtz (CR94) 2014; 14 Lawson, Kessenbrock, Davis, Pervolarakis, Werb (CR13) 2018; 20 Goetz, Minguet, Navarro-Lerida, Lazcano, Samaniego, Calvo (CR78) 2011; 146 Tabassum, Polyak (CR76) 2015; 15 Potts, Krueger, Landis, Eberhard, Young, Schmechel (CR130) 2012; 92 Yang, Cao, Liu, He, Du, Zhang (CR108) 2019; 38 Hu, Li, Ma, Curtis (CR97) 2020; 52 Title, Hong, Pires, Hasenohrl, Godbersen, Stokar-Regenscheit (CR125) 2018; 9 Koren, Reavie, Couto, De Silva, Stadler, Roloff (CR62) 2015; 525 Stemmler, Eccles, Brabletz, Brabletz (CR127) 2019; 21 Dang, Prechtl, Pearson (CR80) 2011; 71 Fischer, Durrans, Lee, Sheng, Li, Wong (CR123) 2015; 527 Perou, Sorlie, Eisen, van de Rijn, Jeffrey, Rees (CR6) 2000; 406 Ellis, Perou (CR9) 2013; 3 Wellner, Schubert, Burk, Schmalhofer, Zhu, Sonntag (CR56) 2009; 11 Koren, Bentires-Alj (CR2) 2015; 60 Brooks, Burness, Wicha (CR12) 2015; 17 CR47 Archetti, Pienta (CR72) 2019; 19 Stankic, Pavlovic, Chin, Brogi, Padua, Norton (CR116) 2013; 5 Junttila, de Sauvage (CR74) 2013; 501 Echeverria, Powell, Seth, Ge, Carugo, Bristow (CR33) 2018; 9 Campbell, Yachida, Mudie, Stephens, Pleasance, Stebbings (CR27) 2010; 467 Nik-Zainal, Alexandrov, Wedge, Van Loo, Greenman, Raine (CR29) 2012; 149 Tata, Rajagopal (CR44) 2016; 43 Shah, Roth, Goya, Oloumi, Ha, Zhao (CR21) 2012; 486 Xu, Lee, Feng, Xu, Bu, Li (CR126) 2017; 114 Kalbasi, Ribas (CR93) 2020; 20 Greaves, Maley (CR25) 2012; 481 Cleary, Leonard, Gestl, Gunther (CR66) 2014; 508 Weidenfeld, Barkan (CR120) 2018; 8 Curtis, Shah, Chin, Turashvili, Rueda, Dunning (CR20) 2012; 486 Gundem, Van Loo, Kremeyer, Alexandrov, Tubio, Papaemmanuil (CR69) 2015; 520 Navin, Kendall, Troge, Andrews, Rodgers, McIndoo (CR18) 2011; 472 Prat, Perou (CR8) 2011; 5 Shaked (CR139) 2019; 19 Paget (CR136) 1889; 8 Mohme, Riethdorf, Pantel (CR91) 2017; 14 Tsai, Donaher, Murphy, Chau, Yang (CR102) 2012; 22 Ombrato, Malanchi (CR89) 2019; 21 Jiang, Zhan (CR92) 2020; 468 Pastushenko, Brisebarre, Sifrim, Fioramonti, Revenco, Boumahdi (CR48) 2018; 556 Reichert, Bakir, Moreira, Pitarresi, Feldmann, Simon (CR121) 2018; 45 Campbell, Rossi, Adams, Pitsidianaki, Barriga, Garcia-Gerique (CR104) 2019; 10 Ye, Brabletz, Kang, Longmore, Nieto, Stanger (CR128) 2017; 547 Szczerba, Castro-Giner, Vetter, Krol, Gkountela, Landin (CR90) 2019; 566 Kitamura, Qian, Pollard (CR65) 2015; 15 Hanahan, Weinberg (CR141) 2011; 144 Lewis, Harney, Pollard (CR85) 2016; 30 Prat, Parker, Karginova, Fan, Livasy, Herschkowitz (CR7) 2010; 12 Nguyen, Pellacani, Lefort, Kannan, Osako, Makarem (CR32) 2015; 528 Arwert, Harney, Entenberg, Wang, Sahai, Pollard (CR87) 2018; 23 Nowell (CR26) 1976; 194 Yachida, Jones, Bozic, Antal, Leary, Fu (CR28) 2010; 467 Trimboli, Fukino, de Bruin, Wei, Shen, Tanner (CR64) 2008; 68 Harbeck, Penault-Llorca, Cortes, Gnant, Houssami, Poortmans (CR1) 2019; 5 Melchor, Molyneux, Mackay, Magnay, Atienza, Kendrick (CR3) 2014; 233 Nieto, Huang, Jackson, Thiery (CR45) 2016; 166 Chaffer, Marjanovic, Lee, Bell, Kleer, Reinhardt (CR58) 2013; 154 Minn, Gupta, Siegel, Bos, Shu, Giri (CR96) 2005; 436 Yu, Bardia, Wittner, Stott, Smas, Ting (CR111) 2013; 339 Krebs, Mitschke, Lasierra Losada, Schmalhofer, Boerries, Busch (CR50) 2017; 19 Marusyk, Tabassum, Altrock, Almendro, Michor, Polyak (CR77) 2014; 514 Friedmann Angeli, Krysko, Conrad (CR140) 2019; 19 Gkountela, Castro-Giner, Szczerba, Vetter, Landin, Scherrer (CR100) 2019; 176 Granit, Masury, Condiotti, Fixler, Gabai, Glikman (CR61) 2018; 24 Malanchi, Santamaria-Martinez, Susanto, Peng, Lehr, Delaloye (CR82) 2011; 481 Bornes, van Scheppingen, Beerling, Schelfhorst, Ellenbroek, Seinstra (CR113) 2019; 29 Su, Liu, Chen, Chen, Chen, He (CR84) 2014; 25 Fumagalli, Oost, Kester, Morgner, Bornes, Bruens (CR119) 2020; 26 Macaulay, Haerty, Kumar, Li, Hu, Teng (CR132) 2015; 12 Bedard, Hansen, Ratain, Siu (CR11) 2013; 501 Kang, Siegel, Shu, Drobnjak, Kakonen, Cordón-Cardo (CR95) 2003; 3 Banerji, Cibulskis, Rangel-Escareno, Brown, Carter, Frederick (CR24) 2012; 486 Van Keymeulen, Lee, Ousset, Brohee, Rorive, Giraddi (CR63) 2015; 525 Matise, Palmer, Ashby, Nashabi, Chytil, Aakre (CR81) 2012; 14 Macaulay, Teng, Haerty, Kumar, Ponting, Voet (CR133) 2016; 11 Wagenblast, Soto, Gutierrez-Angel, Hartl, Gable, Maceli (CR35) 2015; 520 Polzer, Klein (CR138) 2013; 19 Castro-Giner, Aceto (CR114) 2020; 12 Visvader, Stingl (CR5) 2014; 28 Casasent, Schalck, Gao, Sei, Long, Pangburn (CR38) 2018; 172 Chen, Suo, Tam, Han, Peng, Jing (CR131) 2017; 12 Janiszewska, Tabassum, Castano, Cristea, Yamamoto, Kingston (CR88) 2019; 21 Russnes, Lingjaerde, Borresen-Dale, Caldas (CR23) 2017; 187 Gaggioli, Hooper, Hidalgo-Carcedo, Grosse, Marshall, Harrington (CR79) 2007; 9 Valastyan, Weinberg (CR137) 2011; 147 Hunter, Amin, Deasy, Ha, Wakefield (CR36) 2018; 18 Linde, Casanova-Acebes, Sosa, Mortha, Rahman, Farias (CR86) 2018; 9 Ocana, Corcoles, Fabra, Moreno-Bueno, Acloque, Vega (CR101) 2012; 22 Beerling, Seinstra, de Wit, Kester, van der Velden, Maynard (CR112) 2016; 14 Marusyk, Almendro, Polyak (CR14) 2012; 12 Balkwill (CR83) 2004; 4 Aiello, Kang (CR124) 2019; 216 Tran, Luitel, Kim, Zhang, Longmore, Tran (CR115) 2014; 74 CR122 Joyce, Pollard (CR73) 2009; 9 Quail, Joyce (CR75) 2013; 19 Cheung, Gabrielson, Werb, Ewald (CR71) 2013; 155 Pastushenko, Blanpain (CR46) 2019; 29 Kim, Oskarsson, Acharyya, Nguyen, Zhang, Norton (CR68) 2009; 139 Alizadeh, Aranda, Bardelli, Blanpain, Bock, Borowski (CR16) 2015; 21 Del Pozo Martin, Park, Ramachandran, Ombrato, Calvo, Chakravarty (CR117) 2015; 13 Rios, Capaldo, Vaillant, Pal, van Ineveld, Dawson (CR49) 2019; 35 Lawson, Bhakta, Kessenbrock, Prummel, Yu, Takai (CR53) 2015; 526 Yates, Gerstung, Knappskog, Desmedt, Gundem, Van Loo (CR40) 2015; 21 CR129 Aceto, Bardia, Miyamoto, Donaldson, Wittner, Spencer (CR99) 2014; 158 Aiello, Maddipati, Norgard, Balli, Li, Yuan (CR107) 2018; 45 Bockhorn, Jain, Munn (CR109) 2007; 8 McGranahan, Swanton (CR15) 2017; 168 Swanton (CR39) 2012; 72 Nik-Zainal, Van Loo, Wedge, Alexandrov, Greenman, Lau (CR30) 2012; 149 Prindull, Zipori (CR43) 2004; 103 Brabletz, Kalluri, Nieto, Weinberg (CR52) 2018; 18 Obradovic, Hamelin, Manevski, Couto, Sethi, Coissieux (CR98) 2019; 567 Ruscetti, Quach, Dadashian, Mulholland, Wu (CR118) 2015; 75 Polyak, Marusyk (CR67) 2014; 508 Klein (CR37) 2013; 501 Desmedt, Fumagalli, Pietri, Zoppoli, Brown, Nik-Zainal (CR41) 2015; 236 Gupta, Pastushenko, Skibinski, Blanpain, Kuperwasser (CR42) 2019; 24 Ye, Tam, Shibue, Kaygusuz, Reinhardt, Ng Eaton (CR57) 2015; 525 Friedl, Alexander (CR103) 2011; 147 Bissell, Hall, Parry (CR10) 1982; 99 van 't Veer, Dai, van de Vijver, He, Hart, Mao (CR17) 2002; 415 Picelli, Bjorklund, Faridani, Sagasser, Winberg, Sandberg (CR134) 2013; 10 Gupta, Fillmore, Jiang, Shapira, Tao, Kuperwasser (CR59) 2011; 146 Skibinski, Kuperwasser (CR4) 2015; 34 Cancer Genome Atlas (CR22) 2012; 490 Nguyen, Cox, Eirew, Knapp, Pellacani, Kannan (CR31) 2014; 5 Dang, Esparza, Maine, Westcott, Pearson (CR106) 2015; 75 CR105 Zheng, Carstens, Kim, Scheible, Kaye, Sugimoto (CR51) 2015; 527 Ishay-Ronen, Diepenbruck, Kalathur, Sugiyama, Tiede, Ivanek (CR54) 2019; 35 Polioudaki, Agelaki, Chiotaki, Politaki, Mavroudis, Matikas (CR110) 2015; 15 Klevebring, Rosin, Ma, Lindberg, Czene, Kere (CR60) 2014; 16 Y Del Pozo Martin (1328_CR117) 2015; 13 KW Hunter (1328_CR36) 2018; 18 KR Fischer (1328_CR123) 2015; 527 M Greaves (1328_CR25) 2012; 481 G Gundem (1328_CR69) 2015; 520 DM Gilkes (1328_CR94) 2014; 14 F Balkwill (1328_CR83) 2004; 4 D Klevebring (1328_CR60) 2014; 16 A Kalbasi (1328_CR93) 2020; 20 S Valastyan (1328_CR137) 2011; 147 CL Chaffer (1328_CR58) 2013; 154 C Swanton (1328_CR39) 2012; 72 SA Mani (1328_CR55) 2008; 133 PB Gupta (1328_CR59) 2011; 146 S Koren (1328_CR2) 2015; 60 D Merino (1328_CR34) 2019; 10 JE Visvader (1328_CR5) 2014; 28 C Gaggioli (1328_CR79) 2007; 9 G Prindull (1328_CR43) 2004; 103 B Polzer (1328_CR138) 2013; 19 Y Shaked (1328_CR139) 2019; 19 M Mohme (1328_CR91) 2017; 14 MP Stemmler (1328_CR127) 2019; 21 C Yang (1328_CR108) 2019; 38 CA Klein (1328_CR37) 2013; 501 M Ruscetti (1328_CR118) 2015; 75 C Curtis (1328_CR20) 2012; 486 S Picelli (1328_CR134) 2013; 10 I Pastushenko (1328_CR48) 2018; 556 AA Alizadeh (1328_CR16) 2015; 21 M Archetti (1328_CR72) 2019; 19 KJ Cheung (1328_CR71) 2013; 155 PB Gupta (1328_CR42) 2019; 24 X Ye (1328_CR128) 2017; 547 U Wellner (1328_CR56) 2009; 11 T Kitamura (1328_CR65) 2015; 15 BM Szczerba (1328_CR90) 2019; 566 A Marusyk (1328_CR77) 2014; 514 LJ van 't Veer (1328_CR17) 2002; 415 M Janiszewska (1328_CR88) 2019; 21 E Beerling (1328_CR112) 2016; 14 K Polyak (1328_CR67) 2014; 508 N McGranahan (1328_CR15) 2017; 168 LR Yates (1328_CR40) 2015; 21 P Friedl (1328_CR103) 2011; 147 L Bornes (1328_CR113) 2019; 29 D Ishay-Ronen (1328_CR54) 2019; 35 MY Kim (1328_CR68) 2009; 139 N Aceto (1328_CR99) 2014; 158 MJ Ellis (1328_CR9) 2013; 3 AC Title (1328_CR125) 2018; 9 J Chen (1328_CR131) 2017; 12 NM Aiello (1328_CR124) 2019; 216 CM Perou (1328_CR6) 2000; 406 DA Lawson (1328_CR53) 2015; 526 H Polioudaki (1328_CR110) 2015; 15 N Linde (1328_CR86) 2018; 9 S Banerji (1328_CR24) 2012; 486 Y Xu (1328_CR126) 2017; 114 E Wagenblast (1328_CR35) 2015; 520 N Cancer Genome Atlas (1328_CR22) 2012; 490 A Skibinski (1328_CR4) 2015; 34 A Prat (1328_CR8) 2011; 5 NM Aiello (1328_CR107) 2018; 45 S Nik-Zainal (1328_CR30) 2012; 149 Z Hu (1328_CR97) 2020; 52 X Ye (1328_CR57) 2015; 525 M Reichert (1328_CR121) 2018; 45 D Hanahan (1328_CR141) 2011; 144 RZ Granit (1328_CR61) 2018; 24 PJ Campbell (1328_CR27) 2010; 467 AS Cleary (1328_CR66) 2014; 508 N Harbeck (1328_CR1) 2019; 5 T Brabletz (1328_CR52) 2018; 18 Y Kang (1328_CR95) 2003; 3 S Paget (1328_CR136) 1889; 8 PC Nowell (1328_CR26) 1976; 194 SJ Potts (1328_CR130) 2012; 92 I Pastushenko (1328_CR46) 2019; 29 EN Arwert (1328_CR87) 2018; 23 LV Nguyen (1328_CR32) 2015; 528 HD Tran (1328_CR115) 2014; 74 CE Lewis (1328_CR85) 2016; 30 L Ombrato (1328_CR89) 2019; 21 S Nik-Zainal (1328_CR29) 2012; 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| References_xml | – volume: 38 start-page: 7113 year: 2019 end-page: 7132 ident: CR108 article-title: Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas publication-title: Oncogene doi: 10.1038/s41388-019-0899-y – volume: 75 start-page: 2749 year: 2015 end-page: 2759 ident: CR118 article-title: Tracking and functional characterization of epithelial-mesenchymal transition and mesenchymal tumor cells during prostate cancer metastasis publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-3476 – volume: 11 start-page: 2081 year: 2016 end-page: 2103 ident: CR133 article-title: Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T-seq publication-title: Nat. Protoc. doi: 10.1038/nprot.2016.138 – volume: 514 start-page: 54 year: 2014 end-page: 58 ident: CR77 article-title: Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity publication-title: Nature doi: 10.1038/nature13556 – volume: 527 start-page: 525 year: 2015 end-page: 530 ident: CR51 article-title: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer publication-title: Nature doi: 10.1038/nature16064 – volume: 146 start-page: 148 year: 2011 end-page: 163 ident: CR78 article-title: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis publication-title: Cell doi: 10.1016/j.cell.2011.05.040 – volume: 155 start-page: 1639 year: 2013 end-page: 1651 ident: CR71 article-title: Collective invasion in breast cancer requires a conserved basal epithelial program publication-title: Cell doi: 10.1016/j.cell.2013.11.029 – volume: 481 start-page: 85 year: 2011 end-page: 89 ident: CR82 article-title: Interactions between cancer stem cells and their niche govern metastatic colonization publication-title: Nature doi: 10.1038/nature10694 – volume: 19 start-page: 274 year: 2013 end-page: 275 ident: CR138 article-title: Metastasis awakening: the challenges of targeting minimal residual cancer publication-title: Nat. Med. doi: 10.1038/nm.3121 – volume: 5 start-page: 66 year: 2019 ident: CR1 article-title: Breast cancer publication-title: Nat. Rev. Dis. Primers doi: 10.1038/s41572-019-0111-2 – volume: 525 start-page: 256 year: 2015 end-page: 260 ident: CR57 article-title: Distinct EMT programs control normal mammary stem cells and tumour-initiating cells publication-title: Nature doi: 10.1038/nature14897 – volume: 92 start-page: 1342 year: 2012 end-page: 1357 ident: CR130 article-title: Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue publication-title: Lab. Investig. doi: 10.1038/labinvest.2012.91 – volume: 3 start-page: 27 year: 2013 end-page: 34 ident: CR9 article-title: The genomic landscape of breast cancer as a therapeutic roadmap publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-12-0462 – volume: 490 start-page: 61 year: 2012 end-page: 70 ident: CR22 article-title: Comprehensive molecular portraits of human breast tumours publication-title: Nature doi: 10.1038/nature11412 – volume: 14 start-page: 430 year: 2014 end-page: 439 ident: CR94 article-title: Hypoxia and the extracellular matrix: drivers of tumour metastasis publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3726 – volume: 10 start-page: 1096 year: 2013 end-page: 1098 ident: CR134 article-title: Smart-seq2 for sensitive full-length transcriptome profiling in single cells publication-title: Nat. Methods doi: 10.1038/nmeth.2639 – volume: 501 start-page: 355 year: 2013 end-page: 364 ident: CR11 article-title: Tumour heterogeneity in the clinic publication-title: Nature doi: 10.1038/nature12627 – volume: 144 start-page: 646 year: 2011 end-page: 674 ident: CR141 article-title: Hallmarks of cancer: the next generation publication-title: Cell doi: 10.1016/j.cell.2011.02.013 – ident: CR129 – volume: 436 start-page: 518 year: 2005 end-page: 524 ident: CR96 article-title: Genes that mediate breast cancer metastasis to lung publication-title: Nature doi: 10.1038/nature03799 – volume: 9 year: 2018 ident: CR125 article-title: Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion publication-title: Nat. Commun. doi: 10.1038/s41467-018-07130-z – volume: 172 start-page: 205 year: 2018 end-page: 217 e212 ident: CR38 article-title: Multiclonal invasion in breast tumors identified by topographic single cell sequencing publication-title: Cell doi: 10.1016/j.cell.2017.12.007 – volume: 547 start-page: E1 year: 2017 end-page: E3 ident: CR128 article-title: Upholding a role for EMT in breast cancer metastasis publication-title: Nature doi: 10.1038/nature22816 – volume: 17 start-page: 260 year: 2015 end-page: 271 ident: CR12 article-title: Therapeutic implications of cellular heterogeneity and plasticity in breast cancer publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.08.014 – volume: 508 start-page: 113 year: 2014 end-page: 117 ident: CR66 article-title: Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers publication-title: Nature doi: 10.1038/nature13187 – volume: 15 year: 2015 ident: CR110 article-title: Variable expression levels of keratin and vimentin reveal differential EMT status of circulating tumor cells and correlation with clinical characteristics and outcome of patients with metastatic breast cancer publication-title: BMC Cancer doi: 10.1186/s12885-015-1386-7 – volume: 12 start-page: 323 year: 2012 end-page: 334 ident: CR14 article-title: Intra-tumour heterogeneity: a looking glass for cancer? publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3261 – volume: 21 start-page: 846 year: 2015 end-page: 853 ident: CR16 article-title: Toward understanding and exploiting tumor heterogeneity publication-title: Nat. Med. doi: 10.1038/nm.3915 – volume: 18 start-page: 211 year: 2018 end-page: 223 ident: CR36 article-title: Genetic insights into the morass of metastatic heterogeneity publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2017.126 – volume: 22 start-page: 709 year: 2012 end-page: 724 ident: CR101 article-title: Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1 publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.10.012 – volume: 15 start-page: 473 year: 2015 end-page: 483 ident: CR76 article-title: Tumorigenesis: it takes a village publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3971 – volume: 525 start-page: 119 year: 2015 end-page: 123 ident: CR63 article-title: Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity publication-title: Nature doi: 10.1038/nature14665 – volume: 114 start-page: 11494 year: 2017 end-page: 11499 ident: CR126 article-title: Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1618091114 – volume: 35 start-page: 17 year: 2019 end-page: 32 e16 ident: CR54 article-title: Gain fat-lose metastasis: converting invasive breast cancer cells into adipocytes inhibits cancer metastasis publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.12.002 – volume: 486 start-page: 346 year: 2012 end-page: 352 ident: CR20 article-title: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups publication-title: Nature doi: 10.1038/nature10983 – volume: 481 start-page: 306 year: 2012 end-page: 313 ident: CR25 article-title: Clonal evolution in cancer publication-title: Nature doi: 10.1038/nature10762 – volume: 566 start-page: 553 year: 2019 end-page: 557 ident: CR90 article-title: Neutrophils escort circulating tumour cells to enable cell cycle progression publication-title: Nature doi: 10.1038/s41586-019-0915-y – volume: 556 start-page: 463 year: 2018 end-page: 468 ident: CR48 article-title: Identification of the tumour transition states occurring during EMT publication-title: Nature doi: 10.1038/s41586-018-0040-3 – volume: 11 start-page: 1487 year: 2009 end-page: 1495 ident: CR56 article-title: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs publication-title: Nat. Cell Biol. doi: 10.1038/ncb1998 – volume: 486 start-page: 405 year: 2012 end-page: 409 ident: CR24 article-title: Sequence analysis of mutations and translocations across breast cancer subtypes publication-title: Nature doi: 10.1038/nature11154 – ident: CR47 – volume: 468 start-page: 72 year: 2020 end-page: 81 ident: CR92 article-title: Communication between EMT and PD-L1 signaling: new insights into tumor immune evasion publication-title: Cancer Lett. doi: 10.1016/j.canlet.2019.10.013 – volume: 5 start-page: 5 year: 2011 end-page: 23 ident: CR8 article-title: Deconstructing the molecular portraits of breast cancer publication-title: Mol. Oncol. doi: 10.1016/j.molonc.2010.11.003 – volume: 19 start-page: 110 year: 2019 end-page: 117 ident: CR72 article-title: Cooperation among cancer cells: applying game theory to cancer publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-018-0083-7 – volume: 10 year: 2019 ident: CR34 article-title: Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer publication-title: Nat. Commun. doi: 10.1038/s41467-019-08595-2 – volume: 16 year: 2014 ident: CR60 article-title: Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo publication-title: Breast Cancer Res. doi: 10.1186/bcr3687 – volume: 415 start-page: 530 year: 2002 end-page: 536 ident: CR17 article-title: Gene expression profiling predicts clinical outcome of breast cancer publication-title: Nature doi: 10.1038/415530a – volume: 12 year: 2010 ident: CR7 article-title: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer publication-title: Breast Cancer Res. doi: 10.1186/bcr2635 – volume: 166 start-page: 21 year: 2016 end-page: 45 ident: CR45 article-title: Emt: 2016 publication-title: Cell doi: 10.1016/j.cell.2016.06.028 – volume: 139 start-page: 1315 year: 2009 end-page: 1326 ident: CR68 article-title: Tumor self-seeding by circulating cancer cells publication-title: Cell doi: 10.1016/j.cell.2009.11.025 – volume: 24 start-page: 65 year: 2019 end-page: 78 ident: CR42 article-title: Phenotypic plasticity: driver of cancer initiation, progression, and therapy resistance publication-title: Cell Stem Cell doi: 10.1016/j.stem.2018.11.011 – volume: 526 start-page: 131 year: 2015 end-page: 135 ident: CR53 article-title: Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells publication-title: Nature doi: 10.1038/nature15260 – volume: 149 start-page: 979 year: 2012 end-page: 993 ident: CR29 article-title: Mutational processes molding the genomes of 21 breast cancers publication-title: Cell doi: 10.1016/j.cell.2012.04.024 – volume: 472 start-page: 90 year: 2011 end-page: 94 ident: CR18 article-title: Tumour evolution inferred by single-cell sequencing publication-title: Nature doi: 10.1038/nature09807 – volume: 45 start-page: 696 year: 2018 end-page: 711 e698 ident: CR121 article-title: Regulation of epithelial plasticity determines metastatic organotropism in pancreatic cancer publication-title: Dev. Cell doi: 10.1016/j.devcel.2018.05.025 – volume: 158 start-page: 1110 year: 2014 end-page: 1122 ident: CR99 article-title: Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis publication-title: Cell doi: 10.1016/j.cell.2014.07.013 – volume: 52 start-page: 701 year: 2020 end-page: 708 ident: CR97 article-title: Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases publication-title: Nat. Genet. doi: 10.1038/s41588-020-0628-z – volume: 133 start-page: 704 year: 2008 end-page: 715 ident: CR55 article-title: The epithelial-mesenchymal transition generates cells with properties of stem cells publication-title: Cell doi: 10.1016/j.cell.2008.03.027 – volume: 21 start-page: 102 year: 2019 end-page: 112 ident: CR127 article-title: Non-redundant functions of EMT transcription factors publication-title: Nat. Cell Biol. doi: 10.1038/s41556-018-0196-y – volume: 508 start-page: 52 year: 2014 end-page: 53 ident: CR67 article-title: Cancer: clonal cooperation publication-title: Nature doi: 10.1038/508052a – volume: 71 start-page: 6857 year: 2011 end-page: 6866 ident: CR80 article-title: Breast cancer subtype-specific interactions with the microenvironment dictate mechanisms of invasion publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-11-1818 – volume: 154 start-page: 61 year: 2013 end-page: 74 ident: CR58 article-title: Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity publication-title: Cell doi: 10.1016/j.cell.2013.06.005 – volume: 15 start-page: 73 year: 2015 end-page: 86 ident: CR65 article-title: Immune cell promotion of metastasis publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3789 – volume: 26 start-page: 569 year: 2020 end-page: 578 e567 ident: CR119 article-title: Plasticity of Lgr5-negative cancer cells drives metastasis in colorectal cancer publication-title: Cell Stem Cell doi: 10.1016/j.stem.2020.02.008 – volume: 236 start-page: 457 year: 2015 end-page: 466 ident: CR41 article-title: Uncovering the genomic heterogeneity of multifocal breast cancer publication-title: J. Pathol. doi: 10.1002/path.4540 – volume: 43 start-page: 46 year: 2016 end-page: 54 ident: CR44 article-title: Cellular plasticity: 1712 to the present day publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2016.07.005 – volume: 527 start-page: 472 year: 2015 end-page: 476 ident: CR123 article-title: Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance publication-title: Nature doi: 10.1038/nature15748 – volume: 461 start-page: 809 year: 2009 end-page: 813 ident: CR19 article-title: Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution publication-title: Nature doi: 10.1038/nature08489 – volume: 21 start-page: 797 year: 2019 end-page: 798 ident: CR89 article-title: Subclonal cooperation rewrites metastasis publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0353-y – volume: 18 start-page: 128 year: 2018 end-page: 134 ident: CR52 article-title: EMT in cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2017.118 – volume: 68 start-page: 937 year: 2008 end-page: 945 ident: CR64 article-title: Direct evidence for epithelial-mesenchymal transitions in breast cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-2148 – volume: 486 start-page: 395 year: 2012 end-page: 399 ident: CR21 article-title: The clonal and mutational evolution spectrum of primary triple-negative breast cancers publication-title: Nature doi: 10.1038/nature10933 – volume: 149 start-page: 994 year: 2012 end-page: 1007 ident: CR30 article-title: The life history of 21 breast cancers publication-title: Cell doi: 10.1016/j.cell.2012.04.023 – volume: 21 start-page: 751 year: 2015 end-page: 759 ident: CR40 article-title: Subclonal diversification of primary breast cancer revealed by multiregion sequencing publication-title: Nat. Med. doi: 10.1038/nm.3886 – volume: 22 start-page: 725 year: 2012 end-page: 736 ident: CR102 article-title: Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.09.022 – volume: 467 start-page: 1114 year: 2010 end-page: 1117 ident: CR28 article-title: Distant metastasis occurs late during the genetic evolution of pancreatic cancer publication-title: Nature doi: 10.1038/nature09515 – volume: 9 year: 2018 ident: CR33 article-title: High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer publication-title: Nat. Commun. doi: 10.1038/s41467-018-07406-4 – volume: 29 start-page: 212 year: 2019 end-page: 226 ident: CR46 article-title: EMT transition states during tumor progression and metastasis publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2018.12.001 – volume: 74 start-page: 6330 year: 2014 end-page: 6340 ident: CR115 article-title: Transient SNAIL1 expression is necessary for metastatic competence in breast cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0923 – volume: 10 year: 2019 ident: CR104 article-title: Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors publication-title: Nat. Commun. doi: 10.1038/s41467-019-10269-y – volume: 525 start-page: 114 year: 2015 end-page: 118 ident: CR62 article-title: PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours publication-title: Nature doi: 10.1038/nature14669 – volume: 29 start-page: 2565 year: 2019 end-page: 2569 e2563 ident: CR113 article-title: Fsp1-mediated lineage tracing fails to detect the majority of disseminating cells undergoing EMT publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.10.107 – volume: 13 start-page: 2456 year: 2015 end-page: 2469 ident: CR117 article-title: Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.11.025 – volume: 9 year: 2018 ident: CR86 article-title: Macrophages orchestrate breast cancer early dissemination and metastasis publication-title: Nat. Commun. doi: 10.1038/s41467-017-02481-5 – volume: 14 year: 2012 ident: CR81 article-title: Lack of transforming growth factor-beta signaling promotes collective cancer cell invasion through tumor-stromal crosstalk publication-title: Breast Cancer Res. doi: 10.1186/bcr3217 – volume: 21 start-page: 879 year: 2019 end-page: 888 ident: CR88 article-title: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0346-x – volume: 147 start-page: 992 year: 2011 end-page: 1009 ident: CR103 article-title: Cancer invasion and the microenvironment: plasticity and reciprocity publication-title: Cell doi: 10.1016/j.cell.2011.11.016 – volume: 30 start-page: 365 year: 2016 ident: CR85 article-title: The multifaceted role of perivascular macrophages in tumors publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.07.009 – volume: 3 start-page: 537 year: 2003 end-page: 549 ident: CR95 article-title: A multigenic program mediating breast cancer metastasis to bone publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00132-6 – volume: 34 start-page: 5309 year: 2015 end-page: 5316 ident: CR4 article-title: The origin of breast tumor heterogeneity publication-title: Oncogene doi: 10.1038/onc.2014.475 – volume: 8 start-page: 98 year: 1889 end-page: 101 ident: CR136 article-title: The distribution of secondary growths in cancer of the breast. publication-title: Cancer Metastasis Rev. – volume: 103 start-page: 2892 year: 2004 end-page: 2899 ident: CR43 article-title: Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm publication-title: Blood doi: 10.1182/blood-2003-08-2807 – volume: 19 start-page: 518 year: 2017 end-page: 529 ident: CR50 article-title: The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer publication-title: Nat. Cell Biol. doi: 10.1038/ncb3513 – volume: 19 start-page: 405 year: 2019 end-page: 414 ident: CR140 article-title: Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0149-1 – volume: 35 start-page: 618 year: 2019 end-page: 632 e616 ident: CR49 article-title: Intraclonal plasticity in mammary tumors revealed through large-scale single-cell resolution 3D imaging publication-title: Cancer Cell doi: 10.1016/j.ccell.2019.02.010 – volume: 4 start-page: 540 year: 2004 end-page: 550 ident: CR83 article-title: Cancer and the chemokine network publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1388 – volume: 233 start-page: 124 year: 2014 end-page: 137 ident: CR3 article-title: Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models publication-title: J. Pathol. doi: 10.1002/path.4345 – volume: 8 start-page: 444 year: 2007 end-page: 448 ident: CR109 article-title: Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(07)70140-7 – volume: 146 start-page: 633 year: 2011 end-page: 644 ident: CR59 article-title: Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells publication-title: Cell doi: 10.1016/j.cell.2011.07.026 – volume: 567 start-page: 540 year: 2019 end-page: 544 ident: CR98 article-title: Glucocorticoids promote breast cancer metastasis publication-title: Nature doi: 10.1038/s41586-019-1019-4 – ident: CR105 – volume: 20 start-page: 25 year: 2020 end-page: 39 ident: CR93 article-title: Tumour-intrinsic resistance to immune checkpoint blockade publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-019-0218-4 – ident: CR122 – volume: 520 start-page: 358 year: 2015 end-page: 362 ident: CR35 article-title: A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis publication-title: Nature doi: 10.1038/nature14403 – volume: 12 start-page: 519 year: 2015 end-page: 522 ident: CR132 article-title: G&T-seq: parallel sequencing of single-cell genomes and transcriptomes publication-title: Nat. Methods doi: 10.1038/nmeth.3370 – volume: 187 start-page: 2152 year: 2017 end-page: 2162 ident: CR23 article-title: Breast cancer molecular stratification: from intrinsic subtypes to integrative clusters publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2017.04.022 – volume: 216 start-page: 1016 year: 2019 end-page: 1026 ident: CR124 article-title: Context-dependent EMT programs in cancer metastasis publication-title: J. Exp. Med. doi: 10.1084/jem.20181827 – volume: 113 start-page: E854 year: 2016 end-page: E863 ident: CR70 article-title: Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1508541113 – volume: 194 start-page: 23 year: 1976 end-page: 28 ident: CR26 article-title: The clonal evolution of tumor cell populations publication-title: Science doi: 10.1126/science.959840 – volume: 23 start-page: 1239 year: 2018 end-page: 1248 ident: CR87 article-title: A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.04.007 – volume: 406 start-page: 747 year: 2000 end-page: 752 ident: CR6 article-title: Molecular portraits of human breast tumours publication-title: Nature doi: 10.1038/35021093 – volume: 168 start-page: 613 year: 2017 end-page: 628 ident: CR15 article-title: Clonal heterogeneity and tumor evolution: past, present, and the future publication-title: Cell doi: 10.1016/j.cell.2017.01.018 – volume: 12 year: 2020 ident: CR114 article-title: Tracking cancer progression: from circulating tumor cells to metastasis publication-title: Genome Med. doi: 10.1186/s13073-020-00728-3 – volume: 72 start-page: 4875 year: 2012 end-page: 4882 ident: CR39 article-title: Intratumor heterogeneity: evolution through space and time publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-2217 – volume: 24 start-page: 3237 year: 2018 end-page: 3250 ident: CR61 article-title: Regulation of cellular heterogeneity and rates of symmetric and asymmetric divisions in triple-negative breast cancer publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.08.053 – volume: 25 start-page: 605 year: 2014 end-page: 620 ident: CR84 article-title: A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.03.021 – volume: 20 start-page: 1349 year: 2018 end-page: 1360 ident: CR13 article-title: Tumour heterogeneity and metastasis at single-cell resolution publication-title: Nat. Cell. Biol. doi: 10.1038/s41556-018-0236-7 – volume: 9 start-page: 239 year: 2009 end-page: 252 ident: CR73 article-title: Microenvironmental regulation of metastasis publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2618 – volume: 501 start-page: 346 year: 2013 end-page: 354 ident: CR74 article-title: Influence of tumour micro-environment heterogeneity on therapeutic response publication-title: Nature doi: 10.1038/nature12626 – volume: 19 start-page: 1423 year: 2013 end-page: 1437 ident: CR75 article-title: Microenvironmental regulation of tumor progression and metastasis publication-title: Nat. Med. doi: 10.1038/nm.3394 – volume: 176 start-page: 98 year: 2019 end-page: 112 e114 ident: CR100 article-title: Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding publication-title: Cell doi: 10.1016/j.cell.2018.11.046 – volume: 28 start-page: 1143 year: 2014 end-page: 1158 ident: CR5 article-title: Mammary stem cells and the differentiation hierarchy: current status and perspectives publication-title: Genes Dev. doi: 10.1101/gad.242511.114 – volume: 8 start-page: 381 year: 2018 ident: CR120 article-title: EMT and stemness in tumor dormancy and outgrowth: are they intertwined processes? publication-title: Front. Oncol. doi: 10.3389/fonc.2018.00381 – volume: 467 start-page: 1109 year: 2010 end-page: 1113 ident: CR27 article-title: The patterns and dynamics of genomic instability in metastatic pancreatic cancer publication-title: Nature doi: 10.1038/nature09460 – volume: 520 start-page: 353 year: 2015 end-page: 357 ident: CR69 article-title: The evolutionary history of lethal metastatic prostate cancer publication-title: Nature doi: 10.1038/nature14347 – volume: 45 start-page: 681 year: 2018 end-page: 695 e684 ident: CR107 article-title: EMT subtype influences epithelial plasticity and mode of cell migration publication-title: Dev. Cell doi: 10.1016/j.devcel.2018.05.027 – volume: 60 start-page: 537 year: 2015 end-page: 546 ident: CR2 article-title: Breast tumor heterogeneity: source of fitness, hurdle for therapy publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.10.031 – volume: 5 year: 2014 ident: CR31 article-title: DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts publication-title: Nat. Commun. doi: 10.1038/ncomms6871 – volume: 99 start-page: 31 year: 1982 end-page: 68 ident: CR10 article-title: How does the extracellular matrix direct gene expression? publication-title: J. Theor. Biol. doi: 10.1016/0022-5193(82)90388-5 – volume: 12 start-page: 566 year: 2017 end-page: 580 ident: CR131 article-title: Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq publication-title: Nat. Protoc. doi: 10.1038/nprot.2017.003 – volume: 14 start-page: 2281 year: 2016 end-page: 2288 ident: CR112 article-title: Plasticity between epithelial and mesenchymal states unlinks EMT from metastasis-enhancing stem cell capacity publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.02.034 – volume: 9 start-page: 1392 year: 2007 end-page: 1400 ident: CR79 article-title: Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells publication-title: Nat. Cell Biol. doi: 10.1038/ncb1658 – volume: 339 start-page: 580 year: 2013 end-page: 584 ident: CR111 article-title: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition publication-title: Science doi: 10.1126/science.1228522 – volume: 75 start-page: 3925 year: 2015 end-page: 3935 ident: CR106 article-title: DeltaNp63alpha promotes breast cancer cell motility through the selective activation of components of the epithelial-to-mesenchymal transition program publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-3363 – volume: 147 start-page: 275 year: 2011 end-page: 292 ident: CR137 article-title: Tumor metastasis: molecular insights and evolving paradigms publication-title: Cell doi: 10.1016/j.cell.2011.09.024 – volume: 5 start-page: 1228 year: 2013 end-page: 1242 ident: CR116 article-title: TGF-beta-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition publication-title: Cell Rep. doi: 10.1016/j.celrep.2013.11.014 – volume: 19 start-page: 667 year: 2019 end-page: 685 ident: CR139 article-title: The pro-tumorigenic host response to cancer therapies publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0209-6 – volume: 528 start-page: 267 year: 2015 end-page: 271 ident: CR32 article-title: Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells publication-title: Nature doi: 10.1038/nature15742 – volume: 501 start-page: 365 year: 2013 end-page: 372 ident: CR37 article-title: Selection and adaptation during metastatic cancer progression publication-title: Nature doi: 10.1038/nature12628 – volume: 9 start-page: 171 year: 2014 end-page: 181 ident: CR135 article-title: Full-length RNA-seq from single cells using Smart-seq2 publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.006 – volume: 14 start-page: 155 year: 2017 end-page: 167 ident: CR91 article-title: Circulating and disseminated tumour cells—mechanisms of immune surveillance and escape publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2016.144 – volume: 28 start-page: 1143 year: 2014 ident: 1328_CR5 publication-title: Genes Dev. doi: 10.1101/gad.242511.114 – volume: 508 start-page: 52 year: 2014 ident: 1328_CR67 publication-title: Nature doi: 10.1038/508052a – volume: 501 start-page: 355 year: 2013 ident: 1328_CR11 publication-title: Nature doi: 10.1038/nature12627 – volume: 19 start-page: 110 year: 2019 ident: 1328_CR72 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-018-0083-7 – volume: 556 start-page: 463 year: 2018 ident: 1328_CR48 publication-title: Nature doi: 10.1038/s41586-018-0040-3 – volume: 9 year: 2018 ident: 1328_CR33 publication-title: Nat. Commun. doi: 10.1038/s41467-018-07406-4 – volume: 35 start-page: 17 year: 2019 ident: 1328_CR54 publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.12.002 – volume: 4 start-page: 540 year: 2004 ident: 1328_CR83 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1388 – volume: 99 start-page: 31 year: 1982 ident: 1328_CR10 publication-title: J. Theor. Biol. doi: 10.1016/0022-5193(82)90388-5 – volume: 520 start-page: 358 year: 2015 ident: 1328_CR35 publication-title: Nature doi: 10.1038/nature14403 – ident: 1328_CR122 doi: 10.15252/emmm.201809085 – volume: 35 start-page: 618 year: 2019 ident: 1328_CR49 publication-title: Cancer Cell doi: 10.1016/j.ccell.2019.02.010 – volume: 481 start-page: 85 year: 2011 ident: 1328_CR82 publication-title: Nature doi: 10.1038/nature10694 – volume: 14 start-page: 2281 year: 2016 ident: 1328_CR112 publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.02.034 – volume: 29 start-page: 2565 year: 2019 ident: 1328_CR113 publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.10.107 – volume: 149 start-page: 979 year: 2012 ident: 1328_CR29 publication-title: Cell doi: 10.1016/j.cell.2012.04.024 – volume: 15 start-page: 73 year: 2015 ident: 1328_CR65 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3789 – volume: 45 start-page: 696 year: 2018 ident: 1328_CR121 publication-title: Dev. Cell doi: 10.1016/j.devcel.2018.05.025 – volume: 9 year: 2018 ident: 1328_CR125 publication-title: Nat. Commun. doi: 10.1038/s41467-018-07130-z – volume: 19 start-page: 405 year: 2019 ident: 1328_CR140 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0149-1 – volume: 24 start-page: 3237 year: 2018 ident: 1328_CR61 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.08.053 – volume: 15 year: 2015 ident: 1328_CR110 publication-title: BMC Cancer doi: 10.1186/s12885-015-1386-7 – volume: 103 start-page: 2892 year: 2004 ident: 1328_CR43 publication-title: Blood doi: 10.1182/blood-2003-08-2807 – volume: 194 start-page: 23 year: 1976 ident: 1328_CR26 publication-title: Science doi: 10.1126/science.959840 – volume: 514 start-page: 54 year: 2014 ident: 1328_CR77 publication-title: Nature doi: 10.1038/nature13556 – volume: 14 start-page: 430 year: 2014 ident: 1328_CR94 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3726 – volume: 18 start-page: 211 year: 2018 ident: 1328_CR36 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2017.126 – volume: 19 start-page: 274 year: 2013 ident: 1328_CR138 publication-title: Nat. Med. doi: 10.1038/nm.3121 – volume: 472 start-page: 90 year: 2011 ident: 1328_CR18 publication-title: Nature doi: 10.1038/nature09807 – volume: 526 start-page: 131 year: 2015 ident: 1328_CR53 publication-title: Nature doi: 10.1038/nature15260 – volume: 16 year: 2014 ident: 1328_CR60 publication-title: Breast Cancer Res. doi: 10.1186/bcr3687 – volume: 75 start-page: 2749 year: 2015 ident: 1328_CR118 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-3476 – volume: 520 start-page: 353 year: 2015 ident: 1328_CR69 publication-title: Nature doi: 10.1038/nature14347 – volume: 525 start-page: 119 year: 2015 ident: 1328_CR63 publication-title: Nature doi: 10.1038/nature14665 – volume: 14 start-page: 155 year: 2017 ident: 1328_CR91 publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2016.144 – volume: 486 start-page: 395 year: 2012 ident: 1328_CR21 publication-title: Nature doi: 10.1038/nature10933 – volume: 154 start-page: 61 year: 2013 ident: 1328_CR58 publication-title: Cell doi: 10.1016/j.cell.2013.06.005 – volume: 72 start-page: 4875 year: 2012 ident: 1328_CR39 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-2217 – volume: 9 start-page: 171 year: 2014 ident: 1328_CR135 publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.006 – volume: 527 start-page: 472 year: 2015 ident: 1328_CR123 publication-title: Nature doi: 10.1038/nature15748 – volume: 486 start-page: 405 year: 2012 ident: 1328_CR24 publication-title: Nature doi: 10.1038/nature11154 – volume: 22 start-page: 709 year: 2012 ident: 1328_CR101 publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.10.012 – volume: 21 start-page: 846 year: 2015 ident: 1328_CR16 publication-title: Nat. Med. doi: 10.1038/nm.3915 – volume: 501 start-page: 346 year: 2013 ident: 1328_CR74 publication-title: Nature doi: 10.1038/nature12626 – volume: 144 start-page: 646 year: 2011 ident: 1328_CR141 publication-title: Cell doi: 10.1016/j.cell.2011.02.013 – volume: 158 start-page: 1110 year: 2014 ident: 1328_CR99 publication-title: Cell doi: 10.1016/j.cell.2014.07.013 – volume: 15 start-page: 473 year: 2015 ident: 1328_CR76 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3971 – volume: 71 start-page: 6857 year: 2011 ident: 1328_CR80 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-11-1818 – volume: 461 start-page: 809 year: 2009 ident: 1328_CR19 publication-title: Nature doi: 10.1038/nature08489 – volume: 75 start-page: 3925 year: 2015 ident: 1328_CR106 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-3363 – volume: 166 start-page: 21 year: 2016 ident: 1328_CR45 publication-title: Cell doi: 10.1016/j.cell.2016.06.028 – volume: 415 start-page: 530 year: 2002 ident: 1328_CR17 publication-title: Nature doi: 10.1038/415530a – volume: 20 start-page: 1349 year: 2018 ident: 1328_CR13 publication-title: Nat. Cell. Biol. doi: 10.1038/s41556-018-0236-7 – volume: 12 year: 2020 ident: 1328_CR114 publication-title: Genome Med. doi: 10.1186/s13073-020-00728-3 – volume: 187 start-page: 2152 year: 2017 ident: 1328_CR23 publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2017.04.022 – volume: 21 start-page: 751 year: 2015 ident: 1328_CR40 publication-title: Nat. Med. doi: 10.1038/nm.3886 – volume: 10 start-page: 1096 year: 2013 ident: 1328_CR134 publication-title: Nat. Methods doi: 10.1038/nmeth.2639 – volume: 60 start-page: 537 year: 2015 ident: 1328_CR2 publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.10.031 – volume: 467 start-page: 1114 year: 2010 ident: 1328_CR28 publication-title: Nature doi: 10.1038/nature09515 – volume: 490 start-page: 61 year: 2012 ident: 1328_CR22 publication-title: Nature doi: 10.1038/nature11412 – volume: 146 start-page: 633 year: 2011 ident: 1328_CR59 publication-title: Cell doi: 10.1016/j.cell.2011.07.026 – volume: 216 start-page: 1016 year: 2019 ident: 1328_CR124 publication-title: J. Exp. Med. doi: 10.1084/jem.20181827 – volume: 567 start-page: 540 year: 2019 ident: 1328_CR98 publication-title: Nature doi: 10.1038/s41586-019-1019-4 – volume: 233 start-page: 124 year: 2014 ident: 1328_CR3 publication-title: J. Pathol. doi: 10.1002/path.4345 – volume: 12 start-page: 519 year: 2015 ident: 1328_CR132 publication-title: Nat. Methods doi: 10.1038/nmeth.3370 – volume: 547 start-page: E1 year: 2017 ident: 1328_CR128 publication-title: Nature doi: 10.1038/nature22816 – volume: 29 start-page: 212 year: 2019 ident: 1328_CR46 publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2018.12.001 – volume: 19 start-page: 1423 year: 2013 ident: 1328_CR75 publication-title: Nat. Med. doi: 10.1038/nm.3394 – volume: 13 start-page: 2456 year: 2015 ident: 1328_CR117 publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.11.025 – volume: 19 start-page: 667 year: 2019 ident: 1328_CR139 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0209-6 – volume: 168 start-page: 613 year: 2017 ident: 1328_CR15 publication-title: Cell doi: 10.1016/j.cell.2017.01.018 – volume: 24 start-page: 65 year: 2019 ident: 1328_CR42 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2018.11.011 – volume: 68 start-page: 937 year: 2008 ident: 1328_CR64 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-2148 – volume: 113 start-page: E854 year: 2016 ident: 1328_CR70 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1508541113 – volume: 12 year: 2010 ident: 1328_CR7 publication-title: Breast Cancer Res. doi: 10.1186/bcr2635 – volume: 236 start-page: 457 year: 2015 ident: 1328_CR41 publication-title: J. Pathol. doi: 10.1002/path.4540 – volume: 8 start-page: 98 year: 1889 ident: 1328_CR136 publication-title: Cancer Metastasis Rev. – ident: 1328_CR129 doi: 10.1038/s41586-019-1526-3 – volume: 34 start-page: 5309 year: 2015 ident: 1328_CR4 publication-title: Oncogene doi: 10.1038/onc.2014.475 – volume: 527 start-page: 525 year: 2015 ident: 1328_CR51 publication-title: Nature doi: 10.1038/nature16064 – volume: 11 start-page: 1487 year: 2009 ident: 1328_CR56 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1998 – volume: 11 start-page: 2081 year: 2016 ident: 1328_CR133 publication-title: Nat. Protoc. doi: 10.1038/nprot.2016.138 – volume: 3 start-page: 27 year: 2013 ident: 1328_CR9 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-12-0462 – volume: 10 year: 2019 ident: 1328_CR104 publication-title: Nat. Commun. doi: 10.1038/s41467-019-10269-y – ident: 1328_CR47 doi: 10.1038/s41580-020-0237-9 – volume: 146 start-page: 148 year: 2011 ident: 1328_CR78 publication-title: Cell doi: 10.1016/j.cell.2011.05.040 – volume: 52 start-page: 701 year: 2020 ident: 1328_CR97 publication-title: Nat. Genet. doi: 10.1038/s41588-020-0628-z – volume: 19 start-page: 518 year: 2017 ident: 1328_CR50 publication-title: Nat. Cell Biol. doi: 10.1038/ncb3513 – volume: 20 start-page: 25 year: 2020 ident: 1328_CR93 publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-019-0218-4 – volume: 525 start-page: 114 year: 2015 ident: 1328_CR62 publication-title: Nature doi: 10.1038/nature14669 – volume: 5 start-page: 5 year: 2011 ident: 1328_CR8 publication-title: Mol. Oncol. doi: 10.1016/j.molonc.2010.11.003 – volume: 467 start-page: 1109 year: 2010 ident: 1328_CR27 publication-title: Nature doi: 10.1038/nature09460 – volume: 14 year: 2012 ident: 1328_CR81 publication-title: Breast Cancer Res. doi: 10.1186/bcr3217 – volume: 436 start-page: 518 year: 2005 ident: 1328_CR96 publication-title: Nature doi: 10.1038/nature03799 – volume: 18 start-page: 128 year: 2018 ident: 1328_CR52 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2017.118 – volume: 9 start-page: 1392 year: 2007 ident: 1328_CR79 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1658 – volume: 468 start-page: 72 year: 2020 ident: 1328_CR92 publication-title: Cancer Lett. doi: 10.1016/j.canlet.2019.10.013 – volume: 481 start-page: 306 year: 2012 ident: 1328_CR25 publication-title: Nature doi: 10.1038/nature10762 – volume: 5 start-page: 66 year: 2019 ident: 1328_CR1 publication-title: Nat. Rev. Dis. Primers doi: 10.1038/s41572-019-0111-2 – volume: 21 start-page: 797 year: 2019 ident: 1328_CR89 publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0353-y – volume: 172 start-page: 205 year: 2018 ident: 1328_CR38 publication-title: Cell doi: 10.1016/j.cell.2017.12.007 – volume: 147 start-page: 992 year: 2011 ident: 1328_CR103 publication-title: Cell doi: 10.1016/j.cell.2011.11.016 – volume: 508 start-page: 113 year: 2014 ident: 1328_CR66 publication-title: Nature doi: 10.1038/nature13187 – volume: 43 start-page: 46 year: 2016 ident: 1328_CR44 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2016.07.005 – volume: 133 start-page: 704 year: 2008 ident: 1328_CR55 publication-title: Cell doi: 10.1016/j.cell.2008.03.027 – volume: 21 start-page: 879 year: 2019 ident: 1328_CR88 publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0346-x – volume: 92 start-page: 1342 year: 2012 ident: 1328_CR130 publication-title: Lab. Investig. doi: 10.1038/labinvest.2012.91 – volume: 45 start-page: 681 year: 2018 ident: 1328_CR107 publication-title: Dev. Cell doi: 10.1016/j.devcel.2018.05.027 – volume: 38 start-page: 7113 year: 2019 ident: 1328_CR108 publication-title: Oncogene doi: 10.1038/s41388-019-0899-y – volume: 155 start-page: 1639 year: 2013 ident: 1328_CR71 publication-title: Cell doi: 10.1016/j.cell.2013.11.029 – volume: 525 start-page: 256 year: 2015 ident: 1328_CR57 publication-title: Nature doi: 10.1038/nature14897 – volume: 23 start-page: 1239 year: 2018 ident: 1328_CR87 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.04.007 – volume: 17 start-page: 260 year: 2015 ident: 1328_CR12 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.08.014 – volume: 26 start-page: 569 year: 2020 ident: 1328_CR119 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2020.02.008 – volume: 147 start-page: 275 year: 2011 ident: 1328_CR137 publication-title: Cell doi: 10.1016/j.cell.2011.09.024 – volume: 114 start-page: 11494 year: 2017 ident: 1328_CR126 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1618091114 – volume: 3 start-page: 537 year: 2003 ident: 1328_CR95 publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00132-6 – volume: 12 start-page: 566 year: 2017 ident: 1328_CR131 publication-title: Nat. Protoc. doi: 10.1038/nprot.2017.003 – volume: 406 start-page: 747 year: 2000 ident: 1328_CR6 publication-title: Nature doi: 10.1038/35021093 – volume: 12 start-page: 323 year: 2012 ident: 1328_CR14 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3261 – volume: 30 start-page: 365 year: 2016 ident: 1328_CR85 publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.07.009 – volume: 8 start-page: 444 year: 2007 ident: 1328_CR109 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(07)70140-7 – volume: 25 start-page: 605 year: 2014 ident: 1328_CR84 publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.03.021 – volume: 528 start-page: 267 year: 2015 ident: 1328_CR32 publication-title: Nature doi: 10.1038/nature15742 – volume: 339 start-page: 580 year: 2013 ident: 1328_CR111 publication-title: Science doi: 10.1126/science.1228522 – volume: 501 start-page: 365 year: 2013 ident: 1328_CR37 publication-title: Nature doi: 10.1038/nature12628 – volume: 8 start-page: 381 year: 2018 ident: 1328_CR120 publication-title: Front. Oncol. doi: 10.3389/fonc.2018.00381 – volume: 9 year: 2018 ident: 1328_CR86 publication-title: Nat. Commun. doi: 10.1038/s41467-017-02481-5 – volume: 74 start-page: 6330 year: 2014 ident: 1328_CR115 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0923 – volume: 486 start-page: 346 year: 2012 ident: 1328_CR20 publication-title: Nature doi: 10.1038/nature10983 – ident: 1328_CR105 doi: 10.1098/rsif.2017.0512 – volume: 149 start-page: 994 year: 2012 ident: 1328_CR30 publication-title: Cell doi: 10.1016/j.cell.2012.04.023 – volume: 5 start-page: 1228 year: 2013 ident: 1328_CR116 publication-title: Cell Rep. doi: 10.1016/j.celrep.2013.11.014 – volume: 21 start-page: 102 year: 2019 ident: 1328_CR127 publication-title: Nat. Cell Biol. doi: 10.1038/s41556-018-0196-y – volume: 139 start-page: 1315 year: 2009 ident: 1328_CR68 publication-title: Cell doi: 10.1016/j.cell.2009.11.025 – volume: 176 start-page: 98 year: 2019 ident: 1328_CR100 publication-title: Cell doi: 10.1016/j.cell.2018.11.046 – volume: 22 start-page: 725 year: 2012 ident: 1328_CR102 publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.09.022 – volume: 5 year: 2014 ident: 1328_CR31 publication-title: Nat. Commun. doi: 10.1038/ncomms6871 – volume: 9 start-page: 239 year: 2009 ident: 1328_CR73 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2618 – volume: 566 start-page: 553 year: 2019 ident: 1328_CR90 publication-title: Nature doi: 10.1038/s41586-019-0915-y – volume: 10 year: 2019 ident: 1328_CR34 publication-title: Nat. Commun. doi: 10.1038/s41467-019-08595-2 |
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| Title | Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression |
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