Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid, and stem cell markers driven by aberrant allele-specific deregulation of , a master transcription factor responsi...

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Vydáno v:	Cancer discovery Ročník 11; číslo 11; s. 2846
Hlavní autoři:	Montefiori, Lindsey E, Bendig, Sonja, Gu, Zhaohui, Chen, Xiaolong, Pölönen, Petri, Ma, Xiaotu, Murison, Alex, Zeng, Andy, Garcia-Prat, Laura, Dickerson, Kirsten, Iacobucci, Ilaria, Abdelhamed, Sherif, Hiltenbrand, Ryan, Mead, Paul E, Mehr, Cyrus M, Xu, Beisi, Cheng, Zhongshan, Chang, Ti-Cheng, Westover, Tamara, Ma, Jing, Stengel, Anna, Kimura, Shunsuke, Qu, Chunxu, Valentine, Marcus B, Rashkovan, Marissa, Luger, Selina, Litzow, Mark R, Rowe, Jacob M, den Boer, Monique L, Wang, Victoria, Yin, Jun, Kornblau, Steven M, Hunger, Stephen P, Loh, Mignon L, Pui, Ching-Hon, Yang, Wenjian, Crews, Kristine R, Roberts, Kathryn G, Yang, Jun J, Relling, Mary V, Evans, William E, Stock, Wendy, Paietta, Elisabeth M, Ferrando, Adolfo A, Zhang, Jinghui, Kern, Wolfgang, Haferlach, Torsten, Wu, Gang, Dick, John E, Klco, Jeffery M, Haferlach, Claudia, Mullighan, Charles G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.11.2021
Témata:	Enhancer Elements, Genetic Gene Regulatory Networks Hematopoietic Stem Cells - metabolism Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Repressor Proteins - biosynthesis Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors - genetics Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics
ISSN:	2159-8290, 2159-8290
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