Achieving clinical success with BET inhibitors as anti-cancer agents

The transcriptional upregulation of oncogenes is a driving force behind the progression of many tumours. However, until a decade ago, the concept of ‘switching off’ these oncogenic pathways represented a formidable challenge. Research has revealed that members of the bromo- and extra-terminal domain...

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Bibliographic Details
Published in:	British journal of cancer Vol. 124; no. 9; pp. 1478 - 1490
Main Authors:	Shorstova, Tatiana, Foulkes, William D., Witcher, Michael
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.04.2021 Nature Publishing Group
Subjects:	631/67/1059/602 692/53/2423 Antineoplastic Agents - therapeutic use Antitumor agents Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Chromatin Drug Resistance Epidemiology Humans Molecular Medicine Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Oncology Prognosis Proteins - antagonists & inhibitors Review Review Article Transcription Transcription Factors - antagonists & inhibitors Tumors
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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