The roles of long noncoding RNAs in breast cancer metastasis

Breast cancer is the most significant threat to female health. Breast cancer metastasis is the major cause of mortality in breast cancer patients. To fully unravel the molecular mechanisms that underlie the breast cancer cell metastasis is critical for developing strategies to improve survival and p...

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Vydané v:Cell death & disease Ročník 11; číslo 9; s. 749
Hlavní autori: Liu, Lingxia, Zhang, Yu, Lu, Jun
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 14.09.2020
Springer Nature B.V
Predmet:
38
631/67/1347
631/80/84
Antibodies
Biochemistry
Biomedical and Life Sciences
Breast cancer
Breast Neoplasms - genetics
Cell Biology
Cell Culture
Cell Movement
Female
Humans
Immunology
Life Sciences
Medical prognosis
Metastases
Metastasis
Molecular modelling
Neoplasm Metastasis
Prognosis
Review
Review Article
RNA, Long Noncoding - metabolism
ISSN:2041-4889, 2041-4889
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Shrnutí:Breast cancer is the most significant threat to female health. Breast cancer metastasis is the major cause of mortality in breast cancer patients. To fully unravel the molecular mechanisms that underlie the breast cancer cell metastasis is critical for developing strategies to improve survival and prognosis in breast cancer patients. Recent studies have revealed that the long noncoding RNAs (lncRNAs) are involved in breast cancer metastasis through a variety of molecule mechanisms, though the precise functional details of these lncRNAs are yet to be clarified. In the present review, we focus on the functions of lncRNAs in breast cancer invasion and metastasis, with particular emphasis on the functional properties, the regulatory factors, the therapeutic promise, as well as the future challenges in studying these lncRNA.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-020-02954-4