Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer’s disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expressi...

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Veröffentlicht in:	Scientific reports Jg. 8; H. 1; S. 12389 - 16
Hauptverfasser:	Simon, Matthew J., Wang, Marie X., Murchison, Charles F., Roese, Natalie E., Boespflug, Erin L., Woltjer, Randall L., Iliff, Jeffrey J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 17.08.2018 Nature Publishing Group
Schlagworte:	38 631/378/1689/1283 631/378/2596/1308 82/80 Aging Alzheimer's disease Aquaporin 4 Autopsy Correlation analysis Cysts Dementia Dementia disorders Dystrobrevin Dystroglycan Human subjects Humanities and Social Sciences Leukoencephalopathy Localization multidisciplinary Neurofibrillary tangles Pathology Plaques Protein folding Protein interaction Science Science (multidisciplinary) Tau protein Temporal lobe Transcription
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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