One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors

The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT...

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Vydané v:	Haematologica (Roma) Ročník 107; číslo 5; s. 1045 - 1053
Hlavní autori:	Niederwieser, Dietger, Baldomero, Helen, Bazuaye, Nosa, Bupp, Caitrin, Chaudhri, Naeem, Corbacioglu, Selim, Elhaddad, Alaa, Frutos, Cristóbal, Galeano, Sebastian, Hamad, Nada, Hamidieh, Amir Ali, Hashmi, Shahrukh, Ho, Aloysius, Horowitz, Mary M., Iida, Minako, Jaimovich, Gregorio, Karduss, Amado, Kodera, Yoshihisa, Kröger, Nicolaus, Péffault de Latour, Regis, Lee, Jong Wook, Martínez-Rolón, Juliana, Pasquini, Marcelo C., Passweg, Jakob, Paulson, Kristjan, Seber, Adriana, Snowden, John A., Srivastava, Alok, Szer, Jeff, Weisdorf, Daniel, Worel, Nina, Koh, Mickey B.C., Aljurf, Mahmoud, Greinix, Hildegard, Atsuta, Yoshiko, Saber, Wael
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Italy Fondazione Ferrata Storti 01.05.2022 Ferrata Storti Foundation
Predmet:	Europe Hematopoietic Stem Cell Transplantation - methods Humans Tissue Donors Transplantation, Autologous Transplantation, Homologous Europe
ISSN:	0390-6078, 1592-8721, 1592-8721
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Abstract	The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous HCT and 7.0% in allogeneic HCT and bringing the total to 1,298,897 procedures. Assuming a frequency of 84,000/year, 1.5 million HCT were performed by 2019 since 1957. Slightly more autologous (53.5%) than allogeneic and more related (53.6%) than unrelated HCT were reported. A remarkable increase was noted in haploidentical related HCT for leukemias and lymphoproliferative diseases, but even more in non-malignant diseases. Transplant rates (TR; HCT/10 million population) varied according to region reaching 560.8 in North America, 438.5 in Europe, 76.7 in Latin America, 53.6 in South East Asia/Western Pacific (SEA/WPR) and 27.8 in African/East Mediterranean (AFR/EMR). Interestingly, haploidentical TR amounted to 32% in SEA/WPR and 26% in Latin America, but only 14% in Europe and EMR and 4.9% in North America of all allogeneic HCT. HCT team density (teams/10 million population) was highest in Europe (7.7) followed by North America (6.0), SEA/WPR (1.9), Latin America (1.6) and AFR/EMR (0.4). HCT are increasing steadily worldwide with narrowing gaps between regions and greater increase in allogeneic compared to autologous activity. While related HCT is rising, largely due to increase in haploidentical HCT, unrelated HCT is plateauing and cord blood HCT is in decline.
AbstractList	The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous HCT and 7.0% in allogeneic HCT and bringing the total to 1,298,897 procedures. Assuming a frequency of 84,000/year, 1.5 million HCT were performed by 2019 since 1957. Slightly more autologous (53.5%) than allogeneic and more related (53.6%) than unrelated HCT were reported. A remarkable increase was noted in haploidentical related HCT for leukemias and lymphoproliferative diseases, but even more in non-malignant diseases. Transplant rates (TR; HCT/10 million population) varied according to region reaching 560.8 in North America, 438.5 in Europe, 76.7 in Latin America, 53.6 in South East Asia/Western Pacific (SEA/WPR) and 27.8 in African/East Mediterranean (AFR/EMR). Interestingly, haploidentical TR amounted to 32% in SEA/WPR and 26% in Latin America, but only 14% in Europe and EMR and 4.9% in North America of all allogeneic HCT. HCT team density (teams/10 million population) was highest in Europe (7.7) followed by North America (6.0), SEA/WPR (1.9), Latin America (1.6) and AFR/EMR (0.4). HCT are increasing steadily worldwide with narrowing gaps between regions and greater increase in allogeneic compared to autologous activity. While related HCT is rising, largely due to increase in haploidentical HCT, unrelated HCT is plateauing and cord blood HCT is in decline. The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous HCT and 7.0% in allogeneic HCT and bringing the total to 1,298,897 procedures. Assuming a frequency of 84,000/year, 1.5 million HCT were performed by 2019 since 1957. Slightly more autologous (53.5%) than allogeneic and more related (53.6%) than unrelated HCT were reported. A remarkable increase was noted in haploidentical related HCT for leukemias and lymphoproliferative diseases, but even more in non-malignant diseases. Transplant rates (TR; HCT/10 million population) varied according to region reaching 560.8 in North America, 438.5 in Europe, 76.7 in Latin America, 53.6 in South East Asia/Western Pacific (SEA/WPR) and 27.8 in African/East Mediterranean (AFR/EMR). Interestingly, haploidentical TR amounted to 32% in SEA/WPR and 26% in Latin America, but only 14% in Europe and EMR and 4.9% in North America of all allogeneic HCT. HCT team density (teams/10 million population) was highest in Europe (7.7) followed by North America (6.0), SEA/WPR (1.9), Latin America (1.6) and AFR/EMR (0.4). HCT are increasing steadily worldwide with narrowing gaps between regions and greater increase in allogeneic compared to autologous activity. While related HCT is rising, largely due to increase in haploidentical HCT, unrelated HCT is plateauing and cord blood HCT is in decline.The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous HCT and 7.0% in allogeneic HCT and bringing the total to 1,298,897 procedures. Assuming a frequency of 84,000/year, 1.5 million HCT were performed by 2019 since 1957. Slightly more autologous (53.5%) than allogeneic and more related (53.6%) than unrelated HCT were reported. A remarkable increase was noted in haploidentical related HCT for leukemias and lymphoproliferative diseases, but even more in non-malignant diseases. Transplant rates (TR; HCT/10 million population) varied according to region reaching 560.8 in North America, 438.5 in Europe, 76.7 in Latin America, 53.6 in South East Asia/Western Pacific (SEA/WPR) and 27.8 in African/East Mediterranean (AFR/EMR). Interestingly, haploidentical TR amounted to 32% in SEA/WPR and 26% in Latin America, but only 14% in Europe and EMR and 4.9% in North America of all allogeneic HCT. HCT team density (teams/10 million population) was highest in Europe (7.7) followed by North America (6.0), SEA/WPR (1.9), Latin America (1.6) and AFR/EMR (0.4). HCT are increasing steadily worldwide with narrowing gaps between regions and greater increase in allogeneic compared to autologous activity. While related HCT is rising, largely due to increase in haploidentical HCT, unrelated HCT is plateauing and cord blood HCT is in decline.
Author	Koh, Mickey B.C. Szer, Jeff Weisdorf, Daniel Elhaddad, Alaa Aljurf, Mahmoud Paulson, Kristjan Kodera, Yoshihisa Srivastava, Alok Bupp, Caitrin Pasquini, Marcelo C. Lee, Jong Wook Atsuta, Yoshiko Hashmi, Shahrukh Hamad, Nada Worel, Nina Kröger, Nicolaus Galeano, Sebastian Horowitz, Mary M. Bazuaye, Nosa Passweg, Jakob Greinix, Hildegard Hamidieh, Amir Ali Karduss, Amado Frutos, Cristóbal Ho, Aloysius Niederwieser, Dietger Iida, Minako Saber, Wael Seber, Adriana Martínez-Rolón, Juliana Chaudhri, Naeem Jaimovich, Gregorio Corbacioglu, Selim Baldomero, Helen Snowden, John A. Péffault de Latour, Regis
AuthorAffiliation	19 Sheikh Shakhbout Medical City, Abu Dhabi, UAE 22 Singapore General Hospital Singapore, Singapore 20 MAYO Clinic, Rochester, MN, USA 18 Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences , Tehran, Iran 8 The Eastern Mediterranean Blood and Marrow Transplant Group (EMBMT), King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia 27 Department of Stem Cell Transplantation, University Medical Center Hamburg , Hamburg, Germany 33 Pediatric Department, Hospital Samaritano, Sao Paulo, Brazil 10 European Society for Blood and Marrow Transplantation (EBMT) , Barcelona, Spain 12 Department of Pediatric Oncology and Stem Cell Transplantation Unit , Cairo University , Cairo, Egypt 31 Klinik für Hämatologie, Universitätsspital Basel , Basel, Switzerland 34 Department of Hematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK 29 Seoul St. Mary’s Hospital, The Catholic University of Korea , Seoul, Republic of Korea 3 Lithuanian University of Healt
AuthorAffiliation_xml	– name: 10 European Society for Blood and Marrow Transplantation (EBMT) , Barcelona, Spain – name: 8 The Eastern Mediterranean Blood and Marrow Transplant Group (EMBMT), King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia – name: 36 Peter MacCallum Cancer Center and Royal Melbourne Hospital, Parkville, Vicoria, Australia – name: 40 Academic Cell Therapy Facility and Programme Health Sciences Authority Singapore, Singapore – name: 19 Sheikh Shakhbout Medical City, Abu Dhabi, UAE – name: 42 Medical University of Graz , Division of Hematology, Graz, Austria and – name: 24 Aichi Medical University School of Medicine , Deptartment of Promotion for Blood and Marrow Plantation, Nagakute, Japan – name: 38 Medical University of Vienna , Department of Blood Group Serology and Transfusion Medicine, Vienna, Austria – name: 41 King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia – name: 28 Saint-Louis Hospital, 1 avenue Claude Vellefaux, Paris, France – name: 25 Fundación Favaloro, Sanatorio Anchorena, ITAC, Buenos Aires, Argentina – name: 39 Infection and Immunity Clinical Academic Group St George’s Hospital and Medical School, London, UK – name: 35 Christian Medical College, Vellore, India – name: 15 Sebastian Galeano, Hospital Británico, Montevideo, Uruguay – name: 5 African Blood and Marrow Transplantation Group – AfBMT, Bern, Switzerland – name: 6 University of Benin Teaching Hospital , Benin, Nigeria – name: 33 Pediatric Department, Hospital Samaritano, Sao Paulo, Brazil – name: 30 FUNDALEU, Buenos Aires, Argentina – name: 13 Latin American Blood and Marrow Transplantation Group – LABMT, Bern, Switzerland – name: 34 Department of Hematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK – name: 17 St. Vincent's Health Network, Kinghorn Cancer Center, Sydney, New South Wales, Australia – name: 11 Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg , Regensburg, Germany – name: 22 Singapore General Hospital Singapore, Singapore – name: 20 MAYO Clinic, Rochester, MN, USA – name: 37 University of Minnesota , Minneapolis, MN, USA – name: 29 Seoul St. Mary’s Hospital, The Catholic University of Korea , Seoul, Republic of Korea – name: 31 Klinik für Hämatologie, Universitätsspital Basel , Basel, Switzerland – name: 18 Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences , Tehran, Iran – name: 14 Cristóbal Frutos, Instituto de Previsión Social, Asunción, Paraguay – name: 32 Cancercare Manitoba and the University of Manitoba and Cell Therapy Transplant Canada (CTTC) , Winnipeg, Manitoba, Canada – name: 2 Aichi Medical University School of Medicine , Nagakute, Japan – name: 4 The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital , Basel, Switzerland – name: 16 Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), St. Vincent´s Hospital Sydney, Sydney, New South Wales, Australia – name: 21 The Asia Pacific Blood and Marrow Transplant Group (APBMT), Aichi Medical University School of Medicine , Nagakute, Japan – name: 3 Lithuanian University of Health Sciences , Kaunas, Lithuania – name: 7 CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN; USA – name: 27 Department of Stem Cell Transplantation, University Medical Center Hamburg , Hamburg, Germany – name: 43 Japanese Data Center for Hematopoietic Cell Transplantation (JDCHCT), Nagoya, Japan – name: 12 Department of Pediatric Oncology and Stem Cell Transplantation Unit , Cairo University , Cairo, Egypt – name: 9 Oncology Center King Faisal Specialist Hospital & Research Center, Riyadh , Saudi Arabia – name: 26 Instituto de Cancerología-Clínica Las Américas , Medellín, Colombia – name: 1 University of Leipzig , Germany – name: 23 CIBMTR, Medical College of Wisconsin , Milwaukee, WI, USA
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34382386$$D View this record in MEDLINE/PubMed
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Disclosures DN, HB, MA, KB, KF, and FRA designed the study; HB, NB, CB, NC, SC, AE,CF, SG, NH, AAH, SH, AH, MH, MI, GJ, AK, JK, NK, RPL, JWL, JMR, MP, JP, KP, AS, JAS, AS, JS, DW, NW, MK, MA, HG, YA, WS contributed data and assured quality of the data given to the analysis; HB, DN, MP, and LF analysed data; DN, HB, WS, and NH drafted the manuscript; DN, HB, NB, CB, NC, SC, AE, CF, SG, NH, AAH, SH, AH, MH, MI, GJ, AK, JK, NK, RPL, JWL, JMR, MP, JP, KP, AS, JAS, AS, JS, DW, NW, MK, MA, HG, YA processed the manuscript. European data were derived from the European Society for Blood and Marrow Transplantation (EBMT) database for the years 1965–89 and from the EBMT annual activity survey office since 1990. Noneuropean data were initially provided by the Center for International Blood and Marrow Transplant Research (CIBMTR) since 1964. They were supplemented or replaced by the activity surveys of the Asian Pacific Blood and Marrow Transplantation Group (APBMT) since 1974, the Australasian Bone Marrow Transplant Recipient Registry (ABMTRR) since 1992, the Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT) since 1984, the Cell Therapy Transplant Canada (CTTC) since 2002, the Latin American Bone Marrow Transplantation Group (LABMT) since 2009, and the African Blood and Marrow Transplant Group (AFBMT) since 2010. Unrelated donor and cord blood information were derived from the World Marrow Donor Association (WMDA) and Bone Marrow Donors Worldwide (BMDW). Contributions No conflicts of interest to disclose.
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SubjectTerms	Europe Hematopoietic Stem Cell Transplantation - methods Humans Tissue Donors Transplantation, Autologous Transplantation, Homologous
Title	One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors
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