Inflammatory mediators of proliferative vitreoretinopathy: hypothesis and review

Purpose To review the role of inflammatory mediators in proliferative vitreoretinopathy (PVR) development and the current treatment for PVR prevention. Methods A PubMed search was carried out using these keywords “PVR,” “inflammatory mediators,” “growth factors,” “cytokines” and “treatment.” Studies...

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Bibliographic Details
Published in:International ophthalmology Vol. 40; no. 6; pp. 1587 - 1601
Main Authors: Dai, Ying, Dai, Chenghua, Sun, Tao
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01.06.2020
Springer Nature B.V
Subjects:
Biomarkers - metabolism
Cytokines
Growth factors
Humans
Hypotheses
Inflammation
Inflammation Mediators - metabolism
Interleukin 6
Interleukin 8
Interleukins
Medicine
Medicine & Public Health
Ophthalmology
Platelet-derived growth factor
Prevention
Review
Reviews
Therapeutic applications
Transforming growth factor-b
Tumor necrosis factor-α
Vitreoretinopathy, Proliferative - metabolism
Vitreous Body - metabolism
Proliferative vitreoretinopathy (PVR)
Treatment
Inflammatory mediators
Cytokines
Growth factors
ISSN:0165-5701, 1573-2630, 1573-2630
Online Access:Get full text
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Summary:Purpose To review the role of inflammatory mediators in proliferative vitreoretinopathy (PVR) development and the current treatment for PVR prevention. Methods A PubMed search was carried out using these keywords “PVR,” “inflammatory mediators,” “growth factors,” “cytokines” and “treatment.” Studies regarding inflammatory mediators and PVR therapy were included and published up to December 2019. Results Inflammatory mediators, namely growth factors and cytokines, have been implicated in the occurrence and development of PVR. Among various inflammatory mediators, transforming growth factor-β, platelet-derived growth factor, interleukin-6, interleukin-8 and tumor necrosis factor-α are considered to be particularly important. In this review, we focus on the hypothesis that growth factors and cytokines are involved in the development of PVR, and current treatment for the prevention of PVR. Conclusion We support the hypothesis that growth factors and cytokines may participate in the complex process of PVR development. More importantly, the identification of inflammatory mediators provides novel and efficacious therapeutic targets for the treatment of PVR.
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ISSN:0165-5701
1573-2630
1573-2630
DOI:10.1007/s10792-020-01325-4