Mitochondria and cell death-associated inflammation

Mitochondria have recently emerged as key drivers of inflammation associated with cell death. Many of the pro-inflammatory pathways activated during cell death occur upon mitochondrial outer membrane permeabilization (MOMP), the pivotal commitment point to cell death during mitochondrial apoptosis....

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Bibliographic Details
Published in:Cell death and differentiation Vol. 30; no. 2; pp. 304 - 312
Main Authors: Vringer, Esmee, Tait, Stephen W G
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.02.2023
Subjects:
Apoptosis
Apoptosis - physiology
Bacteria
Cell Death
Cytosol
Humans
Inflammation
Inflammation - metabolism
Major outer membrane protein
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Mitochondrial Membranes - metabolism
Signal transduction
ISSN:1350-9047, 1476-5403, 1476-5403
Online Access:Get full text
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Summary:Mitochondria have recently emerged as key drivers of inflammation associated with cell death. Many of the pro-inflammatory pathways activated during cell death occur upon mitochondrial outer membrane permeabilization (MOMP), the pivotal commitment point to cell death during mitochondrial apoptosis. Permeabilised mitochondria trigger inflammation, in part, through the release of mitochondrial-derived damage-associated molecular patterns (DAMPs). Caspases, while dispensable for cell death during mitochondrial apoptosis, inhibit activation of pro-inflammatory pathways after MOMP. Some of these mitochondrial-activated inflammatory pathways can be traced back to the bacterial ancestry of mitochondria. For instance, mtDNA and bacterial DNA are highly similar thereby activating similar cell autonomous immune signalling pathways. The bacterial origin of mitochondria suggests that inflammatory pathways found in cytosol-invading bacteria may be relevant to mitochondrial-driven inflammation after MOMP. In this review, we discuss how mitochondria can initiate inflammation during cell death highlighting parallels with bacterial activation of inflammation. Moreover, we discuss the roles of mitochondrial inflammation during cell death and how these processes may potentially be harnessed therapeutically, for instance to improve cancer treatment.
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ISSN:1350-9047
1476-5403
1476-5403
DOI:10.1038/s41418-022-01094-w