Rate-limiting steps in transcription dictate sensitivity to variability in cellular components

Cell-to-cell variability in cellular components generates cell-to-cell diversity in RNA and protein production dynamics. As these components are inherited, this should also cause lineage-to-lineage variability in these dynamics. We conjectured that these effects on transcription are promoter initiat...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 10588 - 10
Main Authors:	Mäkelä, Jarno, Kandavalli, Vinodh, Ribeiro, Andre S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.09.2017 Nature Publishing Group
Subjects:	14/19 38/1 38/35 38/90 631/337/572/2102 631/553/2707 Cell division E coli Gene expression Humanities and Social Sciences Kinetics multidisciplinary Noise Nucleotide sequence Promoters Proteins Ribonucleic acid RNA RNA polymerase Science Science (multidisciplinary) Stochastic models Transcription factors Transcription initiation Variability
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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