A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells

Compelling evidence shows that cancer persister cells represent a major limit to the long-term efficacy of targeted therapies. However, the phenotype and population dynamics of cancer persister cells remain unclear. We developed a quantitative framework to study persisters by combining experimental...

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Veröffentlicht in:	Nature genetics Jg. 54; H. 7; S. 976 - 984
Hauptverfasser:	Russo, Mariangela, Pompei, Simone, Sogari, Alberto, Corigliano, Mattia, Crisafulli, Giovanni, Puliafito, Alberto, Lamba, Simona, Erriquez, Jessica, Bertotti, Andrea, Gherardi, Marco, Di Nicolantonio, Federica, Bardelli, Alberto, Cosentino Lagomarsino, Marco
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.07.2022 Nature Publishing Group
Schlagworte:	631/208 631/67/1504/1885 639/705 Agriculture Animal Genetics and Genomics Anti-Bacterial Agents - pharmacology Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell cycle Cell division Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics DNA polymerase DNA-directed DNA polymerase Drug dosages Gene Function Genotype & phenotype Human Genetics Humans Mathematical models Microscopy Mutation Mutation Rate Mutation rates Phenotypes Population Population Dynamics Tumors
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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