Serum 4β-hydroxycholesterol increases during fluconazole treatment

Purpose The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity. We tested the effect of another antifungal triazole agent, fluconazole, on serum concentrations of different st...

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Vydané v:	European journal of clinical pharmacology Ročník 77; číslo 5; s. 659 - 669
Hlavní autori:	Lütjohann, Dieter, Stellaard, Frans, Kerksiek, Anja, Lötsch, Jörn, Oertel, Bruno G
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2021 Springer Nature B.V
Predmet:	Antifungal agents Biomedical and Life Sciences Biomedicine Cholesterol Clinical Trial Cytochrome P450 Demethylation Dosage Fluconazole Gas chromatography Hemopoiesis Itraconazole Ketoconazole Lanosterol Lipid metabolism Liver Mass spectroscopy Pharmacology/Toxicology Placebos Sterols Bile acid precursors Antifungal Cholesterol synthesis Cholesterol metabolism Cytochrome P450 Oxysterols
ISSN:	0031-6970, 1432-1041, 1432-1041
On-line prístup:	Získať plný text
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