Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT

Translation affects messenger RNA stability and, in yeast, this is mediated by the Ccr4–Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryogenic electron microscopy (cryo-EM) and crosslinking mass spectrometry to show that mammalian CCR4–NOT specifical...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 30; no. 9; pp. 1314 - 1322
Main Authors:	Absmeier, Eva, Chandrasekaran, Viswanathan, O’Reilly, Francis J., Stowell, James A. W., Rappsilber, Juri, Passmore, Lori A.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.09.2023 Nature Publishing Group
Subjects:	631/337/1645 631/337/1645/2020 631/337/574 631/337/574/1789 631/535/1258/1259 Animals Biochemistry Biological Microscopy Biomedical and Life Sciences Conformation Crosslinking E coli Electron microscopy Elongation Humans Inserts Life Sciences Mammals Mass Spectrometry Mass spectroscopy Membrane Biology Molecular biology mRNA stability mRNA turnover Polypeptides Protein Structure Proteins Rabbits Receptors, CCR4 Ribonucleases Ribosomes Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Stability Stalling Sucrose Transcription Factors Transfer RNA Translation elongation Translations Ubiquitin Ubiquitination Yeast
ISSN:	1545-9993, 1545-9985, 1545-9985
Online Access:	Get full text
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