Serum 4β-hydroxycholesterol increases during fluconazole treatment

Purpose The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity. We tested the effect of another antifungal triazole agent, fluconazole, on serum concentrations of different st...

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Bibliographic Details
Published in:	European journal of clinical pharmacology Vol. 77; no. 5; pp. 659 - 669
Main Authors:	Lütjohann, Dieter, Stellaard, Frans, Kerksiek, Anja, Lötsch, Jörn, Oertel, Bruno G
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2021 Springer Nature B.V
Subjects:	Antifungal agents Biomedical and Life Sciences Biomedicine Cholesterol Clinical Trial Cytochrome P450 Demethylation Dosage Fluconazole Gas chromatography Hemopoiesis Itraconazole Ketoconazole Lanosterol Lipid metabolism Liver Mass spectroscopy Pharmacology/Toxicology Placebos Sterols Bile acid precursors Antifungal Cholesterol synthesis Cholesterol metabolism Cytochrome P450 Oxysterols
ISSN:	0031-6970, 1432-1041, 1432-1041
Online Access:	Get full text
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