CGRP and migraine: from bench to bedside
Migraine treatment has reached a new era with the development of drugs that target the trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. The CGRP related therapies offer considerable improvements over existing drugs as they are the first to be designed to act on the tri...
Uloženo v:
| Vydáno v: | Revue neurologique Ročník 177; číslo 7; s. 785 - 790 |
|---|---|
| Hlavní autor: | |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
France
Elsevier Masson SAS
01.09.2021
|
| Témata: | |
| ISSN: | 0035-3787 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Migraine treatment has reached a new era with the development of drugs that target the trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. The CGRP related therapies offer considerable improvements over existing drugs as they are the first to be designed to act on the trigeminal pain system, more specific and with few adverse events. Small molecule CGRP receptor antagonists, such as rimegepant and ubrogepant, are effective for the acute treatment of migraine headache. In contrast, monoclonal antibodies against CGRP or the CGRP receptor are beneficial for the prophylactic treatments in chronic migraine. Here I will provide a historical overview of the long path that led to their successful development. In addition, I will discuss aspects on the biology of CGRP signalling, the role of CGRP in migraine headache, the efficacy of CGRP targeted treatment, and synthesize what currently is known about the role of CGRP in the trigeminovascular system. |
|---|---|
| AbstractList | Migraine treatment has reached a new era with the development of drugs that target the trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. The CGRP related therapies offer considerable improvements over existing drugs as they are the first to be designed to act on the trigeminal pain system, more specific and with few adverse events. Small molecule CGRP receptor antagonists, such as rimegepant and ubrogepant, are effective for the acute treatment of migraine headache. In contrast, monoclonal antibodies against CGRP or the CGRP receptor are beneficial for the prophylactic treatments in chronic migraine. Here I will provide a historical overview of the long path that led to their successful development. In addition, I will discuss aspects on the biology of CGRP signalling, the role of CGRP in migraine headache, the efficacy of CGRP targeted treatment, and synthesize what currently is known about the role of CGRP in the trigeminovascular system. Migraine treatment has reached a new era with the development of drugs that target the trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. The CGRP related therapies offer considerable improvements over existing drugs as they are the first to be designed to act on the trigeminal pain system, more specific and with few adverse events. Small molecule CGRP receptor antagonists, such as rimegepant and ubrogepant, are effective for the acute treatment of migraine headache. In contrast, monoclonal antibodies against CGRP or the CGRP receptor are beneficial for the prophylactic treatments in chronic migraine. Here I will provide a historical overview of the long path that led to their successful development. In addition, I will discuss aspects on the biology of CGRP signalling, the role of CGRP in migraine headache, the efficacy of CGRP targeted treatment, and synthesize what currently is known about the role of CGRP in the trigeminovascular system.Migraine treatment has reached a new era with the development of drugs that target the trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. The CGRP related therapies offer considerable improvements over existing drugs as they are the first to be designed to act on the trigeminal pain system, more specific and with few adverse events. Small molecule CGRP receptor antagonists, such as rimegepant and ubrogepant, are effective for the acute treatment of migraine headache. In contrast, monoclonal antibodies against CGRP or the CGRP receptor are beneficial for the prophylactic treatments in chronic migraine. Here I will provide a historical overview of the long path that led to their successful development. In addition, I will discuss aspects on the biology of CGRP signalling, the role of CGRP in migraine headache, the efficacy of CGRP targeted treatment, and synthesize what currently is known about the role of CGRP in the trigeminovascular system. |
| Author | Edvinsson, L. |
| Author_xml | – sequence: 1 givenname: L. surname: Edvinsson fullname: Edvinsson, L. email: lars.edvinsson@med.lu.se organization: Department of Medicine, University Hospital, 22185 Lund, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34275653$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkE1LwzAYgHOYuDn9ByI97rKaz6bdQZChUxgooueQJplmtMlMWsF_b0anBw96SQJ5nhfe5wSMnHcGgHMEcwRRcbnNnemDb3IMMcphkUNIRmCSTjYnvORjcBLjFqZPDskxGBOKOSsYmYDZcvX0mEmns9a-BmmdWWSb4NusNk69ZZ1PDx2tNqfgaCObaM4O9xS83N48L-_m64fV_fJ6PVeU025eIMpKpnRdJw9izeoSYlloXCEKIS-YqUqpKlITomFRVxVjlSpLjWhZEQlrMgWzYe4u-PfexE60NirTNNIZ30eBGccY0YrwhF4c0L5ujRa7YFsZPsX3dgmgA6CCjzGYzQ-CoNiHE1sxhBP7cAIWIiVL2uKXpmwnO-tdlwo1_8lXg2xSpA9rgojKppZG22BUJ7S3fw_4Ajt_inQ |
| CitedBy_id | crossref_primary_10_1186_s10194_021_01383_8 crossref_primary_10_1016_j_jtcme_2024_04_011 crossref_primary_10_1177_17448069241240692 crossref_primary_10_1080_14740338_2023_2251390 crossref_primary_10_1080_17581869_2025_2550923 crossref_primary_10_3390_cells11193092 crossref_primary_10_1055_a_2516_5925 crossref_primary_10_3390_antiox14030318 crossref_primary_10_1177_03331024221143538 crossref_primary_10_1111_head_15021 crossref_primary_10_1007_s11916_024_01290_y crossref_primary_10_3390_jcm11061479 crossref_primary_10_1055_a_2331_0783 crossref_primary_10_1038_s41582_022_00741_7 crossref_primary_10_1038_s43856_025_00870_2 crossref_primary_10_7759_cureus_48160 crossref_primary_10_1186_s10194_025_02050_y crossref_primary_10_1080_08923973_2023_2253988 crossref_primary_10_3390_life13030665 crossref_primary_10_1016_j_neurol_2024_09_008 crossref_primary_10_3390_diseases12020037 crossref_primary_10_1016_j_ynpai_2024_100178 crossref_primary_10_7759_cureus_39021 crossref_primary_10_3389_fneur_2024_1402569 crossref_primary_10_1111_head_14921 crossref_primary_10_1136_bmj_2025_085564 crossref_primary_10_3390_biomedicines10040877 crossref_primary_10_1371_journal_pone_0313082 crossref_primary_10_1186_s10194_025_02127_8 crossref_primary_10_1186_s10194_023_01552_x crossref_primary_10_3389_fcell_2023_1072629 crossref_primary_10_1186_s10194_024_01723_4 crossref_primary_10_17116_pain20232101173 crossref_primary_10_3390_ijms24044114 crossref_primary_10_1038_s41598_023_41521_7 crossref_primary_10_3389_fphys_2022_994469 crossref_primary_10_1080_17512433_2024_2417655 crossref_primary_10_1007_s40265_023_01927_z crossref_primary_10_1177_25158163251329568 crossref_primary_10_1007_s11916_025_01403_1 crossref_primary_10_1016_j_ejmech_2022_114898 crossref_primary_10_1016_j_atherosclerosis_2023_06_078 crossref_primary_10_1016_j_ejphar_2025_177690 crossref_primary_10_1097_MD_0000000000032442 crossref_primary_10_7759_cureus_34553 crossref_primary_10_3389_fnmol_2023_1219574 crossref_primary_10_1002_jcph_2331 crossref_primary_10_1080_14737175_2024_2332754 crossref_primary_10_1080_14740338_2024_2393268 crossref_primary_10_1186_s42269_023_01105_x crossref_primary_10_1016_j_neurol_2022_11_001 crossref_primary_10_1016_j_coph_2024_102474 crossref_primary_10_3389_fneur_2023_1205778 crossref_primary_10_1515_revneuro_2024_0045 crossref_primary_10_3389_fbioe_2023_1110604 |
| Cites_doi | 10.1016/0006-8993(83)90402-X 10.1016/0006-8993(76)90951-3 10.1113/jphysiol.1982.sp014142 10.1038/225863a0 10.1186/s10194-018-0905-8 10.1111/j.1748-1716.1982.tb07159.x 10.1016/j.nurt.2010.02.004 10.1016/0304-3959(86)90162-4 10.1016/j.ejphar.2007.04.004 10.1016/0006-8993(76)90356-5 10.1016/0304-3940(85)90296-4 10.1016/0006-8993(78)90146-4 10.1021/ja00822a041 10.1073/pnas.80.5.1472 10.1021/acsptsci.9b00083 10.1038/nrneurol.2010.127 10.1111/j.1748-1716.1981.tb06752.x 10.1056/NEJMoa1705848 10.1016/S0031-6997(25)06575-5 10.1016/0306-4522(84)90036-8 10.1177/0333102420929027 10.1113/jphysiol.1981.sp013862 10.1002/ana.25831 10.1073/pnas.83.15.5731 10.1016/S0031-6997(25)06714-6 10.1046/j.1468-2982.2001.00161.x 10.1177/0333102419896760 10.1038/s41582-018-0003-1 10.1007/BF00225604 10.1002/ana.410330109 10.1007/BF00217397 10.1042/cs0890565 10.1016/S0140-6736(10)60323-6 10.1177/0333102413517775 10.1111/j.1748-1716.1984.tb07493.x 10.1177/0333102419884943 10.1038/265084a0 10.1097/WNF.0000000000000227 10.1016/0166-2236(85)90050-5 10.1016/0165-1838(89)90109-4 10.1038/jcbfm.1987.126 10.1038/304129a0 10.1056/NEJMra1915327 10.1016/j.brainresrev.2004.09.007 10.1111/j.1748-1716.1982.tb07171.x 10.1126/science.6166046 10.1093/brain/117.3.427 10.1016/S0140-6736(19)32504-8 10.1146/annurev-physiol-030212-183717 10.1111/j.1748-1716.1981.tb06771.x 10.1002/ana.410280213 10.1212/WNL.0000000000002801 10.1152/physrev.00034.2015 10.1126/science.242075 10.1016/j.tips.2007.10.005 10.1002/ana.410210503 10.1016/S1474-4422(03)00482-4 10.1038/bjp.2008.334 10.1016/0304-3940(83)90003-4 10.1186/s10194-020-01197-0 10.1056/NEJMoa030505 10.1016/S1474-4422(15)00245-8 10.1016/0304-3940(85)90166-1 10.1046/j.1468-2982.1997.1707785.x 10.1038/sj.bjp.0703110 10.1038/jcbfm.1989.31 10.1111/head.13105 10.1177/0333102419854082 10.1016/0167-0115(86)90071-6 10.1007/s12031-020-01493-z 10.1046/j.1468-2982.1981.0104175.x 10.1016/0304-3940(83)90132-5 10.1177/0333102419867282 |
| ContentType | Journal Article |
| Copyright | 2021 The Author Copyright © 2021 The Author. Published by Elsevier Masson SAS.. All rights reserved. |
| Copyright_xml | – notice: 2021 The Author – notice: Copyright © 2021 The Author. Published by Elsevier Masson SAS.. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.neurol.2021.06.003 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EndPage | 790 |
| ExternalDocumentID | 34275653 10_1016_j_neurol_2021_06_003 S0035378721006068 |
| Genre | Journal Article Review |
| GroupedDBID | --- --M 08J 08T 0R~ 123 4.4 457 53G 5RE 6I. AACTN AADPK AAEDT AAEDW AAFTH AAFWJ AAIAV AAKOC AALRI AAOAW AAXLA AAXUO ABFNM ABIVO ABLVK ABMAC ABMZM ABYKQ ACDAQ ACRLP ADBBV AEBSH AENEX AFKWA AFTJW AFXIZ AGUBO AIEXJ AIKHN AITUG AJBFU ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BNPGV CS3 DU5 EBS EFJIC EFLBG EJD F5P FDB FIRID FYGXN HZ~ KOM O9- P2P ROL SEM SES SPCBC SSH SSN SSZ T5K ZGI ZXP ~G- AAQFI AATTM AAXKI AAYWO AAYXX ABJNI ACIEU ACLOT ACVFH ADCNI AEIPS AEUPX AFJKZ AFPUW AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c474t-614585cdbbbed02d5b802a6d291400765e98ac93b33d06b99559c88d14893a0b3 |
| ISICitedReferencesCount | 58 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000695273200009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0035-3787 |
| IngestDate | Sun Sep 28 06:50:46 EDT 2025 Mon Jul 21 05:49:54 EDT 2025 Sat Nov 29 07:27:06 EST 2025 Tue Nov 18 21:49:47 EST 2025 Fri Feb 23 02:41:16 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | CTR CLR Receptors RAMPs CGRP |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2021 The Author. Published by Elsevier Masson SAS.. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c474t-614585cdbbbed02d5b802a6d291400765e98ac93b33d06b99559c88d14893a0b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://dx.doi.org/10.1016/j.neurol.2021.06.003 |
| PMID | 34275653 |
| PQID | 2572214937 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_2572214937 pubmed_primary_34275653 crossref_primary_10_1016_j_neurol_2021_06_003 crossref_citationtrail_10_1016_j_neurol_2021_06_003 elsevier_sciencedirect_doi_10_1016_j_neurol_2021_06_003 |
| PublicationCentury | 2000 |
| PublicationDate | September 2021 2021-09-00 2021-Sep 20210901 |
| PublicationDateYYYYMMDD | 2021-09-01 |
| PublicationDate_xml | – month: 09 year: 2021 text: September 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | France |
| PublicationPlace_xml | – name: France |
| PublicationTitle | Revue neurologique |
| PublicationTitleAlternate | Rev Neurol (Paris) |
| PublicationYear | 2021 |
| Publisher | Elsevier Masson SAS |
| Publisher_xml | – name: Elsevier Masson SAS |
| References | Everitt, Hokfelt, Terenius, Tatemoto, Mutt, Goldstein (bib0455) 1984; 11 Zeller, Poulsen, Sutton, Abdiche, Collier, Chopra (bib0705) 2008; 155 Willis (bib0390) 1664 Hokfelt, Lundberg, Lagercrantz, Tatemoto, Mutt, Lindberg (bib0460) 1983; 36 McCulloch, Kelly, Uddman, Edvinsson (bib0430) 1983; 80 Edvinsson, Ekman, Jansen, Ottosson, Uddman (bib0575) 1987; 21 Doods, Arndt, Rudolf, Just (bib0635) 2007; 28 Edvinsson, Emson, McCulloch, Tatemoto, Uddman (bib0475) 1983; 43 Ohlsson, Kronvall, Stratton, Edvinsson (bib0735) 2018; 19 Edvinsson, McCulloch, Rosell, Uddman (bib0510) 1982; 116 Edvinsson, Rosendal-Helgesen, Uddman (bib0535) 1983; 234 Liu-Chen, Mayberg, Moskowitz (bib0530) 1983; 268 Uddman, Edvinsson, Jansen, Stiernholm, Jensen, Olesen (bib0585) 1986; 27 Edvinsson, McCulloch, Uddman (bib0505) 1981; 318 Jessell, Iversen, Cuello (bib0495) 1978; 152 Rosell, Olgart, Gazelius, Panopoulos, Folkers, Horig (bib0520) 1981; 111 Edvinsson, Nilsson, Jansen-Olesen (bib0675) 2007; 150 Said, Mutt (bib0425) 1970; 225 Schuster, Rapoport (bib0725) 2017; 40 Edvinsson, Emson, McCulloch, Tatemoto, Uddman (bib0480) 1984; 122 Ashina, Goadsby, Reuter, Silberstein, Dodick, Rippon (bib0745) 2019; 39 Charles, Pozo-Rosich (bib0750) 2019; 394 Garelja, Au, Brimble, Gingell, Hendrikse, Lovell (bib0760) 2020; 3 Noseda, Schain, Melo-Carrillo, Tien, Stratton, Mai (bib0710) 2020; 40 Mayberg, Langer, Zervas, Moskowitz (bib0525) 1981; 213 Pietrobon, Moskowitz (bib0540) 2013; 75 Goadsby, Edvinsson, Ekman (bib0615) 1990; 28 Hokfelt, Kellerth, Nilsson, Pernow (bib0485) 1975; 190 Lundberg, Terenius, Hokfelt, Martling, Tatemoto, Mutt (bib0465) 1982; 116 Goldstein, Offen, Klein, Phebus, Hipskind, Johnson (bib0625) 2001; 21 Edvinsson (bib0565) 1985; 8 Goadsby, Edvinsson (bib0610) 1993; 33 Goadsby, Holland, Martins-Oliveira, Hoffmann, Schankin, Akerman (bib0445) 2017; 97 Juhl, Edvinsson, Olesen, Jansen-Olesen (bib0680) 2007; 567 Rosenfeld, Mermod, Amara, Swanson, Sawchenko, Rivier (bib0550) 1983; 304 Edvinsson, Ekman, Jansen, McCulloch, Uddman (bib0570) 1987; 7 Silberstein, Winner, McAllister, Tepper, Halker, Mahmoud (bib0715) 2017; 57 Edvinsson, Owman, Sjoberg (bib0400) 1976; 115 Bodanszky, Klausner, Lin, Mutt, Said (bib0415) 1974; 96 Edvinsson, Uddman (bib0500) 1981; 1 Goldstein, Wang, Saper, Stoltz, Silberstein, Mathew (bib0630) 1997; 17 McCulloch, Uddman, Kingman, Edvinsson (bib0605) 1986; 83 Larsson, Edvinsson, Fahrenkrug, Hakanson, Owman, Schaffalitzky de Muckadell (bib0410) 1976; 113 McCulloch, Edvinsson (bib0440) 1980; 238 Edvinsson, McCulloch, Uddman (bib0435) 1982; 325 Edvinsson, Hara, Uddman (bib0595) 1989; 9 Goadsby, Reuter, Hallstrom, Broessner, Bonner, Zhang (bib0720) 2017; 377 Edvinsson, MacKenzie (bib0395) 1976; 28 Edvinsson, Haanes, Warfvinge, Krause (bib0545) 2018; 14 Edvinsson (bib0470) 1985; 8 Bigal, Dodick, Krymchantowski, VanderPluym, Tepper, Aycardi (bib0685) 2016; 87 Rubio-Beltran, Chan, Danser, MaassenVanDenBrink, Edvinsson (bib0660) 2020; 40 Bigal, Escandon, Bronson, Walter, Sudworth, Huggins (bib0695) 2014; 34 Edvinsson, Fredholm, Hamel, Jansen, Verrecchia (bib0555) 1985; 58 Uddman, Hara, Edvinsson (bib0600) 1989; 26 Ho, Edvinsson, Goadsby (bib0655) 2010; 6 Bigal, Edvinsson, Rapoport, Lipton, Spierings, Diener (bib0690) 2015; 14 Pernow (bib0490) 1983; 35 Uddman, Edvinsson, Ekblad, Hakanson, Sundler (bib0580) 1986; 15 Olesen, Diener, Husstedt, Goadsby, Hall, Meier (bib0645) 2004; 350 Edvinsson, Uddman (bib0405) 2005; 48 Ashina (bib0740) 2020; 383 Ohlsson, Haanes, Kronvall, Xu, Snellman, Edvinsson (bib0730) 2019; 39 Doods, Hallermayer, Wu, Entzeroth, Rudolf, Engel (bib0640) 2000; 129 Folkers, Horig, Rosell, Bjorkroth (bib0515) 1981; 111 Edvinsson, Linde (bib0650) 2010; 376 Edvinsson, Grell, Warfvinge (bib0755) 2020; 70 Tan, Brown, Hargreaves, Shepheard, Cook, Hill (bib0700) 1995; 89 Uddman, Edvinsson, Hara (bib0590) 1989; 256 Said, Mutt (bib0420) 1977; 265 Goadsby, Edvinsson (bib0620) 1994; 117 Warfvinge, Krause, Maddahi, Grell, Edvinsson, Haanes (bib0770) 2020; 40 Hokfelt, Bartfai, Bloom (bib0450) 2003; 2 Edvinsson, Ho (bib0670) 2010; 7 Uddman, Edvinsson, Ekman, Kingman, McCulloch (bib0560) 1985; 62 Mulder, Li, de Vries, Qin, Yanagisawa, Sugimoto (bib0665) 2020; 88 Warfvinge, Krause, Maddahi, Edvinsson, Edvinsson, Haanes (bib0765) 2020; 21 Edvinsson (10.1016/j.neurol.2021.06.003_bib0435) 1982; 325 McCulloch (10.1016/j.neurol.2021.06.003_bib0605) 1986; 83 Garelja (10.1016/j.neurol.2021.06.003_bib0760) 2020; 3 Uddman (10.1016/j.neurol.2021.06.003_bib0600) 1989; 26 Bigal (10.1016/j.neurol.2021.06.003_bib0690) 2015; 14 Edvinsson (10.1016/j.neurol.2021.06.003_bib0535) 1983; 234 Zeller (10.1016/j.neurol.2021.06.003_bib0705) 2008; 155 Edvinsson (10.1016/j.neurol.2021.06.003_bib0755) 2020; 70 Edvinsson (10.1016/j.neurol.2021.06.003_bib0475) 1983; 43 Edvinsson (10.1016/j.neurol.2021.06.003_bib0595) 1989; 9 Warfvinge (10.1016/j.neurol.2021.06.003_bib0765) 2020; 21 Hokfelt (10.1016/j.neurol.2021.06.003_bib0450) 2003; 2 Rubio-Beltran (10.1016/j.neurol.2021.06.003_bib0660) 2020; 40 Bigal (10.1016/j.neurol.2021.06.003_bib0685) 2016; 87 Charles (10.1016/j.neurol.2021.06.003_bib0750) 2019; 394 Mulder (10.1016/j.neurol.2021.06.003_bib0665) 2020; 88 Goldstein (10.1016/j.neurol.2021.06.003_bib0625) 2001; 21 Schuster (10.1016/j.neurol.2021.06.003_bib0725) 2017; 40 Ashina (10.1016/j.neurol.2021.06.003_bib0745) 2019; 39 McCulloch (10.1016/j.neurol.2021.06.003_bib0440) 1980; 238 Edvinsson (10.1016/j.neurol.2021.06.003_bib0670) 2010; 7 Uddman (10.1016/j.neurol.2021.06.003_bib0580) 1986; 15 Goadsby (10.1016/j.neurol.2021.06.003_bib0720) 2017; 377 Hokfelt (10.1016/j.neurol.2021.06.003_bib0485) 1975; 190 Tan (10.1016/j.neurol.2021.06.003_bib0700) 1995; 89 Goadsby (10.1016/j.neurol.2021.06.003_bib0445) 2017; 97 Folkers (10.1016/j.neurol.2021.06.003_bib0515) 1981; 111 Ohlsson (10.1016/j.neurol.2021.06.003_bib0730) 2019; 39 Said (10.1016/j.neurol.2021.06.003_bib0420) 1977; 265 Doods (10.1016/j.neurol.2021.06.003_bib0640) 2000; 129 Rosell (10.1016/j.neurol.2021.06.003_bib0520) 1981; 111 Doods (10.1016/j.neurol.2021.06.003_bib0635) 2007; 28 Olesen (10.1016/j.neurol.2021.06.003_bib0645) 2004; 350 Lundberg (10.1016/j.neurol.2021.06.003_bib0465) 1982; 116 Goadsby (10.1016/j.neurol.2021.06.003_bib0615) 1990; 28 Edvinsson (10.1016/j.neurol.2021.06.003_bib0500) 1981; 1 Liu-Chen (10.1016/j.neurol.2021.06.003_bib0530) 1983; 268 Willis (10.1016/j.neurol.2021.06.003_bib0390) 1664 Edvinsson (10.1016/j.neurol.2021.06.003_bib0470) 1985; 8 Ashina (10.1016/j.neurol.2021.06.003_bib0740) 2020; 383 Edvinsson (10.1016/j.neurol.2021.06.003_bib0575) 1987; 21 Mayberg (10.1016/j.neurol.2021.06.003_bib0525) 1981; 213 Edvinsson (10.1016/j.neurol.2021.06.003_bib0565) 1985; 8 Goadsby (10.1016/j.neurol.2021.06.003_bib0610) 1993; 33 Edvinsson (10.1016/j.neurol.2021.06.003_bib0650) 2010; 376 Noseda (10.1016/j.neurol.2021.06.003_bib0710) 2020; 40 Edvinsson (10.1016/j.neurol.2021.06.003_bib0510) 1982; 116 Larsson (10.1016/j.neurol.2021.06.003_bib0410) 1976; 113 Goadsby (10.1016/j.neurol.2021.06.003_bib0620) 1994; 117 Edvinsson (10.1016/j.neurol.2021.06.003_bib0505) 1981; 318 Uddman (10.1016/j.neurol.2021.06.003_bib0560) 1985; 62 Edvinsson (10.1016/j.neurol.2021.06.003_bib0545) 2018; 14 Ohlsson (10.1016/j.neurol.2021.06.003_bib0735) 2018; 19 Edvinsson (10.1016/j.neurol.2021.06.003_bib0400) 1976; 115 Edvinsson (10.1016/j.neurol.2021.06.003_bib0405) 2005; 48 Juhl (10.1016/j.neurol.2021.06.003_bib0680) 2007; 567 Pietrobon (10.1016/j.neurol.2021.06.003_bib0540) 2013; 75 Edvinsson (10.1016/j.neurol.2021.06.003_bib0555) 1985; 58 Ho (10.1016/j.neurol.2021.06.003_bib0655) 2010; 6 Uddman (10.1016/j.neurol.2021.06.003_bib0590) 1989; 256 Edvinsson (10.1016/j.neurol.2021.06.003_bib0480) 1984; 122 McCulloch (10.1016/j.neurol.2021.06.003_bib0430) 1983; 80 Jessell (10.1016/j.neurol.2021.06.003_bib0495) 1978; 152 Said (10.1016/j.neurol.2021.06.003_bib0425) 1970; 225 Everitt (10.1016/j.neurol.2021.06.003_bib0455) 1984; 11 Bodanszky (10.1016/j.neurol.2021.06.003_bib0415) 1974; 96 Edvinsson (10.1016/j.neurol.2021.06.003_bib0570) 1987; 7 Edvinsson (10.1016/j.neurol.2021.06.003_bib0675) 2007; 150 Rosenfeld (10.1016/j.neurol.2021.06.003_bib0550) 1983; 304 Goldstein (10.1016/j.neurol.2021.06.003_bib0630) 1997; 17 Edvinsson (10.1016/j.neurol.2021.06.003_bib0395) 1976; 28 Pernow (10.1016/j.neurol.2021.06.003_bib0490) 1983; 35 Hokfelt (10.1016/j.neurol.2021.06.003_bib0460) 1983; 36 Uddman (10.1016/j.neurol.2021.06.003_bib0585) 1986; 27 Silberstein (10.1016/j.neurol.2021.06.003_bib0715) 2017; 57 Bigal (10.1016/j.neurol.2021.06.003_bib0695) 2014; 34 Warfvinge (10.1016/j.neurol.2021.06.003_bib0770) 2020; 40 |
| References_xml | – volume: 2 start-page: 463 year: 2003 end-page: 472 ident: bib0450 article-title: Neuropeptides: opportunities for drug discovery publication-title: Lancet Neurol – volume: 111 start-page: 381 year: 1981 end-page: 382 ident: bib0520 article-title: Inhibition of antidromic and substance P-induced vasodilatation by a substance P antagonist publication-title: Acta Physiol Scand – volume: 304 start-page: 129 year: 1983 end-page: 135 ident: bib0550 article-title: Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing publication-title: Nature – volume: 150 start-page: 633 year: 2007 end-page: 640 ident: bib0675 article-title: Inhibitory effect of BIBN4096BS publication-title: CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery. Br J Pharmacol – volume: 117 start-page: 427 year: 1994 end-page: 434 ident: bib0620 article-title: Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies publication-title: Brain – volume: 8 start-page: 126 year: 1985 end-page: 131 ident: bib0470 article-title: Functional-role of perivascular peptides in the control of cerebral-circulation publication-title: Trends in Neurosciences – volume: 7 start-page: 720 year: 1987 end-page: 728 ident: bib0570 article-title: Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects publication-title: J Cereb Blood Flow Metab – volume: 88 start-page: 771 year: 2020 end-page: 784 ident: bib0665 article-title: Anti-migraine calcitonin gene-related peptide receptor antagonists worsen cerebral ischemic outcome in mice publication-title: Ann Neurol – volume: 28 start-page: 183 year: 1990 end-page: 187 ident: bib0615 article-title: Vasoactive peptide release in the extracerebral circulation of humans during migraine headache publication-title: Ann Neurol – volume: 28 start-page: 275 year: 1976 end-page: 348 ident: bib0395 article-title: Amine mechanisms in the cerebral circulation publication-title: Pharmacol Rev – volume: 9 start-page: 212 year: 1989 end-page: 218 ident: bib0595 article-title: Retrograde tracing of nerve fibers to the rat middle cerebral artery with true blue: colocalization with different peptides publication-title: J Cereb Blood Flow Metab – volume: 17 start-page: 785 year: 1997 end-page: 790 ident: bib0630 article-title: Ineffectiveness of neurokinin-1 antagonist in acute migraine: a crossover study publication-title: Cephalalgia – volume: 40 start-page: 1283 year: 2020 end-page: 1295 ident: bib0770 article-title: Oxytocin as a regulatory neuropeptide in the trigeminovascular system: Localization, expression and function of oxytocin and oxytocin receptors publication-title: Cephalalgia – volume: 19 start-page: 66 year: 2018 ident: bib0735 article-title: Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries publication-title: J Headache Pain – volume: 113 start-page: 400 year: 1976 end-page: 404 ident: bib0410 article-title: Immunohistochemical localization of a vasodilatory polypeptide (VIP) in cerebrovascular nerves publication-title: Brain Res – volume: 14 start-page: 1091 year: 2015 end-page: 1100 ident: bib0690 article-title: Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study publication-title: Lancet Neurol – volume: 40 start-page: 229 year: 2020 end-page: 240 ident: bib0710 article-title: Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier publication-title: Cephalalgia – volume: 70 start-page: 930 year: 2020 end-page: 944 ident: bib0755 article-title: Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion publication-title: J Mol Neurosci – volume: 80 start-page: 1472 year: 1983 end-page: 1476 ident: bib0430 article-title: Functional role for vasoactive intestinal polypeptide in the caudate nucleus: a 2-deoxy[14C]glucose investigation publication-title: Proc Natl Acad Sci U S A – volume: 11 start-page: 443 year: 1984 end-page: 462 ident: bib0455 article-title: Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat publication-title: Neuroscience – volume: 96 start-page: 4973 year: 1974 end-page: 4978 ident: bib0415 article-title: Synthesis of the vasoactive intestinal peptide (VIP) publication-title: J Am Chem Soc – volume: 21 start-page: 102 year: 2001 end-page: 106 ident: bib0625 article-title: Lanepitant, an NK-1 antagonist, in migraine prevention publication-title: Cephalalgia – volume: 129 start-page: 420 year: 2000 end-page: 423 ident: bib0640 article-title: Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist publication-title: Br J Pharmacol – volume: 75 start-page: 365 year: 2013 end-page: 391 ident: bib0540 article-title: Pathophysiology of migraine publication-title: Annu Rev Physiol – volume: 14 start-page: 338 year: 2018 end-page: 350 ident: bib0545 article-title: CGRP as the target of new migraine therapies - successful translation from bench to clinic publication-title: Nat Rev Neurol – volume: 116 start-page: 477 year: 1982 end-page: 480 ident: bib0465 article-title: Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function publication-title: Acta Physiol Scand – volume: 318 start-page: 251 year: 1981 end-page: 258 ident: bib0505 article-title: Substance P: immunohistochemical localization and effect upon cat pial arteries in vitro and in situ publication-title: J Physiol – volume: 116 start-page: 411 year: 1982 end-page: 416 ident: bib0510 article-title: Antagonism by (D-Pro2, D-Trp7,9)-substance P of the cerebrovascular dilatation induced by substance P publication-title: Acta Physiol Scand – volume: 28 start-page: 580 year: 2007 end-page: 587 ident: bib0635 article-title: CGRP antagonists: unravelling the role of CGRP in migraine publication-title: Trends Pharmacol Sci – volume: 62 start-page: 131 year: 1985 end-page: 136 ident: bib0560 article-title: Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P publication-title: Neurosci Lett – volume: 40 start-page: 169 year: 2017 end-page: 174 ident: bib0725 article-title: Calcitonin gene-related peptide-targeted therapies for migraine and cluster headache: a review publication-title: Clin Neuropharmacol – volume: 1 start-page: 175 year: 1981 end-page: 179 ident: bib0500 article-title: Adrenergic, cholinergic and peptidergic nerve fibres in dura mater - involvement in headache? publication-title: Cephalalgia – volume: 567 start-page: 117 year: 2007 end-page: 124 ident: bib0680 article-title: Effect of two novel CGRP-binding compounds in a closed cranial window rat model publication-title: Eur J Pharmacol – volume: 39 start-page: 1455 year: 2019 end-page: 1464 ident: bib0745 article-title: Long-term safety and tolerability of erenumab: Three-plus year results from a five-year open-label extension study in episodic migraine publication-title: Cephalalgia – volume: 34 start-page: 483 year: 2014 end-page: 492 ident: bib0695 article-title: Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program publication-title: Cephalalgia – volume: 213 start-page: 228 year: 1981 end-page: 230 ident: bib0525 article-title: Perivascular meningeal projections from cat trigeminal ganglia: possible pathway for vascular headaches in man publication-title: Science – volume: 383 start-page: 1866 year: 2020 end-page: 1876 ident: bib0740 article-title: Migraine publication-title: N Engl J Med – volume: 325 start-page: 161 year: 1982 end-page: 173 ident: bib0435 article-title: Feline cerebral veins and arteries: comparison of autonomic innervation and vasomotor responses publication-title: J Physiol – volume: 268 start-page: 162 year: 1983 end-page: 166 ident: bib0530 article-title: Immunohistochemical evidence for a substance P-containing trigeminovascular pathway to pial arteries in cats publication-title: Brain Res – volume: 57 start-page: 862 year: 2017 end-page: 876 ident: bib0715 article-title: Early Onset of efficacy and consistency of response across multiple migraine attacks from the randomized COMPASS study: AVP-825 Breath Powered((R)) exhalation delivery system (Sumatriptan Nasal Powder) vs oral sumatriptan publication-title: Headache – volume: 33 start-page: 48 year: 1993 end-page: 56 ident: bib0610 article-title: The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats publication-title: Ann Neurol – volume: 3 start-page: 246 year: 2020 end-page: 262 ident: bib0760 article-title: Molecular mechanisms of class B GPCR activation: insights from adrenomedullin receptors publication-title: ACS Pharmacol Transl Sci – volume: 122 start-page: 155 year: 1984 end-page: 163 ident: bib0480 article-title: Neuropeptide Y: immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ publication-title: Acta Physiol Scand – volume: 97 start-page: 553 year: 2017 end-page: 622 ident: bib0445 article-title: Pathophysiology of migraine: a disorder of sensory processing publication-title: Physiol Rev – volume: 111 start-page: 505 year: 1981 end-page: 506 ident: bib0515 article-title: Chemical design of antagonists of substance P publication-title: Acta Physiol Scand – volume: 83 start-page: 5731 year: 1986 end-page: 5735 ident: bib0605 article-title: Calcitonin gene-related peptide: functional role in cerebrovascular regulation publication-title: Proc Natl Acad Sci U S A – volume: 394 start-page: 1765 year: 2019 end-page: 1774 ident: bib0750 article-title: Targeting calcitonin gene-related peptide: a new era in migraine therapy publication-title: Lancet – volume: 21 start-page: 431 year: 1987 end-page: 437 ident: bib0575 article-title: Peptide-containing nerve fibers in human cerebral arteries: immunocytochemistry, radioimmunoassay, and in vitro pharmacology publication-title: Ann Neurol – volume: 6 start-page: 573 year: 2010 end-page: 582 ident: bib0655 article-title: CGRP and its receptors provide new insights into migraine pathophysiology publication-title: Nat Rev Neurol – volume: 190 start-page: 889 year: 1975 end-page: 890 ident: bib0485 article-title: Substance p: localization in the central nervous system and in some primary sensory neurons publication-title: Science – volume: 8 start-page: 126 year: 1985 end-page: 131 ident: bib0565 article-title: Functional role of perivascular peptides in the control of cerebral circulation publication-title: Trends in Neurosciences – volume: 377 start-page: 2123 year: 2017 end-page: 2132 ident: bib0720 article-title: A controlled trial of erenumab for episodic migraine publication-title: N Engl J Med – volume: 115 start-page: 377 year: 1976 end-page: 393 ident: bib0400 article-title: Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study publication-title: Brain Res – volume: 26 start-page: 69 year: 1989 end-page: 75 ident: bib0600 article-title: Neuronal pathways to the rat middle meningeal artery revealed by retrograde tracing and immunocytochemistry publication-title: J Auton Nerv Syst – volume: 58 start-page: 213 year: 1985 end-page: 217 ident: bib0555 article-title: Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat publication-title: Neurosci Lett – volume: 234 start-page: 1 year: 1983 end-page: 7 ident: bib0535 article-title: Substance P: localization, concentration and release in cerebral arteries, choroid plexus and dura mater publication-title: Cell Tissue Res – volume: 15 start-page: 1 year: 1986 end-page: 23 ident: bib0580 article-title: Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects publication-title: Regul Pept – volume: 350 start-page: 1104 year: 2004 end-page: 1110 ident: bib0645 article-title: Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine publication-title: N Engl J Med – volume: 7 start-page: 164 year: 2010 end-page: 175 ident: bib0670 article-title: CGRP receptor antagonism and migraine publication-title: Neurotherapeutics – volume: 87 start-page: 41 year: 2016 end-page: 48 ident: bib0685 article-title: TEV-48125 for the preventive treatment of chronic migraine: Efficacy at early time points publication-title: Neurology – volume: 48 start-page: 438 year: 2005 end-page: 456 ident: bib0405 article-title: Neurobiology in primary headaches publication-title: Brain Res Brain Res Rev – volume: 256 start-page: 559 year: 1989 end-page: 565 ident: bib0590 article-title: Axonal tracing of autonomic nerve fibers to the superficial temporal artery in the rat publication-title: Cell Tissue Res – volume: 376 start-page: 645 year: 2010 end-page: 655 ident: bib0650 article-title: New drugs in migraine treatment and prophylaxis: telcagepant and topiramate publication-title: Lancet – volume: 43 start-page: 79 year: 1983 end-page: 84 ident: bib0475 article-title: Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat publication-title: Neurosci Lett – volume: 155 start-page: 1093 year: 2008 end-page: 1103 ident: bib0705 article-title: CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat publication-title: Br J Pharmacol – volume: 27 start-page: 391 year: 1986 end-page: 399 ident: bib0585 article-title: Peptide-containing nerve fibres in human extracranial tissue: a morphological basis for neuropeptide involvement in extracranial pain? publication-title: Pain – volume: 39 start-page: 1745 year: 2019 end-page: 1752 ident: bib0730 article-title: Erenumab (AMG 334), a monoclonal antagonist antibody against the canonical CGRP receptor, does not impair vasodilatory or contractile responses to other vasoactive agents in human isolated cranial arteries publication-title: Cephalalgia – volume: 21 start-page: 131 year: 2020 ident: bib0765 article-title: Estrogen receptors alpha, beta and GPER in the CNS and trigeminal system - molecular and functional aspects publication-title: J Headache Pain – volume: 238 start-page: H449 year: 1980 end-page: H456 ident: bib0440 article-title: Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide publication-title: Am J Physiol – volume: 265 start-page: 84 year: 1977 end-page: 86 ident: bib0420 article-title: Relationship of spasmogenic and smooth muscle relaxant peptides from normal lung to other vasoactive compounds publication-title: Nature – volume: 89 start-page: 565 year: 1995 end-page: 573 ident: bib0700 article-title: Calcitonin gene-related peptide as an endogenous vasodilator: immunoblockade studies in vivo with an anti-calcitonin gene-related peptide monoclonal antibody and its Fab’ fragment publication-title: Clin Sci (Lond) – volume: 225 start-page: 863 year: 1970 end-page: 864 ident: bib0425 article-title: Potent peripheral splanchnic vasodilator peptide from normal gut publication-title: Nature – volume: 36 start-page: 217 year: 1983 end-page: 222 ident: bib0460 article-title: Occurrence of neuropeptide Y (NPY)-like immunoreactivity in catecholamine neurons in the human medulla oblongata publication-title: Neurosci Lett – volume: 40 start-page: 357 year: 2020 end-page: 366 ident: bib0660 article-title: Characterisation of the calcitonin gene-related peptide receptor antagonists ubrogepant and atogepant in human isolated coronary, cerebral and middle meningeal arteries publication-title: Cephalalgia – volume: 35 start-page: 85 year: 1983 end-page: 141 ident: bib0490 article-title: Substance P publication-title: Pharmacol Rev – volume: 152 start-page: 183 year: 1978 end-page: 188 ident: bib0495 article-title: Capsaicin-induced depletion of substance P from primary sensory neurones publication-title: Brain Res – year: 1664 ident: bib0390 article-title: Cerebri Anatome – volume: 268 start-page: 162 year: 1983 ident: 10.1016/j.neurol.2021.06.003_bib0530 article-title: Immunohistochemical evidence for a substance P-containing trigeminovascular pathway to pial arteries in cats publication-title: Brain Res doi: 10.1016/0006-8993(83)90402-X – volume: 113 start-page: 400 year: 1976 ident: 10.1016/j.neurol.2021.06.003_bib0410 article-title: Immunohistochemical localization of a vasodilatory polypeptide (VIP) in cerebrovascular nerves publication-title: Brain Res doi: 10.1016/0006-8993(76)90951-3 – volume: 325 start-page: 161 year: 1982 ident: 10.1016/j.neurol.2021.06.003_bib0435 article-title: Feline cerebral veins and arteries: comparison of autonomic innervation and vasomotor responses publication-title: J Physiol doi: 10.1113/jphysiol.1982.sp014142 – volume: 225 start-page: 863 year: 1970 ident: 10.1016/j.neurol.2021.06.003_bib0425 article-title: Potent peripheral splanchnic vasodilator peptide from normal gut publication-title: Nature doi: 10.1038/225863a0 – volume: 19 start-page: 66 year: 2018 ident: 10.1016/j.neurol.2021.06.003_bib0735 article-title: Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries publication-title: J Headache Pain doi: 10.1186/s10194-018-0905-8 – volume: 116 start-page: 411 year: 1982 ident: 10.1016/j.neurol.2021.06.003_bib0510 article-title: Antagonism by (D-Pro2, D-Trp7,9)-substance P of the cerebrovascular dilatation induced by substance P publication-title: Acta Physiol Scand doi: 10.1111/j.1748-1716.1982.tb07159.x – volume: 7 start-page: 164 year: 2010 ident: 10.1016/j.neurol.2021.06.003_bib0670 article-title: CGRP receptor antagonism and migraine publication-title: Neurotherapeutics doi: 10.1016/j.nurt.2010.02.004 – volume: 27 start-page: 391 year: 1986 ident: 10.1016/j.neurol.2021.06.003_bib0585 article-title: Peptide-containing nerve fibres in human extracranial tissue: a morphological basis for neuropeptide involvement in extracranial pain? publication-title: Pain doi: 10.1016/0304-3959(86)90162-4 – volume: 567 start-page: 117 year: 2007 ident: 10.1016/j.neurol.2021.06.003_bib0680 article-title: Effect of two novel CGRP-binding compounds in a closed cranial window rat model publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2007.04.004 – volume: 115 start-page: 377 year: 1976 ident: 10.1016/j.neurol.2021.06.003_bib0400 article-title: Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study publication-title: Brain Res doi: 10.1016/0006-8993(76)90356-5 – volume: 62 start-page: 131 year: 1985 ident: 10.1016/j.neurol.2021.06.003_bib0560 article-title: Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P publication-title: Neurosci Lett doi: 10.1016/0304-3940(85)90296-4 – volume: 152 start-page: 183 year: 1978 ident: 10.1016/j.neurol.2021.06.003_bib0495 article-title: Capsaicin-induced depletion of substance P from primary sensory neurones publication-title: Brain Res doi: 10.1016/0006-8993(78)90146-4 – volume: 96 start-page: 4973 year: 1974 ident: 10.1016/j.neurol.2021.06.003_bib0415 article-title: Synthesis of the vasoactive intestinal peptide (VIP) publication-title: J Am Chem Soc doi: 10.1021/ja00822a041 – volume: 80 start-page: 1472 year: 1983 ident: 10.1016/j.neurol.2021.06.003_bib0430 article-title: Functional role for vasoactive intestinal polypeptide in the caudate nucleus: a 2-deoxy[14C]glucose investigation publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.80.5.1472 – volume: 3 start-page: 246 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0760 article-title: Molecular mechanisms of class B GPCR activation: insights from adrenomedullin receptors publication-title: ACS Pharmacol Transl Sci doi: 10.1021/acsptsci.9b00083 – volume: 6 start-page: 573 year: 2010 ident: 10.1016/j.neurol.2021.06.003_bib0655 article-title: CGRP and its receptors provide new insights into migraine pathophysiology publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2010.127 – volume: 111 start-page: 381 year: 1981 ident: 10.1016/j.neurol.2021.06.003_bib0520 article-title: Inhibition of antidromic and substance P-induced vasodilatation by a substance P antagonist publication-title: Acta Physiol Scand doi: 10.1111/j.1748-1716.1981.tb06752.x – volume: 377 start-page: 2123 year: 2017 ident: 10.1016/j.neurol.2021.06.003_bib0720 article-title: A controlled trial of erenumab for episodic migraine publication-title: N Engl J Med doi: 10.1056/NEJMoa1705848 – volume: 35 start-page: 85 year: 1983 ident: 10.1016/j.neurol.2021.06.003_bib0490 article-title: Substance P publication-title: Pharmacol Rev doi: 10.1016/S0031-6997(25)06575-5 – volume: 11 start-page: 443 year: 1984 ident: 10.1016/j.neurol.2021.06.003_bib0455 article-title: Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat publication-title: Neuroscience doi: 10.1016/0306-4522(84)90036-8 – volume: 40 start-page: 1283 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0770 article-title: Oxytocin as a regulatory neuropeptide in the trigeminovascular system: Localization, expression and function of oxytocin and oxytocin receptors publication-title: Cephalalgia doi: 10.1177/0333102420929027 – volume: 318 start-page: 251 year: 1981 ident: 10.1016/j.neurol.2021.06.003_bib0505 article-title: Substance P: immunohistochemical localization and effect upon cat pial arteries in vitro and in situ publication-title: J Physiol doi: 10.1113/jphysiol.1981.sp013862 – volume: 88 start-page: 771 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0665 article-title: Anti-migraine calcitonin gene-related peptide receptor antagonists worsen cerebral ischemic outcome in mice publication-title: Ann Neurol doi: 10.1002/ana.25831 – volume: 83 start-page: 5731 year: 1986 ident: 10.1016/j.neurol.2021.06.003_bib0605 article-title: Calcitonin gene-related peptide: functional role in cerebrovascular regulation publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.83.15.5731 – volume: 28 start-page: 275 year: 1976 ident: 10.1016/j.neurol.2021.06.003_bib0395 article-title: Amine mechanisms in the cerebral circulation publication-title: Pharmacol Rev doi: 10.1016/S0031-6997(25)06714-6 – volume: 238 start-page: H449 year: 1980 ident: 10.1016/j.neurol.2021.06.003_bib0440 article-title: Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide publication-title: Am J Physiol – volume: 21 start-page: 102 year: 2001 ident: 10.1016/j.neurol.2021.06.003_bib0625 article-title: Lanepitant, an NK-1 antagonist, in migraine prevention publication-title: Cephalalgia doi: 10.1046/j.1468-2982.2001.00161.x – volume: 150 start-page: 633 year: 2007 ident: 10.1016/j.neurol.2021.06.003_bib0675 article-title: Inhibitory effect of BIBN4096BS publication-title: CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery. Br J Pharmacol – volume: 40 start-page: 229 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0710 article-title: Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier publication-title: Cephalalgia doi: 10.1177/0333102419896760 – volume: 14 start-page: 338 year: 2018 ident: 10.1016/j.neurol.2021.06.003_bib0545 article-title: CGRP as the target of new migraine therapies - successful translation from bench to clinic publication-title: Nat Rev Neurol doi: 10.1038/s41582-018-0003-1 – volume: 256 start-page: 559 year: 1989 ident: 10.1016/j.neurol.2021.06.003_bib0590 article-title: Axonal tracing of autonomic nerve fibers to the superficial temporal artery in the rat publication-title: Cell Tissue Res doi: 10.1007/BF00225604 – volume: 33 start-page: 48 year: 1993 ident: 10.1016/j.neurol.2021.06.003_bib0610 article-title: The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats publication-title: Ann Neurol doi: 10.1002/ana.410330109 – volume: 234 start-page: 1 year: 1983 ident: 10.1016/j.neurol.2021.06.003_bib0535 article-title: Substance P: localization, concentration and release in cerebral arteries, choroid plexus and dura mater publication-title: Cell Tissue Res doi: 10.1007/BF00217397 – volume: 89 start-page: 565 year: 1995 ident: 10.1016/j.neurol.2021.06.003_bib0700 article-title: Calcitonin gene-related peptide as an endogenous vasodilator: immunoblockade studies in vivo with an anti-calcitonin gene-related peptide monoclonal antibody and its Fab’ fragment publication-title: Clin Sci (Lond) doi: 10.1042/cs0890565 – volume: 376 start-page: 645 year: 2010 ident: 10.1016/j.neurol.2021.06.003_bib0650 article-title: New drugs in migraine treatment and prophylaxis: telcagepant and topiramate publication-title: Lancet doi: 10.1016/S0140-6736(10)60323-6 – volume: 34 start-page: 483 year: 2014 ident: 10.1016/j.neurol.2021.06.003_bib0695 article-title: Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program publication-title: Cephalalgia doi: 10.1177/0333102413517775 – volume: 122 start-page: 155 year: 1984 ident: 10.1016/j.neurol.2021.06.003_bib0480 article-title: Neuropeptide Y: immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ publication-title: Acta Physiol Scand doi: 10.1111/j.1748-1716.1984.tb07493.x – volume: 40 start-page: 357 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0660 article-title: Characterisation of the calcitonin gene-related peptide receptor antagonists ubrogepant and atogepant in human isolated coronary, cerebral and middle meningeal arteries publication-title: Cephalalgia doi: 10.1177/0333102419884943 – volume: 265 start-page: 84 year: 1977 ident: 10.1016/j.neurol.2021.06.003_bib0420 article-title: Relationship of spasmogenic and smooth muscle relaxant peptides from normal lung to other vasoactive compounds publication-title: Nature doi: 10.1038/265084a0 – volume: 40 start-page: 169 year: 2017 ident: 10.1016/j.neurol.2021.06.003_bib0725 article-title: Calcitonin gene-related peptide-targeted therapies for migraine and cluster headache: a review publication-title: Clin Neuropharmacol doi: 10.1097/WNF.0000000000000227 – volume: 8 start-page: 126 year: 1985 ident: 10.1016/j.neurol.2021.06.003_bib0565 article-title: Functional role of perivascular peptides in the control of cerebral circulation publication-title: Trends in Neurosciences doi: 10.1016/0166-2236(85)90050-5 – volume: 26 start-page: 69 year: 1989 ident: 10.1016/j.neurol.2021.06.003_bib0600 article-title: Neuronal pathways to the rat middle meningeal artery revealed by retrograde tracing and immunocytochemistry publication-title: J Auton Nerv Syst doi: 10.1016/0165-1838(89)90109-4 – volume: 7 start-page: 720 year: 1987 ident: 10.1016/j.neurol.2021.06.003_bib0570 article-title: Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.1987.126 – volume: 304 start-page: 129 year: 1983 ident: 10.1016/j.neurol.2021.06.003_bib0550 article-title: Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing publication-title: Nature doi: 10.1038/304129a0 – volume: 383 start-page: 1866 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0740 article-title: Migraine publication-title: N Engl J Med doi: 10.1056/NEJMra1915327 – volume: 48 start-page: 438 year: 2005 ident: 10.1016/j.neurol.2021.06.003_bib0405 article-title: Neurobiology in primary headaches publication-title: Brain Res Brain Res Rev doi: 10.1016/j.brainresrev.2004.09.007 – volume: 116 start-page: 477 year: 1982 ident: 10.1016/j.neurol.2021.06.003_bib0465 article-title: Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function publication-title: Acta Physiol Scand doi: 10.1111/j.1748-1716.1982.tb07171.x – volume: 213 start-page: 228 year: 1981 ident: 10.1016/j.neurol.2021.06.003_bib0525 article-title: Perivascular meningeal projections from cat trigeminal ganglia: possible pathway for vascular headaches in man publication-title: Science doi: 10.1126/science.6166046 – volume: 117 start-page: 427 issue: Pt 3 year: 1994 ident: 10.1016/j.neurol.2021.06.003_bib0620 article-title: Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies publication-title: Brain doi: 10.1093/brain/117.3.427 – volume: 394 start-page: 1765 year: 2019 ident: 10.1016/j.neurol.2021.06.003_bib0750 article-title: Targeting calcitonin gene-related peptide: a new era in migraine therapy publication-title: Lancet doi: 10.1016/S0140-6736(19)32504-8 – volume: 75 start-page: 365 year: 2013 ident: 10.1016/j.neurol.2021.06.003_bib0540 article-title: Pathophysiology of migraine publication-title: Annu Rev Physiol doi: 10.1146/annurev-physiol-030212-183717 – volume: 111 start-page: 505 year: 1981 ident: 10.1016/j.neurol.2021.06.003_bib0515 article-title: Chemical design of antagonists of substance P publication-title: Acta Physiol Scand doi: 10.1111/j.1748-1716.1981.tb06771.x – volume: 28 start-page: 183 year: 1990 ident: 10.1016/j.neurol.2021.06.003_bib0615 article-title: Vasoactive peptide release in the extracerebral circulation of humans during migraine headache publication-title: Ann Neurol doi: 10.1002/ana.410280213 – volume: 87 start-page: 41 year: 2016 ident: 10.1016/j.neurol.2021.06.003_bib0685 article-title: TEV-48125 for the preventive treatment of chronic migraine: Efficacy at early time points publication-title: Neurology doi: 10.1212/WNL.0000000000002801 – year: 1664 ident: 10.1016/j.neurol.2021.06.003_bib0390 – volume: 97 start-page: 553 year: 2017 ident: 10.1016/j.neurol.2021.06.003_bib0445 article-title: Pathophysiology of migraine: a disorder of sensory processing publication-title: Physiol Rev doi: 10.1152/physrev.00034.2015 – volume: 190 start-page: 889 year: 1975 ident: 10.1016/j.neurol.2021.06.003_bib0485 article-title: Substance p: localization in the central nervous system and in some primary sensory neurons publication-title: Science doi: 10.1126/science.242075 – volume: 28 start-page: 580 year: 2007 ident: 10.1016/j.neurol.2021.06.003_bib0635 article-title: CGRP antagonists: unravelling the role of CGRP in migraine publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2007.10.005 – volume: 21 start-page: 431 year: 1987 ident: 10.1016/j.neurol.2021.06.003_bib0575 article-title: Peptide-containing nerve fibers in human cerebral arteries: immunocytochemistry, radioimmunoassay, and in vitro pharmacology publication-title: Ann Neurol doi: 10.1002/ana.410210503 – volume: 2 start-page: 463 year: 2003 ident: 10.1016/j.neurol.2021.06.003_bib0450 article-title: Neuropeptides: opportunities for drug discovery publication-title: Lancet Neurol doi: 10.1016/S1474-4422(03)00482-4 – volume: 8 start-page: 126 year: 1985 ident: 10.1016/j.neurol.2021.06.003_bib0470 article-title: Functional-role of perivascular peptides in the control of cerebral-circulation publication-title: Trends in Neurosciences doi: 10.1016/0166-2236(85)90050-5 – volume: 155 start-page: 1093 year: 2008 ident: 10.1016/j.neurol.2021.06.003_bib0705 article-title: CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat publication-title: Br J Pharmacol doi: 10.1038/bjp.2008.334 – volume: 36 start-page: 217 year: 1983 ident: 10.1016/j.neurol.2021.06.003_bib0460 article-title: Occurrence of neuropeptide Y (NPY)-like immunoreactivity in catecholamine neurons in the human medulla oblongata publication-title: Neurosci Lett doi: 10.1016/0304-3940(83)90003-4 – volume: 21 start-page: 131 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0765 article-title: Estrogen receptors alpha, beta and GPER in the CNS and trigeminal system - molecular and functional aspects publication-title: J Headache Pain doi: 10.1186/s10194-020-01197-0 – volume: 350 start-page: 1104 year: 2004 ident: 10.1016/j.neurol.2021.06.003_bib0645 article-title: Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine publication-title: N Engl J Med doi: 10.1056/NEJMoa030505 – volume: 14 start-page: 1091 year: 2015 ident: 10.1016/j.neurol.2021.06.003_bib0690 article-title: Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study publication-title: Lancet Neurol doi: 10.1016/S1474-4422(15)00245-8 – volume: 58 start-page: 213 year: 1985 ident: 10.1016/j.neurol.2021.06.003_bib0555 article-title: Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat publication-title: Neurosci Lett doi: 10.1016/0304-3940(85)90166-1 – volume: 17 start-page: 785 year: 1997 ident: 10.1016/j.neurol.2021.06.003_bib0630 article-title: Ineffectiveness of neurokinin-1 antagonist in acute migraine: a crossover study publication-title: Cephalalgia doi: 10.1046/j.1468-2982.1997.1707785.x – volume: 129 start-page: 420 year: 2000 ident: 10.1016/j.neurol.2021.06.003_bib0640 article-title: Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0703110 – volume: 9 start-page: 212 year: 1989 ident: 10.1016/j.neurol.2021.06.003_bib0595 article-title: Retrograde tracing of nerve fibers to the rat middle cerebral artery with true blue: colocalization with different peptides publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.1989.31 – volume: 57 start-page: 862 year: 2017 ident: 10.1016/j.neurol.2021.06.003_bib0715 article-title: Early Onset of efficacy and consistency of response across multiple migraine attacks from the randomized COMPASS study: AVP-825 Breath Powered((R)) exhalation delivery system (Sumatriptan Nasal Powder) vs oral sumatriptan publication-title: Headache doi: 10.1111/head.13105 – volume: 39 start-page: 1455 year: 2019 ident: 10.1016/j.neurol.2021.06.003_bib0745 article-title: Long-term safety and tolerability of erenumab: Three-plus year results from a five-year open-label extension study in episodic migraine publication-title: Cephalalgia doi: 10.1177/0333102419854082 – volume: 15 start-page: 1 year: 1986 ident: 10.1016/j.neurol.2021.06.003_bib0580 article-title: Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects publication-title: Regul Pept doi: 10.1016/0167-0115(86)90071-6 – volume: 70 start-page: 930 year: 2020 ident: 10.1016/j.neurol.2021.06.003_bib0755 article-title: Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion publication-title: J Mol Neurosci doi: 10.1007/s12031-020-01493-z – volume: 1 start-page: 175 year: 1981 ident: 10.1016/j.neurol.2021.06.003_bib0500 article-title: Adrenergic, cholinergic and peptidergic nerve fibres in dura mater - involvement in headache? publication-title: Cephalalgia doi: 10.1046/j.1468-2982.1981.0104175.x – volume: 43 start-page: 79 year: 1983 ident: 10.1016/j.neurol.2021.06.003_bib0475 article-title: Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat publication-title: Neurosci Lett doi: 10.1016/0304-3940(83)90132-5 – volume: 39 start-page: 1745 year: 2019 ident: 10.1016/j.neurol.2021.06.003_bib0730 article-title: Erenumab (AMG 334), a monoclonal antagonist antibody against the canonical CGRP receptor, does not impair vasodilatory or contractile responses to other vasoactive agents in human isolated cranial arteries publication-title: Cephalalgia doi: 10.1177/0333102419867282 |
| SSID | ssj0021703 |
| Score | 2.4800746 |
| SecondaryResourceType | review_article |
| Snippet | Migraine treatment has reached a new era with the development of drugs that target the trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 785 |
| SubjectTerms | Calcitonin Calcitonin Gene-Related Peptide Calcitonin Gene-Related Peptide Receptor Antagonists - therapeutic use CGRP CLR CTR Humans Migraine Disorders - drug therapy RAMPs Receptors Receptors, Calcitonin Gene-Related Peptide |
| Title | CGRP and migraine: from bench to bedside |
| URI | https://dx.doi.org/10.1016/j.neurol.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34275653 https://www.proquest.com/docview/2572214937 |
| Volume | 177 |
| WOSCitedRecordID | wos000695273200009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: ScienceDirect database issn: 0035-3787 databaseCode: AIEXJ dateStart: 20040601 customDbUrl: isFulltext: true dateEnd: 99991231 titleUrlDefault: https://www.sciencedirect.com omitProxy: false ssIdentifier: ssj0021703 providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bS9xAFD5ULaUvpbWt3V4kgg8FyZJkksxM30TsjSoiCvs2zE1ZabPiXvDn98wtLhVrfehLCCGZnOTLnEvmnPMBbKPXraiqbG641XmtOcmZLVuceJIaVylJtPRkE_TwkI1G_CjSg009nQDtOnZ9zS__K9R4DMF2pbMPgLsfFA_gPoKOW4Qdt_8E_N6X4yO_JPBrfO74H3zxua8iUSimL55S1jiWzmXH9Ngu5nbHd7d02jCkYgdf2yzG3TQWZv0YLv8mqMo-D6pXfaRBbRKtW1J9kUIlYEyXFBkNRDrRJtJA6XlL3YbI_2IYpBu6-_puqAW5MS9pSf0Pq9PnAqY0swsRRhFuFOGz7cgKrFW04ait1na_7Y--96F0SQuSGm66h0pFkT5z77Y0dzkddwUV3rk4eQ7PYlSQ7QY0X8Aj263Dk4OY9_ASPjpQMwQ1S6B-yhykmYc0m02yCOkrOP28f7L3NY8cF7muaT3DyL3GgE0bpfC8ojKNYkUlW1Px0jHWt43lTOIMUoSYolXcNQzUjJnSNQ2ShSKvYbWbdPYNZKieW65rqesW3TJNlFRKNpbJxvAzVbYDIOklCB0bwDsekp_ibxAMIO-vugwNUO45n6b3K6ITF5wzgR_NPVduJTgE6ji3cCU7O5lPBZqVqsJQntABbAScellI7QgMGvL2gXK-g6c30-Q9rM6u5vYDPNaL2Xh6tQkrdMQ241f3G0JSecs |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CGRP+and+migraine%3A+from+bench+to+bedside&rft.jtitle=Revue+neurologique&rft.au=Edvinsson%2C+L.&rft.date=2021-09-01&rft.issn=0035-3787&rft.volume=177&rft.issue=7&rft.spage=785&rft.epage=790&rft_id=info:doi/10.1016%2Fj.neurol.2021.06.003&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_neurol_2021_06_003 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0035-3787&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0035-3787&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0035-3787&client=summon |