OPA1 drives macrophage metabolism and functional commitment via p65 signaling

Macrophages are essential players for the host response against pathogens, regulation of inflammation and tissue regeneration. The wide range of macrophage functions rely on their heterogeneity and plasticity that enable a dynamic adaptation of their responses according to the surrounding environmen...

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Vydáno v:Cell death and differentiation Ročník 30; číslo 3; s. 742 - 752
Hlavní autoři: Sánchez-Rodríguez, Ricardo, Tezze, Caterina, Agnellini, Andrielly H R, Angioni, Roberta, Venegas, Francisca C, Cioccarelli, Chiara, Munari, Fabio, Bertoldi, Nicole, Canton, Marcella, Desbats, Maria Andrea, Salviati, Leonardo, Gissi, Rosanna, Castegna, Alessandra, Soriano, Maria Eugenia, Sandri, Marco, Scorrano, Luca, Viola, Antonella, Molon, Barbara
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.03.2023
Témata:
Atrophy
Cell activation
Clonal deletion
Collagen
Cristae
Fusion protein
Immune response
Intermediates
Macrophages
Macrophages - metabolism
Metabolic pathways
Metabolic rate
Metabolism
Metabolites
Mitochondria
Mitochondria - metabolism
Mitochondrial Membranes - metabolism
Myeloid cells
NF-κB protein
Optic atrophy
Signal Transduction
Tricarboxylic acid cycle
ISSN:1350-9047, 1476-5403, 1476-5403
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Shrnutí:Macrophages are essential players for the host response against pathogens, regulation of inflammation and tissue regeneration. The wide range of macrophage functions rely on their heterogeneity and plasticity that enable a dynamic adaptation of their responses according to the surrounding environmental cues. Recent studies suggest that metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the metabolic pathways orchestrating macrophage activation are still under scrutiny. Optic atrophy 1 (OPA1) is a mitochondria-shaping protein controlling mitochondrial fusion, cristae biogenesis and respiration; clear evidence shows that the lack or dysfunctional activity of this protein triggers the accumulation of metabolic intermediates of the TCA cycle. In this study, we show that OPA1 has a crucial role in macrophage activation. Selective Opa1 deletion in myeloid cells impairs M1-macrophage commitment. Mechanistically, Opa1 deletion leads to TCA cycle metabolite accumulation and defective NF-κB signaling activation. In an in vivo model of muscle regeneration upon injury, Opa1 knockout macrophages persist within the damaged tissue, leading to excess collagen deposition and impairment in muscle regeneration. Collectively, our data indicate that OPA1 is a key metabolic driver of macrophage functions.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1350-9047
1476-5403
1476-5403
DOI:10.1038/s41418-022-01076-y