A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of dyslipidemia on immune cell metabolism, we performed in-depth transcriptional, met...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 25; no. 8; pp. 2044 - 2052.e5
Main Authors:	Baardman, Jeroen, Verberk, Sanne G.S., Prange, Koen H.M., van Weeghel, Michel, van der Velden, Saskia, Ryan, Dylan G., Wüst, Rob C.I., Neele, Annette E., Speijer, Dave, Denis, Simone W., Witte, Maarten E., Houtkooper, Riekelt H., O’neill, Luke A., Knatko, Elena V., Dinkova-Kostova, Albena T., Lutgens, Esther, de Winther, Menno P.J., Van den Bossche, Jan
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 20.11.2018 Elsevier
Subjects:	Animals atherosclerosis cardiovascular disease Citric Acid Cycle - drug effects Female foam cells Glycolysis - drug effects hypercholesterolemia Hypercholesterolemia - metabolism Hypercholesterolemia - pathology immunometabolism inflammation Inflammation - pathology Lipopolysaccharides - pharmacology macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Male meta-inflammation metabolic disease Mice, Inbred C57BL NF-E2-Related Factor 2 - metabolism Nrf2 pentose phosphate pathway Pentose Phosphate Pathway - drug effects meta-inflammation foam cells atherosclerosis cardiovascular disease macrophages immunometabolism inflammation Nrf2 metabolic disease hypercholesterolemia pentose phosphate pathway
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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