Mechanisms of PARP inhibitor sensitivity and resistance

BRCA1 and BRCA2 deficient tumor cells are sensitive to inhibitors of Poly ADP Ribose Polymerase (PARP1) through the mechanism of synthetic lethality. Several PARP inhibitors, which are oral drugs and generally well tolerated, have now received FDA approval for various ovarian cancer and breast cance...

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Vydané v:	DNA repair Ročník 71; s. 172 - 176
Hlavný autor:	D’Andrea, Alan D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.11.2018
Predmet:	BRCA1/2 Homologous recombination PARP1 Replication fork BRCA1/2 Replication fork PARP1 Homologous recombination
ISSN:	1568-7864, 1568-7856, 1568-7856
On-line prístup:	Získať plný text
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