Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer’s disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expressi...

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Vydané v:	Scientific reports Ročník 8; číslo 1; s. 12389 - 16
Hlavní autori:	Simon, Matthew J., Wang, Marie X., Murchison, Charles F., Roese, Natalie E., Boespflug, Erin L., Woltjer, Randall L., Iliff, Jeffrey J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 17.08.2018 Nature Publishing Group
Predmet:	38 631/378/1689/1283 631/378/2596/1308 82/80 Aging Alzheimer's disease Aquaporin 4 Autopsy Correlation analysis Cysts Dementia Dementia disorders Dystrobrevin Dystroglycan Human subjects Humanities and Social Sciences Leukoencephalopathy Localization multidisciplinary Neurofibrillary tangles Pathology Plaques Protein folding Protein interaction Science Science (multidisciplinary) Tau protein Temporal lobe Transcription
ISSN:	2045-2322, 2045-2322
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Abstract	The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer’s disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan ( DAG1 ), dystrobrevin ( DTNA ) and alpha-syntrophin ( SNTA1 ), are associated with dementia status and phosphorylated tau (P-tau) levels in temporal cortex. Gene correlation analysis reveals altered expression of a cluster of potential astrocytic endfoot components in human subjects with dementia, with increased expression associated with temporal cortical P-tau levels. The association between perivascular astroglial gene products, including DTNA and megalencephalic leukoencephalopathy with subcortical cysts 1 ( MLC1 ) with AD status was confirmed in a second human transcriptomic dataset and in human autopsy tissue by Western blot. This suggests changes in the astroglial endfoot domain may underlie vulnerability to protein aggregation in AD.
AbstractList	The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer’s disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan ( DAG1 ), dystrobrevin ( DTNA ) and alpha-syntrophin ( SNTA1 ), are associated with dementia status and phosphorylated tau (P-tau) levels in temporal cortex. Gene correlation analysis reveals altered expression of a cluster of potential astrocytic endfoot components in human subjects with dementia, with increased expression associated with temporal cortical P-tau levels. The association between perivascular astroglial gene products, including DTNA and megalencephalic leukoencephalopathy with subcortical cysts 1 ( MLC1 ) with AD status was confirmed in a second human transcriptomic dataset and in human autopsy tissue by Western blot. This suggests changes in the astroglial endfoot domain may underlie vulnerability to protein aggregation in AD. The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer's disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan (DAG1), dystrobrevin (DTNA) and alpha-syntrophin (SNTA1), are associated with dementia status and phosphorylated tau (P-tau) levels in temporal cortex. Gene correlation analysis reveals altered expression of a cluster of potential astrocytic endfoot components in human subjects with dementia, with increased expression associated with temporal cortical P-tau levels. The association between perivascular astroglial gene products, including DTNA and megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) with AD status was confirmed in a second human transcriptomic dataset and in human autopsy tissue by Western blot. This suggests changes in the astroglial endfoot domain may underlie vulnerability to protein aggregation in AD. The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer's disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan (DAG1), dystrobrevin (DTNA) and alpha-syntrophin (SNTA1), are associated with dementia status and phosphorylated tau (P-tau) levels in temporal cortex. Gene correlation analysis reveals altered expression of a cluster of potential astrocytic endfoot components in human subjects with dementia, with increased expression associated with temporal cortical P-tau levels. The association between perivascular astroglial gene products, including DTNA and megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) with AD status was confirmed in a second human transcriptomic dataset and in human autopsy tissue by Western blot. This suggests changes in the astroglial endfoot domain may underlie vulnerability to protein aggregation in AD.The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer's disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan (DAG1), dystrobrevin (DTNA) and alpha-syntrophin (SNTA1), are associated with dementia status and phosphorylated tau (P-tau) levels in temporal cortex. Gene correlation analysis reveals altered expression of a cluster of potential astrocytic endfoot components in human subjects with dementia, with increased expression associated with temporal cortical P-tau levels. The association between perivascular astroglial gene products, including DTNA and megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) with AD status was confirmed in a second human transcriptomic dataset and in human autopsy tissue by Western blot. This suggests changes in the astroglial endfoot domain may underlie vulnerability to protein aggregation in AD.
ArticleNumber	12389
Author	Roese, Natalie E. Wang, Marie X. Iliff, Jeffrey J. Boespflug, Erin L. Woltjer, Randall L. Murchison, Charles F. Simon, Matthew J.
Author_xml	– sequence: 1 givenname: Matthew J. surname: Simon fullname: Simon, Matthew J. organization: Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Neuroscience Graduate Program, Oregon Health & Science University – sequence: 2 givenname: Marie X. surname: Wang fullname: Wang, Marie X. organization: Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University – sequence: 3 givenname: Charles F. surname: Murchison fullname: Murchison, Charles F. organization: Department of Neurology, Oregon Health & Science University – sequence: 4 givenname: Natalie E. surname: Roese fullname: Roese, Natalie E. organization: Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University – sequence: 5 givenname: Erin L. surname: Boespflug fullname: Boespflug, Erin L. organization: Department of Neurology, Oregon Health & Science University – sequence: 6 givenname: Randall L. surname: Woltjer fullname: Woltjer, Randall L. organization: Department of Pathology, Oregon Health & Science University – sequence: 7 givenname: Jeffrey J. orcidid: 0000-0002-6910-0080 surname: Iliff fullname: Iliff, Jeffrey J. email: iliffj@ohsu.edu organization: Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Knight Cardiovascular Institute, Oregon Health & Science University
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Cites_doi	10.1001/jamaneurol.2016.4370 10.1126/science.1197623 10.1002/ana.24066 10.1212/WNL.41.4.479 10.1093/brain/awx191 10.1186/1471-2105-9-559 10.1177/2058460115609635 10.1002/ana.24454 10.1002/ana.24271 10.1007/s00441-014-1837-5 10.1186/s13024-015-0056-1 10.1101/cshperspect.a006189 10.1002/glia.23092 10.1007/s00401-007-0247-0 10.1074/jbc.M110.209296 10.1016/j.neuron.2015.11.013 10.1084/jem.20131685 10.1016/j.neuron.2008.02.003 10.1152/physrev.00011.2013 10.1523/JNEUROSCI.3020-14.2014 10.1038/s41598-017-02505-6 10.1038/embor.2013.15 10.1126/scitranslmed.3003748 10.1038/nm.3457 10.1371/journal.pone.0031302 10.1074/jbc.M808759200 10.1002/cne.23450 10.1093/cercor/bht101 10.1016/j.trci.2017.05.001 10.18637/jss.v046.i11 10.1002/jnr.24082 10.1016/0197-4580(95)00021-6 10.7554/eLife.31126 10.2202/1544-6115.1128
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References	Zeppenfeld (CR14) 2017; 74 Zhang (CR17) 2016; 89 CR18 Zhao (CR19) 2017; 7 CR16 CR15 CR37 Schreiner (CR23) 2014; 522 CR36 Boor (CR25) 2007; 114 Recasens (CR27) 2014; 75 CR34 CR33 CR30 Ringstad, Vatnehol, Eide (CR13) 2017; 140 Eide, Ringstad (CR12) 2015; 4 Mawuenyega (CR3) 2010; 330 Serrano-Pozo, Frosch, Masliah, Hyman (CR1) 2011; 1 Xu (CR9) 2015; 10 Mirra (CR31) 1991; 41 Flugge, Araya-Callis, Garea-Rodriguez, Stadelmann-Nessler, Fuchs (CR24) 2014; 357 Kress (CR11) 2014; 76 Nagelhus, Ottersen (CR20) 2013; 93 Hokama (CR32) 2014; 24 Guo, Lee (CR26) 2014; 20 Liu (CR6) 2012; 7 Frost, Jacks, Diamond (CR28) 2009; 284 Iliff (CR10) 2014; 34 CR21 Pooler, Phillips, Lau, Noble, Hanger (CR29) 2013; 14 Patterson (CR4) 2015; 78 Yamada (CR7) 2014; 211 Langfelder, Horvath (CR35) 2008; 9 Guo, Lee (CR5) 2011; 286 Cirrito (CR2) 2008; 58 Iliff (CR8) 2012; 4 Langer (CR22) 2017; 65 L Liu (30779_CR6) 2012; 7 M Hokama (30779_CR32) 2014; 24 JJ Iliff (30779_CR10) 2014; 34 I Boor (30779_CR25) 2007; 114 AM Pooler (30779_CR29) 2013; 14 DM Zeppenfeld (30779_CR14) 2017; 74 BT Kress (30779_CR11) 2014; 76 P Langfelder (30779_CR35) 2008; 9 ZA Zhao (30779_CR19) 2017; 7 AE Schreiner (30779_CR23) 2014; 522 SS Mirra (30779_CR31) 1991; 41 BW Patterson (30779_CR4) 2015; 78 Z Xu (30779_CR9) 2015; 10 J Langer (30779_CR22) 2017; 65 JJ Iliff (30779_CR8) 2012; 4 Y Zhang (30779_CR17) 2016; 89 30779_CR21 PK Eide (30779_CR12) 2015; 4 JL Guo (30779_CR5) 2011; 286 30779_CR30 KG Mawuenyega (30779_CR3) 2010; 330 G Flugge (30779_CR24) 2014; 357 B Frost (30779_CR28) 2009; 284 K Yamada (30779_CR7) 2014; 211 A Serrano-Pozo (30779_CR1) 2011; 1 A Recasens (30779_CR27) 2014; 75 JL Guo (30779_CR26) 2014; 20 30779_CR18 30779_CR36 30779_CR15 30779_CR37 30779_CR16 JR Cirrito (30779_CR2) 2008; 58 G Ringstad (30779_CR13) 2017; 140 EA Nagelhus (30779_CR20) 2013; 93 30779_CR33 30779_CR34 24816982 - Cell Tissue Res. 2014 Jul;357(1):31-41 19114008 - BMC Bioinformatics. 2008 Dec 29;9:559 29120328 - Elife. 2017 Nov 09;6 21148344 - Science. 2010 Dec 24;330(6012):1774 22312444 - PLoS One. 2012;7(2):e31302 19282288 - J Biol Chem. 2009 May 8;284(19):12845-52 26040676 - Ann Neurol. 2015 Sep;78(3):439-53 24137016 - Physiol Rev. 2013 Oct;93(4):1543-62 22229116 - Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189 26687838 - Neuron. 2016 Jan 6;89(1):37-53 17628813 - Acta Neuropathol. 2007 Oct;114(4):403-10 24504409 - Nat Med. 2014 Feb;20(2):130-8 23050260 - J Stat Softw. 2012 Mar;46(11):null 18400162 - Neuron. 2008 Apr 10;58(1):42-51 23412472 - EMBO Rep. 2013 Apr;14(4):389-94 28533515 - Sci Rep. 2017 May 22;7(1):2254 29067342 - Alzheimers Dement (N Y). 2017 May 26;3(3):348-359 22896675 - Sci Transl Med. 2012 Aug 15;4(147):147ra111 24534188 - J Exp Med. 2014 Mar 10;211(3):387-93 24243558 - Ann Neurol. 2014 Mar;75(3):351-62 28969373 - Brain. 2017 Oct 1;140(10):2691-2705 27893874 - JAMA Neurol. 2017 Jan 1;74(1):91-99 28509351 - J Neurosci Res. 2018 Feb;96(2):180-193 2011243 - Neurology. 1991 Apr;41(4):479-86 27785828 - Glia. 2017 Feb;65(2):293-308 23595620 - Cereb Cortex. 2014 Sep;24(9):2476-88 16646834 - Stat Appl Genet Mol Biol. 2005;4:Article17 23939750 - J Comp Neurol. 2014 Jan 1;522(1):204-24 26526066 - Mol Neurodegener. 2015 Nov 02;10:58 25471560 - J Neurosci. 2014 Dec 3;34(49):16180-93 21372138 - J Biol Chem. 2011 Apr 29;286(17):15317-31 7566337 - Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84 25204284 - Ann Neurol. 2014 Dec;76(6):845-61 26634147 - Acta Radiol Open. 2015 Nov 17;4(11):2058460115609635
References_xml	– volume: 74 start-page: 91 year: 2017 end-page: 99 ident: CR14 article-title: Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains publication-title: JAMA neurology doi: 10.1001/jamaneurol.2016.4370 – volume: 330 start-page: 1774 year: 2010 ident: CR3 article-title: Decreased clearance of CNS beta-amyloid in Alzheimer’s disease publication-title: Science (New York, N.Y.) doi: 10.1126/science.1197623 – ident: CR18 – volume: 75 start-page: 351 year: 2014 end-page: 362 ident: CR27 article-title: Lewy body extracts from Parkinson disease brains trigger alpha-synuclein pathology and neurodegeneration in mice and monkeys publication-title: Annals of neurology doi: 10.1002/ana.24066 – volume: 41 start-page: 479 year: 1991 end-page: 486 ident: CR31 article-title: The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease publication-title: Neurology doi: 10.1212/WNL.41.4.479 – ident: CR16 – ident: CR37 – volume: 140 start-page: 2691 year: 2017 end-page: 2705 ident: CR13 article-title: Glymphatic MRI in idiopathic normal pressure hydrocephalus publication-title: Brain: a journal of neurology doi: 10.1093/brain/awx191 – ident: CR30 – volume: 9 year: 2008 ident: CR35 article-title: WGCNA: an R package for weighted correlation network analysis publication-title: BMC bioinformatics doi: 10.1186/1471-2105-9-559 – volume: 4 start-page: 2058460115609635 year: 2015 ident: CR12 article-title: MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain publication-title: Acta Radiol Open doi: 10.1177/2058460115609635 – ident: CR33 – volume: 78 start-page: 439 year: 2015 end-page: 453 ident: CR4 article-title: Age and amyloid effects on human central nervous system amyloid-beta kinetics publication-title: Annals of neurology doi: 10.1002/ana.24454 – volume: 76 start-page: 845 year: 2014 end-page: 861 ident: CR11 article-title: Impairment of paravascular clearance pathways in the aging brain publication-title: Ann Neurol doi: 10.1002/ana.24271 – volume: 357 start-page: 31 year: 2014 end-page: 41 ident: CR24 article-title: NDRG2 as a marker protein for brain astrocytes publication-title: Cell and tissue research doi: 10.1007/s00441-014-1837-5 – volume: 10 start-page: 58 year: 2015 ident: CR9 article-title: Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Abeta accumulation and memory deficits publication-title: Mol Neurodegener doi: 10.1186/s13024-015-0056-1 – volume: 1 start-page: a006189 year: 2011 ident: CR1 article-title: Neuropathological alterations in Alzheimer disease publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006189 – volume: 65 start-page: 293 year: 2017 end-page: 308 ident: CR22 article-title: Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet publication-title: Glia doi: 10.1002/glia.23092 – volume: 114 start-page: 403 year: 2007 end-page: 410 ident: CR25 article-title: MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet publication-title: Acta Neuropathol doi: 10.1007/s00401-007-0247-0 – volume: 286 start-page: 15317 year: 2011 end-page: 15331 ident: CR5 article-title: Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles publication-title: J Biol Chem doi: 10.1074/jbc.M110.209296 – volume: 89 start-page: 37 year: 2016 end-page: 53 ident: CR17 article-title: Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse publication-title: Neuron doi: 10.1016/j.neuron.2015.11.013 – ident: CR21 – volume: 211 start-page: 387 year: 2014 end-page: 393 ident: CR7 article-title: Neuronal activity regulates extracellular tau publication-title: J Exp Med doi: 10.1084/jem.20131685 – ident: CR15 – volume: 58 start-page: 42 year: 2008 end-page: 51 ident: CR2 article-title: Endocytosis is required for synaptic activity-dependent release of amyloid-beta publication-title: Neuron doi: 10.1016/j.neuron.2008.02.003 – volume: 93 start-page: 1543 year: 2013 end-page: 1562 ident: CR20 article-title: Physiological roles of aquaporin-4 in brain publication-title: Physiol Rev doi: 10.1152/physrev.00011.2013 – volume: 34 start-page: 16180 year: 2014 end-page: 16193 ident: CR10 article-title: Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3020-14.2014 – ident: CR34 – ident: CR36 – volume: 7 year: 2017 ident: CR19 article-title: Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation publication-title: Sci Rep doi: 10.1038/s41598-017-02505-6 – volume: 14 start-page: 389 year: 2013 end-page: 394 ident: CR29 article-title: Physiological release of endogenous tau is stimulated by neuronal activity publication-title: EMBO Rep doi: 10.1038/embor.2013.15 – volume: 4 start-page: 147ra111 year: 2012 ident: CR8 article-title: A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3003748 – volume: 20 start-page: 130 year: 2014 end-page: 138 ident: CR26 article-title: Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases publication-title: Nat Med doi: 10.1038/nm.3457 – volume: 7 start-page: e31302 year: 2012 ident: CR6 article-title: Trans-synaptic spread of tau pathology publication-title: Plos One doi: 10.1371/journal.pone.0031302 – volume: 284 start-page: 12845 year: 2009 end-page: 12852 ident: CR28 article-title: Propagation of tau misfolding from the outside to the inside of a cell publication-title: J Biol Chem doi: 10.1074/jbc.M808759200 – volume: 522 start-page: 204 year: 2014 end-page: 224 ident: CR23 article-title: Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus publication-title: The Journal of comparative neurology doi: 10.1002/cne.23450 – volume: 24 start-page: 2476 year: 2014 end-page: 2488 ident: CR32 article-title: Altered expression of diabetes-related genes in Alzheimer’s disease brains: the Hisayama study publication-title: Cereb Cortex doi: 10.1093/cercor/bht101 – ident: 30779_CR16 – volume: 34 start-page: 16180 year: 2014 ident: 30779_CR10 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3020-14.2014 – ident: 30779_CR21 doi: 10.1016/j.trci.2017.05.001 – volume: 286 start-page: 15317 year: 2011 ident: 30779_CR5 publication-title: J Biol Chem doi: 10.1074/jbc.M110.209296 – volume: 330 start-page: 1774 year: 2010 ident: 30779_CR3 publication-title: Science (New York, N.Y.) doi: 10.1126/science.1197623 – volume: 41 start-page: 479 year: 1991 ident: 30779_CR31 publication-title: Neurology doi: 10.1212/WNL.41.4.479 – volume: 522 start-page: 204 year: 2014 ident: 30779_CR23 publication-title: The Journal of comparative neurology doi: 10.1002/cne.23450 – volume: 75 start-page: 351 year: 2014 ident: 30779_CR27 publication-title: Annals of neurology doi: 10.1002/ana.24066 – volume: 9 year: 2008 ident: 30779_CR35 publication-title: BMC bioinformatics doi: 10.1186/1471-2105-9-559 – volume: 4 start-page: 147ra111 year: 2012 ident: 30779_CR8 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3003748 – ident: 30779_CR36 doi: 10.18637/jss.v046.i11 – volume: 58 start-page: 42 year: 2008 ident: 30779_CR2 publication-title: Neuron doi: 10.1016/j.neuron.2008.02.003 – volume: 93 start-page: 1543 year: 2013 ident: 30779_CR20 publication-title: Physiol Rev doi: 10.1152/physrev.00011.2013 – volume: 89 start-page: 37 year: 2016 ident: 30779_CR17 publication-title: Neuron doi: 10.1016/j.neuron.2015.11.013 – ident: 30779_CR15 – volume: 4 start-page: 205846011560963 year: 2015 ident: 30779_CR12 publication-title: Acta Radiol Open doi: 10.1177/2058460115609635 – volume: 24 start-page: 2476 year: 2014 ident: 30779_CR32 publication-title: Cereb Cortex doi: 10.1093/cercor/bht101 – volume: 284 start-page: 12845 year: 2009 ident: 30779_CR28 publication-title: J Biol Chem doi: 10.1074/jbc.M808759200 – ident: 30779_CR18 doi: 10.1002/jnr.24082 – ident: 30779_CR34 – volume: 1 start-page: a006189 year: 2011 ident: 30779_CR1 publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006189 – volume: 14 start-page: 389 year: 2013 ident: 30779_CR29 publication-title: EMBO Rep doi: 10.1038/embor.2013.15 – volume: 7 year: 2017 ident: 30779_CR19 publication-title: Sci Rep doi: 10.1038/s41598-017-02505-6 – volume: 7 start-page: e31302 year: 2012 ident: 30779_CR6 publication-title: Plos One doi: 10.1371/journal.pone.0031302 – volume: 10 start-page: 58 year: 2015 ident: 30779_CR9 publication-title: Mol Neurodegener doi: 10.1186/s13024-015-0056-1 – volume: 114 start-page: 403 year: 2007 ident: 30779_CR25 publication-title: Acta Neuropathol doi: 10.1007/s00401-007-0247-0 – volume: 20 start-page: 130 year: 2014 ident: 30779_CR26 publication-title: Nat Med doi: 10.1038/nm.3457 – volume: 211 start-page: 387 year: 2014 ident: 30779_CR7 publication-title: J Exp Med doi: 10.1084/jem.20131685 – ident: 30779_CR33 doi: 10.1016/0197-4580(95)00021-6 – volume: 78 start-page: 439 year: 2015 ident: 30779_CR4 publication-title: Annals of neurology doi: 10.1002/ana.24454 – ident: 30779_CR30 doi: 10.7554/eLife.31126 – volume: 74 start-page: 91 year: 2017 ident: 30779_CR14 publication-title: JAMA neurology doi: 10.1001/jamaneurol.2016.4370 – volume: 357 start-page: 31 year: 2014 ident: 30779_CR24 publication-title: Cell and tissue research doi: 10.1007/s00441-014-1837-5 – ident: 30779_CR37 doi: 10.2202/1544-6115.1128 – volume: 140 start-page: 2691 year: 2017 ident: 30779_CR13 publication-title: Brain: a journal of neurology doi: 10.1093/brain/awx191 – volume: 65 start-page: 293 year: 2017 ident: 30779_CR22 publication-title: Glia doi: 10.1002/glia.23092 – volume: 76 start-page: 845 year: 2014 ident: 30779_CR11 publication-title: Ann Neurol doi: 10.1002/ana.24271 – reference: 29120328 - Elife. 2017 Nov 09;6: – reference: 19114008 - BMC Bioinformatics. 2008 Dec 29;9:559 – reference: 19282288 - J Biol Chem. 2009 May 8;284(19):12845-52 – reference: 27785828 - Glia. 2017 Feb;65(2):293-308 – reference: 24137016 - Physiol Rev. 2013 Oct;93(4):1543-62 – reference: 28969373 - Brain. 2017 Oct 1;140(10):2691-2705 – reference: 25471560 - J Neurosci. 2014 Dec 3;34(49):16180-93 – reference: 17628813 - Acta Neuropathol. 2007 Oct;114(4):403-10 – reference: 26634147 - Acta Radiol Open. 2015 Nov 17;4(11):2058460115609635 – reference: 24504409 - Nat Med. 2014 Feb;20(2):130-8 – reference: 27893874 - JAMA Neurol. 2017 Jan 1;74(1):91-99 – reference: 7566337 - Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84 – reference: 16646834 - Stat Appl Genet Mol Biol. 2005;4:Article17 – reference: 23939750 - J Comp Neurol. 2014 Jan 1;522(1):204-24 – reference: 22229116 - Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189 – reference: 29067342 - Alzheimers Dement (N Y). 2017 May 26;3(3):348-359 – reference: 24816982 - Cell Tissue Res. 2014 Jul;357(1):31-41 – reference: 24243558 - Ann Neurol. 2014 Mar;75(3):351-62 – reference: 23050260 - J Stat Softw. 2012 Mar;46(11):null – reference: 28533515 - Sci Rep. 2017 May 22;7(1):2254 – reference: 22896675 - Sci Transl Med. 2012 Aug 15;4(147):147ra111 – reference: 28509351 - J Neurosci Res. 2018 Feb;96(2):180-193 – reference: 18400162 - Neuron. 2008 Apr 10;58(1):42-51 – reference: 26526066 - Mol Neurodegener. 2015 Nov 02;10:58 – reference: 21148344 - Science. 2010 Dec 24;330(6012):1774 – reference: 26687838 - Neuron. 2016 Jan 6;89(1):37-53 – reference: 23412472 - EMBO Rep. 2013 Apr;14(4):389-94 – reference: 25204284 - Ann Neurol. 2014 Dec;76(6):845-61 – reference: 26040676 - Ann Neurol. 2015 Sep;78(3):439-53 – reference: 24534188 - J Exp Med. 2014 Mar 10;211(3):387-93 – reference: 21372138 - J Biol Chem. 2011 Apr 29;286(17):15317-31 – reference: 2011243 - Neurology. 1991 Apr;41(4):479-86 – reference: 23595620 - Cereb Cortex. 2014 Sep;24(9):2476-88 – reference: 22312444 - PLoS One. 2012;7(2):e31302
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Snippet	The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer’s disease (AD).... The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer's disease (AD)....
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SubjectTerms	38 631/378/1689/1283 631/378/2596/1308 82/80 Aging Alzheimer's disease Aquaporin 4 Autopsy Correlation analysis Cysts Dementia Dementia disorders Dystrobrevin Dystroglycan Human subjects Humanities and Social Sciences Leukoencephalopathy Localization multidisciplinary Neurofibrillary tangles Pathology Plaques Protein folding Protein interaction Science Science (multidisciplinary) Tau protein Temporal lobe Transcription
Title	Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology
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