Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas

Patients with pancreatic and biliary carcinomas lack personalized treatment options, in part because biopsies are often inadequate for molecular characterization. Cell-free DNA (cfDNA) sequencing may enable a precision oncology approach in this setting. We attempted to prospectively analyze 54 genes...

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Vydáno v:	Cancer discovery Ročník 5; číslo 10; s. 1040
Hlavní autoři:	Zill, Oliver A, Greene, Claire, Sebisanovic, Dragan, Siew, Lai Mun, Leng, Jim, Vu, Mary, Hendifar, Andrew E, Wang, Zhen, Atreya, Chloe E, Kelley, Robin K, Van Loon, Katherine, Ko, Andrew H, Tempero, Margaret A, Bivona, Trever G, Munster, Pamela N, Talasaz, AmirAli, Collisson, Eric A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.10.2015
Témata:	Bile Duct Neoplasms - blood Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - genetics Bile Duct Neoplasms - therapy Biomarkers, Tumor Carcinoma - blood Carcinoma - genetics Disease Progression DNA, Neoplasm - blood DNA, Neoplasm - genetics Gene Expression Profiling - methods High-Throughput Nucleotide Sequencing Humans Mutation Mutation Rate Neoplasm Staging Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - genetics Pancreatic Neoplasms - therapy Prognosis Reproducibility of Results Sensitivity and Specificity
ISSN:	2159-8290, 2159-8290
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