CHK1 inhibition exacerbates replication stress induced by IGF blockade

We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. Aimin...

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Bibliographic Details
Published in:	Oncogene Vol. 41; no. 4; pp. 476 - 488
Main Authors:	Wu, Xiaoning, Seraia, Elena, Hatch, Stephanie B., Wan, Xiao, Ebner, Daniel V., Aroldi, Francesca, Jiang, Yanyan, Ryan, Anderson J., Bogenrieder, Thomas, Weyer-Czernilofsky, Ulrike, Rieunier, Guillaume, Macaulay, Valentine M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.01.2022 Nature Publishing Group
Subjects:	13/31 14 14/19 631/1647/2163 631/67/1059/602 96/1 96/106 96/109 96/47 96/98 Apoptosis Breast cancer Cell Biology Cell culture Cell death Cell Line, Tumor Cell survival Cell viability Checkpoint Kinase 1 - antagonists & inhibitors CHK1 protein DNA biosynthesis Enzyme inhibitors High-Throughput Screening Assays - methods Human Genetics Humans Insulin Insulin-like growth factors Internal Medicine Lethality Medicine Medicine & Public Health Oncology Phenotypes Receptor, IGF Type 1 - metabolism Replication Single-stranded DNA Transfection Tumor cell lines Tumors
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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