Evaluating the potential role of pleiotropy in Mendelian randomization studies

Abstract Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another ('vertical pleiotropy'), then...

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Vydané v:	Human molecular genetics Ročník 27; číslo R2; s. R195 - R208
Hlavní autori:	Hemani, Gibran, Bowden, Jack, Davey Smith, George
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 01.08.2018
Predmet:	Animals Genetic Pleiotropy - genetics Genetic Pleiotropy - physiology Genetic Variation Genome, Human Genome-Wide Association Study Humans Mendelian Randomization Analysis - methods Phenotype Polymorphism, Single Nucleotide - genetics Reproducibility of Results
ISSN:	0964-6906, 1460-2083, 1460-2083
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