Regulation of senescence traits by MAPKs

A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease. Mitogen-activated protein kinases (MAPKs) are capable of sensing changes in cellular conditions, and in turn elicit adaptive responses including cell se...

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Published in:GeroScience Vol. 42; no. 2; pp. 397 - 408
Main Authors: Anerillas, Carlos, Abdelmohsen, Kotb, Gorospe, Myriam
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.04.2020
Springer Nature B.V
Subjects:
Age differences
Aging
Arrests
Biomedical and Life Sciences
Cell Biology
Cell survival
Cellular Senescence
Elimination
Exploitation
Geriatrics/Gerontology
Inflammation
Kinases
Life Sciences
Mitogen-Activated Protein Kinases
Molecular Medicine
p38 Mitogen-Activated Protein Kinases - metabolism
p53 Protein
Phenotype
Phenotypes
Proteins
Reference (Semantic)
Review
Senescence
Signal Transduction
Senescence
p38
Gene expression programs
SASP
JNK
ERK
ISSN:2509-2715, 2509-2723, 2509-2723
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Abstract A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease. Mitogen-activated protein kinases (MAPKs) are capable of sensing changes in cellular conditions, and in turn elicit adaptive responses including cell senescence. MAPKs modulate the levels and function of many proteins, including proinflammatory factors and factors in the p21/p53 and p16/RB pathways, the main senescence-regulatory axes. Through these actions, MAPKs implement key traits of senescence—growth arrest, cell survival, and the senescence-associated secretory phenotype (SASP). In this review, we summarize and discuss our current knowledge of the impact of MAPKs in senescence. In addition, given that eliminating or suppressing senescent cells can improve health span, we discuss the function and possible exploitation of MAPKs in the elimination (senolysis) or suppression (senostasis) of senescent cells.
AbstractList A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease. Mitogen-activated protein kinases (MAPKs) are capable of sensing changes in cellular conditions, and in turn elicit adaptive responses including cell senescence. MAPKs modulate the levels and function of many proteins, including proinflammatory factors and factors in the p21/p53 and p16/RB pathways, the main senescence-regulatory axes. Through these actions, MAPKs implement key traits of senescence-growth arrest, cell survival, and the senescence-associated secretory phenotype (SASP). In this review, we summarize and discuss our current knowledge of the impact of MAPKs in senescence. In addition, given that eliminating or suppressing senescent cells can improve health span, we discuss the function and possible exploitation of MAPKs in the elimination (senolysis) or suppression (senostasis) of senescent cells.A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease. Mitogen-activated protein kinases (MAPKs) are capable of sensing changes in cellular conditions, and in turn elicit adaptive responses including cell senescence. MAPKs modulate the levels and function of many proteins, including proinflammatory factors and factors in the p21/p53 and p16/RB pathways, the main senescence-regulatory axes. Through these actions, MAPKs implement key traits of senescence-growth arrest, cell survival, and the senescence-associated secretory phenotype (SASP). In this review, we summarize and discuss our current knowledge of the impact of MAPKs in senescence. In addition, given that eliminating or suppressing senescent cells can improve health span, we discuss the function and possible exploitation of MAPKs in the elimination (senolysis) or suppression (senostasis) of senescent cells.
A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease. Mitogen-activated protein kinases (MAPKs) are capable of sensing changes in cellular conditions, and in turn elicit adaptive responses including cell senescence. MAPKs modulate the levels and function of many proteins, including proinflammatory factors and factors in the p21/p53 and p16/RB pathways, the main senescence-regulatory axes. Through these actions, MAPKs implement key traits of senescence—growth arrest, cell survival, and the senescence-associated secretory phenotype (SASP). In this review, we summarize and discuss our current knowledge of the impact of MAPKs in senescence. In addition, given that eliminating or suppressing senescent cells can improve health span, we discuss the function and possible exploitation of MAPKs in the elimination (senolysis) or suppression (senostasis) of senescent cells.
Author Anerillas, Carlos
Gorospe, Myriam
Abdelmohsen, Kotb
Author_xml – sequence: 1
  givenname: Carlos
  orcidid: 0000-0003-4424-7913
  surname: Anerillas
  fullname: Anerillas, Carlos
  organization: Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
– sequence: 2
  givenname: Kotb
  orcidid: 0000-0001-6240-5810
  surname: Abdelmohsen
  fullname: Abdelmohsen, Kotb
  organization: Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
– sequence: 3
  givenname: Myriam
  orcidid: 0000-0001-5439-3434
  surname: Gorospe
  fullname: Gorospe, Myriam
  email: myriam-gorospe@nih.gov
  organization: Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32300964$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1182/blood-2008-05-159392
10.1016/j.cell.2017.05.015
10.1038/ncomms4729
10.1038/nrm.2015.16
10.1038/nature16932
10.18632/aging.100265
10.1016/j.cell.2013.10.019
10.1371/journal.pone.0015583
10.1016/j.tcb.2018.02.001
10.1016/j.bbamcr.2007.01.002
10.1101/gad.331272.119
10.1093/nar/gkz555
10.1111/j.1460-9568.2011.07738.x
10.1158/2159-8290.CD-13-0743
10.1074/jbc.M111.323709
10.1128/MCB.21.17.5889-5898.2001
10.1111/febs.12435
10.1371/journal.pone.0125217
10.1038/ncb3225
10.1038/onc.2010.252
10.1128/MCB.00604-06
10.1093/nar/gks545
10.1016/j.devcel.2004.10.019
10.1242/jcs.02946
10.4049/jimmunol.1301203
10.1016/j.molmed.2009.01.003
10.18632/oncotarget.11505
10.1371/journal.pone.0045069
10.1002/wrna.1372
10.4161/cc.8.8.8147
10.1016/j.bbagen.2014.07.005
10.4161/cc.6.21.4930
10.1002/jcp.22984
10.1038/msb.2010.5
10.1007/s11033-014-3094-9
10.1111/acel.12511
10.1038/nrc2772
10.1074/jbc.M008340200
10.1074/jbc.M808426200
10.1038/ncomms11190
10.1002/ijc.23063
10.1038/s41593-019-0372-9
10.1038/nm.4010
10.1101/gad.297796.117
10.2147/OTT.S147316
10.1111/j.1750-3639.2001.tb00387.x
10.15252/embr.201439245
10.1074/jbc.M300878200
10.1016/j.devcel.2014.11.012
10.18632/oncotarget.17246
10.1074/jbc.M407155200
10.2147/DDDT.S89114
10.1515/tnsci-2018-0022
10.1016/j.cell.2019.10.005
10.1038/nrc2657
10.1016/j.molcel.2012.04.019
10.18632/aging.101000
10.4161/cc.9.18.13049
10.1007/s10522-015-9610-z
10.1371/journal.pone.0004393
10.1016/j.cell.2006.11.050
10.1128/MMBR.00031-10
10.18632/aging.100079
10.1093/nar/gkz082
10.1007/s10555-010-9220-9
10.1038/ng1378
10.1038/onc.2009.355
10.1523/JNEUROSCI.0852-07.2007
10.1038/s41586-018-0543-y
10.1016/j.celrep.2018.03.002
10.1016/j.cmet.2016.05.010
10.1093/jnen/59.10.880
10.1038/ncb1024
10.1016/j.celrep.2017.12.092
10.1016/j.ebiom.2017.04.013
10.1038/ncb3397
10.1158/1541-7786.MCR-08-0084
10.1074/jbc.M111598200
10.1002/bies.201670910
10.1074/jbc.274.29.20657
10.1242/jcs.02505
10.1016/j.bcp.2011.08.010
10.1038/s41419-019-1607-0
10.1016/j.pain.2004.12.022
10.1016/j.freeradbiomed.2017.10.379
10.1101/gad.1971610
10.3892/ijmm.2017.2962
10.1074/jbc.M110.216721
10.1101/cshperspect.a022137
10.1186/s13046-019-1115-1
10.1128/MCB.20.3.760-769.2000
10.1038/sj.embor.7400346
10.1091/mbc.e15-11-0772
10.1083/jcb.201708092
10.1101/gad.203984.112
10.1016/j.arr.2012.02.005
10.1146/annurev-physiol-030212-183653
10.1101/gad.302570.117
10.1093/nar/gky223
10.1158/0008-5472.CAN-06-1236
10.1093/emboj/cdg139
10.1002/jcp.10147
10.1080/15216540500091890
10.3892/ijmm.2014.1658
10.1038/nm754
10.21769/BioProtoc.1481
10.1074/jbc.274.20.13954
10.1371/journal.pone.0000164
10.1038/ncb1909
10.1046/j.1471-4159.1999.0722053.x
10.1007/s12192-016-0740-2
10.1038/sj.onc.1210421
10.1093/nar/gkr818
10.15252/embj.201695553
10.1101/gad.1604407
10.1016/j.febslet.2010.10.057
10.1186/s13195-016-0221-y
10.1074/jbc.M909467199
10.1016/j.cell.2013.05.039
10.1128/MCB.02019-07
10.1016/j.yexcr.2011.12.015
10.1126/science.1218351
10.1016/j.drudis.2017.01.004
10.1016/j.cell.2013.10.041
10.1016/j.arr.2011.09.003
10.18632/aging.101516
10.1128/MCB.22.10.3389-3403.2002
10.1128/MCB.00931-12
10.1016/j.molcel.2008.02.024
10.1038/s41467-018-05258-6
10.1038/s41598-018-20000-4
10.1007/978-1-4419-7002-2_10
10.1111/gtc.12015
10.1038/s41580-019-0110-x
10.1074/jbc.M410344200
10.1074/jbc.M001131200
10.1074/jbc.M211739200
10.1523/ENEURO.0149-16.2017
10.1038/358331a0
10.1016/S0092-8674(03)00401-X
10.1016/j.tibs.2014.04.004
10.1016/j.cellsig.2005.04.008
10.1038/ncb3244
10.1128/MCB.00169-10
10.1158/0008-5472.CAN-15-0173
10.1016/j.cell.2017.02.031
10.1101/gad.415507
10.1038/nature13193
10.1016/j.cell.2006.10.003
10.1038/s41419-018-0303-9
10.1172/JCI95148
10.4161/cbt.3.2.614
10.1038/nrc2440
10.1038/cdd.2013.161
10.1158/1078-0432.CCR-10-2616
10.4161/cc.10.3.14713
10.1111/j.1524-475X.2008.00402.x
10.1038/nrm3823
10.1038/emboj.2011.69
10.2174/18715206113139990114
10.1128/MCB.00210-09
10.1038/ncb3195
10.1128/MCB.00070-18
10.1111/acel.12344
10.1038/35059131
10.1093/emboj/cdf366
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Copyright This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020
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2509-2723
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Sun Sep 28 11:28:49 EDT 2025
Sat Nov 15 05:51:25 EST 2025
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Tue Nov 18 22:26:56 EST 2025
Fri Feb 21 02:42:16 EST 2025
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Issue 2
Keywords Senescence
p38
Gene expression programs
SASP
JNK
ERK
Language English
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PublicationSubtitle Official Journal of the American Aging Association (AGE)
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References Dasari, Bartholomew, Volonte, Galbiati (CR30) 2006; 66
Leontieva, Blagosklonny (CR84) 2010; 2
Pont, Sadri, Hsiao, Smith, Schneider (CR115) 2012; 47
Mebratu, Tesfaigzi (CR98) 2009; 8
Wang, Han, Zhao, Shen, Wang, Sun, Xu, Su, Li, Tong, Chen (CR151) 2016; 15
Kirkland, Tchkonia (CR74) 2017; 21
Lee, Yu, Kim, Kang, Kim, Lee, Choi, Shin, Seo, Kang (CR81) 2016; 8
Lei, Kazlauskas (CR83) 2009; 284
Wiley, Campisi (CR154) 2016; 23
Hoare, Ito, Kang, Weekes, Matheson, Patten, Shetty, Parry, Menon, Salama, Antrobus, Tomimatsu, Howat, Lehner, Zender, Narita (CR59) 2016; 18
Lee, Lee, Ko, Hong, Lee (CR80) 2010; 29
Macedo, Vaz, Bakker, Ribeiro, Bakker, Escandell, Ferreira, Medema, Foijer, Logarinho (CR92) 2018; 9
Chinta, Woods, Demaria, Rane, Zou, McQuade, Rajagopalan, Limbad, Madden, Campisi, Andersen (CR24) 2018; 22
Herranz, Gallage, Mellone, Wuestefeld, Klotz, Hanley, Raguz, Acosta, Innes, Banito, Georgilis, Montoya, Wolter, Dharmalingam, Faull, Carroll, Martinez-Barbera, Cutillas, Reisinger, Heikenwalder, Miller, Withers, Zender, Thomas, Gil (CR58) 2015; 17
Ohtani, Zebedee, Huot, Stinson, Sugimoto, Ohashi, Sharrocks, Peters, Hara (CR108) 2001; 409
Pardali, Kurisaki, Moren, ten Dijke, Kardassis, Moustakas (CR109) 2000; 275
Zou, Lei, Guo, Yu, Xu, Luo, Ke, Huang (CR172) 2019; 19
Reber, Vermeulen, Haegeman, Frossard (CR118) 2009; 4
Igea, Nebreda (CR60) 2015; 75
Mombach, Vendrusculo, Bugs (CR100) 2015; 10
Wu, Xue, Weng, Sun, Zhang, Wang, Tong (CR157) 2007; 2
Maphis, Jiang, Xu, Kokiko-Cochran, Roy, Van Eldik, Watterson, Lamb, Bhaskar (CR94) 2016; 8
Dai, Chen, Pei, Almenara, Kramer, Venditti, Dent, Grant (CR29) 2008; 112
Wang, Chen, Liao, Deng, Zhou, Huang, Sun (CR148) 2002; 22
Noh, Kim, Pandey, Noren Hooten, Munk, Kundu, De, Martindale, Yang, Evans, Abdelmohsen, Gorospe (CR107) 2019; 47
Colavitti, Finkel (CR25) 2005; 57
Kim, Heo, Park, Shin, Kang, Kim, Kim, Kim, Park, Lee (CR72) 2014; 41
Ferrer, Blanco, Carmona, Ribera, Goutan, Puig, Rey, Cardozo, Vinals, Ribalta (CR41) 2001; 11
Alimbetov, Davis, Brook, Cox, Faragher, Nurgozhin, Zhumadilov, Kipling (CR5) 2016; 17
Alspach, Flanagan, Luo, Ruhland, Huang, Pazolli, Donlin, Marsh, Piwnica-Worms, Monahan, Novack, McAllister, Stewart (CR7) 2014; 4
CR48
Simone, Forcales, Hill, Imbalzano, Latella, Puri (CR128) 2004; 36
Kim, Lee, Kim, Kim (CR71) 2014; 33
Lumley, Osborn, Scott, Scholl, Mercado, McMahan, Coffman, Brewster (CR90) 2017; 22
Shin, Kim, Lim, Lee (CR127) 2011; 286
He, Sharpless (CR53) 2017; 169
Campaner, Doni, Verrecchia, Faga, Bianchi, Amati (CR16) 2010; 9
Aarts, Georgilis, Beniazza, Beolchi, Banito, Carroll, Kulisic, Kaemena, Dharmalingam, Martin, Reik, Zuber, Kaji, Chandra, Gil (CR1) 2017; 31
Bruning (CR13) 2013; 13
Davalos, Coppe, Campisi, Desprez (CR32) 2010; 29
Yu, Hebert, Zhang (CR162) 2002; 21
Lujambio (CR89) 2016; 38
Zhang, Gao, Zhao, Han, Lu, Hou, Shi, Liu, Tian, Wang, Huang, Lu (CR165) 2013; 280
Lopez-Otin, Blasco, Partridge, Serrano, Kroemer (CR88) 2013; 153
Passos, Nelson, Wang, Richter, Simillion, Proctor, Miwa, Olijslagers, Hallinan, Wipat, Saretzki, Rudolph, Kirkwood, von Zglinicki (CR111) 2010; 6
Xu, Li, Xiang, Sun (CR159) 2014; 39
Al-Haj, Blackshear, Khabar (CR4) 2012; 40
Viniegra, Martinez, Modirassari, Hernandez Losa, Parada Cobo, Sanchez-Arevalo Lobo, Aceves Luquero, Alvarez-Vallina, y Cajal, Rojas, Sanchez-Prieto (CR142) 2005; 280
Sun, Shi, Zheng, Min, Yang, Li, Liao, Huang, Zhang, Xu, Zhu, Cui, Liu (CR136) 2018; 9
Laberge, Sun, Orjalo, Patil, Freund, Zhou, Curran, Davalos, Wilson-Edell, Liu, Limbad, Demaria, Li, Hubbard, Ikeno, Javors, Desprez, Benz, Kapahi, Nelson, Campisi (CR78) 2015; 17
Abbas, Dutta (CR2) 2009; 9
Bozulic, Surucu, Hynx, Hemmings (CR11) 2008; 30
Kania, Klein (CR62) 2016; 17
Ebisuya, Kondoh, Nishida (CR38) 2005; 118
van Deursen (CR139) 2014; 509
Pearson, Robinson, Beers Gibson, Xu, Karandikar, Berman, Cobb (CR112) 2001; 22
Wang, Furneaux, Cheng, Caldwell, Hutter, Liu, Holbrook, Gorospe (CR146) 2000; 20
Calabrese, Santoro, Monti, Crupi, Di Paola, Latteri, Cuzzocrea, Zappia, Giordano, Calabrese, Franceschi (CR15) 2018; 115
Bhat, Crowe, Bitto, Moh, Katsetos, Garcia, Johnson, Trojanowski, Sell, Torres (CR10) 2012; 7
Voncken, Niessen, Neufeld, Rennefahrt, Dahlmans, Kubben, Holzer, Ludwig, Rapp (CR145) 2005; 280
Weijzen, Rizzo, Braid, Vaishnav, Jonkheer, Zlobin, Osborne, Gottipati, Aster, Hahn, Rudolf, Siziopikou, Kast, Miele (CR152) 2002; 8
Kim, Byun, Yun, Park, Lee, Lee (CR70) 2008; 6
Kim, Noh, Bodogai, Martindale, Yang, Indig, Basu, Ohnuma, Morimoto, Johnson, Biragyn, Abdelmohsen, Gorospe (CR73) 2017; 31
Salminen, Ojala, Kaarniranta, Haapasalo, Hiltunen, Soininen (CR124) 2011; 34
Hafner, Bulyk, Jambhekar, Lahav (CR50) 2019; 20
Russo, Spagnuolo, Tedesco, Bilotto, Russo (CR122) 2012; 83
Zhu, Tchkonia, Pirtskhalava, Gower, Ding, Giorgadze, Palmer, Ikeno, Hubbard, Lenburg, O’Hara, LaRusso, Miller, Roos, Verzosa, LeBrasseur, Wren, Farr, Khosla, Stout, McGowan, Fuhrmann-Stroissnigg, Gurkar, Zhao, Colangelo, Dorronsoro, Ling, Barghouthy, Navarro, Sano, Robbins, Niedernhofer, Kirkland (CR169) 2015; 14
Casella, Munk, Kim, Piao, De, Abdelmohsen, Gorospe (CR19) 2019; 47
Zhuang, Gerner, Woolf, Ji (CR170) 2005; 114
Kim, Bae, Kang, Park, Lee, Lee, Choi, Lee, Han (CR69) 2006; 18
Wu, Kumar, Haque, Castillejo-Lopez, Alarcon-Riquelme (CR158) 2013; 191
Dhillon, Hagan, Rath, Kolch (CR36) 2007; 26
Rodier, Coppe, Patil, Hoeijmakers, Munoz, Raza, Freund, Campeau, Davalos, Campisi (CR119) 2009; 11
Herranz, Gil (CR57) 2018; 128
Kim, Song, Kwak, Park, Lim (CR68) 2003; 278
Tang, Wu, Hirao, Lahti, Liu, Mazza, Kidd, Mak, Ingram (CR137) 2002; 277
Hensley, Floyd, Zheng, Nael, Robinson, Nguyen, Pye, Stewart, Geddes, Markesbery, Patel, Johnson, Bing (CR55) 1999; 72
Kim, Wagner, Liu, O’Reilly, Robbins, Green (CR67) 1992; 358
Volonte, Galbiati (CR144) 2009; 1
Kim, Sharpless (CR66) 2006; 127
Wang, Pan, Chen, Huang, Zhang (CR150) 2012; 40
Montero, Seoane, Ocana, Pandiella (CR101) 2011; 17
Soni, Anand, Padwad (CR130) 2019; 38
Russo, Milito, Spagnuolo, Carbone, Rosen, Minasi, Lauria, Russo (CR123) 2017; 8
Wu (CR156) 2004; 3
Gong, Yang, Zhang, Wang, Gong, Liu (CR46) 2018; 11
CR143
Lee, Jung, Hong, Kim, Chung (CR82) 2018; 46
Druelle, Drullion, Desle, Martin, Saas, Cormenier, Malaquin, Huot, Slomianny, Bouali, Vercamer, Hot, Pourtier, Chevet, Abbadie, Pluquet (CR37) 2016; 7
Faucher, Mons, Micheau, Louis, Beracochea (CR39) 2015; 7
Hernandez-Segura, Nehme, Demaria (CR56) 2018; 28
Shao, Yi, Wells (CR126) 2008; 16
Storer, Mas, Robert-Moreno, Pecoraro, Ortells, Di Giacomo, Yosef, Pilpel, Krizhanovsky, Sharpe, Keyes (CR133) 2013; 155
Zhang, Kim, Ruthazer, McDevitt, Wazer, Paulson, Yee (CR164) 2006; 26
Daulhac, Kowalski-Chauvel, Pradayrol, Vaysse, Seva (CR31) 1999; 274
Khalil, Morgan, Adams, Golding, Dever, Rosenberg, Povirk, Valerie (CR64) 2011; 10
Martinez-Zamudio, Robinson, Roux, Bischof (CR95) 2017; 170
Hanger, Anderton, Noble (CR51) 2009; 15
CR75
Debacq-Chainiaux, Boilan, Dedessus Le Moutier, Weemaels, Toussaint (CR33) 2010; 694
Georgilis, Klotz, Hanley, Herranz, Weirich, Morancho, Leote, D’Artista, Gallage, Seehawer, Carroll, Dharmalingam, Wee, Mellone, Pombo, Heide, Guccione, Arribas, Barbosa-Morais, Heikenwalder, Thomas, Zender, Gil (CR44) 2018; 34
Kia, Gorski, Giannakopoulos, Verrijzer (CR65) 2008; 28
Li, Defren, Brewer (CR87) 2013; 33
Cargnello, Roux (CR18) 2011; 75
Childs, Baker, Kirkland, Campisi, van Deursen (CR23) 2014; 15
Demaria, Ohtani, Youssef, Rodier, Toussaint, Mitchell, Laberge, Vijg, Van Steeg, Dolle, Hoeijmakers, de Bruin, Hara, Campisi (CR34) 2014; 31
Wiley, Schaum, Alimirah, Lopez-Dominguez, Orjalo, Scott, Desprez, Benz, Davalos, Campisi (CR155) 2018; 8
Gutierrez-Uzquiza, Arechederra, Bragado, Aguirre-Ghiso, Porras (CR49) 2012; 287
He, Zhong, Zhang, Zhang, Hu (CR54) 2018; 9
Sun, Yoshizuka, New, Moser, Li, Liao, Xie, Chen, Deng, Yamout, Dong, Frangou, Yates, Wright, Han (CR135) 2007; 128
CR6
Bracken, Kleine-Kohlbrecher, Dietrich, Pasini, Gargiulo, Beekman, Theilgaard-Monch, Minucci, Porse, Marine, Hansen, Helin (CR12) 2007; 21
Deschenes-Simard, Gaumont-Leclerc, Bourdeau, Lessard, Moiseeva, Forest, Igelmann, Mallette, Saba-El-Leil, Meloche, Saad, Mes-Masson, Ferbeyre (CR35) 2013; 27
Feng, Liao, Luo, Zhang, Wang, Zheng, Chen (CR40) 2012; 227
Zhu, Xu, Ghandhi, Hubbard (CR168) 2002; 193
Gong, Liu, Ming, Deng, Jiang (CR45) 2010; 584
Li, Li, Bu, Liu, Tankersley, Wang, Huang (CR86) 2011; 46
Wang, Yang, Cristofalo, Holbrook, Gorospe (CR147) 2001; 21
Zhang, Poustovoitov, Ye, Santos, Chen, Daganzo, Erzberger, Serebriiskii, Canutescu, Dunbrack, Pehrson, Berger, Kaufman, Adams (CR163) 2005; 8
Li, Wang, Liu, Paulson, Yee, Zhang (CR85) 2010; 29
Santini, Valjent, Usiello, Carta, Borgkvist, Girault, Herve, Greengard, Fisone (CR125) 2007; 27
Vermeulen, De Wilde, Van Damme, Vanden Berghe, Haegeman (CR140) 2003; 22
CR121
Wendel, Silva, Malina, Mills, Zhu, Ueda, Watanabe-Fukunaga, Fukunaga, Teruya-Feldstein, Pelletier, Lowe (CR153) 2007; 21
Katz, Amit, Yarden (CR63) 2007; 1773
Meskiene, Baudouin, Schweighofer, Liwosz, Jonak, Rodriguez, Jelinek, Hirt (CR99) 2003; 278
Collado, Serrano (CR26) 2010; 10
Munoz-Espin, Serrano (CR103) 2014; 15
Zhu, Rottkamp, Boux, Takeda, Perry, Smith (CR167) 2000; 59
Moskalev, Smit-McBride, Shaposhnikov, Plyusnina, Zhavoronkov, Budovsky, Tacutu, Fraifeld (CR102) 2012; 11
Munoz-Espin, Canamero, Maraver, Gomez-Lopez, Contreras, Murillo-Cuesta, Rodriguez-Baeza, Varela-Nieto, Ruberte, Collado, Serrano (CR104) 2013; 155
Parrinello, Samper, Krtolica, Goldstein, Melov, Campisi (CR110) 2003; 5
Slobodnyuk, Radic, Ivanova, Llado, Trempolec, Zorzano, Nebreda (CR129) 2019; 10
Pimienta, Pascual (CR113) 2007; 6
Chang, Yi, Guo, Liu, Shang, Tong, Cui, Zhan, Gorospe, Wang (CR21) 2010; 30
Galan-Moya, Hernandez-Losa, Aceves Luquero, de la Cruz-Morcillo, Ramirez-Castillejo, Callejas-Valera, Arriaga, Aranburo, y Cajal, Gutkind, Sanchez-Prieto (CR43) 2008; 122
Macia, Vaquero, Gou-Fabregas, Castelblanco, Valdivielso, Anerillas, Mauricio, Matias-Guiu, Ribera, Encinas (CR93) 2014; 21
Ziaei, Shimada, Kucharavy, Hubbard (CR171) 2012; 318
Kuilman, Michaloglou, Mooi, Peeper (CR77) 2010; 24
Catanzaro, Sheshadri, Pan, Sun, Shi,
A Lujambio (183_CR89) 2016; 38
RI Martinez-Zamudio (183_CR95) 2017; 170
OV Leontieva (183_CR84) 2010; 2
M Demaria (183_CR34) 2014; 31
V Calabrese (183_CR15) 2018; 115
BG Childs (183_CR23) 2014; 15
AA Moskalev (183_CR102) 2012; 11
M Russo (183_CR122) 2012; 83
S Campaner (183_CR16) 2010; 9
EC Lumley (183_CR90) 2017; 22
JE Purvis (183_CR116) 2012; 336
ML Li (183_CR87) 2013; 33
KM Kim (183_CR73) 2017; 31
DP Hanger (183_CR51) 2009; 15
T Ito (183_CR61) 2018; 22
HS Kim (183_CR72) 2014; 41
W Wang (183_CR149) 2005; 6
JM Catanzaro (183_CR20) 2014; 5
F Debacq-Chainiaux (183_CR33) 2010; 694
MJ Kim (183_CR70) 2008; 6
A Igea (183_CR60) 2015; 75
A Freund (183_CR42) 2011; 30
JM van Deursen (183_CR139) 2014; 509
C Gong (183_CR46) 2018; 11
N Herranz (183_CR57) 2018; 128
D McHugh (183_CR97) 2018; 217
G Casella (183_CR19) 2019; 47
J Campisi (183_CR17) 2013; 75
W Wang (183_CR146) 2000; 20
DJ Baker (183_CR9) 2016; 530
X Sun (183_CR136) 2018; 9
S He (183_CR53) 2017; 169
K Hensley (183_CR55) 1999; 72
B Razani (183_CR117) 2001; 276
M Narita (183_CR105) 2003; 113
L Bozulic (183_CR11) 2008; 30
M Katz (183_CR63) 2007; 1773
A Gutierrez-Uzquiza (183_CR49) 2012; 287
L Yu (183_CR162) 2002; 21
N Herranz (183_CR58) 2015; 17
WY Kim (183_CR66) 2006; 127
X Zhu (183_CR167) 2000; 59
SJ Chinta (183_CR24) 2018; 22
D Munoz-Espin (183_CR103) 2014; 15
SY Shin (183_CR127) 2011; 286
D Alimbetov (183_CR5) 2016; 17
JF Passos (183_CR111) 2010; 6
J Zou (183_CR172) 2019; 19
V Gorgoulis (183_CR47) 2019; 179
M Russo (183_CR123) 2017; 8
JC Macedo (183_CR92) 2018; 9
L Feng (183_CR40) 2012; 227
K Pardali (183_CR109) 2000; 275
C Simone (183_CR128) 2004; 36
D Munoz-Espin (183_CR104) 2013; 155
S Ziaei (183_CR171) 2012; 318
183_CR6
JC Montero (183_CR101) 2011; 17
G Pearson (183_CR112) 2001; 22
EM Galan-Moya (183_CR43) 2008; 122
Y Xu (183_CR159) 2014; 39
M Storer (183_CR133) 2013; 155
H Wang (183_CR151) 2016; 15
P Faucher (183_CR39) 2015; 7
CD Wiley (183_CR154) 2016; 23
HS Kim (183_CR68) 2003; 278
T Matsumoto (183_CR96) 1999; 274
F Rodier (183_CR119) 2009; 11
M Collado (183_CR26) 2010; 10
C Lopez-Otin (183_CR88) 2013; 153
ZY Zhuang (183_CR170) 2005; 114
183_CR121
P Zhang (183_CR166) 2019; 22
AP Bracken (183_CR12) 2007; 21
X Deschenes-Simard (183_CR35) 2013; 27
JH Noh (183_CR107) 2019; 47
AS Dhillon (183_CR36) 2007; 26
W Wang (183_CR147) 2001; 21
JW Voncken (183_CR145) 2005; 280
YK Kim (183_CR69) 2006; 18
183_CR48
JG Viniegra (183_CR142) 2005; 280
YY Wu (183_CR158) 2013; 191
R Colavitti (183_CR25) 2005; 57
TJ Bussian (183_CR14) 2018; 562
N Maphis (183_CR94) 2016; 8
I Meskiene (183_CR99) 2003; 278
D Volonte (183_CR144) 2009; 1
R Yosef (183_CR160) 2016; 7
K Tomimatsu (183_CR138) 2015; 17
CD Wiley (183_CR155) 2018; 8
F d’Adda di Fagagna (183_CR28) 2008; 8
X Gong (183_CR45) 2010; 584
L Al-Haj (183_CR4) 2012; 40
L Daulhac (183_CR31) 1999; 274
Y Zhu (183_CR169) 2015; 14
SJ Kim (183_CR67) 1992; 358
J Chang (183_CR22) 2016; 22
H Li (183_CR85) 2010; 29
JH Lee (183_CR82) 2018; 46
Y Zhang (183_CR165) 2013; 280
S Parrinello (183_CR110) 2003; 5
S Soni (183_CR130) 2019; 38
R Kodama (183_CR76) 2013; 18
V Lafarga (183_CR79) 2009; 29
A Macia (183_CR93) 2014; 21
A Pol (183_CR114) 2000; 275
D Zhu (183_CR168) 2002; 193
M Abbaspour Babaei (183_CR3) 2016; 10
P Spallarossa (183_CR132) 2010; 5
N Ohtani (183_CR108) 2001; 409
R Yosef (183_CR161) 2017; 36
CR Ross (183_CR120) 2012; 11
JJ Lee (183_CR80) 2010; 29
S Weijzen (183_CR152) 2002; 8
R Zhang (183_CR163) 2005; 8
E Alspach (183_CR7) 2014; 4
JC Mombach (183_CR100) 2015; 10
L Reber (183_CR118) 2009; 4
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A Georgilis (183_CR44) 2018; 34
JY Lee (183_CR81) 2016; 8
AR Pont (183_CR115) 2012; 47
JL Kirkland (183_CR74) 2017; 21
W Wang (183_CR150) 2012; 40
X Zhang (183_CR164) 2006; 26
E Santini (183_CR125) 2007; 27
R Bhat (183_CR10) 2012; 7
RM Laberge (183_CR78) 2015; 17
HG Wendel (183_CR153) 2007; 21
I Ferrer (183_CR41) 2001; 11
M Hashimoto (183_CR52) 2014; 1840
W Wang (183_CR148) 2002; 22
MM Vihanto (183_CR141) 2006; 119
C Druelle (183_CR37) 2016; 7
M Ebisuya (183_CR38) 2005; 118
T Abbas (183_CR2) 2009; 9
J Sun (183_CR134) 2017; 39
N Chang (183_CR21) 2010; 30
A Hafner (183_CR50) 2019; 20
H Shao (183_CR126) 2008; 16
Y Dai (183_CR29) 2008; 112
R Culerrier (183_CR27) 2016; 27
Y Mebratu (183_CR98) 2009; 8
H Lei (183_CR83) 2009; 284
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AR Davalos (183_CR32) 2010; 29
SK Kia (183_CR65) 2008; 28
M Aarts (183_CR1) 2017; 31
Z Li (183_CR86) 2011; 46
A Hernandez-Segura (183_CR56) 2018; 28
P Sun (183_CR135) 2007; 128
183_CR91
JH Noh (183_CR106) 2018; 10
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GT Kim (183_CR71) 2014; 33
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J Wu (183_CR157) 2007; 2
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References_xml – volume: 31
  start-page: 1529
  year: 2017
  end-page: 1534
  ident: CR73
  article-title: Identification of senescent cell surface targetable protein DPP4
  publication-title: Genes Dev
– volume: 275
  start-page: 29244
  year: 2000
  end-page: 29256
  ident: CR109
  article-title: Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta
  publication-title: J Biol Chem
– volume: 10
  start-page: 376
  year: 2019
  ident: CR129
  article-title: Autophagy-induced senescence is regulated by p38alpha signaling
  publication-title: Cell Death Dis
– volume: 5
  start-page: 3729
  year: 2014
  ident: CR20
  article-title: Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4
  publication-title: Nat Commun
– volume: 5
  start-page: e15583
  year: 2010
  ident: CR132
  article-title: p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells
  publication-title: PLoS One
– volume: 509
  start-page: 439
  year: 2014
  end-page: 446
  ident: CR139
  article-title: The role of senescent cells in ageing
  publication-title: Nature
– volume: 27
  start-page: 900
  year: 2013
  end-page: 915
  ident: CR35
  article-title: Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
  publication-title: Genes Dev
– volume: 31
  start-page: 2085
  year: 2017
  end-page: 2098
  ident: CR1
  article-title: Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence
  publication-title: Genes Dev
– volume: 75
  start-page: 3997
  year: 2015
  end-page: 4002
  ident: CR60
  article-title: The stress kinase p38alpha as a target for cancer therapy
  publication-title: Cancer Res
– volume: 562
  start-page: 578
  year: 2018
  end-page: 582
  ident: CR14
  article-title: Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
  publication-title: Nature
– volume: 276
  start-page: 6727
  year: 2001
  end-page: 6738
  ident: CR117
  article-title: Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
  publication-title: J Biol Chem
– volume: 20
  start-page: 760
  year: 2000
  end-page: 769
  ident: CR146
  article-title: HuR regulates p21 mRNA stabilization by UV light
  publication-title: Mol Cell Biol
– volume: 22
  start-page: 43
  year: 2017
  end-page: 54
  ident: CR90
  article-title: Moderate endoplasmic reticulum stress activates a PERK and p38-dependent apoptosis
  publication-title: Cell Stress Chaperones
– volume: 22
  start-page: 78
  year: 2016
  end-page: 83
  ident: CR22
  article-title: Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
  publication-title: Nat Med
– volume: 9
  start-page: 147
  year: 2018
  end-page: 153
  ident: CR54
  article-title: P38 mitogen-activated protein kinase and Parkinson’s disease
  publication-title: Transl Neurosci
– volume: 1
  start-page: 831
  year: 2009
  end-page: 835
  ident: CR144
  article-title: Caveolin-1, cellular senescence and pulmonary emphysema
  publication-title: Aging (Albany NY)
– ident: CR121
– volume: 274
  start-page: 20657
  year: 1999
  end-page: 20663
  ident: CR31
  article-title: Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors
  publication-title: J Biol Chem
– volume: 127
  start-page: 265
  year: 2006
  end-page: 275
  ident: CR66
  article-title: The regulation of INK4/ARF in cancer and aging
  publication-title: Cell
– volume: 21
  start-page: 525
  year: 2007
  end-page: 530
  ident: CR12
  article-title: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
  publication-title: Genes Dev
– volume: 7
  start-page: 11190
  year: 2016
  ident: CR160
  article-title: Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
  publication-title: Nat Commun
– volume: 8
  start-page: 512
  year: 2008
  end-page: 522
  ident: CR28
  article-title: Living on a break: cellular senescence as a DNA-damage response
  publication-title: Nat Rev Cancer
– volume: 284
  start-page: 6329
  year: 2009
  end-page: 6336
  ident: CR83
  article-title: Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells
  publication-title: J Biol Chem
– volume: 22
  start-page: 3389
  year: 2002
  end-page: 3403
  ident: CR148
  article-title: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic Ras-induced premature senescence
  publication-title: Mol Cell Biol
– volume: 4
  start-page: 716
  year: 2014
  end-page: 729
  ident: CR7
  article-title: p38MAPK plays a crucial role in stromal-mediated tumorigenesis
  publication-title: Cancer Discov
– volume: 5
  start-page: 741
  year: 2003
  end-page: 747
  ident: CR110
  article-title: Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
  publication-title: Nat Cell Biol
– volume: 27
  start-page: 6995
  year: 2007
  end-page: 7005
  ident: CR125
  article-title: Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia
  publication-title: J Neurosci
– volume: 409
  start-page: 1067
  year: 2001
  end-page: 1070
  ident: CR108
  article-title: Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
  publication-title: Nature
– volume: 9
  start-page: 3655
  year: 2010
  end-page: 3661
  ident: CR16
  article-title: Myc, Cdk2 and cellular senescence: old players, new game
  publication-title: Cell Cycle
– volume: 22
  start-page: 153
  year: 2001
  end-page: 183
  ident: CR112
  article-title: Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
  publication-title: Endocr Rev
– volume: 17
  start-page: 240
  year: 2016
  end-page: 256
  ident: CR62
  article-title: Mechanisms of ephrin-Eph signalling in development, physiology and disease
  publication-title: Nat Rev Mol Cell Biol
– volume: 113
  start-page: 703
  year: 2003
  end-page: 716
  ident: CR105
  article-title: Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
  publication-title: Cell
– volume: 13
  start-page: 1025
  year: 2013
  end-page: 1031
  ident: CR13
  article-title: Inhibition of mTOR signaling by quercetin in cancer treatment and prevention
  publication-title: Anti Cancer Agents Med Chem
– volume: 9
  start-page: 2834
  year: 2018
  ident: CR92
  article-title: FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
  publication-title: Nat Commun
– volume: 193
  start-page: 19
  year: 2002
  end-page: 25
  ident: CR168
  article-title: Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence
  publication-title: J Cell Physiol
– volume: 38
  start-page: S56
  issue: Suppl 1
  year: 2016
  end-page: S64
  ident: CR89
  article-title: To clear, or not to clear (senescent cells)? That is the question
  publication-title: Bioessays
– volume: 155
  start-page: 1104
  year: 2013
  end-page: 1118
  ident: CR104
  article-title: Programmed cell senescence during mammalian embryonic development
  publication-title: Cell
– volume: 83
  start-page: 6
  year: 2012
  end-page: 15
  ident: CR122
  article-title: The flavonoid quercetin in disease prevention and therapy: facts and fancies
  publication-title: Biochem Pharmacol
– volume: 30
  start-page: 3875
  year: 2010
  end-page: 3886
  ident: CR21
  article-title: HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay
  publication-title: Mol Cell Biol
– volume: 20
  start-page: 199
  year: 2019
  end-page: 210
  ident: CR50
  article-title: The multiple mechanisms that regulate p53 activity and cell fate
  publication-title: Nat Rev Mol Cell Biol
– volume: 38
  start-page: 121
  year: 2019
  ident: CR130
  article-title: MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
  publication-title: J Exp Clin Cancer Res
– volume: 10
  start-page: e0125217
  year: 2015
  ident: CR100
  article-title: A model for p38MAPK-induced astrocyte senescence
  publication-title: PLoS One
– volume: 66
  start-page: 10805
  year: 2006
  end-page: 10814
  ident: CR30
  article-title: Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements
  publication-title: Cancer Res
– volume: 15
  start-page: 112
  year: 2009
  end-page: 119
  ident: CR51
  article-title: Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
  publication-title: Trends Mol Med
– volume: 191
  start-page: 6110
  year: 2013
  end-page: 6116
  ident: CR158
  article-title: BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway
  publication-title: J Immunol
– volume: 75
  start-page: 50
  year: 2011
  end-page: 83
  ident: CR18
  article-title: Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
  publication-title: Microbiol Mol Biol Rev
– volume: 34
  start-page: 3
  year: 2011
  end-page: 11
  ident: CR124
  article-title: Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
  publication-title: Eur J Neurosci
– volume: 29
  start-page: 4341
  year: 2009
  end-page: 4351
  ident: CR79
  article-title: p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
  publication-title: Mol Cell Biol
– ident: CR91
– volume: 21
  start-page: 5889
  year: 2001
  end-page: 5898
  ident: CR147
  article-title: Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence
  publication-title: Mol Cell Biol
– volume: 75
  start-page: 685
  year: 2013
  end-page: 705
  ident: CR17
  article-title: Aging, cellular senescence, and cancer
  publication-title: Annu Rev Physiol
– volume: 8
  start-page: 54
  year: 2016
  ident: CR94
  article-title: Selective suppression of the alpha isoform of p38 MAPK rescues late-stage tau pathology
  publication-title: Alzheimers Res Ther
– volume: 10
  start-page: 1856
  year: 2018
  end-page: 1866
  ident: CR106
  article-title: GRSF1 suppresses cell senescence
  publication-title: Aging (Albany NY)
– volume: 15
  start-page: 482
  year: 2014
  end-page: 496
  ident: CR103
  article-title: Cellular senescence: from physiology to pathology
  publication-title: Nat Rev Mol Cell Biol
– volume: 3
  start-page: 156
  year: 2004
  end-page: 161
  ident: CR156
  article-title: The functional interactions between the p53 and MAPK signaling pathways
  publication-title: Cancer Biol Ther
– ident: CR6
– volume: 11
  start-page: 144
  year: 2001
  end-page: 158
  ident: CR41
  article-title: Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick’s disease, progressive supranuclear palsy and corticobasal degeneration
  publication-title: Brain Pathol
– volume: 155
  start-page: 1119
  year: 2013
  end-page: 1130
  ident: CR133
  article-title: Senescence is a developmental mechanism that contributes to embryonic growth and patterning
  publication-title: Cell
– volume: 59
  start-page: 880
  year: 2000
  end-page: 888
  ident: CR167
  article-title: Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease
  publication-title: J Neuropathol Exp Neurol
– volume: 47
  start-page: 5
  year: 2012
  end-page: 15
  ident: CR115
  article-title: mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription
  publication-title: Mol Cell
– volume: 26
  start-page: 8252
  year: 2006
  end-page: 8266
  ident: CR164
  article-title: The HBP1 transcriptional repressor participates in RAS-induced premature senescence
  publication-title: Mol Cell Biol
– volume: 287
  start-page: 2632
  year: 2012
  end-page: 2642
  ident: CR49
  article-title: p38alpha mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway
  publication-title: J Biol Chem
– volume: 153
  start-page: 1194
  year: 2013
  end-page: 1217
  ident: CR88
  article-title: The hallmarks of aging
  publication-title: Cell
– volume: 8
  start-page: 42571
  year: 2017
  end-page: 42587
  ident: CR123
  article-title: CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia
  publication-title: Oncotarget
– volume: 15
  start-page: 1139
  year: 2014
  end-page: 1153
  ident: CR23
  article-title: Senescence and apoptosis: dueling or complementary cell fates?
  publication-title: EMBO Rep
– volume: 128
  start-page: 1238
  year: 2018
  end-page: 1246
  ident: CR57
  article-title: Mechanisms and functions of cellular senescence
  publication-title: J Clin Invest
– volume: 1773
  start-page: 1161
  year: 2007
  end-page: 1176
  ident: CR63
  article-title: Regulation of MAPKs by growth factors and receptor tyrosine kinases
  publication-title: Biochim Biophys Acta
– volume: 11
  start-page: 973
  year: 2009
  end-page: 979
  ident: CR119
  article-title: Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
  publication-title: Nat Cell Biol
– volume: 31
  start-page: 722
  year: 2014
  end-page: 733
  ident: CR34
  article-title: An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
  publication-title: Dev Cell
– volume: 18
  start-page: 236
  year: 2006
  end-page: 243
  ident: CR69
  article-title: Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF-beta1 induction of p21WAF1/Cip1
  publication-title: Cell Signal
– volume: 10
  start-page: 2443
  year: 2016
  end-page: 2459
  ident: CR3
  article-title: Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells
  publication-title: Drug Des Devel Ther
– volume: 278
  start-page: 37497
  year: 2003
  end-page: 37510
  ident: CR68
  article-title: Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence
  publication-title: J Biol Chem
– volume: 280
  start-page: 4625
  year: 2013
  end-page: 4639
  ident: CR165
  article-title: Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells
  publication-title: FEBS J
– volume: 17
  start-page: 305
  year: 2016
  end-page: 315
  ident: CR5
  article-title: Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
  publication-title: Biogerontology
– volume: 2
  start-page: 924
  year: 2010
  end-page: 935
  ident: CR84
  article-title: DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
  publication-title: Aging (Albany NY)
– volume: 39
  start-page: 1338
  year: 2017
  end-page: 1346
  ident: CR134
  article-title: The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: a potential therapeutic target (Review)
  publication-title: Int J Mol Med
– volume: 6
  start-page: 1872
  year: 2008
  end-page: 1880
  ident: CR70
  article-title: c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation
  publication-title: Mol Cancer Res
– volume: 9
  start-page: 400
  year: 2009
  end-page: 414
  ident: CR2
  article-title: p21 in cancer: intricate networks and multiple activities
  publication-title: Nat Rev Cancer
– volume: 72
  start-page: 2053
  year: 1999
  end-page: 2058
  ident: CR55
  article-title: p38 kinase is activated in the Alzheimer’s disease brain
  publication-title: J Neurochem
– volume: 169
  start-page: 132
  year: 2017
  end-page: 47 e16
  ident: CR8
  article-title: Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging
  publication-title: Cell
– volume: 7
  start-page: e45069
  year: 2012
  ident: CR10
  article-title: Astrocyte senescence as a component of Alzheimer’s disease
  publication-title: PLoS One
– volume: 169
  start-page: 1000
  year: 2017
  end-page: 1011
  ident: CR53
  article-title: Senescence in health and disease
  publication-title: Cell
– volume: 6
  start-page: 158
  year: 2005
  end-page: 164
  ident: CR149
  article-title: Increased stability of the p16 mRNA with replicative senescence
  publication-title: EMBO Rep
– volume: 40
  start-page: 7739
  year: 2012
  end-page: 7752
  ident: CR4
  article-title: Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements
  publication-title: Nucleic Acids Res
– volume: 22
  start-page: 3480
  year: 2018
  end-page: 3492
  ident: CR61
  article-title: Regulation of cellular senescence by Polycomb chromatin modifiers through distinct DNA damage- and histone methylation-dependent pathways
  publication-title: Cell Rep
– volume: 15
  start-page: 1063
  year: 2016
  end-page: 1073
  ident: CR151
  article-title: hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability
  publication-title: Aging Cell
– volume: 30
  start-page: 1536
  year: 2011
  end-page: 1548
  ident: CR42
  article-title: p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
  publication-title: EMBO J
– volume: 28
  start-page: 3457
  year: 2008
  end-page: 3464
  ident: CR65
  article-title: SWI/SNF mediates Polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
  publication-title: Mol Cell Biol
– volume: 39
  start-page: 268
  year: 2014
  end-page: 276
  ident: CR159
  article-title: Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence
  publication-title: Trends Biochem Sci
– volume: 17
  start-page: 1049
  year: 2015
  end-page: 1061
  ident: CR78
  article-title: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
  publication-title: Nat Cell Biol
– volume: 6
  start-page: 2628
  year: 2007
  end-page: 2632
  ident: CR113
  article-title: Canonical and alternative MAPK signaling
  publication-title: Cell Cycle
– volume: 1840
  start-page: 3079
  year: 2014
  end-page: 3087
  ident: CR52
  article-title: Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-kappaB
  publication-title: Biochim Biophys Acta
– volume: 286
  start-page: 26860
  year: 2011
  end-page: 26872
  ident: CR127
  article-title: The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells
  publication-title: J Biol Chem
– volume: 30
  start-page: 203
  year: 2008
  end-page: 213
  ident: CR11
  article-title: PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
  publication-title: Mol Cell
– volume: 336
  start-page: 1440
  year: 2012
  end-page: 1444
  ident: CR116
  article-title: p53 dynamics control cell fate
  publication-title: Science
– volume: 530
  start-page: 184
  year: 2016
  end-page: 189
  ident: CR9
  article-title: Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
  publication-title: Nature
– volume: 10
  start-page: 481
  year: 2011
  end-page: 491
  ident: CR64
  article-title: ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks
  publication-title: Cell Cycle
– volume: 33
  start-page: 2315
  year: 2013
  end-page: 2326
  ident: CR87
  article-title: Hsp27 and F-box protein beta-TrCP promote degradation of mRNA decay factor AUF1
  publication-title: Mol Cell Biol
– volume: 9
  start-page: 260
  year: 2018
  ident: CR136
  article-title: Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway
  publication-title: Cell Death Dis
– volume: 115
  start-page: 80
  year: 2018
  end-page: 91
  ident: CR15
  article-title: Aging and Parkinson’s Disease: inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis
  publication-title: Free Radic Biol Med
– volume: 128
  start-page: 295
  year: 2007
  end-page: 308
  ident: CR135
  article-title: PRAK is essential for Ras-induced senescence and tumor suppression
  publication-title: Cell
– volume: 2
  start-page: e164
  year: 2007
  ident: CR157
  article-title: Sp1 is essential for p16 expression in human diploid fibroblasts during senescence
  publication-title: PLoS One
– volume: 36
  start-page: 2280
  year: 2017
  end-page: 2295
  ident: CR161
  article-title: p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
  publication-title: EMBO J
– volume: 14
  start-page: 644
  year: 2015
  end-page: 658
  ident: CR169
  article-title: The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
  publication-title: Aging Cell
– volume: 22
  start-page: 930
  year: 2018
  end-page: 940
  ident: CR24
  article-title: Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson’s disease
  publication-title: Cell Rep
– volume: 274
  start-page: 13954
  year: 1999
  end-page: 13960
  ident: CR96
  article-title: Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
  publication-title: J Biol Chem
– volume: 112
  start-page: 2439
  year: 2008
  end-page: 2449
  ident: CR29
  article-title: Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells
  publication-title: Blood
– volume: 8
  start-page: 2410
  year: 2018
  ident: CR155
  article-title: Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype
  publication-title: Sci Rep
– volume: 278
  start-page: 18945
  year: 2003
  end-page: 18952
  ident: CR99
  article-title: Stress-induced protein phosphatase 2C is a negative regulator of a mitogen-activated protein kinase
  publication-title: J Biol Chem
– volume: 36
  start-page: 738
  year: 2004
  end-page: 743
  ident: CR128
  article-title: p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci
  publication-title: Nat Genet
– volume: 21
  start-page: 3749
  year: 2002
  end-page: 3759
  ident: CR162
  article-title: TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
  publication-title: EMBO J
– volume: 34
  start-page: e9
  issue: 85-102
  year: 2018
  ident: CR44
  article-title: PTBP1-mediated alternative splicing regulates the inflammatory secretome and the pro-tumorigenic effects of senescent cells
  publication-title: Cancer Cell
– volume: 7
  start-page: 67699
  year: 2016
  end-page: 67715
  ident: CR37
  article-title: ATF6alpha regulates morphological changes associated with senescence in human fibroblasts
  publication-title: Oncotarget
– ident: CR75
– volume: 19
  start-page: 759
  year: 2019
  end-page: 770
  ident: CR172
  article-title: Mechanisms shaping the role of ERK1/2 in cellular senescence (Review)
  publication-title: Mol Med Rep
– volume: 21
  start-page: 3232
  year: 2007
  end-page: 3237
  ident: CR153
  article-title: Dissecting eIF4E action in tumorigenesis
  publication-title: Genes Dev
– volume: 11
  start-page: 17
  year: 2018
  end-page: 27
  ident: CR46
  article-title: Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway
  publication-title: Onco Targets Ther
– volume: 275
  start-page: 30566
  year: 2000
  end-page: 30572
  ident: CR114
  article-title: Epidermal growth factor-mediated caveolin recruitment to early endosomes and MAPK activation. Role of cholesterol and actin cytoskeleton
  publication-title: J Biol Chem
– volume: 47
  start-page: 7294
  year: 2019
  end-page: 7305
  ident: CR19
  article-title: Transcriptome signature of cellular senescence
  publication-title: Nucleic Acids Res
– volume: 11
  start-page: 473
  year: 2012
  end-page: 484
  ident: CR120
  article-title: Tristetraprolin: roles in cancer and senescence
  publication-title: Ageing Res Rev
– volume: 22
  start-page: 786
  year: 2017
  end-page: 795
  ident: CR131
  article-title: Therapeutic interventions for aging: the case of cellular senescence
  publication-title: Drug Discov Today
– volume: 280
  start-page: 4029
  year: 2005
  end-page: 4036
  ident: CR142
  article-title: Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
  publication-title: J Biol Chem
– volume: 26
  start-page: 3279
  year: 2007
  end-page: 3290
  ident: CR36
  article-title: MAP kinase signalling pathways in cancer
  publication-title: Oncogene
– volume: 18
  start-page: 979
  year: 2016
  end-page: 992
  ident: CR59
  article-title: NOTCH1 mediates a switch between two distinct secretomes during senescence
  publication-title: Nat Cell Biol
– volume: 46
  start-page: 4271
  year: 2018
  end-page: 4285
  ident: CR82
  article-title: Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA
  publication-title: Nucleic Acids Res
– volume: 17
  start-page: 1230
  year: 2015
  end-page: 1232
  ident: CR138
  article-title: Translating the effects of mTOR on secretory senescence
  publication-title: Nat Cell Biol
– volume: 27
  start-page: 2726
  year: 2016
  end-page: 2734
  ident: CR27
  article-title: MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
  publication-title: Mol Biol Cell
– volume: 29
  start-page: 561
  year: 2010
  end-page: 575
  ident: CR80
  article-title: Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species
  publication-title: Oncogene
– volume: 22
  start-page: 1313
  year: 2003
  end-page: 1324
  ident: CR140
  article-title: Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
  publication-title: EMBO J
– volume: 28
  start-page: 436
  year: 2018
  end-page: 453
  ident: CR56
  article-title: Hallmarks of cellular senescence
  publication-title: Trends Cell Biol
– volume: 8
  start-page: 1168
  year: 2009
  end-page: 1175
  ident: CR98
  article-title: How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer?
  publication-title: Cell Cycle
– volume: 358
  start-page: 331
  year: 1992
  end-page: 334
  ident: CR67
  article-title: Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2
  publication-title: Nature
– volume: 277
  start-page: 12710
  year: 2002
  end-page: 12717
  ident: CR137
  article-title: ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53
  publication-title: J Biol Chem
– volume: 227
  start-page: 2480
  year: 2012
  end-page: 2491
  ident: CR40
  article-title: Caveolin-1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae
  publication-title: J Cell Physiol
– volume: 280
  start-page: 5178
  year: 2005
  end-page: 5187
  ident: CR145
  article-title: MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the Polycomb group protein Bmi1
  publication-title: J Biol Chem
– volume: 114
  start-page: 149
  year: 2005
  end-page: 159
  ident: CR170
  article-title: ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
  publication-title: Pain
– ident: CR143
– volume: 217
  start-page: 65
  year: 2018
  end-page: 77
  ident: CR97
  article-title: Senescence and aging: causes, consequences, and therapeutic avenues
  publication-title: J Cell Biol
– volume: 41
  start-page: 2397
  year: 2014
  end-page: 2408
  ident: CR72
  article-title: Transcriptional activation of p21(WAF(1)/CIP(1)) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts
  publication-title: Mol Biol Rep
– volume: 17
  start-page: 5546
  year: 2011
  end-page: 5552
  ident: CR101
  article-title: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors
  publication-title: Clin Cancer Res
– volume: 6
  start-page: 347
  year: 2010
  ident: CR111
  article-title: Feedback between p21 and reactive oxygen production is necessary for cell senescence
  publication-title: Mol Syst Biol
– volume: 11
  start-page: 51
  year: 2012
  end-page: 66
  ident: CR102
  article-title: Gadd45 proteins: relevance to aging, longevity and age-related pathologies
  publication-title: Ageing Res Rev
– volume: 46
  start-page: 694
  year: 2011
  end-page: 702
  ident: CR86
  article-title: Age-induced augmentation of p38 MAPK phosphorylation in mouse lung
  publication-title: Exp Gerontol
– volume: 17
  start-page: 1205
  year: 2015
  end-page: 1217
  ident: CR58
  article-title: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
  publication-title: Nat Cell Biol
– volume: 24
  start-page: 2463
  year: 2010
  end-page: 2479
  ident: CR77
  article-title: The essence of senescence
  publication-title: Genes Dev
– volume: 23
  start-page: 1013
  year: 2016
  end-page: 1021
  ident: CR154
  article-title: From ancient pathways to aging cells-connecting metabolism and cellular senescence
  publication-title: Cell Metab
– volume: 119
  start-page: 2299
  year: 2006
  end-page: 2309
  ident: CR141
  article-title: Caveolin-1 is required for signaling and membrane targeting of EphB1 receptor tyrosine kinase
  publication-title: J Cell Sci
– volume: 8
  start-page: 979
  year: 2002
  end-page: 986
  ident: CR152
  article-title: Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
  publication-title: Nat Med
– volume: 179
  start-page: 813
  year: 2019
  end-page: 827
  ident: CR47
  article-title: Cellular senescence: defining a path forward
  publication-title: Cell
– volume: 33
  start-page: 863
  year: 2014
  end-page: 869
  ident: CR71
  article-title: Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner
  publication-title: Int J Mol Med
– volume: 18
  start-page: 32
  year: 2013
  end-page: 41
  ident: CR76
  article-title: ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence
  publication-title: Genes Cells
– volume: 22
  start-page: 719
  year: 2019
  end-page: 728
  ident: CR166
  article-title: Senolytic therapy alleviates Abeta-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
  publication-title: Nat Neurosci
– volume: 29
  start-page: 273
  year: 2010
  end-page: 283
  ident: CR32
  article-title: Senescent cells as a source of inflammatory factors for tumor progression
  publication-title: Cancer Metastasis Rev
– volume: 21
  start-page: 21
  year: 2017
  end-page: 28
  ident: CR74
  article-title: Cellular senescence: a translational perspective
  publication-title: EBioMedicine
– volume: 584
  start-page: 4711
  year: 2010
  end-page: 4716
  ident: CR45
  article-title: UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate
  publication-title: FEBS Lett
– volume: 4
  start-page: e4393
  year: 2009
  ident: CR118
  article-title: Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation
  publication-title: PLoS One
– volume: 122
  start-page: 289
  year: 2008
  end-page: 297
  ident: CR43
  article-title: c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy
  publication-title: Int J Cancer
– ident: CR48
– volume: 10
  start-page: 51
  year: 2010
  end-page: 57
  ident: CR26
  article-title: Senescence in tumours: evidence from mice and humans
  publication-title: Nat Rev Cancer
– volume: 8
  start-page: 19
  year: 2005
  end-page: 30
  ident: CR163
  article-title: Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
  publication-title: Dev Cell
– volume: 694
  start-page: 126
  year: 2010
  end-page: 137
  ident: CR33
  article-title: p38(MAPK) in the senescence of human and murine fibroblasts
  publication-title: Adv Exp Med Biol
– volume: 40
  start-page: 981
  year: 2012
  end-page: 995
  ident: CR150
  article-title: The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression
  publication-title: Nucleic Acids Res
– volume: 57
  start-page: 277
  year: 2005
  end-page: 281
  ident: CR25
  article-title: Reactive oxygen species as mediators of cellular senescence
  publication-title: IUBMB Life
– volume: 47
  start-page: 2472
  year: 2019
  end-page: 2486
  ident: CR107
  article-title: Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
  publication-title: Nucleic Acids Res
– volume: 16
  start-page: 551
  year: 2008
  end-page: 558
  ident: CR126
  article-title: Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways
  publication-title: Wound Repair Regen
– volume: 170
  start-page: e1
  issue: 816-16
  year: 2017
  ident: CR95
  article-title: SnapShot: cellular senescence pathways
  publication-title: Cell
– volume: 21
  start-page: 333
  year: 2014
  end-page: 343
  ident: CR93
  article-title: Sprouty1 induces a senescence-associated secretory phenotype by regulating NFkappaB activity: implications for tumorigenesis
  publication-title: Cell Death Differ
– volume: 7
  start-page: 245
  year: 2015
  ident: CR39
  article-title: Hippocampal injections of oligomeric amyloid beta-peptide (1-42) induce selective working memory deficits and long-lasting alterations of ERK signaling pathway
  publication-title: Front Aging Neurosci
– volume: 118
  start-page: 2997
  year: 2005
  end-page: 3002
  ident: CR38
  article-title: The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
  publication-title: J Cell Sci
– volume: 8
  start-page: 1670
  year: 2016
  end-page: 1689
  ident: CR81
  article-title: BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1
  publication-title: Aging (Albany NY)
– volume: 29
  start-page: 5083
  year: 2010
  end-page: 5094
  ident: CR85
  article-title: Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence
  publication-title: Oncogene
– volume: 318
  start-page: 500
  year: 2012
  end-page: 508
  ident: CR171
  article-title: MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1
  publication-title: Exp Cell Res
– volume: 112
  start-page: 2439
  year: 2008
  ident: 183_CR29
  publication-title: Blood
  doi: 10.1182/blood-2008-05-159392
– volume: 169
  start-page: 1000
  year: 2017
  ident: 183_CR53
  publication-title: Cell
  doi: 10.1016/j.cell.2017.05.015
– volume: 5
  start-page: 3729
  year: 2014
  ident: 183_CR20
  publication-title: Nat Commun
  doi: 10.1038/ncomms4729
– volume: 17
  start-page: 240
  year: 2016
  ident: 183_CR62
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm.2015.16
– volume: 530
  start-page: 184
  year: 2016
  ident: 183_CR9
  publication-title: Nature
  doi: 10.1038/nature16932
– volume: 2
  start-page: 924
  year: 2010
  ident: 183_CR84
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.100265
– volume: 155
  start-page: 1104
  year: 2013
  ident: 183_CR104
  publication-title: Cell
  doi: 10.1016/j.cell.2013.10.019
– volume: 5
  start-page: e15583
  year: 2010
  ident: 183_CR132
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0015583
– volume: 19
  start-page: 759
  year: 2019
  ident: 183_CR172
  publication-title: Mol Med Rep
– volume: 28
  start-page: 436
  year: 2018
  ident: 183_CR56
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2018.02.001
– volume: 1773
  start-page: 1161
  year: 2007
  ident: 183_CR63
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbamcr.2007.01.002
– ident: 183_CR143
  doi: 10.1101/gad.331272.119
– volume: 47
  start-page: 7294
  year: 2019
  ident: 183_CR19
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz555
– volume: 34
  start-page: 3
  year: 2011
  ident: 183_CR124
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2011.07738.x
– volume: 4
  start-page: 716
  year: 2014
  ident: 183_CR7
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-13-0743
– volume: 287
  start-page: 2632
  year: 2012
  ident: 183_CR49
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.323709
– volume: 21
  start-page: 5889
  year: 2001
  ident: 183_CR147
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.21.17.5889-5898.2001
– volume: 280
  start-page: 4625
  year: 2013
  ident: 183_CR165
  publication-title: FEBS J
  doi: 10.1111/febs.12435
– volume: 10
  start-page: e0125217
  year: 2015
  ident: 183_CR100
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0125217
– volume: 17
  start-page: 1205
  year: 2015
  ident: 183_CR58
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3225
– volume: 29
  start-page: 5083
  year: 2010
  ident: 183_CR85
  publication-title: Oncogene
  doi: 10.1038/onc.2010.252
– volume: 26
  start-page: 8252
  year: 2006
  ident: 183_CR164
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00604-06
– volume: 40
  start-page: 7739
  year: 2012
  ident: 183_CR4
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gks545
– volume: 8
  start-page: 19
  year: 2005
  ident: 183_CR163
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2004.10.019
– volume: 119
  start-page: 2299
  year: 2006
  ident: 183_CR141
  publication-title: J Cell Sci
  doi: 10.1242/jcs.02946
– volume: 191
  start-page: 6110
  year: 2013
  ident: 183_CR158
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301203
– volume: 15
  start-page: 112
  year: 2009
  ident: 183_CR51
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2009.01.003
– volume: 7
  start-page: 67699
  year: 2016
  ident: 183_CR37
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.11505
– volume: 7
  start-page: e45069
  year: 2012
  ident: 183_CR10
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0045069
– ident: 183_CR48
  doi: 10.1002/wrna.1372
– volume: 8
  start-page: 1168
  year: 2009
  ident: 183_CR98
  publication-title: Cell Cycle
  doi: 10.4161/cc.8.8.8147
– volume: 1840
  start-page: 3079
  year: 2014
  ident: 183_CR52
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbagen.2014.07.005
– volume: 6
  start-page: 2628
  year: 2007
  ident: 183_CR113
  publication-title: Cell Cycle
  doi: 10.4161/cc.6.21.4930
– volume: 227
  start-page: 2480
  year: 2012
  ident: 183_CR40
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.22984
– volume: 6
  start-page: 347
  year: 2010
  ident: 183_CR111
  publication-title: Mol Syst Biol
  doi: 10.1038/msb.2010.5
– volume: 41
  start-page: 2397
  year: 2014
  ident: 183_CR72
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-014-3094-9
– volume: 15
  start-page: 1063
  year: 2016
  ident: 183_CR151
  publication-title: Aging Cell
  doi: 10.1111/acel.12511
– volume: 10
  start-page: 51
  year: 2010
  ident: 183_CR26
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2772
– volume: 276
  start-page: 6727
  year: 2001
  ident: 183_CR117
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M008340200
– volume: 284
  start-page: 6329
  year: 2009
  ident: 183_CR83
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M808426200
– volume: 34
  start-page: e9
  issue: 85-102
  year: 2018
  ident: 183_CR44
  publication-title: Cancer Cell
– volume: 7
  start-page: 11190
  year: 2016
  ident: 183_CR160
  publication-title: Nat Commun
  doi: 10.1038/ncomms11190
– volume: 122
  start-page: 289
  year: 2008
  ident: 183_CR43
  publication-title: Int J Cancer
  doi: 10.1002/ijc.23063
– volume: 22
  start-page: 719
  year: 2019
  ident: 183_CR166
  publication-title: Nat Neurosci
  doi: 10.1038/s41593-019-0372-9
– volume: 22
  start-page: 78
  year: 2016
  ident: 183_CR22
  publication-title: Nat Med
  doi: 10.1038/nm.4010
– volume: 31
  start-page: 2085
  year: 2017
  ident: 183_CR1
  publication-title: Genes Dev
  doi: 10.1101/gad.297796.117
– volume: 11
  start-page: 17
  year: 2018
  ident: 183_CR46
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S147316
– volume: 11
  start-page: 144
  year: 2001
  ident: 183_CR41
  publication-title: Brain Pathol
  doi: 10.1111/j.1750-3639.2001.tb00387.x
– volume: 15
  start-page: 1139
  year: 2014
  ident: 183_CR23
  publication-title: EMBO Rep
  doi: 10.15252/embr.201439245
– volume: 278
  start-page: 18945
  year: 2003
  ident: 183_CR99
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M300878200
– volume: 31
  start-page: 722
  year: 2014
  ident: 183_CR34
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2014.11.012
– volume: 22
  start-page: 153
  year: 2001
  ident: 183_CR112
  publication-title: Endocr Rev
– volume: 8
  start-page: 42571
  year: 2017
  ident: 183_CR123
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.17246
– volume: 280
  start-page: 5178
  year: 2005
  ident: 183_CR145
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M407155200
– volume: 10
  start-page: 2443
  year: 2016
  ident: 183_CR3
  publication-title: Drug Des Devel Ther
  doi: 10.2147/DDDT.S89114
– volume: 9
  start-page: 147
  year: 2018
  ident: 183_CR54
  publication-title: Transl Neurosci
  doi: 10.1515/tnsci-2018-0022
– volume: 179
  start-page: 813
  year: 2019
  ident: 183_CR47
  publication-title: Cell
  doi: 10.1016/j.cell.2019.10.005
– volume: 9
  start-page: 400
  year: 2009
  ident: 183_CR2
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2657
– volume: 47
  start-page: 5
  year: 2012
  ident: 183_CR115
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.04.019
– volume: 8
  start-page: 1670
  year: 2016
  ident: 183_CR81
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.101000
– volume: 9
  start-page: 3655
  year: 2010
  ident: 183_CR16
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.18.13049
– volume: 170
  start-page: e1
  issue: 816-16
  year: 2017
  ident: 183_CR95
  publication-title: Cell
– volume: 17
  start-page: 305
  year: 2016
  ident: 183_CR5
  publication-title: Biogerontology
  doi: 10.1007/s10522-015-9610-z
– volume: 4
  start-page: e4393
  year: 2009
  ident: 183_CR118
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0004393
– volume: 128
  start-page: 295
  year: 2007
  ident: 183_CR135
  publication-title: Cell
  doi: 10.1016/j.cell.2006.11.050
– volume: 75
  start-page: 50
  year: 2011
  ident: 183_CR18
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.00031-10
– volume: 1
  start-page: 831
  year: 2009
  ident: 183_CR144
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.100079
– volume: 47
  start-page: 2472
  year: 2019
  ident: 183_CR107
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz082
– volume: 29
  start-page: 273
  year: 2010
  ident: 183_CR32
  publication-title: Cancer Metastasis Rev
  doi: 10.1007/s10555-010-9220-9
– volume: 36
  start-page: 738
  year: 2004
  ident: 183_CR128
  publication-title: Nat Genet
  doi: 10.1038/ng1378
– volume: 29
  start-page: 561
  year: 2010
  ident: 183_CR80
  publication-title: Oncogene
  doi: 10.1038/onc.2009.355
– volume: 46
  start-page: 694
  year: 2011
  ident: 183_CR86
  publication-title: Exp Gerontol
– volume: 27
  start-page: 6995
  year: 2007
  ident: 183_CR125
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0852-07.2007
– volume: 562
  start-page: 578
  year: 2018
  ident: 183_CR14
  publication-title: Nature
  doi: 10.1038/s41586-018-0543-y
– volume: 22
  start-page: 3480
  year: 2018
  ident: 183_CR61
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.03.002
– volume: 23
  start-page: 1013
  year: 2016
  ident: 183_CR154
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2016.05.010
– volume: 59
  start-page: 880
  year: 2000
  ident: 183_CR167
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1093/jnen/59.10.880
– volume: 5
  start-page: 741
  year: 2003
  ident: 183_CR110
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1024
– volume: 22
  start-page: 930
  year: 2018
  ident: 183_CR24
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2017.12.092
– volume: 21
  start-page: 21
  year: 2017
  ident: 183_CR74
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2017.04.013
– volume: 18
  start-page: 979
  year: 2016
  ident: 183_CR59
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3397
– volume: 6
  start-page: 1872
  year: 2008
  ident: 183_CR70
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-08-0084
– volume: 277
  start-page: 12710
  year: 2002
  ident: 183_CR137
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111598200
– volume: 38
  start-page: S56
  issue: Suppl 1
  year: 2016
  ident: 183_CR89
  publication-title: Bioessays
  doi: 10.1002/bies.201670910
– volume: 274
  start-page: 20657
  year: 1999
  ident: 183_CR31
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.29.20657
– volume: 118
  start-page: 2997
  year: 2005
  ident: 183_CR38
  publication-title: J Cell Sci
  doi: 10.1242/jcs.02505
– volume: 83
  start-page: 6
  year: 2012
  ident: 183_CR122
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2011.08.010
– volume: 10
  start-page: 376
  year: 2019
  ident: 183_CR129
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1607-0
– volume: 114
  start-page: 149
  year: 2005
  ident: 183_CR170
  publication-title: Pain
  doi: 10.1016/j.pain.2004.12.022
– volume: 115
  start-page: 80
  year: 2018
  ident: 183_CR15
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2017.10.379
– volume: 24
  start-page: 2463
  year: 2010
  ident: 183_CR77
  publication-title: Genes Dev
  doi: 10.1101/gad.1971610
– volume: 39
  start-page: 1338
  year: 2017
  ident: 183_CR134
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2017.2962
– volume: 286
  start-page: 26860
  year: 2011
  ident: 183_CR127
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.216721
– ident: 183_CR91
  doi: 10.1101/cshperspect.a022137
– volume: 38
  start-page: 121
  year: 2019
  ident: 183_CR130
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-019-1115-1
– volume: 20
  start-page: 760
  year: 2000
  ident: 183_CR146
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.20.3.760-769.2000
– volume: 6
  start-page: 158
  year: 2005
  ident: 183_CR149
  publication-title: EMBO Rep
  doi: 10.1038/sj.embor.7400346
– volume: 27
  start-page: 2726
  year: 2016
  ident: 183_CR27
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e15-11-0772
– volume: 217
  start-page: 65
  year: 2018
  ident: 183_CR97
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201708092
– volume: 27
  start-page: 900
  year: 2013
  ident: 183_CR35
  publication-title: Genes Dev
  doi: 10.1101/gad.203984.112
– volume: 11
  start-page: 473
  year: 2012
  ident: 183_CR120
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2012.02.005
– volume: 75
  start-page: 685
  year: 2013
  ident: 183_CR17
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev-physiol-030212-183653
– volume: 31
  start-page: 1529
  year: 2017
  ident: 183_CR73
  publication-title: Genes Dev
  doi: 10.1101/gad.302570.117
– volume: 46
  start-page: 4271
  year: 2018
  ident: 183_CR82
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gky223
– volume: 66
  start-page: 10805
  year: 2006
  ident: 183_CR30
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-06-1236
– volume: 22
  start-page: 1313
  year: 2003
  ident: 183_CR140
  publication-title: EMBO J
  doi: 10.1093/emboj/cdg139
– volume: 193
  start-page: 19
  year: 2002
  ident: 183_CR168
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.10147
– volume: 57
  start-page: 277
  year: 2005
  ident: 183_CR25
  publication-title: IUBMB Life
  doi: 10.1080/15216540500091890
– volume: 33
  start-page: 863
  year: 2014
  ident: 183_CR71
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2014.1658
– volume: 8
  start-page: 979
  year: 2002
  ident: 183_CR152
  publication-title: Nat Med
  doi: 10.1038/nm754
– ident: 183_CR6
  doi: 10.21769/BioProtoc.1481
– volume: 7
  start-page: 245
  year: 2015
  ident: 183_CR39
  publication-title: Front Aging Neurosci
– volume: 274
  start-page: 13954
  year: 1999
  ident: 183_CR96
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.20.13954
– volume: 2
  start-page: e164
  year: 2007
  ident: 183_CR157
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0000164
– volume: 11
  start-page: 973
  year: 2009
  ident: 183_CR119
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1909
– volume: 72
  start-page: 2053
  year: 1999
  ident: 183_CR55
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.1999.0722053.x
– volume: 22
  start-page: 43
  year: 2017
  ident: 183_CR90
  publication-title: Cell Stress Chaperones
  doi: 10.1007/s12192-016-0740-2
– volume: 26
  start-page: 3279
  year: 2007
  ident: 183_CR36
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210421
– volume: 40
  start-page: 981
  year: 2012
  ident: 183_CR150
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr818
– volume: 36
  start-page: 2280
  year: 2017
  ident: 183_CR161
  publication-title: EMBO J
  doi: 10.15252/embj.201695553
– volume: 21
  start-page: 3232
  year: 2007
  ident: 183_CR153
  publication-title: Genes Dev
  doi: 10.1101/gad.1604407
– volume: 584
  start-page: 4711
  year: 2010
  ident: 183_CR45
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2010.10.057
– volume: 8
  start-page: 54
  year: 2016
  ident: 183_CR94
  publication-title: Alzheimers Res Ther
  doi: 10.1186/s13195-016-0221-y
– volume: 275
  start-page: 29244
  year: 2000
  ident: 183_CR109
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M909467199
– volume: 153
  start-page: 1194
  year: 2013
  ident: 183_CR88
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.039
– volume: 28
  start-page: 3457
  year: 2008
  ident: 183_CR65
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.02019-07
– volume: 318
  start-page: 500
  year: 2012
  ident: 183_CR171
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2011.12.015
– volume: 336
  start-page: 1440
  year: 2012
  ident: 183_CR116
  publication-title: Science
  doi: 10.1126/science.1218351
– volume: 22
  start-page: 786
  year: 2017
  ident: 183_CR131
  publication-title: Drug Discov Today
  doi: 10.1016/j.drudis.2017.01.004
– volume: 155
  start-page: 1119
  year: 2013
  ident: 183_CR133
  publication-title: Cell
  doi: 10.1016/j.cell.2013.10.041
– volume: 11
  start-page: 51
  year: 2012
  ident: 183_CR102
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2011.09.003
– volume: 10
  start-page: 1856
  year: 2018
  ident: 183_CR106
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.101516
– volume: 22
  start-page: 3389
  year: 2002
  ident: 183_CR148
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.22.10.3389-3403.2002
– volume: 33
  start-page: 2315
  year: 2013
  ident: 183_CR87
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00931-12
– volume: 30
  start-page: 203
  year: 2008
  ident: 183_CR11
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2008.02.024
– volume: 9
  start-page: 2834
  year: 2018
  ident: 183_CR92
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-05258-6
– volume: 8
  start-page: 2410
  year: 2018
  ident: 183_CR155
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-20000-4
– volume: 694
  start-page: 126
  year: 2010
  ident: 183_CR33
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-1-4419-7002-2_10
– volume: 18
  start-page: 32
  year: 2013
  ident: 183_CR76
  publication-title: Genes Cells
  doi: 10.1111/gtc.12015
– volume: 20
  start-page: 199
  year: 2019
  ident: 183_CR50
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-019-0110-x
– volume: 280
  start-page: 4029
  year: 2005
  ident: 183_CR142
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M410344200
– volume: 275
  start-page: 30566
  year: 2000
  ident: 183_CR114
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M001131200
– volume: 278
  start-page: 37497
  year: 2003
  ident: 183_CR68
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M211739200
– ident: 183_CR75
  doi: 10.1523/ENEURO.0149-16.2017
– volume: 358
  start-page: 331
  year: 1992
  ident: 183_CR67
  publication-title: Nature
  doi: 10.1038/358331a0
– volume: 113
  start-page: 703
  year: 2003
  ident: 183_CR105
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00401-X
– volume: 39
  start-page: 268
  year: 2014
  ident: 183_CR159
  publication-title: Trends Biochem Sci
  doi: 10.1016/j.tibs.2014.04.004
– volume: 18
  start-page: 236
  year: 2006
  ident: 183_CR69
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2005.04.008
– volume: 17
  start-page: 1230
  year: 2015
  ident: 183_CR138
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3244
– volume: 30
  start-page: 3875
  year: 2010
  ident: 183_CR21
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00169-10
– volume: 75
  start-page: 3997
  year: 2015
  ident: 183_CR60
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-15-0173
– volume: 169
  start-page: 132
  year: 2017
  ident: 183_CR8
  publication-title: Cell
  doi: 10.1016/j.cell.2017.02.031
– volume: 21
  start-page: 525
  year: 2007
  ident: 183_CR12
  publication-title: Genes Dev
  doi: 10.1101/gad.415507
– volume: 509
  start-page: 439
  year: 2014
  ident: 183_CR139
  publication-title: Nature
  doi: 10.1038/nature13193
– volume: 127
  start-page: 265
  year: 2006
  ident: 183_CR66
  publication-title: Cell
  doi: 10.1016/j.cell.2006.10.003
– volume: 9
  start-page: 260
  year: 2018
  ident: 183_CR136
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-018-0303-9
– volume: 128
  start-page: 1238
  year: 2018
  ident: 183_CR57
  publication-title: J Clin Invest
  doi: 10.1172/JCI95148
– volume: 3
  start-page: 156
  year: 2004
  ident: 183_CR156
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.3.2.614
– volume: 8
  start-page: 512
  year: 2008
  ident: 183_CR28
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2440
– volume: 21
  start-page: 333
  year: 2014
  ident: 183_CR93
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2013.161
– volume: 17
  start-page: 5546
  year: 2011
  ident: 183_CR101
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-10-2616
– volume: 10
  start-page: 481
  year: 2011
  ident: 183_CR64
  publication-title: Cell Cycle
  doi: 10.4161/cc.10.3.14713
– volume: 16
  start-page: 551
  year: 2008
  ident: 183_CR126
  publication-title: Wound Repair Regen
  doi: 10.1111/j.1524-475X.2008.00402.x
– volume: 15
  start-page: 482
  year: 2014
  ident: 183_CR103
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3823
– volume: 30
  start-page: 1536
  year: 2011
  ident: 183_CR42
  publication-title: EMBO J
  doi: 10.1038/emboj.2011.69
– volume: 13
  start-page: 1025
  year: 2013
  ident: 183_CR13
  publication-title: Anti Cancer Agents Med Chem
  doi: 10.2174/18715206113139990114
– volume: 29
  start-page: 4341
  year: 2009
  ident: 183_CR79
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00210-09
– volume: 17
  start-page: 1049
  year: 2015
  ident: 183_CR78
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3195
– ident: 183_CR121
  doi: 10.1128/MCB.00070-18
– volume: 14
  start-page: 644
  year: 2015
  ident: 183_CR169
  publication-title: Aging Cell
  doi: 10.1111/acel.12344
– volume: 409
  start-page: 1067
  year: 2001
  ident: 183_CR108
  publication-title: Nature
  doi: 10.1038/35059131
– volume: 21
  start-page: 3749
  year: 2002
  ident: 183_CR162
  publication-title: EMBO J
  doi: 10.1093/emboj/cdf366
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Snippet A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease....
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SubjectTerms Age differences
Aging
Arrests
Biomedical and Life Sciences
Cell Biology
Cell survival
Cellular Senescence
Elimination
Exploitation
Geriatrics/Gerontology
Inflammation
Kinases
Life Sciences
Mitogen-Activated Protein Kinases
Molecular Medicine
p38 Mitogen-Activated Protein Kinases - metabolism
p53 Protein
Phenotype
Phenotypes
Proteins
Reference (Semantic)
Review
Senescence
Signal Transduction
Title Regulation of senescence traits by MAPKs
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