Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition

HPV-negative head and neck squamous cell carcinomas (HNSCCs) develop in precancerous changes in the mucosal lining of the upper-aerodigestive tract. These precancerous cells contain cancer-associated genomic changes and cause primary tumors and local relapses. Therapeutic strategies to eradicate the...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 2330
Main Authors:	van Harten, Anne M., de Boer, D. Vicky, Martens-de Kemp, Sanne R., Buijze, Marijke, Ganzevles, Sonja H., Hunter, Keith D., Leemans, C. René, van Beusechem, Victor W., Wolthuis, Rob M. F., de Menezes, Renée X., Brakenhoff, Ruud H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.02.2020 Nature Publishing Group
Subjects:	13/106 13/31 13/51 13/89 14/63 38/47 631/67/1059/602 692/4028/67/1059/602 692/4028/67/1536 82/80 96/95 Apoptosis Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cell Cycle Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Movement Cell Proliferation DNA Damage Fibroblasts Gene Expression Regulation, Neoplastic Head & neck cancer Head and neck Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - prevention & control High-Throughput Screening Assays Humanities and Social Sciences Humans Keratinocytes Kinases Lethality Mucosa multidisciplinary Precancerous Conditions - genetics Precancerous Conditions - pathology Precancerous Conditions - prevention & control Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism RNA, Small Interfering - genetics Science Science (multidisciplinary) siRNA Squamous cell carcinoma Tumor cell lines Tumor Cells, Cultured Tumors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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