Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis
Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndro...
Uloženo v:
| Vydáno v: | Haematologica (Roma) Ročník 99; číslo 8; s. 1292 - 1303 |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Italy
Ferrata Storti Foundation
01.08.2014
|
| Témata: | |
| ISSN: | 0390-6078, 1592-8721, 1592-8721 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndrome. Harnessing the therapeutic potential of histone deacetylase inhibitors requires full knowledge of individual histone deacetylases in vivo. As hematologic malignancies show increased sensitivity towards histone deacetylase inhibitors we targeted deletion of class I Hdac1 and Hdac2 to hematopoietic cell lineages. Here, we show that Hdac1 and Hdac2 together control hematopoietic stem cell homeostasis, in a cell-autonomous fashion. Simultaneous loss of Hdac1 and Hdac2 resulted in loss of hematopoietic stem cells and consequently bone marrow failure. Bone-marrow-specific deletion of Sin3a, a major Hdac1/2 co-repressor, phenocopied loss of Hdac1 and Hdac2 indicating that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis. Although Hdac1 and Hdac2 show compensatory and overlapping functions in hematopoiesis, mice expressing mono-allelic Hdac1 or Hdac2 revealed that Hdac1 and Hdac2 contribute differently to the development of specific hematopoietic lineages. |
|---|---|
| AbstractList | Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndrome. Harnessing the therapeutic potential of histone deacetylase inhibitors requires full knowledge of individual histone deacetylases in vivo. As hematologic malignancies show increased sensitivity towards histone deacetylase inhibitors we targeted deletion of class I Hdac1 and Hdac2 to hematopoietic cell lineages. Here, we show that Hdac1 and Hdac2 together control hematopoietic stem cell homeostasis, in a cell-autonomous fashion. Simultaneous loss of Hdac1 and Hdac2 resulted in loss of hematopoietic stem cells and consequently bone marrow failure. Bone-marrow-specific deletion of Sin3a, a major Hdac1/2 co-repressor, phenocopied loss of Hdac1 and Hdac2 indicating that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis. Although Hdac1 and Hdac2 show compensatory and overlapping functions in hematopoiesis, mice expressing mono-allelic Hdac1 or Hdac2 revealed that Hdac1 and Hdac2 contribute differently to the development of specific hematopoietic lineages. Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndrome. Harnessing the therapeutic potential of histone deacetylase inhibitors requires full knowledge of individual histone deacetylases in vivo. As hematologic malignancies show increased sensitivity towards histone deacetylase inhibitors we targeted deletion of class I Hdac1 and Hdac2 to hematopoietic cell lineages. Here, we show that Hdac1 and Hdac2 together control hematopoietic stem cell homeostasis, in a cell-autonomous fashion. Simultaneous loss of Hdac1 and Hdac2 resulted in loss of hematopoietic stem cells and consequently bone marrow failure. Bone-marrow-specific deletion of Sin3a, a major Hdac1/2 co-repressor, phenocopied loss of Hdac1 and Hdac2 indicating that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis. Although Hdac1 and Hdac2 show compensatory and overlapping functions in hematopoiesis, mice expressing mono-allelic Hdac1 or Hdac2 revealed that Hdac1 and Hdac2 contribute differently to the development of specific hematopoietic lineages.Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndrome. Harnessing the therapeutic potential of histone deacetylase inhibitors requires full knowledge of individual histone deacetylases in vivo. As hematologic malignancies show increased sensitivity towards histone deacetylase inhibitors we targeted deletion of class I Hdac1 and Hdac2 to hematopoietic cell lineages. Here, we show that Hdac1 and Hdac2 together control hematopoietic stem cell homeostasis, in a cell-autonomous fashion. Simultaneous loss of Hdac1 and Hdac2 resulted in loss of hematopoietic stem cells and consequently bone marrow failure. Bone-marrow-specific deletion of Sin3a, a major Hdac1/2 co-repressor, phenocopied loss of Hdac1 and Hdac2 indicating that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis. Although Hdac1 and Hdac2 show compensatory and overlapping functions in hematopoiesis, mice expressing mono-allelic Hdac1 or Hdac2 revealed that Hdac1 and Hdac2 contribute differently to the development of specific hematopoietic lineages. |
| Author | Proost, N. Dannenberg, J.-H. Jacobs, H. Yanover, E. Heideman, M. R. Lancini, C. |
| AuthorAffiliation | 2 Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, the Netherlands 3 Division of Biological Stress Response, Netherlands Cancer Institute, Amsterdam, the Netherlands 1 Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, the Netherlands |
| AuthorAffiliation_xml | – name: 1 Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, the Netherlands – name: 2 Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, the Netherlands – name: 3 Division of Biological Stress Response, Netherlands Cancer Institute, Amsterdam, the Netherlands |
| Author_xml | – sequence: 1 givenname: M. R. surname: Heideman fullname: Heideman, M. R. – sequence: 2 givenname: C. surname: Lancini fullname: Lancini, C. – sequence: 3 givenname: N. surname: Proost fullname: Proost, N. – sequence: 4 givenname: E. surname: Yanover fullname: Yanover, E. – sequence: 5 givenname: H. surname: Jacobs fullname: Jacobs, H. – sequence: 6 givenname: J.-H. surname: Dannenberg fullname: Dannenberg, J.-H. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24763403$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1u1DAUhS1URKeFN0DISzaZ-jdOWCChCmilSiyAtXVj33RcJfFge5D6ALw3mUmnalmwsmXf8x1f33NGTqY4ISFvOVtLKdTFBnCEEoe1YFyuWStqJV-QFdetqBoj-AlZMdmyqmamOSVnOd8xJljbmlfkVChTS8Xkivz5HiYJFeQcXYCCnl55cJzCtOwEhYQUc8apBBhoHxPdHIy3MWAJjuaCI3U4DHQTR4y5QA75oHdxKil0u4LUh77HtDCGe1riE8hc_pq87GHI-OZhPSc_v3z-cXlV3Xz7en356aZyyqhS1Z2rTcN0I4RqGDM1euZY543SIFXXeS81CHTaCek7bJhrW6-NUKIVPedcnpPrhesj3NltCiOkexsh2MNBTLcW0tzUgNZzzxvFus55oRBZp3tfewe17nWvTDuzPi6s7a4b0bu5uQTDM-jzmyls7G38bRXndSPMDHj_AEjx1w5zsWPI-4-ECeMuW641Z7zlav_ud0-9Hk2Oc5wLPiwFLsWcE_bWhQIl7CcAYbCc2X1o7DE0dh8au4RmFqt_xEf-f2V_ATuCy84 |
| CitedBy_id | crossref_primary_10_1002_gepi_22217 crossref_primary_10_3389_fcell_2021_688128 crossref_primary_10_3390_ijms23179790 crossref_primary_10_1016_j_stem_2015_05_009 crossref_primary_10_3389_fmolb_2023_1273046 crossref_primary_10_1111_jcmm_17559 crossref_primary_10_1080_15548627_2023_2274251 crossref_primary_10_1186_s13072_018_0188_y crossref_primary_10_1186_s12943_019_1127_7 crossref_primary_10_1038_ncomms6406 crossref_primary_10_3389_fnmol_2021_782375 crossref_primary_10_1007_s00018_019_03199_x crossref_primary_10_1371_journal_pone_0153767 crossref_primary_10_1182_blood_2016_06_721746 crossref_primary_10_1016_j_molimm_2019_08_003 crossref_primary_10_1038_s41392_021_00646_9 crossref_primary_10_1182_blood_2016_11_750521 crossref_primary_10_1007_s12185_016_2075_2 crossref_primary_10_1093_nar_gkz195 crossref_primary_10_3390_ijms21228460 crossref_primary_10_1016_j_bbrc_2023_09_023 crossref_primary_10_1038_cti_2015_46 crossref_primary_10_1016_j_csbj_2022_09_008 crossref_primary_10_1097_BS9_0000000000000018 crossref_primary_10_1007_s13346_024_01647_1 crossref_primary_10_3390_epigenomes7040032 crossref_primary_10_1158_2159_8290_CD_20_0336 crossref_primary_10_1097_MOH_0000000000000579 crossref_primary_10_1042_BCJ20170314 crossref_primary_10_15252_embj_2022112348 crossref_primary_10_1002_pd_4862 crossref_primary_10_1080_07853890_2025_2490824 crossref_primary_10_1242_dev_149708 crossref_primary_10_1016_j_intimp_2021_108114 crossref_primary_10_1016_j_semcdb_2019_04_015 crossref_primary_10_1182_blood_2017_03_771386 crossref_primary_10_1038_nrm_2016_76 crossref_primary_10_15252_embr_202255326 crossref_primary_10_1093_nar_gkaf650 |
| ContentType | Journal Article |
| Copyright | Copyright© Ferrata Storti Foundation. Copyright© Ferrata Storti Foundation 2014 |
| Copyright_xml | – notice: Copyright© Ferrata Storti Foundation. – notice: Copyright© Ferrata Storti Foundation 2014 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA |
| DOI | 10.3324/haematol.2013.092643 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1592-8721 |
| EndPage | 1303 |
| ExternalDocumentID | oai_doaj_org_article_d1d1840bbcd24ee0b5fd6dca65f5f479 PMC4116827 24763403 10_3324_haematol_2013_092643 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- 29I 2WC 53G 5GY 5RE 5VS AAFWJ AAYXX ADBBV AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV BTFSW CITATION CS3 DIK E3Z EBS EJD F5P FRP GROUPED_DOAJ H13 HYE KQ8 OK1 OVT P2P RHI RNS RPM SJN TFS TR2 W8F WOQ WOW C1A CGR CUY CVF ECM EIF NPM UDS 7X8 5PM |
| ID | FETCH-LOGICAL-c474t-6bc67805822480076ed0c0bd745a34bbdd35a2ec5c23dbe80c99d5724292f1113 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 52 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000342834300012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0390-6078 1592-8721 |
| IngestDate | Fri Oct 03 12:43:57 EDT 2025 Tue Sep 30 16:48:32 EDT 2025 Fri Jul 11 15:27:11 EDT 2025 Mon Jul 21 06:00:43 EDT 2025 Sat Nov 29 06:32:36 EST 2025 Tue Nov 18 22:08:51 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | Copyright© Ferrata Storti Foundation. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-6bc67805822480076ed0c0bd745a34bbdd35a2ec5c23dbe80c99d5724292f1113 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/d1d1840bbcd24ee0b5fd6dca65f5f479 |
| PMID | 24763403 |
| PQID | 1551019141 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_d1d1840bbcd24ee0b5fd6dca65f5f479 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4116827 proquest_miscellaneous_1551019141 pubmed_primary_24763403 crossref_citationtrail_10_3324_haematol_2013_092643 crossref_primary_10_3324_haematol_2013_092643 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-08-01 2014-Aug 20140801 |
| PublicationDateYYYYMMDD | 2014-08-01 |
| PublicationDate_xml | – month: 08 year: 2014 text: 2014-08-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Italy |
| PublicationPlace_xml | – name: Italy |
| PublicationTitle | Haematologica (Roma) |
| PublicationTitleAlternate | Haematologica |
| PublicationYear | 2014 |
| Publisher | Ferrata Storti Foundation |
| Publisher_xml | – name: Ferrata Storti Foundation |
| References | 19801979 - Nat Genet. 2009 Nov;41(11):1207-15 10724173 - Nature. 2000 Mar 9;404(6774):193-7 23327920 - Blood. 2013 Mar 14;121(11):2038-50 21045206 - Sci Signal. 2010;3(146):ra80 16940357 - Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13789-94 19698979 - Cell. 2009 Sep 4;138(5):1019-31 16055712 - Mol Cell Biol. 2005 Aug;25(16):6990-7004 22156375 - Nucleic Acids Res. 2012 Apr;40(7):2925-39 22286122 - Cell Mol Life Sci. 2012 Jul;69(13):2173-87 11602581 - J Biol Chem. 2001 Dec 14;276(50):47733-41 16633340 - Nature. 2006 May 25;441(7092):518-22 15050820 - J Mol Biol. 2004 Apr 16;338(1):17-31 7660125 - Science. 1995 Sep 8;269(5229):1427-9 16598206 - Nature. 2006 May 25;441(7092):475-82 18451107 - Genes Dev. 2008 May 1;22(9):1174-89 24140890 - Gene Expr Patterns. 2014 Jan;14(1):19-29 18585351 - Cell. 2008 Jun 27;133(7):1162-74 21258344 - Nat Biotechnol. 2011 Mar;29(3):255-65 19424149 - Nature. 2009 May 7;459(7243):55-60 23014989 - J Biol Chem. 2012 Nov 23;287(48):40279-91 23223453 - Science. 2013 Jan 11;339(6116):211-4 23287868 - Blood. 2013 Feb 21;121(8):1335-44 17707228 - Mol Cell. 2007 Aug 17;27(4):562-72 18568017 - Nat Biotechnol. 2008 Jul;26(7):795-7 22206758 - Dev Biol. 2012 Mar 1;363(1):62-73 21545841 - Neurobiol Learn Mem. 2011 Jul;96(1):41-52 22901256 - Ann N Y Acad Sci. 2012 Aug;1266:55-62 20572009 - Stem Cells. 2010 Aug;28(8):1424-34 22230954 - Nature. 2012 Jan 19;481(7381):335-40 20362541 - Cell Stem Cell. 2010 Apr 2;6(4):369-81 18292778 - Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18 12702876 - Science. 2003 Apr 18;300(5618):489-92 19139101 - J Biol Chem. 2009 Mar 13;284(11):6998-7006 20194438 - Genes Dev. 2010 Mar 1;24(5):455-69 23043573 - J Med Imaging Radiat Oncol. 2012 Oct;56(5):538-44 19729656 - Science. 2009 Sep 4;325(5945):1254-7 11960997 - J Biol Chem. 2002 Jun 28;277(26):23658-63 21660052 - Nat Rev Immunol. 2011 Jul;11(7):478-88 23516383 - PLoS Genet. 2013;9(3):e1003377 15998811 - Genes Dev. 2005 Jul 1;19(13):1581-95 17211407 - Nat Biotechnol. 2007 Jan;25(1):84-90 22699452 - Leukemia. 2012 Sep;26(9):2039-51 22837004 - Nature. 2012 Jul 26;487(7408):482-5 19047631 - Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19183-7 22822071 - J Biol Chem. 2012 Sep 14;287(38):32006-16 18454139 - Nat Cell Biol. 2008 Jun;10(6):731-9 19608861 - Science. 2009 Aug 14;325(5942):834-40 9692885 - Eur J Immunol. 1998 Jul;28(7):2159-66 23085237 - Dev Biol. 2013 Jan 1;373(1):83-94 10615135 - Nat Genet. 2000 Jan;24(1):88-91 16762839 - Mol Cell. 2006 Jun 9;22(5):669-79 22735594 - FEBS Lett. 2012 Jul 30;586(16):2300-5 20571512 - EMBO J. 2010 Aug 4;29(15):2586-97 21241896 - Cell. 2011 Jan 21;144(2):296-309 |
| References_xml | – reference: 22230954 - Nature. 2012 Jan 19;481(7381):335-40 – reference: 23085237 - Dev Biol. 2013 Jan 1;373(1):83-94 – reference: 12702876 - Science. 2003 Apr 18;300(5618):489-92 – reference: 23327920 - Blood. 2013 Mar 14;121(11):2038-50 – reference: 17211407 - Nat Biotechnol. 2007 Jan;25(1):84-90 – reference: 18585351 - Cell. 2008 Jun 27;133(7):1162-74 – reference: 19729656 - Science. 2009 Sep 4;325(5945):1254-7 – reference: 21045206 - Sci Signal. 2010;3(146):ra80 – reference: 23043573 - J Med Imaging Radiat Oncol. 2012 Oct;56(5):538-44 – reference: 11602581 - J Biol Chem. 2001 Dec 14;276(50):47733-41 – reference: 21545841 - Neurobiol Learn Mem. 2011 Jul;96(1):41-52 – reference: 18451107 - Genes Dev. 2008 May 1;22(9):1174-89 – reference: 7660125 - Science. 1995 Sep 8;269(5229):1427-9 – reference: 16598206 - Nature. 2006 May 25;441(7092):475-82 – reference: 10724173 - Nature. 2000 Mar 9;404(6774):193-7 – reference: 19608861 - Science. 2009 Aug 14;325(5942):834-40 – reference: 19139101 - J Biol Chem. 2009 Mar 13;284(11):6998-7006 – reference: 19047631 - Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19183-7 – reference: 22837004 - Nature. 2012 Jul 26;487(7408):482-5 – reference: 23516383 - PLoS Genet. 2013;9(3):e1003377 – reference: 18292778 - Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18 – reference: 15998811 - Genes Dev. 2005 Jul 1;19(13):1581-95 – reference: 20571512 - EMBO J. 2010 Aug 4;29(15):2586-97 – reference: 16055712 - Mol Cell Biol. 2005 Aug;25(16):6990-7004 – reference: 22822071 - J Biol Chem. 2012 Sep 14;287(38):32006-16 – reference: 23287868 - Blood. 2013 Feb 21;121(8):1335-44 – reference: 18454139 - Nat Cell Biol. 2008 Jun;10(6):731-9 – reference: 21258344 - Nat Biotechnol. 2011 Mar;29(3):255-65 – reference: 16762839 - Mol Cell. 2006 Jun 9;22(5):669-79 – reference: 20572009 - Stem Cells. 2010 Aug;28(8):1424-34 – reference: 23014989 - J Biol Chem. 2012 Nov 23;287(48):40279-91 – reference: 19424149 - Nature. 2009 May 7;459(7243):55-60 – reference: 20362541 - Cell Stem Cell. 2010 Apr 2;6(4):369-81 – reference: 22206758 - Dev Biol. 2012 Mar 1;363(1):62-73 – reference: 17707228 - Mol Cell. 2007 Aug 17;27(4):562-72 – reference: 16940357 - Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13789-94 – reference: 11960997 - J Biol Chem. 2002 Jun 28;277(26):23658-63 – reference: 21660052 - Nat Rev Immunol. 2011 Jul;11(7):478-88 – reference: 22735594 - FEBS Lett. 2012 Jul 30;586(16):2300-5 – reference: 19698979 - Cell. 2009 Sep 4;138(5):1019-31 – reference: 22699452 - Leukemia. 2012 Sep;26(9):2039-51 – reference: 22156375 - Nucleic Acids Res. 2012 Apr;40(7):2925-39 – reference: 23223453 - Science. 2013 Jan 11;339(6116):211-4 – reference: 9692885 - Eur J Immunol. 1998 Jul;28(7):2159-66 – reference: 18568017 - Nat Biotechnol. 2008 Jul;26(7):795-7 – reference: 22286122 - Cell Mol Life Sci. 2012 Jul;69(13):2173-87 – reference: 20194438 - Genes Dev. 2010 Mar 1;24(5):455-69 – reference: 15050820 - J Mol Biol. 2004 Apr 16;338(1):17-31 – reference: 19801979 - Nat Genet. 2009 Nov;41(11):1207-15 – reference: 10615135 - Nat Genet. 2000 Jan;24(1):88-91 – reference: 22901256 - Ann N Y Acad Sci. 2012 Aug;1266:55-62 – reference: 24140890 - Gene Expr Patterns. 2014 Jan;14(1):19-29 – reference: 21241896 - Cell. 2011 Jan 21;144(2):296-309 – reference: 16633340 - Nature. 2006 May 25;441(7092):518-22 |
| SSID | ssj0020997 |
| Score | 2.347116 |
| Snippet | Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1292 |
| SubjectTerms | Animals Bone Marrow Cells - physiology Cell Lineage - physiology Hematopoiesis - physiology Hematopoietic Stem Cells - metabolism Histone Deacetylase 1 - deficiency Histone Deacetylase 2 - deficiency Homeostasis - physiology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Repressor Proteins - deficiency |
| Title | Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24763403 https://www.proquest.com/docview/1551019141 https://pubmed.ncbi.nlm.nih.gov/PMC4116827 https://doaj.org/article/d1d1840bbcd24ee0b5fd6dca65f5f479 |
| Volume | 99 |
| WOSCitedRecordID | wos000342834300012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1592-8721 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0020997 issn: 0390-6078 databaseCode: DOA dateStart: 19940101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWgQogLghbo8lEZCXEzTRwndo4FUfUAFRIg7c3yV7SRtk61u0XqD-B_M2Mnq12E1Au3KHEcxzOO38Tj9wh5x6WD6NgI5qSRDL6SJWsraxkUbrrAPVcmWfqLvLxU83n7bUfqC3PCMj1w7rhTX3oMQqx1nosQClt3vvFQU93VnZBp6x6gnimYGkMt3A-a1g9aCI5gFsyb5ipAD6cLg2SoAy47lNWHogVEUO1NSom7_1-A8--8yZ2J6PwJeTwiSHqWW_6U3AvxkBydRXja1S19T1NOZ_pZfkgefh2Xzo_I7-99rAwzozmCpxfeuJKamI84NatAkUk8wqBfUgCzNBG6DtdDjzsdKVI-U_zRTxfDVRgAVq77dbo_5bujcFagk-AK1rG8pZthpxIo_oz8PP_849MFGzUYmBNSbFhjXYOyB5hsqnDZLvjCFdZLUZtKWOt9VRseXO145W1QhWtbX0uOKlgdytg_JwdxiOGYUCtRhJ37tlRKWKlaFWpAy4AnPcASW85INRlBu5GgHHUylhoCFTSdnkyn0XQ6m25G2Pau60zQcUf5j2jfbVmk104nwOn06HT6LqebkbeTd2gYjtj1JobhZq0RgRbImQev8yJ7y_ZRXMDHXBTQBLnnR3tt2b8S-0Wi_BZl2SguX_6Pxr8ij6A_RM5ifE0ONqub8IY8cL82_Xp1Qu7LuTpJo-kPpbQmjg |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sin3a-associated+Hdac1+and+Hdac2+are+essential+for+hematopoietic+stem+cell+homeostasis+and+contribute+differentially+to+hematopoiesis&rft.jtitle=Haematologica+%28Roma%29&rft.au=Heideman%2C+Marinus+R&rft.au=Lancini%2C+Cesare&rft.au=Proost%2C+Natalie&rft.au=Yanover%2C+Eva&rft.date=2014-08-01&rft.issn=1592-8721&rft.eissn=1592-8721&rft.volume=99&rft.issue=8&rft.spage=1292&rft_id=info:doi/10.3324%2Fhaematol.2013.092643&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0390-6078&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0390-6078&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0390-6078&client=summon |