MicroRNA sequence codes for small extracellular vesicle release and cellular retention

Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released from one cell are taken up by cells at a distance where they can enact changes in gene expression 1 – 3 . However, the mechanism by which miRNA...

Full description

Saved in:

Bibliographic Details
Published in:	Nature (London) Vol. 601; no. 7893; pp. 446 - 451
Main Authors:	Garcia-Martin, Ruben, Wang, Guoxiao, Brandão, Bruna B., Zanotto, Tamires M., Shah, Samah, Kumar Patel, Sandip, Schilling, Birgit, Kahn, C. Ronald
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.01.2022 Nature Publishing Group
Subjects:	38/77 38/91 42/44 45/41 45/70 631/337/384/331 631/443/319 82/58 96/106 96/109 Adipocytes Adipocytes - cytology Cell Communication Cell interactions Clonal deletion Endothelium Endothelium - cytology Exosomes Exosomes - genetics Exosomes - metabolism Extracellular vesicles Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Gene expression Humanities and Social Sciences Insertion Liver - cytology MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA multidisciplinary Muscles Muscles - cytology Retention Ribonucleic acid RNA RNA-binding protein Science Science (multidisciplinary) Secretion
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released from one cell are taken up by cells at a distance where they can enact changes in gene expression 1 – 3 . However, the mechanism by which miRNAs are sorted into exosomes/sEVs or retained in cells remains largely unknown. Here we demonstrate that miRNAs possess sorting sequences that determine their secretion in sEVs (EXOmotifs) or cellular retention (CELLmotifs) and that different cell types, including white and brown adipocytes, endothelium, liver and muscle, make preferential use of specific sorting sequences, thus defining the sEV miRNA profile of that cell type. Insertion or deletion of these CELLmotifs or EXOmotifs in a miRNA increases or decreases retention in the cell of production or secretion into exosomes/sEVs. Two RNA-binding proteins, Alyref and Fus, are involved in the export of miRNAs carrying one of the strongest EXOmotifs, CGGGAG. Increased miRNA delivery mediated by EXOmotifs leads to enhanced inhibition of target genes in distant cells. Thus, this miRNA code not only provides important insights that link circulating exosomal miRNAs to tissues of origin, but also provides an approach for improved targeting in RNA-mediated therapies. MicroRNAs encode sorting sequences that determine whether they are secreted in exosomal vesicles to regulate gene expression in distant cells or retained in cells that produced them, with different sequences used by individual cell types.
AbstractList	Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released from one cell are taken up by cells at a distance where they can enact changes in gene expression . However, the mechanism by which miRNAs are sorted into exosomes/sEVs or retained in cells remains largely unknown. Here we demonstrate that miRNAs possess sorting sequences that determine their secretion in sEVs (EXOmotifs) or cellular retention (CELLmotifs) and that different cell types, including white and brown adipocytes, endothelium, liver and muscle, make preferential use of specific sorting sequences, thus defining the sEV miRNA profile of that cell type. Insertion or deletion of these CELLmotifs or EXOmotifs in a miRNA increases or decreases retention in the cell of production or secretion into exosomes/sEVs. Two RNA-binding proteins, Alyref and Fus, are involved in the export of miRNAs carrying one of the strongest EXOmotifs, CGGGAG. Increased miRNA delivery mediated by EXOmotifs leads to enhanced inhibition of target genes in distant cells. Thus, this miRNA code not only provides important insights that link circulating exosomal miRNAs to tissues of origin, but also provides an approach for improved targeting in RNA-mediated therapies. Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released from one cell are taken up by cells at a distance where they can enact changes in gene expression1-3. However, the mechanism by which miRNAs are sorted into exosomes/ sEVs or retained in cells remains largely unknown. Here we demonstrate that miRNAs possess sorting sequences that determine their secretion in sEVs (EXOmotifs) or cellular retention (CELLmotifs) and that different cell types, including white and brown adipocytes, endothelium, liver and muscle, make preferential use of specific sorting sequences, thus defining the sEV miRNA profile of that cell type. Insertion or deletion ofthese CELLmotifs or EXOmotifs in a miRNA increases or decreases retention in the cell of production or secretion into exosomes/sEVs. Two RNA-binding proteins, Alyref and Fus, are involved in the export of miRNAs carrying one of the strongest EXOmotifs, CGGGAG. Increased miRNA delivery mediated by EXOmotifs leads to enhanced inhibition of target genes in distant cells. Thus, this miRNA code not only provides important insights that link circulating exosomal miRNAs to tissues of origin, but also provides an approach for improved targeting in RNA-mediated therapies. Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released from one cell are taken up by cells at a distance where they can enact changes in gene expression1-3. However, the mechanism by which miRNAs are sorted into exosomes/sEVs or retained in cells remains largely unknown. Here we demonstrate that miRNAs possess sorting sequences that determine their secretion in sEVs (EXOmotifs) or cellular retention (CELLmotifs) and that different cell types, including white and brown adipocytes, endothelium, liver and muscle, make preferential use of specific sorting sequences, thus defining the sEV miRNA profile of that cell type. Insertion or deletion of these CELLmotifs or EXOmotifs in a miRNA increases or decreases retention in the cell of production or secretion into exosomes/sEVs. Two RNA-binding proteins, Alyref and Fus, are involved in the export of miRNAs carrying one of the strongest EXOmotifs, CGGGAG. Increased miRNA delivery mediated by EXOmotifs leads to enhanced inhibition of target genes in distant cells. Thus, this miRNA code not only provides important insights that link circulating exosomal miRNAs to tissues of origin, but also provides an approach for improved targeting in RNA-mediated therapies.Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released from one cell are taken up by cells at a distance where they can enact changes in gene expression1-3. However, the mechanism by which miRNAs are sorted into exosomes/sEVs or retained in cells remains largely unknown. Here we demonstrate that miRNAs possess sorting sequences that determine their secretion in sEVs (EXOmotifs) or cellular retention (CELLmotifs) and that different cell types, including white and brown adipocytes, endothelium, liver and muscle, make preferential use of specific sorting sequences, thus defining the sEV miRNA profile of that cell type. Insertion or deletion of these CELLmotifs or EXOmotifs in a miRNA increases or decreases retention in the cell of production or secretion into exosomes/sEVs. Two RNA-binding proteins, Alyref and Fus, are involved in the export of miRNAs carrying one of the strongest EXOmotifs, CGGGAG. Increased miRNA delivery mediated by EXOmotifs leads to enhanced inhibition of target genes in distant cells. Thus, this miRNA code not only provides important insights that link circulating exosomal miRNAs to tissues of origin, but also provides an approach for improved targeting in RNA-mediated therapies. Exosomes/small extracellular vesicles (sEV) provide a unique mode of cell-to-cell communication in which miRNAs produced and released from one cell are taken up by cells at a distance where they can lead to changes in gene expression1–3. However, the mechanism by which miRNAs get sorted into exosomes/sEV or retained in cells remains largely unknown. Here, we demonstrate that miRNAs possess sorting sequences that determine their sEV secretion or cellular retention and that different cell-types, including white and brown adipocytes, endothelium, liver and muscle, make preferential use of specific sorting sequences, thus defining the sEV miRNA profile of that cell-type. Insertion or deletion of these CELLmotifs or EXOmotifs into a miRNA increases or decreases their retention in the cell of production or secretion into sEV/exosomes. Two RNA-binding proteins, Alyref and Fus, are involved in the export of miRNAs carrying one of the strongest EXOmotifs, CGGGAG. Increased miRNA delivery mediated by EXOmotifs leads to enhanced inhibition of target genes in distant cells. Thus, this miRNA code not only provides important insights in linking circulating exosomal miRNAs to tissue-of-origin, it also provides an approach to improved targeting in RNA-mediated therapies. Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released from one cell are taken up by cells at a distance where they can enact changes in gene expression 1 – 3 . However, the mechanism by which miRNAs are sorted into exosomes/sEVs or retained in cells remains largely unknown. Here we demonstrate that miRNAs possess sorting sequences that determine their secretion in sEVs (EXOmotifs) or cellular retention (CELLmotifs) and that different cell types, including white and brown adipocytes, endothelium, liver and muscle, make preferential use of specific sorting sequences, thus defining the sEV miRNA profile of that cell type. Insertion or deletion of these CELLmotifs or EXOmotifs in a miRNA increases or decreases retention in the cell of production or secretion into exosomes/sEVs. Two RNA-binding proteins, Alyref and Fus, are involved in the export of miRNAs carrying one of the strongest EXOmotifs, CGGGAG. Increased miRNA delivery mediated by EXOmotifs leads to enhanced inhibition of target genes in distant cells. Thus, this miRNA code not only provides important insights that link circulating exosomal miRNAs to tissues of origin, but also provides an approach for improved targeting in RNA-mediated therapies. MicroRNAs encode sorting sequences that determine whether they are secreted in exosomal vesicles to regulate gene expression in distant cells or retained in cells that produced them, with different sequences used by individual cell types.
Author	Zanotto, Tamires M. Garcia-Martin, Ruben Shah, Samah Schilling, Birgit Brandão, Bruna B. Kumar Patel, Sandip Kahn, C. Ronald Wang, Guoxiao
AuthorAffiliation	1 Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA 2 The Buck Institute for Research on Aging, Novato, California 94945, USA
AuthorAffiliation_xml	– name: 2 The Buck Institute for Research on Aging, Novato, California 94945, USA – name: 1 Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Author_xml	– sequence: 1 givenname: Ruben orcidid: 0000-0003-2049-4960 surname: Garcia-Martin fullname: Garcia-Martin, Ruben organization: Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School – sequence: 2 givenname: Guoxiao surname: Wang fullname: Wang, Guoxiao organization: Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School – sequence: 3 givenname: Bruna B. orcidid: 0000-0001-8762-6310 surname: Brandão fullname: Brandão, Bruna B. organization: Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School – sequence: 4 givenname: Tamires M. surname: Zanotto fullname: Zanotto, Tamires M. organization: Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School – sequence: 5 givenname: Samah surname: Shah fullname: Shah, Samah organization: The Buck Institute for Research on Aging – sequence: 6 givenname: Sandip orcidid: 0000-0002-0651-4438 surname: Kumar Patel fullname: Kumar Patel, Sandip organization: The Buck Institute for Research on Aging – sequence: 7 givenname: Birgit orcidid: 0000-0001-9907-2749 surname: Schilling fullname: Schilling, Birgit organization: The Buck Institute for Research on Aging – sequence: 8 givenname: C. Ronald orcidid: 0000-0002-7583-9228 surname: Kahn fullname: Kahn, C. Ronald email: c.ronald.kahn@joslin.harvard.edu organization: Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34937935$$D View this record in MEDLINE/PubMed
BookMark	eNp9UcFuFSEUJabGvlZ_wIUhceNmFLjAMBuTpqnVpGpi1C3hMXcqDQ8qzDT69-X52qpddAMJ95zDuecckL2UExLynLPXnIF5UyVXRndM8I5JAbKDR2TFZa87qU2_R1aMCdMxA3qfHNR6wRhTvJdPyD7IAfoB1Ip8_xh8yV8-HdGKPxdMHqnPI1Y65ULrxsVI8ddcnMcYl-gKvcIafERaMKKrSF0a6d2w4IxpDjk9JY8nFys-u7kPybd3J1-P33dnn08_HB-ddV72cu7cWq-lhwHcyPw0mgnai5dmGpR30ulh4rodIxccJ61w1E4OnCnjlYPRCzgkb3e6l8t6g6NvvxcX7WUJG1d-2-yC_X-Swg97nq_swEAJrZrAqxuBktv-dbabULf7uIR5qVZoDsIMLasGfXkPepGXktp6DSUEMK7VFvXiX0d3Vm4jbwCzA7Tcay04WR9mtw2tGQzRcma37dpdu7a1a_-0a6FRxT3qrfqDJNiRagOncyx_bT_AugZvl7jF
CitedBy_id	crossref_primary_10_1016_j_phymed_2025_156748 crossref_primary_10_1016_j_tranon_2025_102543 crossref_primary_10_1093_hmg_ddac088 crossref_primary_10_1016_j_ese_2025_100609 crossref_primary_10_3389_fendo_2025_1530374 crossref_primary_10_1016_j_jacbts_2025_05_002 crossref_primary_10_1016_j_bonr_2022_101627 crossref_primary_10_5582_bst_2025_01120 crossref_primary_10_1016_j_pbi_2022_102272 crossref_primary_10_1186_s12864_023_09552_6 crossref_primary_10_5812_jjcmb_131153 crossref_primary_10_1038_s12276_024_01209_y crossref_primary_10_3390_bios13010129 crossref_primary_10_3390_ncrna8030031 crossref_primary_10_3389_fonc_2023_1272883 crossref_primary_10_3389_fendo_2024_1422279 crossref_primary_10_4093_dmj_2025_0184 crossref_primary_10_3390_cells12172145 crossref_primary_10_1016_j_pbi_2023_102441 crossref_primary_10_3389_fmolb_2023_1327985 crossref_primary_10_1016_j_mce_2024_112250 crossref_primary_10_1360_TB_2024_1008 crossref_primary_10_3390_ijms24010191 crossref_primary_10_1038_s41419_023_05663_w crossref_primary_10_3390_diagnostics13061048 crossref_primary_10_3389_fcell_2025_1608902 crossref_primary_10_1186_s12882_024_03688_7 crossref_primary_10_1016_j_jcyt_2025_02_004 crossref_primary_10_1038_s41556_025_01667_0 crossref_primary_10_1038_s41419_023_06279_w crossref_primary_10_3389_fcell_2024_1394582 crossref_primary_10_1016_j_drup_2023_100937 crossref_primary_10_1016_j_jconrel_2023_03_055 crossref_primary_10_1016_j_isci_2023_108282 crossref_primary_10_3389_fcell_2025_1561856 crossref_primary_10_1038_s41413_025_00430_3 crossref_primary_10_3892_ijo_2023_5562 crossref_primary_10_1186_s12951_022_01352_6 crossref_primary_10_1016_j_vetmic_2025_110394 crossref_primary_10_1016_j_ymthe_2023_02_013 crossref_primary_10_1016_j_jaccao_2023_12_009 crossref_primary_10_1016_j_csbj_2024_12_025 crossref_primary_10_1038_s41398_024_02935_7 crossref_primary_10_1186_s13287_024_04040_4 crossref_primary_10_1016_j_biopha_2022_113126 crossref_primary_10_1016_j_coemr_2025_100572 crossref_primary_10_1002_advs_202500964 crossref_primary_10_1016_j_copbio_2024_103067 crossref_primary_10_1186_s13046_025_03380_0 crossref_primary_10_3389_fcvm_2023_1144849 crossref_primary_10_1186_s12964_024_01474_4 crossref_primary_10_3389_fimmu_2024_1362996 crossref_primary_10_1136_jitc_2025_012270 crossref_primary_10_1016_j_molcel_2025_01_012 crossref_primary_10_3390_ijms25147943 crossref_primary_10_1002_jex2_70023 crossref_primary_10_1186_s13287_022_02822_2 crossref_primary_10_1002_advs_202504064 crossref_primary_10_1016_j_psj_2025_105480 crossref_primary_10_3390_toxins14110806 crossref_primary_10_1016_j_psj_2025_105482 crossref_primary_10_1016_j_jconrel_2022_08_010 crossref_primary_10_1016_j_canlet_2025_217794 crossref_primary_10_3390_ijms26115118 crossref_primary_10_1002_jex2_70010 crossref_primary_10_3390_ijms23158518 crossref_primary_10_1016_j_semcancer_2022_06_001 crossref_primary_10_1016_j_job_2024_04_001 crossref_primary_10_1016_j_vesic_2024_100049 crossref_primary_10_1016_j_scitotenv_2025_179825 crossref_primary_10_1038_s41467_022_33436_0 crossref_primary_10_2147_IJN_S442876 crossref_primary_10_3390_ijms24076862 crossref_primary_10_1016_j_intimp_2024_112667 crossref_primary_10_1016_j_copbio_2022_102776 crossref_primary_10_1186_s12951_024_03063_6 crossref_primary_10_2147_IJN_S403192 crossref_primary_10_1016_j_tcb_2023_01_002 crossref_primary_10_1021_acssensors_5c01282 crossref_primary_10_1007_s13353_022_00730_y crossref_primary_10_1016_j_biopha_2023_114836 crossref_primary_10_1186_s13073_024_01400_w crossref_primary_10_3390_v17010049 crossref_primary_10_1016_j_tox_2024_153858 crossref_primary_10_7554_eLife_76319 crossref_primary_10_1038_s41598_025_12175_4 crossref_primary_10_1523_JNEUROSCI_0365_24_2024 crossref_primary_10_1002_smll_202206888 crossref_primary_10_1038_s41417_024_00742_2 crossref_primary_10_1186_s13046_024_03048_1 crossref_primary_10_3389_fimmu_2022_1102405 crossref_primary_10_1186_s13046_023_02685_2 crossref_primary_10_3390_ijms24043704 crossref_primary_10_1021_acssensors_5c01275 crossref_primary_10_3390_biology12101334 crossref_primary_10_4103_neurol_india_Neurol_India_D_24_00920 crossref_primary_10_1242_jcs_260887 crossref_primary_10_1038_s41392_023_01726_8 crossref_primary_10_1021_acs_analchem_4c07068 crossref_primary_10_7554_eLife_105017_4 crossref_primary_10_1016_j_intimp_2025_114942 crossref_primary_10_1016_j_molmet_2025_102229 crossref_primary_10_1016_j_biopha_2024_116206 crossref_primary_10_1186_s12951_024_02609_y crossref_primary_10_3390_ani12202881 crossref_primary_10_1007_s12035_024_04017_7 crossref_primary_10_3390_polym15234563 crossref_primary_10_1007_s10456_022_09848_3 crossref_primary_10_1016_j_pbi_2024_102672 crossref_primary_10_1016_j_tem_2023_12_004 crossref_primary_10_1186_s13059_025_03566_x crossref_primary_10_1016_j_tips_2024_02_006 crossref_primary_10_3390_ijms26093956 crossref_primary_10_3390_biom14111354 crossref_primary_10_1016_j_canlet_2023_216261 crossref_primary_10_1007_s10147_025_02856_5 crossref_primary_10_1093_nar_gkad1142 crossref_primary_10_3390_cells11233711 crossref_primary_10_1038_s41467_025_58312_5 crossref_primary_10_1016_j_mcn_2024_103933 crossref_primary_10_1016_j_matt_2024_09_012 crossref_primary_10_1038_s41419_022_05398_0 crossref_primary_10_1016_j_tem_2024_10_002 crossref_primary_10_1016_j_ccell_2024_06_003 crossref_primary_10_1002_jev2_12511 crossref_primary_10_1016_j_jare_2024_08_026 crossref_primary_10_1093_burnst_tkaf023 crossref_primary_10_1016_j_cmet_2022_08_004 crossref_primary_10_1016_j_canlet_2024_216747 crossref_primary_10_3390_cells11182851 crossref_primary_10_1007_s00203_023_03636_3 crossref_primary_10_1038_s41590_023_01479_0 crossref_primary_10_3389_fcimb_2024_1424838 crossref_primary_10_3389_fonc_2022_887532 crossref_primary_10_1021_prechem_5c00007 crossref_primary_10_1134_S0006297924070058 crossref_primary_10_1002_jcp_31061 crossref_primary_10_1021_acsami_5c02551 crossref_primary_10_1161_CIRCRESAHA_123_323054 crossref_primary_10_3389_fcimb_2025_1582131 crossref_primary_10_3389_fendo_2022_873865 crossref_primary_10_1186_s12964_025_02177_0 crossref_primary_10_1016_j_ejphar_2025_177976 crossref_primary_10_1038_s42003_023_04743_z crossref_primary_10_34133_bmr_0201 crossref_primary_10_1016_j_jconrel_2023_01_057 crossref_primary_10_1111_bph_17336 crossref_primary_10_1016_j_lfs_2025_123695 crossref_primary_10_1172_JCI170762 crossref_primary_10_1371_journal_pone_0280425 crossref_primary_10_1080_07853890_2025_2534851 crossref_primary_10_1186_s12575_024_00241_6 crossref_primary_10_31083_j_fbl2901038 crossref_primary_10_1038_s41388_024_03039_8 crossref_primary_10_1016_j_cnd_2024_07_002 crossref_primary_10_1053_j_gastro_2023_06_021 crossref_primary_10_1016_j_molmet_2023_101730 crossref_primary_10_1007_s12079_022_00705_y crossref_primary_10_1016_j_gene_2023_148014 crossref_primary_10_1038_s41388_024_03213_y crossref_primary_10_3390_ijms24032071 crossref_primary_10_1016_j_aca_2024_342704 crossref_primary_10_1038_s41598_024_63633_4 crossref_primary_10_3390_s22093252 crossref_primary_10_1111_all_15824 crossref_primary_10_1016_j_csbj_2024_04_021 crossref_primary_10_1186_s13046_025_03471_y crossref_primary_10_3390_cells13231996 crossref_primary_10_1002_adhm_202404398 crossref_primary_10_1002_biof_2033 crossref_primary_10_2147_IJN_S498599 crossref_primary_10_3389_fonc_2024_1382398 crossref_primary_10_1186_s13046_023_02634_z crossref_primary_10_1186_s12575_023_00220_3 crossref_primary_10_1016_j_genrep_2025_102208 crossref_primary_10_1096_fj_202400841R crossref_primary_10_3390_ijms24097942 crossref_primary_10_3389_fphar_2022_1009952 crossref_primary_10_1186_s13048_023_01181_7 crossref_primary_10_3233_JAD_230347 crossref_primary_10_1007_s12035_024_04118_3 crossref_primary_10_1007_s10238_023_01122_0 crossref_primary_10_15252_embr_202357339 crossref_primary_10_2174_0109298673253678230920054220 crossref_primary_10_1177_09636897221148775 crossref_primary_10_3389_fphys_2023_1143966 crossref_primary_10_1039_D4FO03993A crossref_primary_10_1007_s00439_023_02588_4 crossref_primary_10_1016_j_theriogenology_2023_11_028 crossref_primary_10_2147_IJN_S424731 crossref_primary_10_1016_j_jos_2023_10_004 crossref_primary_10_1007_s11095_022_03404_w crossref_primary_10_1093_narmme_ugaf025 crossref_primary_10_1016_j_bpc_2025_107421 crossref_primary_10_1016_j_tig_2024_05_005 crossref_primary_10_1016_j_bioactmat_2022_07_022 crossref_primary_10_3389_fnmol_2023_1300864 crossref_primary_10_1038_s41467_023_41160_6 crossref_primary_10_1007_s10753_025_02275_8 crossref_primary_10_14348_molcells_2022_0110 crossref_primary_10_3390_ph18050708 crossref_primary_10_1016_j_isci_2024_110988 crossref_primary_10_1016_j_bbadis_2024_167211 crossref_primary_10_1016_j_fmre_2023_12_022 crossref_primary_10_1016_j_phrs_2024_107244 crossref_primary_10_3389_fimmu_2023_1154217 crossref_primary_10_1038_s41551_023_01033_1 crossref_primary_10_3390_ijms25189936 crossref_primary_10_3390_ijms24043443 crossref_primary_10_3389_fendo_2022_828780 crossref_primary_10_3390_cancers14112627 crossref_primary_10_1371_journal_pbio_3002074 crossref_primary_10_1038_s41598_025_11799_w crossref_primary_10_1007_s12035_024_04605_7 crossref_primary_10_1002_jev2_12210 crossref_primary_10_1007_s11033_025_11015_y crossref_primary_10_1038_s41420_024_01897_5 crossref_primary_10_1016_j_phrs_2025_107753 crossref_primary_10_1016_j_cmet_2024_10_012 crossref_primary_10_1016_j_actbio_2025_03_042 crossref_primary_10_1038_s41598_024_81352_8 crossref_primary_10_1016_j_biomaterials_2025_123552 crossref_primary_10_1016_j_jagp_2024_04_012 crossref_primary_10_3390_ijms252413488 crossref_primary_10_1038_s43587_024_00612_4 crossref_primary_10_1016_j_mtbio_2025_101881 crossref_primary_10_3389_fphys_2023_1241010 crossref_primary_10_3390_cells13060543 crossref_primary_10_1016_j_biocel_2024_106713 crossref_primary_10_1016_j_addr_2025_115522 crossref_primary_10_1186_s13046_024_03204_7 crossref_primary_10_1186_s13048_023_01312_0 crossref_primary_10_1038_s41423_025_01323_5 crossref_primary_10_1080_10408363_2024_2309935 crossref_primary_10_1016_j_addr_2024_115461 crossref_primary_10_1016_j_ymthe_2023_05_012 crossref_primary_10_1097_IN9_0000000000000027 crossref_primary_10_3390_biom13030568 crossref_primary_10_1002_advs_202402509 crossref_primary_10_1002_advs_202404822 crossref_primary_10_1007_s00109_022_02278_0 crossref_primary_10_1063_5_0220157 crossref_primary_10_3390_ijms23137052 crossref_primary_10_1038_s41368_024_00302_2 crossref_primary_10_1093_cvr_cvaf100 crossref_primary_10_1155_sci_3218993 crossref_primary_10_1016_j_ijbiomac_2024_130044 crossref_primary_10_1017_S0033291725000741 crossref_primary_10_1158_1940_6207_CAPR_23_0156 crossref_primary_10_1002_jcp_30809 crossref_primary_10_1016_j_bbrc_2024_150336 crossref_primary_10_1016_j_tcm_2022_01_014 crossref_primary_10_1111_imr_13134 crossref_primary_10_1186_s12943_022_01698_3 crossref_primary_10_1016_j_diff_2025_100911 crossref_primary_10_3390_ijms26146770 crossref_primary_10_1016_j_ymthe_2023_04_001 crossref_primary_10_3390_ncrna9040045 crossref_primary_10_1002_ctm2_70086 crossref_primary_10_1016_j_jconrel_2025_114068 crossref_primary_10_3389_fbioe_2022_876151 crossref_primary_10_1038_s41592_023_02117_1 crossref_primary_10_1073_pnas_2122053120 crossref_primary_10_3389_fcell_2022_849938 crossref_primary_10_3389_fphys_2022_837001 crossref_primary_10_1007_s12015_023_10595_1 crossref_primary_10_3390_proteomes11020018 crossref_primary_10_1016_j_talanta_2025_127556 crossref_primary_10_3390_pharmaceutics16121586 crossref_primary_10_1016_j_snb_2024_135978 crossref_primary_10_1002_jex2_40 crossref_primary_10_1016_j_cclet_2022_107906 crossref_primary_10_1097_PR9_0000000000001198 crossref_primary_10_1002_anse_202200083 crossref_primary_10_1038_s41417_024_00836_x crossref_primary_10_4103_0304_4920_359800 crossref_primary_10_1007_s12268_024_2191_0 crossref_primary_10_1186_s13059_024_03420_6 crossref_primary_10_1016_j_phrs_2025_107725 crossref_primary_10_3389_fgene_2024_1461404 crossref_primary_10_1016_j_dci_2024_105174 crossref_primary_10_1093_nar_gkae1094 crossref_primary_10_1111_imr_13074 crossref_primary_10_1039_D3FO00137G crossref_primary_10_1016_j_compositesb_2024_111928 crossref_primary_10_1080_08958378_2024_2356839 crossref_primary_10_1097_SHK_0000000000002252 crossref_primary_10_3390_ijms26167750 crossref_primary_10_7717_peerj_19188 crossref_primary_10_1038_s41587_023_01751_6 crossref_primary_10_1186_s41927_025_00502_1 crossref_primary_10_1016_j_biochi_2023_01_014 crossref_primary_10_3389_fphar_2024_1452276 crossref_primary_10_2147_IJN_S483621 crossref_primary_10_1016_j_apsb_2024_12_013 crossref_primary_10_3390_foods13050712 crossref_primary_10_1016_j_ijbiomac_2023_123792 crossref_primary_10_1007_s13311_022_01232_9 crossref_primary_10_3389_fcell_2022_877344 crossref_primary_10_3389_fdmed_2021_806001 crossref_primary_10_1016_j_lfs_2024_122542 crossref_primary_10_3389_fgene_2023_1249678 crossref_primary_10_1016_j_heliyon_2025_e41632 crossref_primary_10_1016_j_lfs_2023_121934 crossref_primary_10_3389_fonc_2024_1441429 crossref_primary_10_3389_fendo_2022_1057407 crossref_primary_10_1038_s41368_024_00293_0 crossref_primary_10_1261_rna_079098_122 crossref_primary_10_1016_j_bioactmat_2024_08_021 crossref_primary_10_1038_s41581_023_00725_w crossref_primary_10_1016_j_bios_2022_114879 crossref_primary_10_1016_j_heliyon_2025_e41983 crossref_primary_10_1093_nar_gkad392 crossref_primary_10_1016_j_labinv_2024_102206 crossref_primary_10_1093_lifemedi_lnad013 crossref_primary_10_1186_s12935_023_02974_y crossref_primary_10_3390_ijms24065159 crossref_primary_10_3390_pharmaceutics16030311 crossref_primary_10_1016_j_pt_2023_07_001 crossref_primary_10_1146_annurev_pathmechdis_031521_022116 crossref_primary_10_1080_10408398_2024_2388888 crossref_primary_10_1002_jev2_70113 crossref_primary_10_3389_fimmu_2022_939504 crossref_primary_10_1080_02713683_2025_2459888 crossref_primary_10_1073_pnas_2316544121 crossref_primary_10_3390_genes14051093 crossref_primary_10_1016_j_bios_2024_116520 crossref_primary_10_1096_fj_202302587RRR crossref_primary_10_1002_jev2_70065 crossref_primary_10_1016_j_trac_2022_116840 crossref_primary_10_1038_s41467_024_45249_4 crossref_primary_10_1002_advs_202305339 crossref_primary_10_3389_fonc_2023_1167717 crossref_primary_10_2215_CJN_00850122 crossref_primary_10_1016_j_exer_2024_109912 crossref_primary_10_1186_s13287_025_04546_5 crossref_primary_10_3389_fimmu_2024_1419660 crossref_primary_10_1016_j_isci_2024_110243 crossref_primary_10_3389_fnmol_2023_1090556 crossref_primary_10_1111_imm_13647 crossref_primary_10_1007_s40265_022_01743_x crossref_primary_10_1038_s41467_025_62688_9 crossref_primary_10_3389_fvets_2022_944370 crossref_primary_10_4251_wjgo_v17_i4_103591 crossref_primary_10_1016_j_cell_2022_03_010 crossref_primary_10_1007_s11033_023_09196_5 crossref_primary_10_1002_tox_24197 crossref_primary_10_1186_s40104_023_00960_y crossref_primary_10_1002_wnan_1969 crossref_primary_10_1038_s41467_024_45520_8 crossref_primary_10_1016_j_tjnut_2024_10_007 crossref_primary_10_1016_j_chempr_2024_07_037 crossref_primary_10_1002_advs_202304222 crossref_primary_10_1016_j_abb_2023_109785 crossref_primary_10_1016_j_tice_2024_102669 crossref_primary_10_1038_s41569_022_00680_2 crossref_primary_10_3390_biology13121066 crossref_primary_10_1002_jev2_70040 crossref_primary_10_1002_tpg2_20289 crossref_primary_10_1016_j_trsl_2022_03_008 crossref_primary_10_1177_20417314251319474 crossref_primary_10_1016_j_jconrel_2023_12_050 crossref_primary_10_1038_s41574_023_00898_1 crossref_primary_10_1146_annurev_bioeng_081922_021233 crossref_primary_10_3390_cancers16030567 crossref_primary_10_1016_j_omtn_2023_102040 crossref_primary_10_3389_fendo_2023_1157194 crossref_primary_10_1113_JP283200 crossref_primary_10_1038_s41417_023_00637_8 crossref_primary_10_3390_biom14020224 crossref_primary_10_1002_jev2_70153 crossref_primary_10_1177_0271678X251338971 crossref_primary_10_1016_j_advnut_2025_100510 crossref_primary_10_1016_j_exger_2023_112142 crossref_primary_10_1016_j_psj_2024_104169 crossref_primary_10_3389_fphar_2025_1529375 crossref_primary_10_1016_j_ymthe_2023_11_023 crossref_primary_10_1016_j_omtm_2024_101259 crossref_primary_10_4103_aja202243 crossref_primary_10_1007_s12672_025_03485_0 crossref_primary_10_3389_fendo_2024_1444940 crossref_primary_10_1038_s41392_025_02312_w crossref_primary_10_1016_j_gene_2023_147992 crossref_primary_10_1016_j_pt_2023_12_003 crossref_primary_10_3390_ijms26189155 crossref_primary_10_1007_s12015_024_10781_9 crossref_primary_10_1002_wrna_1768 crossref_primary_10_1038_s41598_024_71353_y crossref_primary_10_15252_embr_202154312 crossref_primary_10_1016_j_celrep_2025_115732 crossref_primary_10_7554_eLife_83584 crossref_primary_10_1016_j_celrep_2024_114369 crossref_primary_10_1002_agt2_663 crossref_primary_10_1186_s13287_025_04216_6 crossref_primary_10_1016_j_jbc_2024_105750 crossref_primary_10_1111_1753_0407_13456 crossref_primary_10_1002_advs_202503014 crossref_primary_10_1111_all_16117 crossref_primary_10_3390_biom15020231 crossref_primary_10_1016_j_device_2024_100428 crossref_primary_10_1016_j_freeradbiomed_2025_03_027 crossref_primary_10_1002_smll_202205813 crossref_primary_10_1016_j_bioactmat_2025_08_026 crossref_primary_10_1016_j_tem_2023_09_006 crossref_primary_10_1016_j_celrep_2024_114491 crossref_primary_10_1016_j_chom_2023_11_020 crossref_primary_10_7554_eLife_105017 crossref_primary_10_1080_15583724_2023_2281462 crossref_primary_10_1007_s00018_025_05781_y crossref_primary_10_1096_fj_202401464R crossref_primary_10_1016_j_intimp_2025_114285 crossref_primary_10_1186_s40543_023_00370_9 crossref_primary_10_1016_j_jtha_2023_07_028 crossref_primary_10_1016_j_jconrel_2023_10_048 crossref_primary_10_1186_s12943_022_01650_5 crossref_primary_10_1093_lifemeta_loae003 crossref_primary_10_1146_annurev_physiol_042222_024535 crossref_primary_10_1186_s12864_023_09746_y crossref_primary_10_3390_cells13070569 crossref_primary_10_7554_eLife_92075_3 crossref_primary_10_1038_s41580_023_00576_0 crossref_primary_10_1093_pcmedi_pbae032 crossref_primary_10_3390_plants13192712 crossref_primary_10_7554_eLife_92075 crossref_primary_10_1038_s41467_025_59861_5 crossref_primary_10_1186_s13098_023_01137_3 crossref_primary_10_1242_jcs_261575 crossref_primary_10_1002_pmic_70043 crossref_primary_10_20517_evcna_2025_47 crossref_primary_10_1186_s12859_024_05985_2 crossref_primary_10_1155_2024_8520489 crossref_primary_10_1093_nar_gkaf176
Cites_doi	10.1021/acs.jproteome.7b00170 10.1073/pnas.1408301111 10.1016/j.cmet.2019.07.011 10.1007/978-1-4939-6747-6_16 10.7554/eLife.07197 10.1093/hmg/dds129 10.1074/jbc.M004046200 10.1186/1471-2105-7-261 10.3233/JAD-150432 10.1073/pnas.1019055108 10.1016/j.cell.2019.02.029 10.1093/nar/gkx597 10.1038/nmeth.4185 10.1038/ncomms3980 10.1038/ncb1596 10.1038/s41467-017-00249-5 10.1093/nar/gkv432 10.1016/j.cell.2018.09.005 10.1038/s41467-017-01196-x 10.1016/j.celrep.2019.08.036 10.1016/j.cell.2015.04.042 10.1093/toxsci/kfu002 10.1038/ncb1800 10.1186/s12864-018-4528-x 10.1371/journal.pone.0195969 10.1371/journal.pone.0003694 10.1016/j.ydbio.2015.12.013 10.1093/nar/gks1246 10.1016/j.molcel.2018.02.001 10.1261/rna.939908 10.1016/j.celrep.2016.09.031 10.1038/nature21365 10.4161/rna.18827 10.1016/j.cell.2018.03.006 10.1074/jbc.M110.107821 10.1016/S0960-9822(02)00809-6 10.1080/20013078.2018.1535750 10.1016/j.molcel.2010.05.004 10.1214/aoms/1177729694 10.7554/eLife.19276 10.7554/eLife.47544
ContentType	Journal Article
Copyright	The Author(s), under exclusive licence to Springer Nature Limited 2021 2021. The Author(s), under exclusive licence to Springer Nature Limited. Copyright Nature Publishing Group Jan 20, 2022
Copyright_xml	– notice: The Author(s), under exclusive licence to Springer Nature Limited 2021 – notice: 2021. The Author(s), under exclusive licence to Springer Nature Limited. – notice: Copyright Nature Publishing Group Jan 20, 2022
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 5PM
DOI	10.1038/s41586-021-04234-3
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) SciTech Premium Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary AUTh Library subscriptions: ProQuest Central Technology collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection (ProQuest) Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database Health & Medical Collection (Alumni Edition) Medical Database ProQuest Psychology Database ProQuest research library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering collection Environmental Science Collection (ProQuest) ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE Agricultural Science Database MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Physics
EISSN	1476-4687
EndPage	451
ExternalDocumentID	PMC9035265 34937935 10_1038_s41586_021_04234_3
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIDDK NIH HHS grantid: P30 DK036836 – fundername: NIDDK NIH HHS grantid: R01 DK082659
GroupedDBID	--- --Z -DZ -ET -~X .55 .CO .XZ 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z AAEEF AAHBH AAHTB AAIKC AAKAB AAMNW AASDW AAVBQ AAYEP AAYZH AAZLF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACWUS ADBBV ADFRT ADUKH AENEX AEUYN AFBBN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGHSJ AGHTU AGOIJ AGSOS AHMBA AHSBF AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARAPS ARMCB ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC BBNVY BCU BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DU5 DWQXO E.- E.L EAP EBS EE. EMH EPS EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HG6 HMCUK HVGLF HZ~ IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR K6- KB. KOO L6V L7B LK5 LK8 LSO M0K M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEPJS O9- OBC OES OHH OMK OVD P2P P62 PATMY PCBAR PDBOC PKN PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ TAE TAOOD TBHMF TDRGL TEORI TN5 TSG TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YZZ Z5M ZCA ~02 ~7V ~88 ~KM AARCD AAYXX ABFSG ABUFD ACSTC AEZWR AFANA AFFHD AFHIU AGSTI AHWEU AIXLP ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB TUS .-4 .GJ .HR 00M 08P 1CY 1VW 354 3EH 3O- 4.4 41~ 42X 4R4 663 79B 9M8 A8Z AAJYS AAKAS AAYOK ABAWZ ABDBF ABDPE ABEFU ABMOR ABNNU ABTAH ACBNA ACBTR ACRPL ACTDY ACUHS ADNMO ADRHT ADYSU ADZCM AETEA AFFDN AFHKK AGCDD AGGDT AGNAY AIDAL AIYXT AJUXI APEBS ARTTT B0M BCR BDKGC BES BKOMP BLC CGR CUY CVF DB5 DO4 EAD EAS EAZ EBC EBD EBO ECC ECM EIF EJD EMB EMF EMK EMOBN EPL ESE ESN ESX FA8 FAC I-F ITC J5H L-9 LGEZI LOTEE MVM N4W NADUK NEJ NFIDA NPM NXXTH ODYON OHT P-O PEA PM3 PV9 QS- R4F RHI SKT SV3 TH9 TUD UAO UBY UHB USG VOH X7L XOL YJ6 YQI YQJ YV5 YXA YYP YYQ ZCG ZE2 ZGI ZHY ZKB ZKG ZY4 ~8M ~G0 3V. 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c474t-ab6b4c393ad0cfd8f3ab6c48f95ca4a69f1669fd121ef65ed6a491058c5a3dc23
IEDL.DBID	M7P
ISICitedReferencesCount	520
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000733875500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0028-0836 1476-4687
IngestDate	Tue Nov 04 01:37:03 EST 2025 Wed Oct 01 14:29:38 EDT 2025 Tue Oct 07 07:09:45 EDT 2025 Thu Apr 03 07:01:03 EDT 2025 Sat Nov 29 03:48:57 EST 2025 Tue Nov 18 20:02:46 EST 2025 Fri Feb 21 02:38:43 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	7893
Language	English
License	2021. The Author(s), under exclusive licence to Springer Nature Limited.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c474t-ab6b4c393ad0cfd8f3ab6c48f95ca4a69f1669fd121ef65ed6a491058c5a3dc23
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 RGM designed research, performed experiments and analyzed the data shown in Fig. 1–4 and Extended Data Fig. 1–10, and wrote the manuscript. GW helped with vector generations for miRNA overexpression shown in Fig. 3a–f and Extended Data Fig. 7–9. BBB helped with size exclusion chromatography experiments shown in Extended Data Fig. 6. TMZ helped with analysis of miRNA profiling and motifs shown in Fig. 1 and 2. SS, SKP and BS performed the proteomic study and its analysis shown in Fig.3g–j and Extended Data Fig.10a–c. CRK designed the research, wrote the manuscript, and supervised the project. Author contributions
ORCID	0000-0002-7583-9228 0000-0001-9907-2749 0000-0001-8762-6310 0000-0002-0651-4438 0000-0003-2049-4960
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/9035265
PMID	34937935
PQID	2622301655
PQPubID	40569
PageCount	6
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_9035265 proquest_miscellaneous_2613289935 proquest_journals_2622301655 pubmed_primary_34937935 crossref_citationtrail_10_1038_s41586_021_04234_3 crossref_primary_10_1038_s41586_021_04234_3 springer_journals_10_1038_s41586_021_04234_3
PublicationCentury	2000
PublicationDate	2022-01-20
PublicationDateYYYYMMDD	2022-01-20
PublicationDate_xml	– month: 01 year: 2022 text: 2022-01-20 day: 20
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationSubtitle	International weekly journal of science
PublicationTitle	Nature (London)
PublicationTitleAbbrev	Nature
PublicationTitleAlternate	Nature
PublicationYear	2022
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Statello (CR25) 2018; 13 Thery, Amigorena, Raposo, Clayton (CR34) 2006; Chapter 3 Chevillet (CR32) 2014; 111 Wei (CR13) 2017; 8 Peltier, Latham (CR35) 2008; 14 Santangelo (CR16) 2016; 17 Hu (CR29) 2015; 48 Burger (CR39) 2018; 17 CR17 Shi (CR26) 2017; 45 Consortium (CR42) 2017; 14 Zomer (CR9) 2015; 161 CR12 Valadi (CR2) 2007; 9 Collins (CR36) 2017; 8 Cha (CR14) 2015; 4 Jopling (CR21) 2012; 9 Ritchie (CR38) 2006; 7 Villarroya-Beltri (CR18) 2013; 4 Thery (CR19) 2018; 7 Mori, Ludwig, Garcia-Martin, Brandao, Kahn (CR4) 2019; 30 Tosar (CR5) 2015; 43 Bartel (CR24) 2018; 173 Kullback, Leibler (CR41) 1951; 22 Schilling, Gibson, Hunter (CR37) 2017; 1550 Arroyo (CR6) 2011; 108 Paraskevopoulou (CR31) 2013; 41 Hunter (CR7) 2008; 3 Crewe (CR8) 2018; 175 Zhang (CR27) 2018; 69 Abels (CR10) 2019; 28 Fasshauer (CR33) 2000; 275 Horaka, Bienertova-Vaskuac (CR22) 2016; 410 Bae (CR28) 2012; 21 Lagos-Quintana (CR20) 2002; 12 Thomou (CR1) 2017; 542 Skog (CR3) 2008; 10 Ngalame, Tokar, Person, Xu, Waalkes (CR30) 2014; 138 Jeppesen (CR15) 2019; 177 Kosaka (CR11) 2010; 285 Gao, Shu, Cui (CR23) 2018; 19 Heinz (CR40) 2010; 38 M Fasshauer (4234_CR33) 2000; 275 T Burger (4234_CR39) 2018; 17 C Jopling (4234_CR21) 2012; 9 T Thomou (4234_CR1) 2017; 542 JD Arroyo (4234_CR6) 2011; 108 NN Ngalame (4234_CR30) 2014; 138 N Kosaka (4234_CR11) 2010; 285 DJ Cha (4234_CR14) 2015; 4 M Lagos-Quintana (4234_CR20) 2002; 12 ME Ritchie (4234_CR38) 2006; 7 C Villarroya-Beltri (4234_CR18) 2013; 4 ER Abels (4234_CR10) 2019; 28 M Shi (4234_CR26) 2017; 45 A Zomer (4234_CR9) 2015; 161 MP Hunter (4234_CR7) 2008; 3 T Gao (4234_CR23) 2018; 19 JP Tosar (4234_CR5) 2015; 43 DP Bartel (4234_CR24) 2018; 173 H Valadi (4234_CR2) 2007; 9 MA Mori (4234_CR4) 2019; 30 L Santangelo (4234_CR16) 2016; 17 MNJ Horaka (4234_CR22) 2016; 410 4234_CR17 L Statello (4234_CR25) 2018; 13 Z Wei (4234_CR13) 2017; 8 4234_CR12 T Zhang (4234_CR27) 2018; 69 Y Bae (4234_CR28) 2012; 21 HJ Peltier (4234_CR35) 2008; 14 MD Paraskevopoulou (4234_CR31) 2013; 41 S Heinz (4234_CR40) 2010; 38 J Skog (4234_CR3) 2008; 10 C Crewe (4234_CR8) 2018; 175 B Schilling (4234_CR37) 2017; 1550 C Thery (4234_CR19) 2018; 7 S Hu (4234_CR29) 2015; 48 E-T Consortium (4234_CR42) 2017; 14 JR Chevillet (4234_CR32) 2014; 111 C Thery (4234_CR34) 2006; Chapter 3 DK Jeppesen (4234_CR15) 2019; 177 BC Collins (4234_CR36) 2017; 8 S Kullback (4234_CR41) 1951; 22 35364031 - Cell. 2022 Mar 31;185(7):1114-1116. doi: 10.1016/j.cell.2022.03.010
References_xml	– volume: 17 start-page: 12 year: 2018 end-page: 22 ident: CR39 article-title: Gentle introduction to the statistical foundations of false discovery rate in quantitative proteomics publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.7b00170 – volume: 111 start-page: 14888 year: 2014 end-page: 14893 ident: CR32 article-title: Quantitative and stoichiometric analysis of the microRNA content of exosomes publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1408301111 – volume: 30 start-page: 656 year: 2019 end-page: 673 ident: CR4 article-title: Extracellular miRNAs: from biomarkers to mediators of physiology and disease publication-title: Cell Metab. doi: 10.1016/j.cmet.2019.07.011 – volume: 1550 start-page: 223 year: 2017 end-page: 233 ident: CR37 article-title: Generation of high-quality SWATH( ) acquisition data for label-free quantitative proteomics studies using tripleTOF( ) mass spectrometers publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-6747-6_16 – ident: CR12 – volume: 4 start-page: e07197 year: 2015 ident: CR14 article-title: KRAS-dependent sorting of miRNA to exosomes publication-title: eLife doi: 10.7554/eLife.07197 – volume: 21 start-page: 2991 year: 2012 end-page: 3000 ident: CR28 article-title: miRNA-34c regulates Notch signaling during bone development publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds129 – volume: 275 start-page: 25494 year: 2000 end-page: 25501 ident: CR33 article-title: Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M004046200 – volume: 7 start-page: 261 year: 2006 ident: CR38 article-title: Empirical array quality weights in the analysis of microarray data publication-title: BMC Bioinf. doi: 10.1186/1471-2105-7-261 – volume: 48 start-page: 673 year: 2015 end-page: 686 ident: CR29 article-title: MicroRNA-34c downregulation ameliorates amyloid-β-induced synaptic failure and memory deficits by targeting VAMP2 publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-150432 – volume: 108 start-page: 5003 year: 2011 end-page: 5008 ident: CR6 article-title: Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1019055108 – volume: 177 start-page: 428 year: 2019 end-page: 445 ident: CR15 article-title: Reassessment of exosome composition publication-title: Cell doi: 10.1016/j.cell.2019.02.029 – volume: 45 start-page: 9640 year: 2017 end-page: 9653 ident: CR26 article-title: ALYREF mainly binds to the 5′ and the 3′ regions of the mRNA in vivo publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx597 – volume: 14 start-page: 228 year: 2017 end-page: 232 ident: CR42 article-title: EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research publication-title: Nat. Methods doi: 10.1038/nmeth.4185 – volume: 4 year: 2013 ident: CR18 article-title: Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs publication-title: Nat. Commun. doi: 10.1038/ncomms3980 – volume: 9 start-page: 654 year: 2007 end-page: 659 ident: CR2 article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells publication-title: Nat.Cell Biol. doi: 10.1038/ncb1596 – volume: 8 year: 2017 ident: CR36 article-title: Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry publication-title: Nat. Commun. doi: 10.1038/s41467-017-00249-5 – volume: 43 start-page: 5601 year: 2015 end-page: 5616 ident: CR5 article-title: Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv432 – volume: 175 start-page: 695 year: 2018 end-page: 708 ident: CR8 article-title: An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state publication-title: Cell doi: 10.1016/j.cell.2018.09.005 – volume: 8 year: 2017 ident: CR13 article-title: Coding and noncoding landscape of extracellular RNA released by human glioma stem cells publication-title: Nat. Commun. doi: 10.1038/s41467-017-01196-x – volume: 28 start-page: 3105 year: 2019 end-page: 3119 ident: CR10 article-title: Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21 publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.08.036 – volume: 161 start-page: 1046 year: 2015 end-page: 1057 ident: CR9 article-title: In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior publication-title: Cell doi: 10.1016/j.cell.2015.04.042 – volume: 138 start-page: 268 year: 2014 end-page: 277 ident: CR30 article-title: Aberrant microRNA expression likely controls oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfu002 – volume: 10 start-page: 1470 year: 2008 end-page: 1476 ident: CR3 article-title: Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers publication-title: Nat.Cell Biol. doi: 10.1038/ncb1800 – volume: 19 year: 2018 ident: CR23 article-title: A systematic approach to RNA-associated motif discovery publication-title: BMC Genomics doi: 10.1186/s12864-018-4528-x – volume: 13 start-page: e0195969 year: 2018 ident: CR25 article-title: Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes publication-title: PLoS ONE doi: 10.1371/journal.pone.0195969 – ident: CR17 – volume: 3 start-page: e3694 year: 2008 ident: CR7 article-title: Detection of microRNA expression in human peripheral blood microvesicles publication-title: PLoS ONE doi: 10.1371/journal.pone.0003694 – volume: 410 start-page: 1 year: 2016 end-page: 13 ident: CR22 article-title: Muscle-specific microRNAs in skeletal muscle development publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2015.12.013 – volume: 41 start-page: D239 year: 2013 end-page: D245 ident: CR31 article-title: DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1246 – volume: Chapter 3 start-page: Unit 3.22 year: 2006 ident: CR34 article-title: Isolation and characterization of exosomes from cell culture supernatants and biological fluids publication-title: Curr. Protoc. Cell Biol. – volume: 69 start-page: 787 year: 2018 end-page: 801 ident: CR27 article-title: FUS regulates activity of microRNA-mediated gene silencing publication-title: Mol. Cell doi: 10.1016/j.molcel.2018.02.001 – volume: 14 start-page: 844 year: 2008 end-page: 852 ident: CR35 article-title: Normalization of microRNA expression levels in quantitative RT–PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues publication-title: RNA doi: 10.1261/rna.939908 – volume: 17 start-page: 799 year: 2016 end-page: 808 ident: CR16 article-title: The RNA-binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNA sorting publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.09.031 – volume: 542 start-page: 450 year: 2017 end-page: 455 ident: CR1 article-title: Adipose-derived circulating miRNAs regulate gene expression in other tissues publication-title: Nature doi: 10.1038/nature21365 – volume: 9 start-page: 137 year: 2012 end-page: 142 ident: CR21 article-title: Liver-specific microRNA-122: biogenesis and function publication-title: RNA Biol. doi: 10.4161/rna.18827 – volume: 173 start-page: 20 year: 2018 end-page: 51 ident: CR24 article-title: Metazoan microRNAs publication-title: Cell doi: 10.1016/j.cell.2018.03.006 – volume: 285 start-page: 17442 year: 2010 end-page: 17452 ident: CR11 article-title: Secretory mechanisms and intercellular transfer of microRNAs in living cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.107821 – volume: 12 start-page: 735 year: 2002 end-page: 739 ident: CR20 article-title: Identification of tissue-specific microRNAs from mouse publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)00809-6 – volume: 7 start-page: 1535750 year: 2018 ident: CR19 article-title: Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines publication-title: J. Extracell. Vesicles doi: 10.1080/20013078.2018.1535750 – volume: 38 start-page: 576 year: 2010 end-page: 589 ident: CR40 article-title: Simple combinations of lineage-determining transcription factors prime -regulatory elements required for macrophage and B cell identities publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 – volume: 22 start-page: 79 year: 1951 end-page: 86 ident: CR41 article-title: On information and sufficiency publication-title: Ann. Math. Stat. doi: 10.1214/aoms/1177729694 – volume: 177 start-page: 428 year: 2019 ident: 4234_CR15 publication-title: Cell doi: 10.1016/j.cell.2019.02.029 – volume: 275 start-page: 25494 year: 2000 ident: 4234_CR33 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M004046200 – volume: 9 start-page: 137 year: 2012 ident: 4234_CR21 publication-title: RNA Biol. doi: 10.4161/rna.18827 – volume: 10 start-page: 1470 year: 2008 ident: 4234_CR3 publication-title: Nat.Cell Biol. doi: 10.1038/ncb1800 – volume: 108 start-page: 5003 year: 2011 ident: 4234_CR6 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1019055108 – volume: 161 start-page: 1046 year: 2015 ident: 4234_CR9 publication-title: Cell doi: 10.1016/j.cell.2015.04.042 – volume: 111 start-page: 14888 year: 2014 ident: 4234_CR32 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1408301111 – volume: 22 start-page: 79 year: 1951 ident: 4234_CR41 publication-title: Ann. Math. Stat. doi: 10.1214/aoms/1177729694 – volume: 14 start-page: 228 year: 2017 ident: 4234_CR42 publication-title: Nat. Methods doi: 10.1038/nmeth.4185 – volume: 542 start-page: 450 year: 2017 ident: 4234_CR1 publication-title: Nature doi: 10.1038/nature21365 – volume: 30 start-page: 656 year: 2019 ident: 4234_CR4 publication-title: Cell Metab. doi: 10.1016/j.cmet.2019.07.011 – volume: 175 start-page: 695 year: 2018 ident: 4234_CR8 publication-title: Cell doi: 10.1016/j.cell.2018.09.005 – volume: 17 start-page: 799 year: 2016 ident: 4234_CR16 publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.09.031 – volume: 7 start-page: 1535750 year: 2018 ident: 4234_CR19 publication-title: J. Extracell. Vesicles doi: 10.1080/20013078.2018.1535750 – volume: 43 start-page: 5601 year: 2015 ident: 4234_CR5 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv432 – volume: 8 year: 2017 ident: 4234_CR13 publication-title: Nat. Commun. doi: 10.1038/s41467-017-01196-x – volume: 17 start-page: 12 year: 2018 ident: 4234_CR39 publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.7b00170 – volume: 14 start-page: 844 year: 2008 ident: 4234_CR35 publication-title: RNA doi: 10.1261/rna.939908 – ident: 4234_CR12 doi: 10.7554/eLife.19276 – volume: 3 start-page: e3694 year: 2008 ident: 4234_CR7 publication-title: PLoS ONE doi: 10.1371/journal.pone.0003694 – volume: 19 year: 2018 ident: 4234_CR23 publication-title: BMC Genomics doi: 10.1186/s12864-018-4528-x – volume: 69 start-page: 787 year: 2018 ident: 4234_CR27 publication-title: Mol. Cell doi: 10.1016/j.molcel.2018.02.001 – volume: Chapter 3 start-page: Unit 3.22 year: 2006 ident: 4234_CR34 publication-title: Curr. Protoc. Cell Biol. – volume: 21 start-page: 2991 year: 2012 ident: 4234_CR28 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds129 – volume: 38 start-page: 576 year: 2010 ident: 4234_CR40 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 – volume: 410 start-page: 1 year: 2016 ident: 4234_CR22 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2015.12.013 – volume: 8 year: 2017 ident: 4234_CR36 publication-title: Nat. Commun. doi: 10.1038/s41467-017-00249-5 – volume: 1550 start-page: 223 year: 2017 ident: 4234_CR37 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-6747-6_16 – volume: 138 start-page: 268 year: 2014 ident: 4234_CR30 publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfu002 – volume: 285 start-page: 17442 year: 2010 ident: 4234_CR11 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.107821 – volume: 13 start-page: e0195969 year: 2018 ident: 4234_CR25 publication-title: PLoS ONE doi: 10.1371/journal.pone.0195969 – volume: 48 start-page: 673 year: 2015 ident: 4234_CR29 publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-150432 – volume: 28 start-page: 3105 year: 2019 ident: 4234_CR10 publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.08.036 – volume: 45 start-page: 9640 year: 2017 ident: 4234_CR26 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx597 – volume: 41 start-page: D239 year: 2013 ident: 4234_CR31 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1246 – volume: 4 start-page: e07197 year: 2015 ident: 4234_CR14 publication-title: eLife doi: 10.7554/eLife.07197 – ident: 4234_CR17 doi: 10.7554/eLife.47544 – volume: 4 year: 2013 ident: 4234_CR18 publication-title: Nat. Commun. doi: 10.1038/ncomms3980 – volume: 12 start-page: 735 year: 2002 ident: 4234_CR20 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)00809-6 – volume: 173 start-page: 20 year: 2018 ident: 4234_CR24 publication-title: Cell doi: 10.1016/j.cell.2018.03.006 – volume: 9 start-page: 654 year: 2007 ident: 4234_CR2 publication-title: Nat.Cell Biol. doi: 10.1038/ncb1596 – volume: 7 start-page: 261 year: 2006 ident: 4234_CR38 publication-title: BMC Bioinf. doi: 10.1186/1471-2105-7-261 – reference: 35364031 - Cell. 2022 Mar 31;185(7):1114-1116. doi: 10.1016/j.cell.2022.03.010
SSID	ssj0005174
Score	2.7367086
Snippet	Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released... Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released... Exosomes/small extracellular vesicles (sEV) provide a unique mode of cell-to-cell communication in which miRNAs produced and released from one cell are taken...
SourceID	pubmedcentral proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	446
SubjectTerms	38/77 38/91 42/44 45/41 45/70 631/337/384/331 631/443/319 82/58 96/106 96/109 Adipocytes Adipocytes - cytology Cell Communication Cell interactions Clonal deletion Endothelium Endothelium - cytology Exosomes Exosomes - genetics Exosomes - metabolism Extracellular vesicles Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Gene expression Humanities and Social Sciences Insertion Liver - cytology MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA multidisciplinary Muscles Muscles - cytology Retention Ribonucleic acid RNA RNA-binding protein Science Science (multidisciplinary) Secretion
Title	MicroRNA sequence codes for small extracellular vesicle release and cellular retention
URI	https://link.springer.com/article/10.1038/s41586-021-04234-3 https://www.ncbi.nlm.nih.gov/pubmed/34937935 https://www.proquest.com/docview/2622301655 https://www.proquest.com/docview/2613289935 https://pubmed.ncbi.nlm.nih.gov/PMC9035265
Volume	601
WOSCitedRecordID	wos000733875500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAQT databaseName: Nature (UW-Madison Shared) customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest - Health & Medical Complete保健、医学与药学数据库 customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241208 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwED6xDSRegI1fhVEZiQcQhCWxkzhPaJs2IY2WqEBV8RK5diwmlXQ03f5-7lwnVTexF14-KbXT1rnz3Tn-fAfwJtWGc5FOAxlZGQgMQAKFYQJe5laFkdTKlfMZf8mGQzmZ5IV_4dZ4WmVrE52hNnNN78gP4hQdGZ29ST5d_AmoahTtrvoSGluwQ1kSuKPuFWuKx7UszP7QTMjlQYOOSxL9FhfTGFGIgG86phvR5k3S5LWdU-eQTh_-71AewQMfirLDle7swp2q3oN7jhKqmz3Y9dO-YW99bup3j2E8IALfaHjIWg42o0PxDcPYlzW_1WzG0NovFO0HEMGVXVUNfTuj2izoMJmqDesaFxSxk2Y8gR-nJ9-PPwe-NEOgRSaWgZqmU6F5zpUJtTXScvxEC2nzRCuh0txGKYJBqVQ2TSqTKtSDMJE6UdzomD-F7XpeV8-BGauUNUZVKeXyz6NcJAotsOKRtcrGVQ-iVi6l9nnLqXzGrHT751yWK1mWKMvSybLkPXjf3XOxytpxa-_9Vk6ln8FNuRZSD153zTj36BmpuppfUh9cy-OClWOfZyvt6H6OCwz8XEu2oTddB8rrvdlSn_9y-b3z0BUt6MGHVsPWf-vfo3hx-yhewv2YTm6EERrGfdheLi6rV3BXXy3Pm0UftrLRmHCSOZSI8jjqw87RybAY4dXZ0UfEQXhGGA8cfnVY9N2sc_gNsUh-_gXMIyo5
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5VBQQXoOW1UMBIIIEgahw7WeeAUAVUrbpdoaqsegteP0SlJVs22yL-FL-RGeex2lb01gOXSMk4DztfZsbxNzMALzNjhZDZOFLcq0iiAxJpdBNwN_c65sroUM5nNOgPh-roKP-yAn_aWBiiVbY6MShqOzX0j3wzydCQUexN-uHkZ0RVo2h1tS2hUcNiz_3-hVO26v3uJ3y_r5Jk-_Phx52oqSoQGdmX80iPs7E0IhfaxsZb5QUeMVL5PDVa6iz3PMON5Ql3PkudzTR2IU6VSbWwhhIdoMq_hnqcE4WsfzBaUErOZX1ugnRioTYrNJSK6L44eUcPRkZi2RBe8G4vkjTPrdQGA7h9538burtwu3G12Vb9bazBiivX4UagvJpqHdYatVax103u7Tf3YLRPBMWD4RZrOeaMgv4rhr49q37oyYShNZtpWu8gAi87cxVdnVHtGXQImC4t64QzmpEQ8u_D1yvp6QNYLaelewTMeq29tdplVKsg57lMNVoYLbj32ieuB7zFQWGavOxUHmRSBH6AUEWNnQKxUwTsFKIHb7tzTuqsJJe23mhxUTQaqioWoOjBi06MuoXGSJduekptuKAJucA2D2s0drcTEh3bIOkv4bRrQHnLlyXl8feQvzyPQ1GGHrxrEb14rH_34vHlvXgON3cO9wfFYHe49wRuJRSlEnM0AhuwOp-duqdw3ZzNj6vZs_DNMvh21Uj_C8_Efhc
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5V5aFegBYoCwWMBBIIoo1jJ-scEKpaVlQtqwpB1Vvw-iEqLdmy2Rbx1_h1zDiPsq3orQcukRI7j0k-z4zjb2YAnmfGCiGzcaS4V5FEByTS6Cbgbu51zJXRoZzPwd5gNFKHh_n-EvxuY2GIVtnqxKCo7dTQP_J-kqEho9ibtO8bWsT-9vDd8Y-IKkjRSmtbTqOGyK779ROnb9XbnW381i-SZPj-89aHqKkwEBk5kPNIj7OxNCIX2sbGW-UFHjFS-Tw1Wuos9zzDjeUJdz5Lnc00ihOnyqRaWENJD1D9XxsIRDFFqW_9RS85lwG6CdiJhepXaDQVUX9xIo_ejIzEolG84OleJGyeW7UNxnB4-39-jXfgVuOCs816zKzCkivX4EagwppqDVYbdVexl01O7ld34eAjERc_jTZZyz1nlAygYujzs-q7nkwYyjjTtA5CxF526iq6OqOaNOgoMF1a1jXOaKZCI-IefLkSSe_Dcjkt3QNg1mvtrdUuoxoGOc9lqtHyaMG91z5xPeAtJgrT5GunsiGTIvAGhCpqHBWIoyLgqBA9eN2dc1xnK7m090aLkaLRXFVxBpAePOuaUefQO9Klm55QHy5ooi6wz3qNzO52QqLDG1oGC5jtOlA-88WW8uhbyGuex6FYQw_etOg-e6x_S_Hwcimewk0EeLG3M9p9BCsJBa_EHG3DBizPZyfuMVw3p_OjavYkDF8GX68a6H8AQgWGcg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MicroRNA+sequence+codes+for+small+extracellular+vesicle+release+and+cellular+retention&rft.jtitle=Nature+%28London%29&rft.au=Garcia-Martin%2C+Ruben&rft.au=Wang%2C+Guoxiao&rft.au=Brand%C4%81o%2C+Bruna+B&rft.au=Zanotto%2C+Tamires+M&rft.date=2022-01-20&rft.pub=Nature+Publishing+Group&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=601&rft.issue=7893&rft.spage=446&rft.epage=3&rft_id=info:doi/10.1038%2Fs41586-021-04234-3&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon