Population variability in the generation and selection of T-cell repertoires

The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented on the major histocompatibility complex. These processes le...

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Bibliographic Details

Published in:	PLoS computational biology Vol. 16; no. 12; p. e1008394
Main Authors:	Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra M., Elhanati, Yuval
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.12.2020 Public Library of Science (PLoS)
Subjects:	Adaptive Immunity Biology and Life Sciences Humans Medicine and Health Sciences Physical Sciences Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Antigen, T-Cell, alpha-beta - metabolism Research and Analysis Methods T-Lymphocytes - immunology T-Lymphocytes - metabolism V(D)J Recombination
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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