PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis

Using proteomic approaches, we uncovered a DNA damage response (DDR) function for peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA damage sensor MRE11-RAD50-NBS1 (MRN) and the E3 ubiquitin ligase UBR5. We show that PPARγ promotes ATM signaling and is essentia...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 26; no. 5; pp. 1333 - 1343.e7
Main Authors:	Li, Caiyun G., Mahon, Cathal, Sweeney, Nathaly M., Verschueren, Erik, Kantamani, Vivek, Li, Dan, Hennigs, Jan K., Marciano, David P., Diebold, Isabel, Abu-Halawa, Ossama, Elliott, Matthew, Sa, Silin, Guo, Feng, Wang, Lingli, Cao, Aiqin, Guignabert, Christophe, Sollier, Julie, Nickel, Nils P., Kaschwich, Mark, Cimprich, Karlene A., Rabinovitch, Marlene
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 29.01.2019 Elsevier
Subjects:	Ataxia Telangiectasia Mutated Proteins - metabolism ATM DNA Damage DNA Repair endothelial cells Endothelial Cells - metabolism Genomic Instability HEK293 Cells Homeostasis Humans Models, Biological MRN PPAR gamma - metabolism PPARγ Protein Binding Pulmonary Artery - pathology pulmonary hypertension Signal Transduction Transcription Factors - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination vascular biology endothelial cells DNA damage pulmonary hypertension MRN vascular biology ATM PPARγ
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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