An Italian multicenter retrospective-prospective observational study on neurological manifestations of COVID-19 (NEUROCOVID)

Neurological manifestations of COVID-19 have been described in both single case reports and retrospective scanty case series. They may be linked to the potential neurotropism of the SARS-COV-2 virus, as previously demonstrated for other coronaviruses. We report here the description of a multicenter...

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Vydané v:Neurological sciences Ročník 41; číslo 6; s. 1355 - 1359
Hlavní autori: Ferrarese, Carlo, Silani, Vincenzo, Priori, Alberto, Galimberti, Stefania, Agostoni, Elio, Monaco, Salvatore, Padovani, Alessandro, Tedeschi, Gioacchino
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cham Springer International Publishing 01.06.2020
Springer Nature B.V
Predmet:
Betacoronavirus
Case reports
Cerebrospinal fluid
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - therapy
Coronaviruses
COVID-19
Data collection
Humans
Italy - epidemiology
Medicine
Medicine & Public Health
Muscles
Nervous System Diseases - diagnosis
Nervous System Diseases - epidemiology
Nervous System Diseases - therapy
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Observational studies
Pandemics
Patients
Peripheral nerves
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - therapy
Primary care
Prospective Studies
Psychiatry
Retrospective Studies
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Italy
COVID-19
Neurological manifestations
Observational study
NEUROCOVID
ISSN:1590-1874, 1590-3478, 1590-3478
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Shrnutí:Neurological manifestations of COVID-19 have been described in both single case reports and retrospective scanty case series. They may be linked to the potential neurotropism of the SARS-COV-2 virus, as previously demonstrated for other coronaviruses. We report here the description of a multicenter retrospective-prospective observational study promoted by the Italian Society of Neurology (SIN), involving the Italian Neurological Departments, who will consecutively recruit patients with neurological symptoms and/or signs, occurred at the onset or as a complication of COVID-19. Hospitalized patients will be recruited either in neurological wards or in COVID wards; in the latter cases, they will be referred from other specialists to participant neurologists. Outpatients with clinical signs of COVID and neurological manifestations will be also referred to participating neurologists from primary care physicians. A comprehensive data collection, in the form of electronic case report form (eCRF), will register all possible neurological manifestations involving central nervous systems, peripheral nerves, and muscles, together with clinical, laboratory (including cerebrospinal fluid, if available), imaging, neurological, neurophysiological, and neuropsychological data. A follow-up at hospital discharge (in hospitalized patients), and for all patients after 3 and 6 months, is also planned. We believe that this study may help to intercept the full spectrum of neurological manifestations of COVID-19 and, given the large diffusion at national level, can provide a large cohort of patients available for future more focused investigations. Similar observational studies might also be proposed at international level to better define the neurological involvement of COVID-19.
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ISSN:1590-1874
1590-3478
1590-3478
DOI:10.1007/s10072-020-04450-1