Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study

Aberrant alternative splicing (AS) has been highly involved in the tumorigenesis and progression of most cancers. The potential role of AS in invasive breast cancer (IBC) remains largely unknown. In this study, RNA sequencing of IBC samples from The Cancer Genome Atlas was acquired. AS events were s...

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Veröffentlicht in:	Scientific reports Jg. 10; H. 1; S. 16504
Hauptverfasser:	Wang, Linbang, Wang, Yuanyuan, Su, Bao, Yu, Ping, He, Junfeng, Meng, Lei, Xiao, Qi, Sun, Jinhui, Zhou, Kai, Xue, Yuzhou, Tan, Jinxiang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 05.10.2020 Nature Publishing Group
Schlagworte:	631/114 631/67 692/4017 692/4028 692/499 692/53 Alternative splicing Alternative Splicing - genetics Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Chemotherapy China DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Epoxide Hydrolases - genetics Epoxide Hydrolases - metabolism Female Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Gene Regulatory Networks Genomes Humanities and Social Sciences Humans Invasiveness Kaplan-Meier Estimate Mastectomy Medical prognosis multidisciplinary Patients Polymerase chain reaction Prognosis Reverse transcription Ribonucleic acid RNA RNA Splicing Factors - metabolism RNA, Messenger - genetics Science Science (multidisciplinary) Sequence Analysis, RNA Splicing factors Transcriptome - genetics Tumorigenesis Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism China
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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